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95.81 SPEAKER195.81 -95.81 Any95.81 further96.13 discussion?96.77

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220.55 SPEAKER6220.55 -220.55 I220.55 can220.71 wait220.87 for221.11 my221.19 turn.221.35 I221.59 apologize221.75 for222.47 unmuting222.71 myself.223.19

226.04 SPEAKER1226.04 -226.04 Yeah.226.04 That's226.28 some226.53 we've226.84 seen227 a227.25 lot227.32 on227.49 this227.65 committee,227.81 but228.13 we228.21 definitely228.36 have228.76 not228.93 seen229.16 an230.21 applicant230.44 make231.56 a231.81 public231.88 comment232.28 and232.76 then233 go233.75 through233.99 third234.63 question.234.95 So235.59 maybe235.99 someday.236.39 Okay.238.63 Any239.59 okay.241.27 242.53 PARSONS242.53 -242.53 Alright.242.53 Not242.93 seeing243.25 any243.56 more,243.81 public244.53 comments.244.93 We245.49 will245.72 move246.84 on247.09 to248.61 number248.84 four.249.17 So249.49 we249.65 had249.81 a249.97 last250.04 minute250.28 addition,251.85 but252.81 I'm252.97 gonna253.05 honor253.37 the254.09 original254.57 agenda,255.13 which255.53 is,255.69 Kymera256.89 first,257.85 and258.09 then258.33 we'll258.49 go258.73 over259.05 Orna's260.4 amendment263.29 as263.85 well.264 So264.96 Kymera.266.96 So267.44 we267.61 have267.76 Michele268 and268.49 Ramya.268.73 My269.84 apologies270 if270.48 I270.64 mispronounce270.8 your271.36 name.271.52 Looks273.2 like273.52 we're273.84 ready274.16 for274.64 your275.28 vivarium276.16 at277.36 500,278.4 is278.48 that278.48 correct?278.72 279.82 MICHELE279.82 PICARD279.82 -279.82 KYMERA280.06 THERAPEUTICS280.46 -280.46 Yes,280.46 we280.46 are.280.46 281.35 I281.35 have281.43 a281.66 couple281.75 of282.87 slides.283.19 I283.82 just283.99 can't284.31 see284.54 a284.79 sharing284.94 option.285.58

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291.05 SPEAKER6291.05 -291.05 Okay.291.05

