BRAD15.13 PARSONS15.13 -15.13 BIOSAFETY15.13 COMMITTEE15.13 CHAIR15.13 -15.13 Good15.13 evening,15.46 everyone.15.7 This16.18 is16.41 the16.73 April17.94 202518.79 meeting20.18 of20.73 the21.05 Watertown21.21 Biosafety21.61 Committee.22.18 Maureen,22.73 we're23.21 calling23.45 it23.86 to25.43 order25.67 at26.39 07:03.26.71 Everyone30.39 is30.71 present30.87 except31.19 for31.43 Deb,31.59 who31.83 is31.99 expected32.23 to32.71 be32.87 a33.59 little33.75 late34.07 this34.31 evening.34.55 Number38.95 two,39.36 acceptance39.76 of40.23 minutes.40.4 Does41.12 anyone41.27 have41.59 any41.76 comments,42.08 questions,42.64 or43.03 suggestions43.2 for43.68 edits43.91 to44.32 Maureen44.4 for45.12 the45.52 minutes45.84 from46.32 March46.55 6th46.91 as47.27 submitted?47.52 Seeing52.56 none,52.88 I53.2 will53.28 just53.44 do53.6 a53.76 quick53.84 vote.54.08 All54.32 those54.48 in54.8 favor55.68 of56 approving56.24 the56.64 minutes56.72 as57.04 submitted,57.2 please,57.76 say58.24 yes58.48 or58.72 raise58.88 your59.04 hand.59.2 Maureen,61.76 for62.16 the62.32 record,62.48 everyone63.12 voted63.6 yes.64 Again,65.2 thank65.44 you65.69 very65.84 much66.08 for66.24 your66.41 work,67.13 very67.36 hard67.36 work.67.6 This70.97 time72.64 is72.64 for72.88 public73.05 comment.73.44 So,74.24 if74.48 anyone74.64 from75.05 the75.28 public75.36 would75.77 like76 to76.17 make76.64 a76.81 comment76.97 to77.28 the77.44 committee77.52 or77.84 ask78.08 us78.33 any78.41 questions,78.64 now80 is80.32 the80.64 time80.88 to81.2 do81.28 so.81.52 Please82.08 keep82.4 in82.56 mind,82.72 but84.08 I84.16 think84.24 everyone84.48 here84.8 is85.04 from85.2 the86.32 companies.86.48 Questions88.24 to89.12 the89.28 applicants89.6 are90.32 reserved90.72 for91.12 the91.28 safety91.68 committee,92 not92.48 the92.64 public.92.8 So,93.76 can95.17 they95.34 raise95.5 their95.66 hands95.9 in96.3 this98.06 format?98.3 99.81 MIA99.81 LIEBERMAN99.81 -99.81 BIOSAFETY99.81 COMMITTEE99.81 MEMBER99.81 -99.81 I99.81 think99.9 everybody100.22 who100.86 is101.09 not101.26 a101.42 panelist101.58 is102.06 permitted102.22 to102.78 talk.102.94 104.14 PARSONS104.14 -104.14 Okay.104.14 Alright.104.69 So,105.02 if106.22 anyone106.38 from106.86 the107.02 public107.09 has107.5 a107.66 comment107.73 or108.06 a108.22 question,108.3 now108.69 is108.86 your109.02 time.109.26 Okay,115.58 Maureen,116.46 seeing116.78 none,116.78 we118.14 will118.38 move118.7 on119.1 to119.42 number119.98 four120.22 of120.54 the120.7 agenda,120.86 and121.34 this121.66 is121.9 permit125.97 from125.97 Prime126.28 Medicine.126.84 So,130.04 just130.28 I130.69 understand130.84 this131.25 correctly131.81 because131.97 some132.21 of132.37 this132.53 seem132.76 very133 familiar,133.25 you're134.21 moving134.53 to134.76 a135 bigger135.16 facility.135.49 Correct?136.04 But137.49 it's137.72 a138.78 pretty138.94 big139.26 move139.5 from139.74 the139.98 looks140.06 of140.3 these140.46 floor140.7 plans?141.02 141.82 EMILY141.82 DAILEY141.82 -141.82 PRIME142.14 MEDICINE142.38 -142.38 Yes,142.38 so142.38 we142.38 are142.62 moving142.78 our143.66 whole144.38 chemistry144.62 site145.18 from145.42 480145.66 Arsenal146.14 Way146.54 right146.86 across147.1 the147.34 street147.42 to147.74 500147.82 Arsenal148.3 Street.148.62 Then149.9 most150.14 of150.38 our150.62 biology150.86 work151.42 happens151.66 in151.98 Cambridge,152.14 but152.7 we're152.86 moving153.02 over153.26 one153.66 specific153.9 team154.75 to155 this155.4 new155.63 Watertown155.88 site.156.35 157.31 PARSONS157.31 -157.31 Great.157.63 Well,157.88 thank158.03 you.158.28 So,158.44 you158.51 have158.68 the158.83 floor.159 If159.47 you159.63 have159.72 a159.88 deck159.96 that160.12 you160.35 want160.44 to160.68 share,160.68 by160.91 all161.07 means,161.24 you162.19 want162.28 to162.59 give162.59 us162.75 an163.24 overview163.47 of163.96 your164.12 company164.28 and164.68 the164.83 move,165 that165.31 would165.47 be165.63 great.165.79 166.59 DAILEY166.59 -166.59 Okay.166.59 Perfect.167.07 I'm167.56 trying167.79 to168.12 share168.28 the169.34 deck169.58 now.169.74 It170.14 seems170.3 like170.46 there's170.62 some170.86 sort171.02 of171.18 a171.34 strange171.5 security171.9 setting,172.62 which174.38 could174.62 potentially174.86 be175.34 on175.42 my175.58 