Watertown Board of Health
RICHARD15.05 ARNOLD15.05 -15.05 BOARD15.05 OF15.05 HEALTH15.05 MEMBER15.05 -15.05 Okay.15.05 I'd16.66 like16.73 to16.82 call16.89 to17.14 order17.3 the17.61 meeting18.18 for18.57 August19.21 21,20.02 2024.21.45 First23.94 item24.18 on24.49 the24.65 agenda24.81 is25.38 the25.94 review26.1 of26.49 the26.57 minutes26.73 of27.28 July27.52 17th.28.08 Did29.84 anybody30.08 have30.72 any30.88 edits31.2 or31.52 suggestions?31.76 36.32 DOMINIC36.32 AMIRTHARAJ36.32 -36.32 BOARD36.32 OF36.32 HEALTH36.32 MEMBER36.32 -36.32 No.36.32 36.96 ARNOLD36.96 -36.96 Okay.36.96 Do37.28 I37.44 hear37.52 a37.64 motion37.76 to38.08 approve?38.32 42.95 KIM42.95 NETTER42.95 -42.95 BOARD42.95 OF42.95 HEALTH42.95 MEMBER42.95 -42.95 Motion42.95 to43.35 approve.43.67 47.67 ARNOLD47.67 -47.67 Second?47.67 Okay.47.67 I'll47.99 second.48.23 49.27 AMIRTHARAJ49.27 -49.27 Sorry.49.27 I49.52 wasn't49.67 there,49.84 so50.08 I50.23 wasn't50.31 sure50.48 if50.72 I50.88 should50.95 be51.11 51.76 ARNOLD51.76 -51.76 Oh,51.76 yeah.51.91 Yeah.52.4 Alright.53.2 Maureen,53.91 do54.31 you54.4 have54.55 to54.72 do54.88 anything55.03 with55.35 that?55.52 58.09 MAUREEN58.09 FOLEY58.09 -58.09 CITY58.09 OF58.09 WATERTOWN58.09 -58.09 Yes.58.09 I58.89 do.59.05 73.39 ARNOLD73.39 -73.39 Next73.39 item73.7 on74.03 the74.19 agenda74.27 is74.67 time75.15 for75.39 public75.55 comment.75.94 Is76.27 there76.51 anybody76.75 from77.94 the78.19 public78.42 currently78.83 signed79.87 in?80.19 87.68 NETTER87.68 -87.68 We87.68 might88.08 have88.48 one,89.12 but89.68 I89.92 don't90.16 see90.4 anyone90.64 raising91.04 their91.36 hand.91.68 93.2 ARNOLD93.2 -93.2 Okay.93.2 If93.6 anyone94.08 is94.4 in94.8 the94.96 meeting95.12 and95.36 you95.52 want95.76 to96 participate96.72 to97.36 the97.52 public97.68 comment98 section,98.32 please98.8 raise99.28 your99.52 hand.99.76 Or100.51 if100.67 you100.83 don't100.91 know101.15 how101.31 to101.39 do101.55 that101.7 on101.94 the102.11 Zoom,102.19 just102.51 speak102.83 up103.06 please,104.51 or104.75 wave104.75 and105.39 maybe105.78 Abby106.11 can106.27 pick106.51 it106.67 up.106.83 Okay.113.87 We'll114.59 move114.91 on.115.15 Item116.59 number117.07 4117.39 is117.71 the118.35 biosafety119.47 committee120.11 amendment120.59 regarding121.23 Kymera124.19 Therapeutics124.67 at124.67 500124.67 North125.23 Beacon125.47 Street.125.87 MICHELLE145.39 PICARD145.39 -145.39 KYMERA145.39 -145.39 Hi,145.39 everyone.145.79 146.83 ARNOLD146.83 -146.83 Hello.146.83 148.11 PICARD148.11 -148.11 Nice148.11 to148.35 meet148.51 you148.67 all.148.83 149.55 ARNOLD149.55 -149.55 You149.55 too.149.87 Would150.83 you151.15 like151.39 to151.55 tell151.87 us152.11 a152.27 little152.35 bit152.59 about152.83 Chimera?153.63 154.76 PICARD154.76 -154.76 Sure.154.76 Sure.155.33 I'm156.04 Michelle156.21 Picard.156.76 I'm157.25 the157.56 senior158.37 director158.76 of159 operations159.17 at159.97 the160.21 company.161.49 And162.21 I162.21 can162.37 start162.69 my,163.09 I163.33 have163.49 a163.56 little163.65 