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vivarium.389.97 So391.38 we're391.78 now392.02 ready392.26 for392.66 commissioning.392.9 The393.38 work393.54 is393.62 done,395.14 and396.18 so396.5 we're396.66 submitting396.9 this397.38 request.397.7 The399.49 animal399.73 program,400.05 as400.76 it401 stands,401.65 is401.88 pretty402.05 much402.21 exactly402.44 the402.85 same403 as403.17 it403.32 was403.49 in403.73 the403.88 vivarium404.05 at405.25 Arsenal405.49 Yards,405.97 but406.29 I'll406.44 describe406.68 that406.92 a407.8 little407.96 bit408.12 briefly.408.28 And408.68 feel408.92 free409.08 to409.24 ask409.4 me409.64 any409.8 questions409.96 as410.44 I410.6 go410.76 through410.92 it.411.08 And412.2 then412.36 our412.6 biosafety412.84 practices413.48 and414.04 bio414.2 waste414.52 management414.76 is415.89 the416.13 same416.21 as416.62 we416.77 presented417.01 in417.5 the417.65 original420.53 application421.01 with422.06 the422.29 exception422.53 of423.83 the,424.19 we're424.19 using424.43 disposable424.83 caging,425.39 and426.27 we're426.43 incinerating426.75 the427.47 cages427.63 and428.35 the428.59 animal428.75 waste429.07 due429.47 to429.79 some430.49 of430.64 the430.88 unknown430.96 properties431.52 of431.93 the432.08 chemicals,432.25 of432.88 the433.2 test433.52 articles433.93 that434.4 we're434.64 using.434.81 We436.25 just436.49 don't436.64 wanna436.81 introduce437.04 that437.52 since437.84 we438.08 don't438.25 know438.49 what438.64 the438.88 off440.06 target440.3 effects440.78 could441.1 be.441.26 442.46 So442.46 a443.1 little443.26 bit443.42 of443.58 a443.74 refresher.443.9 We444.46 have444.7 three445.58 floors,445.82 oops.445.82 Sorry.445.82 We446.7 have446.78 three447.34 floors448.5 in448.5 500448.89 North449.38 Beacon,449.62 the450.5 second,451.13 third,451.69 and452.01 fourth453.69 floors,453.94 the453.94 second453.94 floor454.33 is456.24 where456.48 the456.72 vivarium456.96 is.457.44 So457.68 the457.92 vivarium458.08 is,458.72 you459.76 can459.84 see460.08 it's460.24 colored460.48 in460.88 blue461.12 on461.6 this461.84 map,462.16 and462.97 then463.13 we463.25 have463.38 a463.69 chemistry463.94 lab464.41 and464.89 an465.38 adjacent,465.62 and467.45 sort467.69 of467.85 the468.01 pink468.18 color468.57 next468.89 to469.21 the469.38 vivarium469.45 is470.18 our471.41 in471.65 vitro471.89 pharmacology472.61 lab.473.33 So,473.65 basically,473.89 they'll474.29 do474.61 ex474.85 vivo475.09 studies,475.41 preparing476.85 samples477.25 for477.73 use477.97 in478.13 the478.21 vivarium.478.37 And479.75 there's479.84 a480.07 pass480.4 through480.71 connecting481.04 both482.31 the483.12 vivarium483.36 and484 this484.24 lab484.56 so484.88 that484.96 we485.19 can485.36 move485.68 chemicals486.07 and,486.63 not486.88 chemicals,487.12 but487.6 test488.16 articles488.48 and489.04 materials489.76 in490.32 and490.48 out490.64 of490.72 the490.88 vivarium491.04 without491.52 having491.76 to492.08 go492.16 into492.32 the492.48 main492.64 hallway.492.96 I494.96 can495.2 orient495.44 you495.84 a496 little496.08 bit.496.32 The498.01 stairways498.25 are498.81 sort499.13 of499.38 with499.54 the499.78 half500.1 circles.500.42 The501.94 freight503.38 lobby503.78 is504.42 right505.13 next505.46 to505.78 the506.74 left507.61 of507.93 the509.05 stairway509.29 over509.77 here.510.01 And510.41 then510.57 I510.89 don't511.05 know511.13 if511.21 you511.29 can511.45 see511.61 my511.69 pointer,512.57 can512.81 you?512.81 Yeah.514.01 Okay.514.25 And515.39 then515.63 this515.88 is516.2 the,516.43 the517.48 passenger517.63 lobby518.27 is518.6 right518.75 here.519.08 Any520.91 questions521.15 on521.55 this521.71 one?521.96 524.07 So524.07 I'll524.31 dig524.55 down524.87 a525.27 little525.35 bit525.59 into526.31 the529.03 vivarium529.19 itself.529.91 So530.99 on531.23 the531.46 right532.11 hand532.26 side532.5 is532.83 the533.07 layout,533.71 and534.18 this534.59 is534.75 the534.9 rack535.14 layout.535.38 So536.35 you536.59 can536.66 see536.99 the537.38 bottom,537.71 the537.71 three539.26 rooms539.5 on539.82 the539.98 bottom540.06 are540.38 the540.54 holding540.7 rooms,540.94 and541.98 then542.22 two543.42 for543.66 mice,543.9 one544.38 for544.62 rats.544.94 And545.82 then546.06 at546.38 the546.54 top546.7 of547.02 the,547.74 on548.79 the548.95 hallway549.18 end549.75 of550.07 the550.23 facility,550.38 there551.83 are551.99 three552.14 procedure552.38 rooms,552.87 a553.42 clean553.67 material,555.11 there's555.42 an555.42 entry,555.75 a556.23 gowning556.38 area,556.79 and557.42 a557.74 restroom557.82 in559.1 the559.26 facility.559.42 And560.06 at560.46 the560.62 end560.78 of561.02 the561.18 facility,561.34 there's561.9 a562.22 dirty562.38 material562.94 storage.563.98 So566.63 the566.88 space567.04 itself567.43 is,568.24 you569.12 know,569.27 built569.84 to570.08 the570.24 guide,570.39 and570.88 there's571.2 15571.51 air572 changes572.24 per572.72 hour572.88 with573.82 a574.46 backup574.7 system575.18 and575.98 supplemental576.22 cooling.576.86 We577.98 have578.22 timed578.38 light578.7 cycles578.94 with579.42 red579.66 light579.98 capabilities.580.3 So581.1 if581.5 we're581.66 running581.9 certain582.97 studies583.37 ,when583.61 you583.85 open584 one584.33 of584.57 the584.64 holding584.73 room585.04 doors586 at586.25 night,586.4 the586.8 red586.97 lights587.13 will587.37 go587.52 on.587.68 We're589.04 using589.29 Innovive589.68 racks,590.33 and590.64 all590.8 the591.04 racks591.13 are591.52 on591.68 standby591.92 power,593.6 as594.56 well594.8 as595.04 some595.36 critical595.6 equipment596 in596.96 the598.64 procedure599.12 rooms.599.6 We're600.75 designating601 this601.55 as601.71 a601.88 VL2602.36 space602.67 because603.07 we'll604.27 be604.51 introducing604.75 potentially605.48 human606.03 cell606.36 lines606.6 in607.32 the607.48 tumor607.63 models608.03 that608.51 we're608.67 using.609 And611.35 the611.59 capacity611.83 of612.55 the612.71 facility613.03 is613.91 about615.11 5,040615.67 mice,616.47 depending618.04 on618.36 how618.51 many618.6 mice618.84 per619.08 cage.619.24 I619.8 calculated620.04 it620.75 with620.92 five.621.08 And622.36 the622.6 rat622.75 holding623 room623.32 has623.63 about623.88 240624.2 capacity.626.24 627.12 In627.12 the627.36 procedure627.52 rooms,627.92 we628.16 have628.32 piped628.56 O2629.2 and629.52 CO2630.16 and630.4 vacuum630.64 for631.84 anesthesia,633.03 for633.83 euthanasia,634.07 and634.88 for635.12 just635.43 general635.83 vacuum636.39 use636.88 in637.27 the637.51 biosafety637.67 cabinets.638.32 The639.51 rat639.91 holding640.24 room,640.55 the640.95 last642.69 procedure643.09 room,643.49 this643.73 one643.97 here,644.13 has645.49 a646.13 downdraft646.37 table646.93 and647.33 a647.57 vented647.73 biosafety648.45 cabinet.649.09 So649.57 we649.73 can649.89 use650.05 it650.29 for650.61 formal651.5 and651.82 fixation,652.86 we653.01 can653.01 use653.18 volatiles653.82 in654.46 those654.62 two655.25 vented656.46 biosafety656.46 cabinet656.93 and657.34 the657.42 downdraft657.58 table.657.98 And658.97 then659.13 in659.37 this659.45 first659.77 room660.01 over660.25 here,660.41 we662.89 have662.97 basically663.13 a663.53 funnel663.69 I664.17 mean,664.25 a664.57 draft665.85 for666.33 potential667.58 use668.06 of668.3 a668.54 IVUS668.87 machine669.42 to669.9 do670.06 NVO670.23 imaging,670.7 which671.42 comes671.9 with672.46 anesthesia672.78 machines,673.75 and674.14 that674.38 will674.46 be674.63 the674.87 scavenger674.94 for675.42 volatile675.66 anesthesia677.01 gases.677.49 And679.17 then679.41 I679.49 just679.65 went679.81 over680.05 the680.21 support680.45 spaces,680.85 and682.37 then682.53 the682.77 adjacent,682.93 pharmacology684.29 lab,685.17 as685.75 I685.9 mentioned686.07 before,686.46 has686.87 material687.66 transfer688.23 into688.7 the688.95 ACF689.11 in690.14 the690.3 pass690.46 through.690.7 There's690.95 two691.82 tissue692.07 culture692.38 rooms692.7 in692.95 there,693.11 some693.95 ex694.19 vivo694.47 bench694.75 space,695.07 room695.63 for695.95 sample696.19 processing.696.59 And697.87 on698.35 the698.51 corner698.75 over699.39 here699.71 is700.11 where700.27 the700.59 oxygen700.83 manifold701.31 is702.03 that703.29 services703.77 the704.65 ACF.704.89 So705.46 in706.34 the706.58 ACF,706.74 there's707.22 no707.53 manifold708.34 for708.89 oxygen709.13 except709.53 for709.86 the,710.01 there711.22 will711.46 be711.62 some712.18 storage712.42 for712.98 individual713.38 small714.26 oxygen715.86 tanks716.26 for716.58 the716.74 isoflurane716.82 machines.717.46 Any719.37 questions719.61 on720 that?720.09 721.52 PARSONS721.52 -721.52 Yes.721.52 722.33 PICARD722.33 -722.33 Okay.722.33 725.13 PARSONS725.13 -725.13 So,725.13 you725.28 said725.45 use726.78 of727.02 vol727.26 2,727.82 so,728.06 basically,728.06 formalin728.62 fixing729.18 in729.5 a729.66 biosafety729.82 cabinet,731.98 is732.14 this732.14 a732.3 recirculating732.54 biosafety733.66 cabinet734.14 or734.54 is734.7 this734.86 a735.1 vented735.18 biosafety736.17 cabinet?736.74 737.38 PICARD737.38 -737.38 So737.38 it's737.53 both.737.77 It738.1 recirculates,738.41 and739.21 then739.38 there's739.7 a740.1 vent.740.33 So741.21 it741.45 takes741.62 in741.86 fresh742.1 air742.33 at742.57 the742.65 top742.74 and743.05 also743.21 vents743.62 a744.21 portion744.37 of744.61 the745.09 volatiles745.57 would746.05 end746.29 up746.53 in746.77 the746.93 in747.33 the747.49 plenum.747.65 748.61 PARSONS748.61 -748.61 Okay.748.61 749.09 PICARD749.09 -749.09 Kind749.09 of749.25 like749.41 a,749.57 it's749.81 like749.97 a750.21 combo.750.29 751.41 PARSONS751.41 -751.41 Okay.751.41 I752.1 just752.25 wanted752.58 to753.05 clarify753.22 that.753.77 754.17 PICARD754.17 -754.17 Yeah.754.17 Yep.755.3 756.42 PARSONS756.42 -756.42 And756.42 then756.58 you756.82 said757.13 so,757.77 will758.1 there758.34 be758.5 isoflurane758.65 use759.46 in759.77 this760.01 space?760.17 760.58 PICARD760.58 -760.58 Yes.760.58 760.58 PARSONS760.58 -760.58 Okay.760.58 761.05 PICARD761.05 -761.05 Yes.761.05 761.76 PARSONS761.76 -761.76 But761.76 that's762.24 on762.48 the762.64 downdraft762.72 table,763.12 like,763.52 not763.76 in764 a764.16 biosafety764.64 cabinet,765.4 or?766.8 766.8 PICARD766.8 -766.8 We'll767.12 be767.44 doing767.6 animal768 studies768.4 in768.72 the768.88 end,769.2 so769.36 yes,769.36 it'll769.68 be771.26 adjacent,772.23 the772.38 unit772.38 itself.774.07 Right,774.3 it'll774.3 be774.3 adjacent,774.87 it774.94 won't774.94 be775.11 inside775.35 the775.66 biosafety775.75 cabinet.776.23 777.11 PARSONS777.11 -777.11 Right.777.11 Okay.777.42 Just777.82 wanna778.07 make778.3 sure778.38 on778.63 that778.7 too778.87 because779.02 it's779.26 like,779.42 I779.58 know779.75 there's781.01 gonna781.17 be782.37 clearly782.45 some782.93 recirculation.783.25 So784.29 formalin785.17 not785.81 as786.13 bad786.21 as787.65 isoflurane787.97 if788.69 someone's788.93 sitting789.33 in789.57 front789.73 of789.97 that790.05 or790.54 working790.7 in790.93 the791.1 biosafety791.25 cabinet.791.89 But792.13 that792.3 would792.54 be,792.77 okay.792.93 Alright.793.42 Cool.793.65 793.98 PICARD793.98 -793.98 So793.98 that794.13 won't794.22 be794.38 in794.62 it.794.7 That794.93 will795.01 be795.17 on795.34 the795.5 side795.58 of795.74 it.795.82 796.3 PARSONS796.3 -796.3 Alright.796.3 Just796.62 wanted797.5 to797.82 confirm797.89 that.798.38 Thank798.62 you.798.77 799.35 LIEBERMAN799.35 -799.35 Well,799.35 I799.43 assume799.51 that799.67 we'll800.69 have801.03 canisters,802.05 and802.39 stuff802.47 anyway.802.71 803.19 PICARD803.19 -803.19 Yeah.803.19 Correct.803.51 Correct.804.15