end,175.74 but175.9 I176.02 think176.14 I176.38 should176.54 be176.7 able176.78 to176.94 share177.1 my177.34 screen.177.66 Can187.03 you187.19 all187.34 see187.5 my187.75 slides?187.91 191.34 PARSONS191.34 -191.34 No.191.34 207.51 DAILEY207.51 -207.51 Okay,207.51 I207.51 think207.59 it207.75 might207.91 be207.99 because208.31 the211.75 meeting211.91 is212.22 being212.47 recorded.212.78 219.91 PARSONS219.91 -219.91 Is219.91 there,220.15 like,220.31 a220.55 security220.63 setting221.11 you221.43 have221.5 on221.67 your221.83 Zoom221.99 that222.31 doesn't222.47 allow?223.15 226.19 FATIMA226.19 GUEVARA226.19 -226.19 PRIME226.19 MEDICINE226.59 -226.59 Mia,226.59 would226.59 you226.83 be227.07 able227.15 to227.55 share227.79 the228.27 slide228.43 setting228.75 and229.15 help229.39 you229.71 guys?229.87 230.27 LIEBERMAN230.27 -230.27 That's230.27 what230.43 I'm230.67 trying230.91 to231.31 pull231.47 up231.71 right231.87 now.232.19 233.39 PARSONS233.39 -233.39 Well,233.39 we233.63 could233.79 also234.03 do234.35 a234.67 couple234.75 of235.07 things.235.15 Also,235.47 we235.79 could236.19 stop236.67 recording237.15 because239.25 the239.88 deck240.13 is240.44 great240.69 and241 informative241.25 to241.81 the241.88 committee,242.04 but242.6 for243 the245 public,245.25 it's245.56 really245.81 about246.04 the246.28 questions246.37 and246.76 answering246.93 that247.32 takes247.49 place247.72 afterwards.247.97 So,248.69 we248.76 could249 resume249.17 recording249.72 after251.34 the251.58 presentation.251.82 Or252.54 if252.86 someone253.1 from253.42 the253.58 biosafety253.74 committee254.22 does254.54 have254.78 the254.94 deck255.02 and255.18 would...255.34 256.22 LIEBERMAN256.22 -256.22 I256.22 have256.38 it.256.62 I've269.52 got269.76 other270 work270.25 PowerPoints270.49 open,271.05 which271.37 should271.76 not272 be272.25 shared272.49 on272.81 Zoom.274 I'm289.26 not289.5 going289.67 to289.82 go289.82 into289.9 presentation290.14 mode290.63 because290.94 that's291.19 going293.11 to293.11 screw293.11 things293.43 up.293.67 Can293.99 you294.23 guys294.31 see294.63 that?294.87 295.82 DAILEY295.99 -295.99 Yes,295.99 we295.99 can.295.99 Thank296.23 you296.46 so296.7 much.296.94 I297.43 appreciate297.67 that.298.14 299.19 LIEBERMAN299.19 -299.19 Not299.19 a299.43 problem.299.5 302.11 BAILEY302.11 -302.11 Alright.302.43 Thank302.75 you302.99 guys303.07 so303.23 much.303.47 My303.71 name303.87 is304.03 Emily304.19 Daley.304.51 I'm304.83 the305.07 EHS305.31 manager305.71 at306.19 Prime306.35 Medicine,306.59 and307.31 I'm307.55 joined307.71 here308.03 today308.43 by308.83 Bridge309.07 Hunter309.39 who309.71 will309.87 be310.03 our310.19 biosafety310.35 officer310.99 at311.39 this311.55 new311.79 facility.312.03 So,313.47 we'll313.79 start314.03 off314.27 with314.51 a314.79 company314.88 overview315.19 and315.6 an315.75 overview315.92 of316.31 our316.48 main316.63 project316.88 registration317.27 that317.75 we're317.92 hoping318.07 to318.39 get318.48 approved318.63 today,318.95 and319.19 Bridge319.44 will319.68 sort319.83 of320.07 present320.39 on320.79 those320.95 parts.321.19 Then321.68 I321.92 will322.15 present322.39 on322.88 the323.04 biosafety323.27 program323.83 and324.24 the324.48 facility324.63 overview.325.27 So,326.31 we326.56 can326.63 move326.88 on327.12 to327.27 the327.44 next327.51 slide.327.92 Alright.329.81 Bridge,330.13 take330.45 it330.61 away.330.69 331.65 BRIDGE331.65 HUNTER331.65 -331.65 PRIME331.97 MEDICINE332.21 -332.21 Okay,332.21 thank332.21 you,332.21 Emily,333.57 and333.81 thank333.81 you334.05 to334.29 the334.53 Watertown334.61 health335.81 department336.13 for336.69 letting338.29 us338.53 speak338.69 today.338.93 So339.25 just339.57 wanted339.73 to340.05 give340.13 you340.29 a340.45 little340.53 bit340.77 of340.93 an341.01 overview.341.17 First341.73 of341.89 all,341.97 I'm342.13 Bridge342.45 Hunter,342.77 I'm343.09 a343.17 senior343.33 director343.73 at344.71 Prime344.96 Medicine345.56 overseeing,346.16 non-clinical347.36 development348.15 at349.04 Prime349.12 Medicine,349.36 and349.75 I'm349.92 also350 the350.31 biosafety350.63 officer351.36 for351.92 500352.88 Arsenal353.36 Street.353.83 So354.4 just354.63 a354.88 little354.96 background355.19 on355.68 the355.75 company.355.92 Prime356.63 