bit163.89 of163.97 a164.13 slide164.21 that164.61 has164.76 some165.49 information165.72 about166.28 us.166.44 And167.64 you167.8 can167.88 stop168.04 me,168.36 ask168.6 me168.84 any168.92 questions169.16 anytime,169.56 or170.04 tell170.28 me170.44 I'm170.68 telling170.76 you171 too171.24 much171.32 information.171.56 So175 let175.24 me175.4 share175.72 that,176.12 and176.44 we176.68 can,176.84 if177.88 that's178.04 okay?178.36 179.48 ARNOLD179.48 -179.48 Sure.179.48 199.1 PICARD199.1 -199.1 Share199.1 this199.42 with199.66 you,201.02 and203.1 talk203.34 a203.58 little203.66 bit203.9 about204.14 our204.46 company.204.62 We're207.18 a207.66 small,208.06 biotech208.94 company,209.5 small-ish.210.3 We211.43 were211.59 founded211.83 in212.31 2017.213.27 We're215.03 publicly215.27 traded215.75 in217.34 the217.5 clinic,217.75 and218.31 we're218.55 developing218.78 some219.43 new219.67 drugs220.22 that221.27 are221.5 broadly222.06 called222.47 targeted222.87 protein223.34 degradation.223.75 And224.47 that224.63 means224.94 that225.43 the227.31 modality227.63 that228.11 we're228.35 building,228.67 uses229.71 the230.11 body's230.27 natural230.83 protein231.47 degradation232.11 system232.67 to233.39 break233.47 down233.71 any234.03 disease234.35 causing234.67 proteins235.07 and235.79 remove236.27 them236.75 from236.99 the237.15 body.237.31 So,238.11 we238.91 think239.06 that239.31 this239.38 approach239.78 is240.1 really240.34 gonna241.06 be241.38 kind241.71 of241.87 a242.03 great242.19 potential242.58 to243.06 try243.22 to244.03 treat244.19 some244.5 diseases244.66 that245.31 are245.63 previously245.87 untreatable.246.5 So248.19 we248.5 are248.75 working248.91 out250.03 of250.26 our250.66 current251.38 location251.71 at252.1 500252.26 North252.82 Beacon253.06 Street.253.47 We254.9 were255.22 originally255.54 in256.1 Kendall256.34 Square,256.82 at257.62 the257.78 beginning,257.94 moved258.9 to259.22 Arsenal260.5 Yards261.06 in261.94 2020,262.18 and263.54 then263.78 outgrew265.22 that265.7 space265.94 and266.42 moved266.74 in267.22 February267.54 of268.1 this268.34 year.268.58 269.57 We269.57 currently269.81 have270.13 about270.38 200271.25 employees271.98 with272.62 a272.86 projected273.01 growth274.21 of,274.62 like,274.77 50275.1 to275.42 60275.57 people275.9 next276.69 year277.01 and277.42 going277.65 forward,277.98 hopefully278.3 more.280.3 So281.81 our282.06 labs282.38 support282.94 research283.92 and284.16 development284.4 efforts284.96 in285.52 immunology,286.64 oncology,287.76 proteomics,289.28 which290 is290.16 really290.4 the290.64 study290.8 of291.12 protein291.2 protein291.6 interactions292.08 and292.72 how292.88 our293.04 drugs293.2 are293.6 working.293.76 And295.12 we295.28 have295.44 some296.4 high296.64 throughput296.8 cell297.52 based297.76 screenings,298 which298.71 allows299.04 us299.36 to299.6 test299.68 many300.8 compounds301.28 in301.92 a302.15 very302.31 short302.48 period302.8 of303.04 time.303.12 We304.31 do304.48 use304.71 on-site305.19 recombinant306.24 DNA306.88 