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LIEBERMAN871.97 -871.97 Okay,872.21 so872.37 your872.37 holding872.61 rooms872.85 are873.09 at873.33 negative873.33 since873.73 they're873.97 a874.13 BL2?874.53 875.13 PICARD875.13 -875.13 Correct.875.13 875.93 LIEBERMAN875.93 -875.93 Great.875.93 Excellent.876.65 878.82 PICARD878.82 -878.82 Anybody878.82 else?879.29 Okay,883.02 I'll883.9 just884.14 talk884.38 a884.5 little884.62 bit884.78 about885.02 our885.26 research886.54 program.887.02 Our887.42 research887.66 program887.9 is888.3 kind888.62 of888.86 led888.94 by889.18 three889.42 different889.66 groups,889.98 our890.3 immunology890.46 group,891.18 our891.83 in891.99 vivo892.14 pharmacology892.71 group,893.43 and893.75 our893.9 preclinical894.23 talks895.02 groups.895.43 And897.11 the897.35 three897.5 leaders897.75 work898.23 really898.55 well898.79 together,899.02 so899.43 this899.75 is900.07 good900.14 for900.3 us.900.47 And901.51 the901.75 studies901.91 are902.23 gonna902.31 be902.55 a902.63 continuation902.79 of903.19 the903.35 studies903.43 we903.75 were903.99 doing904.15 at904.39 Arsenal904.55 Yards.904.95 We905.75 were906.23 doing906.47 oncology906.79 studies,907.35 some907.75 tumor907.99 modeling908.39 with909.03 murine909.35 and910.07 human910.31 cell912.07 lines912.38 in912.63 immunodeficient912.87 mice.913.67 On915.43 the915.5 immunology915.67 side,916.31 we916.55 were916.71 doing916.95 T918.15 and918.31 B918.39 cell918.71 inflammation919.03 models,919.59 some920.71 primary921.03 cell921.43 studies921.75 on922.39 taking923.83 cells924.55 from924.95 animals925.19 that925.59 have925.75 been925.91 treated926.15 with926.47 our926.71 test926.79 articles.927.11 And927.93 then928.18 we're928.25 in928.5 the928.65 future928.82 starting929.13 to929.54 look929.62 at,929.86 potentially,930.18 doing931.93 some932.25 autoimmune932.5 models,933.54 but934.01 we934.18 don't934.34 have934.58 any934.89 protocols935.13 for935.62 those935.77 at935.93 the936.1 moment.936.18 And937.61 then937.77 for938.33 pharmacology,938.81 they're939.85 gonna940.01 start940.25 doing940.49 some940.73 PKPD941.13 studies942.01 in942.49 rats,942.81 which943.37 is943.61 why943.69 we943.93 built944.09 that944.41 rat944.65 capability.944.97 And947.09 we're947.4 not947.64 gonna,947.8 we948.04 don't948.21 do948.37 any949.33 RDNA949.8 work949.8 with950.04 the950.28 animals,950.45 and951.16 we951.49 don't951.73 plan952.37 to953.97 use954.13 any954.37 infectious954.68 agents955.25 in955.93 that956.17 work.956.41 Any957.93 questions958.25 on958.57 that?958.73 961.61 And963.21 then963.45 we963.61 use963.93 Mispro964.33 Biotech964.89 Services.965.37 They967.2 manage,967.43 they968.08 administer968.71 the969.12 IACUC,970.39 they970.79 do970.79 protocol971.27 reviews971.83 for972.24 us,972.48 and973.92 they974.08 basically974.32 run974.96 our975.28 facility.975.52 They976 do976.16 the976.4 facility976.64 management,977.04 husbandry,977.6 animal978.88 health979.2 monitoring.979.52 They980.61 provide980.85 veterinary981.16 services981.88 with982.68 24983 hour983.49 emergency984.04 support984.61 if985.73 we985.96 need986.13 it.986.28 Most987.25 of987.57 our987.73 models987.8 probably988.28 wouldn't,988.61 but989 it's989.36 possible.989.52 And990.88 then,991.12 also,991.36 they992.16 provide992.4 technical992.8 services993.92 should994.48 we994.64 need994.8 it.994.96 So995.2 if995.36 we995.52 need995.68 help995.84 dosing996.16 or996.64 things996.96 like997.2 that,997.36 that's997.76 sort998 of998.16 an998.32 ad998.56 hoc998.8 kind1000.25 of1000.4 service1000.8 that1001.28 we1001.52 use1002 on1002.4 occasion.1002.57 I1005.2 wasn't1005.28 sure1005.52 how1005.85 much1005.92 detail1006.16 you1006.49 guys1006.64 wanted.1006.88 Happy1008.76 to1009 answer1009.16 any1009.48 questions.1009.72 1010.84 PARSONS1010.84 -1010.84 No.1010.84 This1011.16 is1011.32 great.1011.48 Thank1011.72 you1011.96 very1012.04 much.1012.28 Okay.1012.68