Medicine357.04 got358.76 its359 roots,359.24 really360.04 out360.28 of360.52 a360.76 publication360.92 from361.96 an362.2 academic362.44 lab.363 It363.48 was363.56 published363.72 in364.04 Nature364.2 in364.52 2019.364.84 Since366.52 then,366.76 we've366.92 actually367.16 had367.48 a367.72 kind367.88 of368.12 a368.36 very368.52 quick368.84 rise369.16 to369.48 where369.56 we369.8 are369.88 today.370.12 We're371.01 a371.81 publicly371.89 traded372.38 company,373.1 we373.33 have373.33 a373.74 little373.89 over374.06 200374.38 employees,374.86 and376.54 we're376.69 spread377.57 out377.89 in378.38 a378.54 couple378.62 different378.94 areas,379.25 primarily379.74 in380.62 Cambridge,381.33 but381.74 we381.98 also382.13 have382.38 now382.69 presence383.3 at383.7 400384.42 Arsenal384.98 Way,385.3 which385.62 as386.5 was386.82 mentioned387.06 before,387.46 moving387.94 over388.34 just388.66 across388.9 the389.22 street389.3 to389.62 500389.78 Arsenal.390.26 392.02 So394.02 what394.26 does395.22 Prime396.42 Medicine396.82 do,396.82 and397.14 what397.38 is397.62 their397.78 technology?397.94 So,398.66 really,399.94 our400.26 focus400.43 is400.82 around400.99 rare401.38 genetic401.7 diseases.402.19 So402.75 as403.54 some404.34 of404.5 you404.66 may404.9 know,405.06 there's405.31 a405.54 lot405.63 of405.87 patients405.94 out406.43 there406.58 that406.9 have407.14 these407.38 rare407.63 genetic408.9 mutation409.87 or410.5 rare410.58 genetic410.9 diseases,411.31 usually412.26 caused412.66 by412.99 a413.22 specific413.31 mutation413.7 in414.26 a414.43 specific414.74 gene.415.14 So,416.18 what416.34 our416.58 technology417.46 does418.1 is418.5 actually,418.66 we419.54 can419.7 identify419.94 what420.66 those420.98 mutations421.46 are,422.18 We422.66 can422.9 design423.14 our,423.78 where424.74 we424.98 call425.22 our425.38 prime425.62 editors,425.94 We427.63 can427.79 go427.95 in,428.12 recognize428.91 that429.56 specific429.88 mutation,430.35 and431.24 essentially,431.47 correct433.15 it.433.56 So,433.88 we434.12 can434.27 take434.68 out434.91 the435.15 old435.31 mutated436.68 sequence437.24 and437.95 end438.12 up438.35 putting438.91 in439.31 the439.56 corrected439.79 sequence.440.35 So,441.33 I'm441.57 not441.73 going441.97 to442.13 go442.13 into442.29 all442.61 the442.77 the443.09 molecular443.33 biology443.81 details444.37 of444.77 how444.93 this445.09 works,445.33 but445.97 it's446.13 a446.29 really446.45 efficient447.25 way447.73 to448.13 correct450.13 mutations450.53 in451.17 these451.25 rare451.81 disease452.13 populations.452.45 There's453.71 a453.94 lot454.11 of454.26 other454.35 companies454.58 out454.99 there455.06 that455.23 do455.46 a455.63 similar456.58 type456.99 of457.15 approach,458.11 ours458.35 uses458.35 a458.82 slightly459.06 different459.46 technology.459.87 Again,460.75 won't460.99 go461.31 into461.46 all461.71 the461.87 details462.02 there,462.58 but462.99 it463.38 is463.55 more463.79 specific,465.23 our465.63 technology465.79 is466.35 more466.58 specific466.75 and467.15 allows467.71 for468.11 less468.35 off469.54 target469.86 kind470.26 of470.42 negative470.9 effects.471.38 472.02 So,472.66 very,472.66 very473.14 specific473.54 and474.1 highly,474.74 effective,475.7 work.476.9 What483.41 kind483.65 of483.89 diseases484.06 do484.45 we484.62 target?484.77 Actually,485.33 this485.74 technology485.89 is487.1 really487.33 agnostic489.57 to490.21 what490.38 tissue492.21 or492.62 what492.77 disease492.94 it493.33 can493.5 target.493.65 Really,494.38 once494.69 inside495.01 the495.33 cell,495.57 it496.17 can496.33 target496.57 any496.97 specific497.37 gene.497.93 So,499.37 the499.85 other500.01 portion500.33 to500.73 this500.89 is501.13 around501.29 which501.69 tissues503.37 can503.85 we504.01 deliver504.17 to.504.57 So,505.05 we506.09 currently506.33 have506.81 a506.97 limited507.13 set507.69 of508.09 areas508.41 where508.81 we509.05 can509.21 deliver509.37 to.509.93 Primarily,510.54 our511.1 technology511.33 delivers511.89 to512.22 liver,512.46 but513.17 we513.34 also513.5 have513.82 the513.98 ability514.46 to514.86 target515.01 other515.5 tissues517.17 such517.58 as517.82 bone518.22 marrow,518.46 CNS,519.01 and519.74 heart521.82 as522.22 well.522.38 So,523.52 with525.52 this525.76 technology,526 we're526.8 