technologies.307.36 These308.48 are308.71 really308.96 essential309.19 for309.75 building310.07 these310.56 cell310.88 based311.12 assays311.51 for313.09 screening.313.41 We314.53 also314.69 have315.09 some315.41 chemistry315.65 labs316.21 and317.17 those317.57 support317.89 the318.29 external318.45 manufacturing.318.93 They320.21 do320.37 small320.69 scale321.01 synthesis321.81 of322.53 some323.09 of323.25 our323.41 molecules.323.73 They324.88 do325.19 formulation325.44 about326.24 how326.48 to326.72 deliver326.88 that327.28 to327.6 our328.15 patients328.48 and329.51 then329.68 some329.92 analytical330.31 assays330.88 so331.19 we331.36 understand331.6 how332.07 the332.31 drugs332.48 are332.72 working332.88 and333.36 how333.51 they're333.68 being333.92 degraded.334.15 Anyone336.8 have337.36 questions337.51 about337.84 that338.15 before342.07 I342.31 keep342.39 going?342.63 No?343.03 Okay.344.79 346.39 And346.39 then346.55 just347.11 a347.35 little347.43 bit347.67 about347.83 our348.15 status,348.39 our348.79 current348.95 permit349.27 status.349.67 Abby351.19 mentioned351.67 that352.07 we352.31 had353.56 our353.81 biosafety353.96 department354.52 originally355.17 reviewed356.37 in356.85 January357.25 before357.88 we358.13 moved358.29 in358.52 and358.85 received359.17 a359.64 conditional360.44 approval362.76 at363.32 that363.49 point363.73 because364.61 our364.93 vivarium365.17 was365.81 not365.96 completed.366.13 It366.76 wasn't366.85 done.367.17 So368.58 we've368.98 just369.38 finished369.62 it,369.94 and371.06 so371.3 this371.46 amendment371.7 is372.18 to372.34 request372.58 the373.14 addition373.38 of373.78 the373.94 vivarium374.1 to375.38 our375.54 permit375.78 and376.5 then,376.58 basically,377.46 to378.1 have378.26 your378.58 group378.9 review379.38 our381.01 application381.25 and381.98 give382.54 us382.77 the382.86 go383.01 ahead.383.18 And385.74 then385.89 we386.13 also386.3 have386.62 a386.77 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have430.59 three430.91 group431.31 leaders431.63 that432.11 are432.27 gonna432.35 be,432.67 basically432.99 scientists433.63 that434.51 are434.67 going434.91 to435.03 be435.15 leading435.31 this435.63 research.435.87 There's437.31 an437.55 immunology437.79 core,438.59 some439.24 in439.56 vivo439.63 pharmacology,440.19 which440.92 basically441.63 tests442.12 how442.44 the442.68 drugs442.75 are443.15 metabolized443.31 within445.39 the445.8 body446.04 of446.36 the446.51 animals.447.48 And447.63 then447.63 understanding448.04 if448.68 there's448.83 any449.07 toxic451.07 effects451.56 of451.95 these452.12 chemicals452.44 or453.22 the453.46 medicines453.7 that454.26 we're454.42 making.455.06 We456.26 also456.5 have456.74 some456.9 research457.14 studies.457.54 So458.34 we'll458.66 be458.82 doing459.14 some459.62 oncology459.94 work460.58 with460.82 some461.06 tumor461.22 studies461.62 to462.42 see462.58 how462.74 the463.06 tumors463.78 are464.5 affected464.74 by465.38 the465.78 medicines466.57 that466.89 we're467.06 giving467.29 