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1072.73 SPEAKER51072.73 -1072.73 Yep.1072.73 Yep.1073.13 That's1073.29 all1073.45 for1073.62 me.1073.77

1074.41 SPEAKER11074.41 -1074.41 Okay.1074.41 Ralph,1075.13 any1075.53 questions1075.69 for1076.1 Michelle?1076.26

1077.38 SPEAKER31077.38 -1077.38 No1077.38 questions.1077.62

1079.78 SPEAKER61079.78 -1079.78 We'll1079.78 see1080.1 you1080.26 in1080.34 a1080.5 few1080.58 months.1080.82 Right?1081.06

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1087.48 SPEAKER71087.48 -1087.48 No.1087.48 And1087.72 that1087.88 was1088.13 the1088.37 perfect1088.45 amount1088.77 of1089.01 detail.1089.09 Thank1089.48 you.1089.72

1090.05 SPEAKER61090.05 -1090.05 Yeah.1090.05 Oh,1090.53 great.1090.77 I1091.64 never1091.88 know.1092.21

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1219.27 SPEAKER11219.27 -1219.27 Alright.1219.27 Well,1219.59 thank1219.83 you.1219.99 You're1220.47 welcome1220.71 to1221.03 stay.1221.11 You're1221.35 welcome1221.43 to1221.67 go.1221.75 It's1221.99 completely1222.23 up1222.63 to1222.79 you,1222.87 and1223.19 we1225.47 won't1225.63 be1225.88 offended1226.04 if1226.43 you1226.6 leave.1226.67