able527.04 to527.28 treat527.44 a528.08 variety528.24 of528.8 diseases529.04 across530.88 the531.28 rare531.44 disease531.76 spectrum.532.32 So,542.8 basically,542.96 what544.15 we're544.48 doing545.36 at545.84 500546.15 Arsenal547.27 Street547.68 is548 we're549.75 developing550.48 a552.71 genome552.87 editing553.27 proteins553.59 and554.15 RNA554.31 using555.35 standard555.91 mammalian556.47 cell556.95 culture557.19 and557.59 recombinant557.83 DNA558.39 techniques.558.87 We561.83 also561.99 characterize562.55 new563.11 genome563.35 editors,563.75 mammalian564.15 cells,564.87 and565.68 that565.85 includes566.33 immortalized566.8 cell567.37 lines,567.61 patient568.08 derived568.49 cells,568.96 and569.85 new570 cell570.25 lines570.49 using571.76 standard572.08 techniques572.49 using572.88 lentiviral573.28 transduction.574.25 576.8 We577.61 also577.76 develop578.08 reagents578.57 for579.81 in579.87 vivo579.93 delivery579.99 of580.05 genome580.21 editing580.61 proteins580.93 and581.41 RNA581.65 in582.05 mice582.21 as583.33 well583.49 as583.81 NHP.583.97 We584.45 obviously584.61 don't584.93 do585.17 any585.33 NHP585.57 work,586.05 but586.69 we586.85 do587.01 that587.17 outsourced,587.49 not588.77 in589.09 Watertown.589.65 We591.79 do591.96 this592.24 by592.51 using593 standard593.32 techniques593.79 using594.36 lipid594.6 encapsulation595.08 of595.79 messenger595.96 RNA,597.24 and597.39 then597.39 also597.63 for598.12 delivery,598.43 we598.91 use599 these599.24 replication599.88 incompetent,600.67 lentiviral601.96 and602.67 AAV602.91 vectors.603.39 So,604.83 at604.99 this605.07 site605.31 at605.63 500605.87 Arsenal,606.43 the606.91 primary607.07 work608.99 that's609.23 going609.47 to609.71 be609.71 done609.79 there609.95 is610.19 our610.35 animal610.59 care610.99 facility.611.39 So,611.87 all612.43 of612.59 the612.75 animal612.91 work613.31 that613.63 we're613.79 doing614.11 that's614.99 within615.39 Prime615.95 and616.59 not616.83 outsourced617.07 through617.55 a617.71 CRO617.79 will619.05 be619.21 done619.45 in620.89 Watertown.621.13 We622.57 do622.82 have623.05 a624.98 CRO625.21 that625.86 manages626.33 the627.05 husbandry627.93 of628.5 the628.98 animals,629.13 and629.62 they629.69 oversee629.93 all630.41 of630.57 that.630.74 They630.98 also631.21 are632.17 responsible632.5 for633.29 our633.77 IACUC.634.1 So,635.27 they635.43 manage635.59 all636.15 of636.39 that,636.71 so636.87 we636.87 don't637.03 have637.19 an637.35 internal637.59 IACUC.638.15 It's638.55 all638.79 managed639.27 by639.75 the641.67 CRO641.91 called642.31 Ozgene.644.95 I645.75 think645.91 I've646.23 pretty646.55 much646.79 covered647.27 everything647.75 there,649.76 so,649.92 I649.92 think650 I'll650.16 pass650.25 it650.4 back650.56 to650.8 you,650.88 Emily.651.13 652.4 DAILEY652.4 -652.4 Great.652.4 So654.49 Prime655.13 essentially655.61 already656.08 has656.4 a656.64 relatively656.73 robust657.68 biosafety658.88 program659.52 just659.92 because660.16 of660.49 the660.56 two660.73 facilities660.88 we661.44 already661.61 have661.92 open662.16 in662.4 Cambridge.662.56 So663.67 these663.83 are663.91 the663.99 procedures664.23 that664.63 we664.79 already664.95 have665.19 in665.43 place,665.59 and665.83 the666.07 folks666.15 who666.47 are666.63 going666.71 to666.87 be666.87 working666.95 at667.27 this667.35 ACF667.59 are668.39 moving668.55 over668.87 from669.19 an669.43 ACF669.59 in669.99 Cambridge.670.15 So,670.55 they're670.71 already670.87 familiar671.19 with671.59 these673.03 procedures673.11 as673.67 well.673.83 But674.63 sort674.79 of675.03 standard675.19 biosafety675.98 level676.45 2676.93 procedures,677.89 so678.21 folks678.21 have678.62 to678.77 wear678.86 a679.1 button679.17 lab679.57 coat,679.82 safety680.45 glasses,680.86 and681.57 gloves681.89 in682.29 their682.38 handling682.62 materials683.01 in683.5 the683.57 lab.683.74 They683.89 need684.05 to684.21 wear684.62 safety684.86 glasses685.17 and685.57 the685.82 lab686.05 coats686.21 just686.53 to686.69 enter.686.86 We687.5 do687.57 also687.74 have687.98 a688.13 couple688.21 folks688.53 who688.86 when689.1 they're689.25 interacting689.41 with689.82 animals,690.05 need690.53 to690.69 be690.77 wearing690.93 respirators.691.63 So,691.95 we692.27 have692.43 PAPR692.59 respirators692.91 