the467.54 mice.468.89 Some469.21 immunology469.21 models471.13 for472.57 autoimmune472.57 diseases,473.29 things474.18 like474.41 lupus474.74 and475.29 those475.77 kinds476.01 of476.33 multi477.38 organ478.01 system478.5 diseases.478.89 480.16 We'll480.16 be480.4 doing480.48 some480.72 pharmacology480.96 to481.6 understand481.84 how482.24 the482.48 drug482.64 is482.8 metabolized483.04 in483.84 their484.32 bodies.484.56 But486.4 we486.56 will486.72 not486.88 be487.04 doing487.2 any487.44 recombinant487.6 work488.08 in488.32 the488.4 animals.488.56 It's488.96 really489.2 trying489.76 to490.08 understand490.16 how490.56 the490.8 drugs490.88 are491.28 working491.36 in492.32 the492.48 animals.492.64 The494.75 vivarium494.99 itself495.71 is496.26 about496.43 2800497.38 square498.26 feet.498.67 We499.63 have499.87 three500.11 holding500.43 rooms,500.82 two501.38 for501.63 mice501.87 and502.26 one502.43 for502.67 rats.502.9 We504.43 can504.58 probably504.82 house505.23 about505.63 5800507.17 mice,507.65 240508.53 rats.509.57 We510.69 also510.85 have511.09 some511.33 procedure511.49 rooms511.89 where512.21 you512.45 could512.61 do,512.77 basically514.13 dosing514.61 the515.09 animals515.25 and515.73 that515.89 kind516.13 of516.29 work.516.37 And517.41 then517.57 we517.81 have517.97 some518.13 support518.37 spaces518.77 for519.25 storing520.35 clean520.83 and521.07 soiled521.95 materials522.35 in523.38 the523.63 animal523.79 facility,524.11 as525.3 well525.54 as525.79 a526.11 restroom526.35 and526.75 lockers526.9 for527.3 the527.47 workers527.63 in527.95 there.528.11 Sorry.530.75 Go530.99 ahead.531.14 Did532.97 you533.13 have533.21 a533.29 question,533.37 Richard?533.93 534.57 ARNOLD534.57 -534.57 No.534.57 I'm535.45 just535.85 following536.09 along.536.41 Just,536.73 I'm537.05 happy537.45 you537.97 included538.49 this538.97 information539.29 for540.01 the540.17 rDNA540.41 and540.97 infectious541.29 agents.541.77 That's542.17 always542.41 one543.29 of543.53 my543.69 primary543.85 concerns.544.41 So546.01 this546.25 all546.49 looks546.73 good.547.05 And548.45 I548.62 don't548.77 wanna,549.01 this549.82 is549.93 not550.05 a550.29 pop550.38 quiz,550.7 but551.01 I'm,551.41 What552.29 is552.53 IACUC,552.86 if554.7 you554.93 know?555.01 555.65 PICARD555.65 -555.65 It555.65 stands555.89 for556.21 the556.38 Institutional556.62 Animal557.41 Use557.82 and558.05 Care558.29 Committee,558.62 and559.5 it's559.65 an559.89 independent560.13 body560.77 that561.17 oversees561.41 the562.05 work562.21 that562.53 we562.7 do562.86 with563.25 animals.563.5 So565.23 there's565.63 regulations567.15 around567.87 who,568.27 and568.91 most569.15 of569.39 them569.47 are569.79 put570.67 forward570.91 in571.39 through571.79 the572.43 Animal573.39 Welfare574.59 Act.574.59 And,574.59 basically,575.23 it's575.71 for575.95 people577.37 doing577.61 research578.09 that578.88 are579.04 receiving579.13 government579.61 funding.580 So580.64 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Wednesday August 21, 2024