1227.23 SPEAKER61227.23 -1227.23 Okay.1227.23 Well,1228.36 have1228.76 a1228.91 great1228.99 evening1229.23 and1229.56 a1229.8 good1229.88 rest1230.04 of1230.28 the1230.36 summer.1230.52 Thank1230.91 you1231.15 all.1231.32

1232.04 SPEAKER11232.04 -1232.04 You1232.04 too.1232.19 Michelle.1232.36 You1232.76 too.1232.91

1233.15 SPEAKER41233.15 -1233.15 Like1233.15 a1233.23 new1233.39 space.1233.56

1234.65 SPEAKER61234.65 -1234.65 Yes.1234.65 Thank1234.89 you.1235.21 Bye1235.53 bye.1235.69

1235.93 SPEAKER51235.93 -1235.93 Thank1235.93 you.1237.05 1242.29 PARSONS1242.29 -1242.29 Okay.1242.29 So1243.01 up1243.49 next,1243.82 we1244.45 have,1244.77 oh,1247.17 so1247.34 the1247.41 web,1247.65 alright.1248.62 I'm1249.85 sorry,1250.25 I1251.13 don't1251.37 thrive1251.61 in1252.17 this1252.41 weather.1252.57 So1253.45 the1254.73 agenda1255.13 on1255.61 the1255.69 website1255.85 has,1256.33 okay,1257.21 but1257.8 in1257.96 a1258.12 different1258.2 font.1258.52 That's1258.84 what's1258.99 messing1259.23 with1259.56 my1259.63 head.1259.88 Oh,1260.12 no.1260.36 It's1260.43 not.1260.67 Okay.1260.99 Alright.1263.08 Anyway,1263.39 Orna1264.36 is1264.36 up1264.52 next.1264.76

1266.02 SPEAKER31266.02 -1266.02 So1266.02 we1266.18 do1266.34 have1266.5 a1266.66 presentation.1266.82 So1267.38 if1267.54 I1267.7 could1267.78 get1267.94 a1268.26 presentation1268.34

1268.82 SPEAKER41268.82 -1268.82 Yeah.1268.82 Yeah.1269.06 Yeah.1269.46 Brandon,1269.86 are1270.26 you1270.34 drive1270.58 who's1271.06 driving?1271.38

1272.1 SPEAKER31272.1 -1272.1 I'll1272.1 drive.1272.34 1273.99 PARSONS1273.99 -1273.99 So1273.99 if1274.08 I1274.32 understand1274.47 correctly,1274.88 Orna1276.15 acquired1276.55 a1277.36 company1277.99 that1278.71 is1279.12 doing1279.6 very1279.99 similar,1280.39 if1280.71 not1280.88 identical,1281.12 research.1282.15 However,1282.71 one1283.35 protocol1283.67 is1284.71 different1285.43 enough1285.83 that1286.31 you1287.35 guys1287.59 are1287.83 here1287.99 to1288.23 discuss1288.47 it1288.79 with1288.95 us.1289.11 Did1289.68 I1290.01 summarize1291.2 that1291.68 correctly?1291.92 Alright,1296.01 cool.1305.45

1305.45 SPEAKER31305.45 -1305.45 Everyone1305.45 see1305.61 my1305.68 screen?1305.77 Beautiful.1307.85 Yes.1308.81 1309.92 BRANDON1309.92 LINZ1309.92 -1309.92 ORNA1309.92 -1309.92 So1309.92 I1310.16 popped1310.57 out1310.81 during1310.97 Brad's1311.61 explanation1312.01 but1312.48 I1312.64 think1312.72 he1312.97 gave1313.13 a1313.29 good1313.61 explanation.1313.93 But1314.65 I1314.81 will1314.97 kick1315.53 it1315.69 off1315.77 to1316.01 Kathleen,1316.49 to1317.29 introduce1317.45 herself1317.85 as1318.41 well1318.65 as1319.13 Orna1319.29 and1319.69 ReNAgade.1319.85