and693.47 N95697.39 respirators,697.55 and697.55 those697.55 personnel697.79 are698.19 assigned698.35 through698.75 our698.99 agreement699.15 with699.47 Mount699.63 Auburn699.79 Occupational700.11 Health.700.67 So700.91 we701.07 do701.23 animal702.11 allergy702.51 screening702.91 at703.31 the703.47 beginning703.55 of703.87 the704.74 year,704.82 and705.06 then,705.13 you705.3 know,705.62 those705.77 folks705.94 are706.18 identified706.34 and706.89 they706.98 have707.13 access707.3 to707.62 those707.7 materials707.94 as708.42 needed.708.58 710.5 Obviously,710.5 we710.82 have710.98 biohazard711.22 symbols711.77 posted712.18 throughout712.65 the713.06 labs713.13 on713.46 all713.62 the713.86 doors713.94 to714.34 the714.42 labs,714.58 where715.22 this715.46 work715.7 is715.86 going716.01 to716.25 be716.25 taking716.34 place.716.58 Any717.5 work717.66 that's717.9 going717.98 to718.3 generate718.3 aerosols,718.78 you719.34 know,719.58 pipetting,720.06 centrifuging,720.78 etcetera,721.42 we're721.98 considering722.22 those722.78 things723.02 and723.26 and723.5 adding723.66 the723.98 applicable724.14 controls.724.7 So,725.1 things725.34 that725.58 can725.74 be725.82 done725.98 in726.14 a726.42 biosafety726.7 cabinet727.26 or727.66 done727.82 in727.94 a728.06 biosafety728.22 cabinet.728.78 When729.42 it729.58 comes729.66 to729.82 centrifuging,730.06 things731.02 that731.26 can't731.42 go731.66 into731.74 BSC,731.98 we732.64 have732.73 the732.97 centrifuge733.05 safety733.61 caps733.93 available,734.33 and734.73 folks734.97 either735.21 need735.45 to735.61 open735.76 up736.09 those736.25 caps736.64 inside737.21 of737.52 a737.61 biosafety737.76 cabinet738.33 when738.64 they're738.8 done738.97 centrifuging739.21 or739.68 they739.85 need740 to740.17 wait740.25 at740.49 least740.57 10740.73 minutes740.97 for741.29 those741.45 aerosols741.61 to742.09 settle.742.25 We743.45 have743.68 a744.09 relatively744.25 strict744.97 liquid746 bio746.49 waste746.8 policy.747.05 So,747.52 we747.68 have747.76 a747.93 lot749.02 of749.1 signage749.74 that750.14 will750.38 be750.46 posted750.7 in751.02 the751.18 lab,751.26 but,752.14 essentially,752.38 pre752.86 bleaching754.3 aspiration754.94 traps755.5 so755.82 that756.06 as756.22 waste756.46 is756.78 generated,756.94 it's757.42 being757.58 decontaminated,757.9 and758.94 that759.18 waste759.34 is759.66 dumped759.82 daily760.14 so760.46 that760.62 we760.78 don't760.86 have761.42 gross761.66 waste761.98 building762.22 up762.54 for762.67 days762.75 and763 weeks763.15 at763.32 a763.39 time,763.55 and763.71 that763.88 bleach764.12 should764.43 stay764.6 effective765.55 throughout766.03 the766.36 workday.766.51 767.55 Of767.55 course,767.63 we767.88 also768.03 have768.36 the768.6 inline768.75 vacuum769.71 protection770.2 filters770.91 in771.32 place771.55 as771.79 well.771.96 10%773.24 bleach774.12 kind774.6 of774.75 standard,775 is776.12 sort776.27 of776.43 what776.75 we776.91 aim777.15 for.777.39 For778.77 surface779.09 decontamination,779.49 we780.77 largely781.09 use781.57 70%782.13 alcohol,782.85 so783.17 ethanol783.41 or783.81 isopropanol.783.97 But785.17 folks785.33 do785.65 have785.89 the786.13 option786.37 to786.77 use787.01 shelf787.33 stable787.65 bleach788.05 rate788.45 as788.69 well.788.93 Most789.65 folks789.97 are790.29 not790.45 using792.26 freshly792.42 mixed792.9 bleach793.23 on793.47 a793.63 day793.71 to793.87 day793.95 basis.794.11 If794.42 they're794.59 opting794.9 for795.23 sodium795.63 hypochlorite,795.95 they're796.5 going796.67 to796.83 be796.83 using796.99 bleach797.47 rate797.79 sort798.02 of798.11 to798.26 make798.35 sure798.5 that798.67 that798.83 bleach798.99 stays799.3 fresh800.02 and800.26 effective,800.83 and800.99 then,800.99 of801.14 course,801.23 hand801.54 washing801.79 is802.26 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we1292.73 want1292.81 more1293.05 detail1293.21 on1293.53 lenti.1293.69 Okay,1294.81 because1295.05 what1295.05 I1295.21 have1295.37 is1295.53 a1295.61 whole1295.69 bunch1295.85 of1296.09 AAVs,1296.33 pseudo1297.13 type1297.69 lenti,1297.69 the1298.49 mouse1298.73 and1299.21 rat1299.45 models,1302.33 and1302.64 so1302.64 there's1302.88 no1303.13 human1303.28 blood1303.52 or1303.85 serum1304.01 or1304.33 anything1304.57 