1322.17 SPEAKER81322.17 -1322.17 So1322.17 can1322.26 everyone1322.65 hear1322.97 me?1323.13 Or1323.38 yeah.1323.78

1324.26 SPEAKER11324.26 -1324.26 Yes.1324.26

1324.97 KATHLEEN1324.97 MOECKEL1324.97 -1324.97 ORNA1324.97 -1324.97 Okay.1324.97 So,1326.41 yeah,1326.65 so,1326.97 ReNAgade1327.86 Therapeutics1328.34 was1328.97 founded1329.13 in1329.54 2021,1330.02 and1332.45 our1332.69 mission1333.01 is1333.33 to1333.49 overcome1333.65 the1334.05 limitations1334.21 of1334.77 RNA1334.93 medicines.1335.41 We1336.29 apply1336.45 our1336.69 comprehensive1336.85 deliver1337.41 code,1337.89 edit,1338.21 and1338.62 insert1338.93 technologies,1339.41 and1340.06 we're1340.22 looking1340.38 to1340.7 correct1340.86 disease1341.26 on1341.65 an1341.82 unprecedented1341.97 scale.1342.86 We1343.65 started1343.89 our1344.3 operations1344.46 at1345.1 7901345.34 Memorial1345.89 Drive,1346.38 subsequently1347.2 moved1347.84 into1348.24 6401348.64 Memorial1349.28 Drive1349.84 in1350.24 January1350.48 of1350.88 2023,1351.2 into1352.72 the1352.96 second1353.12 floor1353.44 only.1353.84 And1354.8 then1354.88 in1355.13 January1355.2 2024,1355.92 just1356.64 a1356.88 few1357.04 short1357.29 months1357.44 ago,1357.68 we1358.01 extended1358.4 our1359.68 lab1360.01 space1360.24 to1360.64 the1360.8 first1360.96 floor.1361.37 Then1362.7 on1362.86 May1363.1 23rd,1363.42 we1364.22 were1364.54 acquired1364.86 by1365.26 Orna1365.5 Therapeutics.1365.82 And1366.78 on1367.02 June1367.26 29th,1367.58 we1368.14 relocated1368.38 to1368.94 Orna's1369.18 facilities1369.58 at1370.45 5001370.54 Forge1371.17 Road1371.49 in1371.73 Watertown.1371.89 1382.23 LINZ1382.23 -1382.23 So1382.23 as1382.31 part1382.47 of1382.71 the1382.95 onboarding1383.11 ReNAgade's1384.47 work1385.03 onto1385.27 the1385.59 Orna1385.67 platform,1385.99 we1386.39 looked1386.79 at1386.95 the1387.11 risk1387.27 assessments1387.51 that1387.91 were1388.07 performed1388.31 at1388.71 the1389.04 Cambridge1389.2 site,1389.44 looked1389.85 at1390.09 what1390.16 we1390.33 had1390.48 previously1390.64 done.1391.2 And1391.92 the1392.09 vast1392.16 majority1392.4 of1392.8 the1392.88 work1393.2 was1393.28 previously1393.44 contained1393.85 on1394.33 the1394.48 previous1394.64 Orna1395.04 IBC1395.37 registrations1397.13 with1397.37 minor1397.68 modifications.1398.09 The1399.42 only1399.66 project1399.9 that1400.22 was1400.46 not1400.62 covered1400.86 is1401.1 the1401.34 one1401.66 we're1401.9 talking1402.14 about1402.46 today,1402.7 which1403.9 is1404.06 the1404.22 use1404.3 of1404.46 a1404.62 lentiviral1404.78 vector1405.42 library1405.82 for1406.46 a1406.78 Cas12a1407.58 targeted1409.01 experiment.1413.01

1417.7 SPEAKER31417.7 -1417.7 Is1417.7 Dan1417.86 on1418.26 the1418.42 call?1418.5 Dan,1420.42 can1420.66 you1420.82 hear1420.98 me?1421.1 There1421.22 he1421.38 is.1421.54 Excellent.1421.78 Alright.1422.5 Dan,1422.82 take1423.3 it1423.46 away.1423.62

1425.78 SPEAKER91425.78 -1425.78 Yeah.1425.78 Hi.1426.1 Can1426.26 everyone1426.49 hear1426.82 me?1427.05

1428.02 SPEAKER31428.02 -1428.02 Yes.1428.02

1428.97 DAN1428.97 EGAN1428.97 -1428.97 ORNA1428.97 -1428.97 Okay.1428.97 Yeah.1430.34 So1430.58 as1430.97 Brandon1431.13 said,1431.45 we're1431.86 looking1432.89 to1433.15 introduce1433.23 a1433.55 Lenti1433.63 protocol.1434.11 So1434.59 this1434.75 is1434.91 the1435.15 title1435.31 is1435.63 screening1435.79 and1436.19 identification1436.43 of1437.07 active1437.23 Cas12a1438.75 CRISPR1438.99 RNAs1439.39 targeting1439.87 a1440.35 therapeutically1440.51 relevant1441.15 locus.1441.84 And1444.56 yeah,1444.8 so1444.8 in1444.8 general,1444.96 the1445.28 goal1445.43 is1445.67 to1445.76 use1446.56 third1446.8 generation1446.8 lentiviral1447.43 vectors1448.24 to1448.72 screen1448.96 and1449.36 identify1449.36 type1450.32 51450.63 cas1452.22 editing1452.62 reagents1452.86 targeting1453.34 these1454.62 different1454.78 loci1455.1 of1455.66 interest1455.82 to1456.3 ReNAgade1457.34 and1457.58 now1457.74 Orna.1457.98 And1464.31 so1464.55 in1464.71 general,1464.95 what1465.27 we're1465.35 doing1465.51 is1465.9 a1465.99 very1466.14 standard1466.55 lentivirus1468.36 protocol.1469 So1469.48 this1469.64 is1469.8 used1469.88 standardly1470.12 throughout1470.6 academia1471.32 and1471.8 industry.1471.96 We're1473.48 using1473.64 a1473.96 lentivirus1474.12 library1475.48 encoding1475.96 the1476.36 CRISPR1476.52 RNA1477 cassette.1477.64 It'll1478.85 be1479.16 transduced1479.33 into1479.88 cell1480.2 lines.1480.52 Afterwards,1481.4 the1481.88 genomic1482.85 DNA1483.33 will1483.8 be1483.96 extracted,1484.2 and1484.76 we'll1485.58 use1485.74 next1486.06 generation1486.38 sequencing1486.78 to1487.34 analyze1487.5 it.1487.9 And1488.54 this1488.7 is1488.86 all1489.02 in1489.26 vitro1489.5 work,1489.82 so1490.06 just1490.3 cells1490.46 in1490.94 addition1491.18 and1491.82 no1492.06 animal1492.94 work1493.34 is1493.5 planned1493.66 for1493.98 these1494.06 viruses.1494.38 1501.01 LINZ1501.01 -1501.01 So1501.01 our1501.48 IDC1501.81 did1502.29 meet1502.53 to1502.77 review1503.09 this.1503.48 So1504.14 we1504.38 are1504.46 using1504.7 pre1505.02 established1505.34 human1505.66 tumor1505.9 cell1506.3 lines1506.54 for1506.86 this.1507.02 All1507.42 of1507.58 them1507.74 had1507.9 screened1508.06 and1508.7 cleared1509.02 for1509.26 blood1509.58 borne1509.9 pathogen1510.14 profiles,1510.62 but1511.59 we'll1511.66 still1511.74 handle1512.07 what1512.27 might1512.46 be1512.7 a1512.78 cell1512.87 21513.11 under1513.35 universal1513.59 precautions.1514.07 The1515.59 third1516.07 generation1516.95 viral1516.95 vectors1517.27 in1517.59 place1517.74 are1518.22 self1520.33 inactivating,1520.65 have1521.29 replication1521.85 and1522.33 competence,1522.49 and1523.21 our1523.37 inserts1523.61 are1524.01 nontoxic1524.09 and1524.65 non1524.73 oncogenic.1525.05 But1525.77 because1526.01 of1526.17 the1526.33 library1526.41 aspects1526.97 of1527.37 it,1527.45 we1528.11 did1528.27 approve1528.66 that1528.98 as1529.22 a1529.31 committee1529.38 at1529.71 BSL21530.59 plus1531.38 some1531.38 enhancements.1531.71 So1539.12 because1539.44 the1540 system1540.4 is1540.64 limited1540.8 to1541.12 our1541.28 human1541.6 cell1541.92 line,1542.16 our1542.72 mirroring1542.96 cell1543.36 line1543.6 cultures,1543.92 we're1544.64 targeting1544.88 loss1545.2 of1545.44 functions1545.6 with1546 very1546.43 dedicated1546.67 tools1548.03 in1548.36 place1548.43 to1548.99 minimize1549.23 the1549.55 off1549.71 target1549.88 effects.1550.19 We've1551.15 put1551.39 this1551.55 within1551.71 our1552.03 BSL21552.6 plus1552.76 bucket,1552.99 which1553.32 we1553.55 discussed1553.71 at1554.12 previous1554.19 Watertown1555.09 Board1555.49 of1556.05 Health1556.21 and1556.53 Biosafety1556.85 Committee1557.41 meetings1557.73 for1557.97 our1558.13 nonhuman1558.21 primate1558.69 work.1559.09 But1560.53 additional1560.93 PPE1561.41 is1561.73 in1561.89 place,1562.05 including1562.21 disposable1562.77 gloves,1563.8 double1564.28 layered1564.67 gloves,1564.99 safety1565.72 glasses,1566.12 as1567.39 well1567.48 as1567.63 BSL21568.91 plus1569.15 training1569.39 specific1569.88 to1570.36 the1570.67 practices1570.91 in1571.48 place1571.63 as1572.04 well1572.12 as1572.28 the1572.44 viral1572.52 vectors1572.92 in1573.24 use.1573.32 And1574.52 then1574.68 we've1574.84 just1575.08 reiterated1575.32 that1575.8 all1575.96 work1576.04 is1576.2 done1576.36 in1576.52 a1576.6 biosafety1576.76 cabinet1577.16 or1577.56 some1577.64 other1577.8 engineering1578.04 control.1578.52 And1582.81 that1582.96 brings1583.13 us1583.37 to1583.53 the1583.68 end1583.85 of1584.09 our1584.88 formal1585.05 presentation.1585.37