like1304.8 that?1304.96 N1305.44 1305.44 GUEVARA1305.44 -1305.44 No.1305.44 1306.24 HUNTER1306.24 -1306.24 No.1306.24 1307.85 LIEBERMAN1307.85 -1307.85 Okay.1307.85 And1308.64 NHP1309.04 blood1310.01 or1310.4 serum1310.64 coming1310.96 from1311.2 your1311.44 CRO?1311.61 1312.4 HUNTER1312.88 -1312.88 No,1312.88 because1313.2 we1313.2 we1313.44 do1313.61 all1313.76 that1313.92 work1314.09 in1314.33 China,1314.57 and1314.88 we1315.04 can't1315.13 ship1315.44 that1315.76 to1315.92 the1316.24 US.1316.24 1321.1 GUEVARA1321.1 -1321.1 So1321.1 for1321.34 lenti1321.66 work,1322.06 Mia,1322.54 I1322.78 just1322.86 kind1323.34 of1323.58 want1323.58 to1323.58 clarify.1323.58 You1324.06 want1324.22 to1324.54 know,1324.54 like,1325.18 what1325.42 generation?1325.66 1326.94 LIEBERMAN1326.94 -1326.94 Yes,1327.34 we1327.5 can1327.5 place1327.66 it1327.9 on1328.06 the1328.22 list1328.78 so1329.02 we1329.18 know.1329.26 1330.09 PARSONS1330.09 -1330.09 Yes,1330.4 because1330.48 you1330.48 mentioned1330.72 it1331.05 in1331.29 the1331.44 presentation.1331.68 1333.77 GUEVARA1333.77 -1333.77 I1334.64 can1334.81 update1334.96 that1335.29 in1335.53 the1335.68 organism1335.85 list.1336.4 1336.81 PARSONS1336.81 -1336.81 Hey,1336.96 Deb.1337.29 1340.01 DEBORAH1340.01 MCEWAN1340.01 -1340.01 BIOSAFETY1342.72 COMMITTEE1342.72 MEMBER1342.72 -1342.72 Apologies1343.13 to1343.53 everyone1343.77 for1344.09 being1344.24 late.1344.48 1345.51 PARSONS1345.51 -1345.51 No1345.51 problem,1346.07 it1346.23 happens.1346.23 We1346.87 just1347.03 started1347.27 the1347.59 Q1347.75 and1347.91 A,1348.07 session1349.43 with1349.91 Prime.1350.87 Tim,1353.51 you're1354.39 asking1354.55 questions.1354.79 1355.75 MAGUIRE1355.75 -1355.75 Yes.1355.99 So,1356.15 is1356.15 all1356.23 the1356.47 LMP1356.63 encapsulation1357.19 work,1357.91 is1358.15 that1358.31 all1358.62 just1358.86 microfluidics1359.02 that1359.82 can1360.06 fit1360.22 within1360.38 a1360.78 biosafety1361.02 cabinet,1361.73 or1362.22 is1362.54 it1362.7 larger1363.02 than1363.58 that1363.82 and1364.13 requires1364.7 some1365.34 other1365.49 closed1365.73 process1366.22 outside1366.7 of1367.1 a1367.26 biosafety1367.73 cabinet?1368.3 1370.46 HUNTER1370.46 -1370.46 Do1370.46 you1370.87 want1370.95 to1371.03 take1371.03 this1371.27 one,1371.51 Emily?1371.75 1372.39 DAILEY1372.39 -1372.39 I1372.39 was1372.47 going1372.55 to1372.79 ask1372.79 if1373.11 you1373.19 did.1373.35 1373.99 HUNTER1373.99 -1373.99 All1376.07 that1376.31 work1376.39 is1376.63 actually1376.87 done1377.11 in1377.27 Cambridge,1378.39 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the1430.88 pressurization,1430.96 you1432.88 can1432.96 just1433.12 do1433.28 pluses1433.44 and1433.76 minuses1433.92 to1434.4 indicate1434.56 what's1435.12 positive1435.44 and1435.76 what's1435.92 negative,1436.24 just1436.96 so1437.2 we1437.28 can1437.36 look1437.52 at1437.68 that.1437.76 You1438.08 said1438.24 the1438.4 whole1438.56 thing1438.72 is1438.96 BL2,1440.07 so1440.38 I'm1440.7 assuming1441.03 it's1441.51 negative1441.83 to1442.22 the1442.55 in1442.79 vivo1443.03 lab1443.42 space.1443.66 1444.7 GUEVARA1444.7 -1444.7 Correct.1444.7 1445.83 LIEBERMAN1445.83 -1445.83 Which,1446.14 by1446.38 the1446.63 way,1446.7 is1446.87 very1447.11 confusing1447.35 calling1447.83 it1448.07 an1448.38 in1448.55 vivo1448.79 lab1449.27 space1449.42 if1449.66 there's1449.83 not1450.07 actually1450.31 in1450.7 vivo1450.79 work.1451.27 So,1451.51 I1451.66 was1451.83 really1452.08 confused1452.4 looking1452.64 at1452.88 these1453.04 slides1453.28 until1453.52 you1453.84 explained1454 that1454.4 animals1454.56 weren't1454.96 going1455.2 into1455.44 the1455.68 in1455.92 vivo1456 lab1456.48 space.1456.64 Did1457.44 you1457.6 mean1458.3 to1458.4 call1458.48 that1458.64 in1458.96 vitro?1459.2 I'm1460 not1460.16 sure.1460.4 1461.84 HUNTER1461.84 -1461.84 Yes,1462.08 it's1462.24 just1462.24 part1462.48 of1462.72 the1462.8 in1462.96 vivo1463.12 teams,1464.24 sorry1464.88 for1465.2 misleading1465.52 there.1466.08 1467.55 DAILEY1467.55 -1467.55 I1467.55 could1467.7 see1467.87 how1468.03 that'd1468.18 be1468.35 confusing.1468.51 1469.46 LIEBERMAN1469.46 -1469.46 I1474.03 guess1474.18 my1474.42 last1475.14 question1475.38 was,1475.87 is1477.07 the1477.38 attending1478.51 veterinarian1478.98 local1482.29 because1482.45 she1482.45 has1482.45 a1482.61 phone1482.69 number1483.09 from,1483.49 when1484.77 I1484.93 tried1485.09 to1485.33 look1485.41 her1485.57 up,1485.73 it1485.89 seems1486.05 like1486.29 she1486.45 does1486.53 not1486.69 live1486.85 in1486.93 Massachusetts.1487.17 So,1487.73 I1487.97 was1488.05 just1488.13 curious1488.37 about1488.69 that.1488.93 1489.17 GUEVARA1489.17 -1489.17 Yes,1489.73 she1489.97 will1489.97 be1490.13 local.1490.37 1491.81 LIEBERMAN1491.81 -1491.81 Okay.1491.81 I1494.77 think1494.93 that's1495.17 all1495.41 I1495.57 have1495.73 for1495.89 now.1496.05 1497.63 GUEVARA1497.63 -1497.63 Great.1497.63 So1498.11 just1498.42 want1499.22 to1499.54 summarize,1499.54 what1500.83 we're1501.07 going1501.22 to1501.46 follow-up1501.46 on.1501.94 We1502.66 will1502.83 update1503.07 the1503.38 list1503.46 of1503.7 organisms1503.87 and1504.66 add1505.63 the1505.87 third1506.03 and1506.18 fourth1506.35 generation.1506.59 Is1507.07 there1507.22 anything1507.46 specific1508.03 that1508.35 you1508.51 want1508.66 for1508.9 the1509.07 lenti?1509.22 1510.52 LIEBERMAN1510.52 -1510.52 Just1510.52 third1510.68 and1510.92 fourth1511 generation1511.16 is1511.64 fine.1511.72 Then1512.12 the1512.44 pressurization1512.6 on1513.56 the,1513.72 animal1514.44 care1514.92 floor1515.32 plan,1515.56 and1517.32 then1517.48 you're1517.64 using1517.8 formalin1518.28 in1518.76 the1518.92 animal1519.08 care1519.32 facility,1519.56 presumably?1519.96 1520.68 HUNTER1520.68 -1520.68 Yes.1520.68 1521 LIEBERMAN1521.56 -1521.56 Okay.1521.56 So1521.88 that'll1522.12 be1522.36 in1522.44 one1522.52 of1522.68 the1522.76 rooms1522.92 of1523.08 the1523.24 hoods,1523.32 I1523.8 assume.1523.96 1524.69 GUEVARA1524.69 -1524.69 Yes.1524.69 1525.58 LIEBERMAN1525.58 -1525.58 And1525.58 I1525.73 saw1525.89 you1526.05 marked1526.21 your1526.45 isoflurane,1527.26 and1527.41 you're1527.41 using1527.65 oxygen1529.41 tanks,1529.89 or1530.21 is1530.38 it1530.54 house1530.69 oxygen?1530.93 1533.02 GUEVARA1533.02 -1533.02 The1535.26 tanks,1535.97 technically,1535.97 are1536.34 the1536.69 ones1536.86 that,1537.02 like,1537.26 can1537.41 travel,1537.65 like,1538.05 the1538.13 little1538.3 cylinders,1540.63 that's1540.87 what1540.95 we're1541.35 going1541.59 to1541.83 be1541.83 using.1541.99 1542.63 LIEBERMAN1542.63 -1542.63 Ralph,1542.63 do1543.11 you1543.27 need1543.35 that1543.59 info1543.75 about1544.55 oxygen1544.79 tanks?1545.19 1546.23 RALPH1546.23 MELE1546.23 -1546.23 BIOSAFETY1546.23 COMMITTEE1546.23 MEMBER1546.23 -1546.23 I1546.23 have1546.39 it1546.55 already.1546.71 1547.27 LIEBERMAN1548.71 -1548.71 Okay.1548.71 And1549.35 then1549.51 you're1549.75 using1549.91 disposable1550.39 caging?1551.19 1552.47 GUEVARA1552.47 -1552.47 The1555.01 cage1555.09 will1555.48 be1555.72 cleaned1556.28 in1556.61 house.1556.85 1558.92 LIEBERMAN1558.92 -1558.92 So1558.92 where's1559.4 your1559.72 cage1560.04 wash?1560.44 1561.72 GUEVARA1561.72 -1561.72 I1562.44 can1562.52 mark1562.68 it1562.92 in1563.01 the1563.16 floor1563.33 plan1563.57 when1563.88 I1564.04 send1564.13 over1564.37 the1564.61 pressurized.1564.77 I'll1569.26 mark1569.5 it1569.74 on1569.9 the1570.06 floor1570.3 plan.1570.54 1573.1 LIEBERMAN1573.1 -1573.1 Doesn't1573.1 seem1573.42 like1573.58 you1573.66 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DAILEY1627.15 -1627.15 I1627.15 think1627.31 we1627.55 just1627.79 requested1628.19 that1628.75 change1628.99 last1629.31 week,1629.47 so1629.63 thank1629.87 you1630.03 for1630.11 flagging1630.27 that,1631.87 we1632.11 should1632.11 get1632.27 the1632.43 updated1632.59 letter.1632.99 1633.39 GUEVARA1633.39 -1633.39 Yes,1633.71 and1633.87 once1633.87 we1634.11 do,1634.27 we1634.43 can1634.59 upload1634.75 it1635.07 onto1635.15 the1635.47 portal.1635.63 1636.92 MELE1636.92 -1636.92 That's1637.33 all1637.57 I1637.68 have.1637.8 1638.61 PARSONS1638.61 -1638.61 Thank1638.61 you,1641.01 Ralph.1641.33 Deb,1642.29 any1642.61 questions1642.77 for1643.16 Prime?1643.4 1644.2 MCEWAN1644.2 -1644.2 No,1644.44 all1644.61 of1644.61 mine1644.77 have1644.92 been1645.01 answered.1645.24 Thank1645.57 you.1645.72 1646.68 PARSONS1646.68 -1646.68 Great.1647.09 I1647.88 do1648.04 have1648.13 a1648.29 couple1648.37 questions,1648.61 