1586.96 SPEAKER11586.96 -1586.96 Great.1586.96 Thank1587.29 you,1587.45 everyone.1587.68 Appreciate1588.57 it1589.05 very1589.2 much.1589.37 I'm1591.11 gonna1591.35 go1591.51 around1592.39 the1592.71 other1592.87 way.1593.11 So,1593.35 Tim,1593.91 do1595.43 you1595.55 have1595.67 any1595.83 questions1596.07 for1597.03 the1597.27 Werner,1597.59 slash1598.95 1599.55 PARSONS1599.55 -1599.55 So1599.55 are1599.63 you1599.88 guys1599.95 going1600.19 just1600.36 by1600.6 ORNA,1600.84 or1601.08 is1601.15 it1601.32 as1602.84 ReNAgade1604.6 then?1604.6 1604.6 MOECKEL1604.6 -1604.6 Yes.1604.6 Just1604.84 by1605.08 ORNA.1605.23 1605.95 PARSONS1605.95 -1605.95 Just1605.95 by1606.12 ORNA.1606.28 Okay.1606.52 I1606.67 don't1606.76 wanna1606.91 offend1607.23 anyone1607.55 here.1607.88 Tim,1609.24 do1609.4 you1609.48 have1609.56 any1609.64 questions1609.88 for1610.2 for1610.44 the1610.68 ORNA1610.92 crew?1611.56 1612.44 TIMOTHY1612.44 MAGUIRE1612.44 -1612.44 WBSC1612.44 MEMBER1612.44 -1612.44 No.1612.44 The1612.68 only1612.76 one1612.92 I1613.16 had1613.24 was1613.4 on1613.56 cloning1614.12 but1614.52 it1614.52 was1614.52 covered1614.68 in1615 this1615.08 slide.1615.24 So,1615.56 thank1615.96 you1616.12 and1616.28 great1616.52 presentation.1616.76

1619.32 SPEAKER11619.32 -1619.32 Ralph,1619.32 any1619.8 questions1619.95 for1620.28 Orna?1620.52

1621.71 SPEAKER31621.71 -1621.71 No1621.71 questions1621.95 for1622.28 Orna.1622.52

1624.19 SPEAKER11624.19 -1624.19 Mia.1624.19

1625.63 SPEAKER41625.63 -1625.63 Okay1625.63 for1625.95 me.1626.19 1628.32 PARSONS1628.32 -1628.32 Okay.1628.32 Nothing1628.88 from1629.2 me1629.44 either.1629.76 So1630.16 I1630.48 wanna1630.88 echo1631.2 Tim's,1631.68 sentiment1633.2 that1633.68 that1633.92 was1634 a1634.16 great1634.32 presentation,1636.32 very1636.56 clear,1636.56 thank1636.56 you1636.56 very1636.72 much.1636.96 I1639.29 don't1639.53 really1639.85 see1640.24 this1640.57 needing1640.96 to1641.29 go1641.37 in1641.68 front1641.85 of1642.09 the1642.16 Board1642.33 of1642.57 Health,1642.72 so1644.4 we1644.64 appreciate1644.88 your1645.37 transparency,1646.24 we1646.48 appreciate1646.48 your1646.96 time,1647.44 thank1647.61 you1647.61 for1647.77 coming1647.96 here.1648.2 Best1649.8 of1650.12 luck1650.2 with1650.44 your1650.6 research.1650.76 Hopefully,1651.72 congratulations1652.2 on1653.08 the1653.24 merger.1653.32 I1655.24 know1655.4 how1655.56 that1656.52 could1656.84 be1657 interpreted1658.51 in1658.9 many1658.98 different1659.22 ways.1659.46 So1659.63 I1659.78 hope1659.87 it1660.11 goes1660.18 well.1660.42 It1661.94 will1662.11 probably1662.59 most1662.9 likely1663.14 at1663.54 least1663.63 be1663.78 more1663.94 efficient.1664.11 So1665.54 best1665.94 of1666.11 luck1666.26 with1666.42 your1666.66 research,1666.74 and1667.07 thank1667.22 you1667.45 very1667.61 much.1667.85

1668.89 SPEAKER81668.89 -1668.89 Thank1668.89 you1669.13 very1669.29 much.1669.53

1670.09 SPEAKER31670.09 -1670.09 Thanks,1670.09

1671.21 SPEAKER11671.21 -1671.21 Joel.1671.21 Thank1671.45 you.1671.69 1680.34 PARSONS1680.34 -1680.34 Alright.1680.34 So1683.59 we1684.79 got1684.95 ORNA1685.19 on1685.51 the1685.59 agenda,1685.67 so1686.07 we're1686.23 not1686.39 gonna1686.47 put1686.63 them1686.87 in1687.03 other1687.27 business.1687.51 Do1687.99 we1688.15 have1688.31 any1688.55 other1688.79 other1689.51 business?1689.83 1690.79 FOLEY1690.79 -1690.79 You1691.51 said1691.75 they1692.66 don't1693.31 go1693.71 to1693.95 the1694.03 Board1694.18 of1694.42 Health,1694.9 correct?1695.38 1695.38 PARSONS1695.38 -1695.38 ORNA,1697.87 correct.1698.66 ORNA,1698.66 yeah.1698.66 No,1698.66 Kymera.1698.66 1698.66 FOLEY-1698.66 I1698.99 just1698.99 couldn't1698.99 hear1698.99 it,1700.17 sorry.1701.09 1701.09 PARSONS1701.09 -1701.09 These1701.41 headphones1701.57 are1701.97 also1702.13 dying.1702.45 So,1703.25 yeah,1703.41 no,1703.97 ORNA1704.21 does1704.21 not1704.45 need1704.69 to1704.85 go1704.93 for1705.81 this1705.97 in1707.17 front1707.25 of1707.49 the1707.57 Board1707.73 of1707.97 Health.1717.2 Okay,1717.44 any1717.44 items1717.44 that1717.76 were1718 not1718.16 anticipated1718.4 before1719.04 the1719.36 publication1719.6 of1720.32 this1720.48 agenda?1720.96 Okay.1727.38 Alright,1728.58 so1728.98 future1728.98 meetings.1729.46 This1733.23 is1733.31 gonna1733.39 be1733.63 a1733.71 long1733.79 time1734.11 between1734.99 meetings.1735.47 So,1738.59 September1738.99 5th1740.03 is1742.76 the1743.57 first1743.72 Thursday1744.13 of1744.61 September.1744.92 So1745.96 is1747.16 anyone1747.4 taking1747.96 a1748.28 lot1748.44 of1748.61 time1748.76 off1749.01 for1749.16 Labor1749.33 Day1749.64 this1750.52 year?1750.68 Mie,1752.72 do1753.04 you1753.2 you1753.36 anticipate1753.52 being1754.32 available1754.72 on1755.2 September1755.44 5th?1755.84 Ralph,1757.52 do1758.08 you1758.32 anticipate,1758.4 Tim,1759.91 do1760.08 you1760.24 think1760.39 you'll1760.56 be1760.72 around1760.96 on1761.28 September1761.52 5th?1761.84 1762.32 MAGUIRE1762.32 -1762.32 I'm1762.32 good1762.48 to1762.63 go.1762.8 Yep.1762.96 1763.76 PARSONS1763.76 -1763.76 Okay,1764.15 me1764.63 too.1764.8 So,1765.28 hopefully,1765.91 Deb1766.32 will,1766.63 but1766.88 if1767.2 she's1767.36 not,1767.67 we'll1767.91 have1768.08 a1768.24 quorum.1768.39 So1770.7 we'll1771.02 go1771.18 with1771.26 September1771.58 5th,1772.06 20241773.98 as1775.58 our1775.9 next1776.06 meeting.1776.38 This1779.01 was1779.24 super1779.48 quick,1779.8 so1780.04 I1780.2 still1780.37 wanna1780.61 throw1780.92 it1781.09 out.1781.16 I1781.8 feel1781.96 like1782.13 we,1785.52 nothing.1785.52

1786.24 Okay.1786.24 Alright.1788.08 Well,1788.64 I'm1790.56 gonna1790.72 go1790.96 water1791.12 my1791.36 garden1791.52 because1791.84 I1792 haven't1792.16 had1792.4 time1792.56 since1792.8 I1793.12 got1793.2 home,1793.44 and1793.85 it1793.92 was1794.09 really1794.24 hot1794.57 today.1794.81 So1795.13 What1796.09 time1796.33

1796.81 SPEAKER31796.81 -1796.81 is1796.81 it1796.96 hot?1797.05

1798.48 SPEAKER11798.48 -1798.48 I1798.48 I1798.72 so1799.05 I'm1799.2 gonna1799.37 adjourn1799.77 this1800.09 meeting1800.33 at1800.72 7:38.1801.13