but1648.85 I1649.01 just1649.09 wanted1649.24 to1649.57 make1649.64 a1649.8 clarification1649.88 statement.1650.61 I1651.09 heard1651.24 it's1651.48 third1651.85 and1652.01 fourth1652.25 generation1652.57 lentivirus,1653.13 but1653.77 in1653.93 the1654.09 presentation,1654.25 it1654.73 definitely1654.89 said1655.21 second1655.45 and1655.77 third.1655.93 1656.89 GUEVARA1656.89 -1656.89 I'll1656.89 confirm1657.05 that.1657.61 1658.57 PARSONS1658.57 -1658.57 Yes,1659.21 so1659.61 they1659.85 both1660.09 should1660.33 be1660.49 saying1661.93 the1662.33 same1662.41 thing.1662.65 Okay.1665.77 So,1668.86 I1669.65 think1669.82 I've1670.06 asked1670.22 this1670.46 question1670.62 before,1671.02 I1671.49 feel1671.73 I1671.97 was1672.06 getting1672.22 crazy1672.46 deja1672.93 vu1673.34 looking1673.49 at1673.82 this1673.97 floor1674.22 plan.1674.46 But1675.97 on1676.22 one1676.38 floor1676.7 plan,1677.02 Room1677.65 A1431678.62 is1679.49 labeled1679.65 as1680.06 gas1680.3 storage,1680.54 and1681.47 then1681.71 on1681.95 another1682.27 floor1682.51 plan,1682.83 it's1683.15 listed1683.39 as1683.79 NMR.1684.03 So1687.23 those1687.71 are1687.95 two1688.35 wildly1688.59 different1689.07 uses.1690.03 So1690.67 are1691.07 you1691.23 going1691.31 to1691.63 have1691.63 an1691.79 NMR1692.19 facility1692.99 here?1693.71 1694.6 DAILEY1694.6 -1694.6 No,1695.55 apologies,1695.88 the1695.88 floor1696.04 plans1696.36 came1696.67 from1696.99 a1697.23 previous1697.32 tenant1697.79 where1698.19 they1698.43 had1698.6 NMR,1699.39 we1699.55 do1699.55 not1699.63 have1699.88 NMR.1700.04 So,1701.55 in1701.88 all1702.12 places1702.28 that1702.67 we've1702.91 found,1703.23 we've1703.55 tried1703.71 to1704.19 update1704.52 the1704.91 room1705.23 names1705.55 to1705.95 be1706.12 what1706.52 we're1706.67 actually1706.91 using1707.39 those1707.71 spaces1707.88 for,1708.28 but1708.36 that's1708.52 just1708.76 a1708.91 relic1708.99 from1709.39 the1709.55 previous1709.71 tenant.1710.51 1710.51 PARSONS1710.51 -1710.51 Yes,1711.15 it's1711.31 in1711.55 one1711.71 of1711.87 them.1711.95 So1712.67 the1712.91 one1713.07 that1713.23 reads1713.47 gas1713.71 storage1714.03 clearly,1714.43 it1714.91 was,1714.99 like1715.63 a1715.79 Photoshop1715.95 or1716.43 something1716.51 like1716.83 that.1716.91 So,1717.15 it1717.39 blocks1717.55 out1717.87 the1718.03 entire1718.19 room,1718.51 and1718.83 it's1718.91 nice1719.23 and1719.39 neat.1719.55 And1720.99 then,1721.15 yes,1721.47 another1721.71 one1722.03 was1722.27 a1722.59 different,1722.67 I1722.99 think1723.07 it1723.23 was1723.31 the1723.47 egress1723.63 map1724.51 showed1726.69 NMR1727.65 facility1728.3 for1728.69 A143.1730.21 Okay,1730.45 so1730.45 no1730.45 NMR,1737.65 okay.1738.13 So,1738.13 Prime1738.13 maintains1738.13 an1739.49 internal1739.65 spill1740.7 response1740.94 team1741.42 with1741.74 the1741.9 HAZWOPER1742.06 training,1742.7 or1743.26 is1743.66 it1743.9 just1744.22 EC1745.74 training?1745.82 1747.02 DAILEY1747.02 -1747.02 So1747.02 we1747.5 have1747.74 both.1748.46 We1748.94 have1749.18 folks1749.5 trained1749.9 to1750.22 the1750.38 81750.62 hour1750.78 FROL1751.66 FRALL1752.46 level,1753.02 but1753.98 we1754.14 really1754.3 only1754.54 use1754.86 that1755.1 for1755.26 incidental1755.5 spills.1757.47 You1759.08 know,1759.23 they're1759.32 sort1759.56 of1759.8 good1759.88 references1760.12 for1760.6 us1760.76 to1760.91 have1760.99 on-site1761.15 for1761.63 those1761.8 controlled1762.04 spills,1762.52 but1762.99 we1763.15 have1763.32 Triumvirate1763.56 as1764.2 our1764.43 24/71765.15 spill1765.56 response1765.88 vendor.1766.36 So,1766.67 if1766.91 we1767.08 have1767.23 a1767.32 larger1767.47 spill,1767.8 they'll1768.2 come1768.36 in1768.52 and1768.76 do1768.84 that1768.99 response.1769.15 1770.41 PARSONS1770.41 -1770.41 Yes,1770.41 I1770.57 saw1770.73 that.1770.81 So1770.97 that's1771.05 why1771.21 I1771.37 was1771.45 confused,1771.93 so,1771.97 I1771.97 just1772.01 wanted1772.17 to1772.41 to1772.65 clarify1772.81 that1773.21 because1773.37 it1773.61 sounds,1773.85 I1774.89 mean,1775.05 it's1775.21 great1775.45 training1775.61 for1776.73 those1776.89 who1777.13 enjoy1777.29 it,1777.61 but1780.57 you1780.81 guys1780.97 fall1781.13 under1781.37 HASCOM,1781.69 so1782.25 you1782.57 don't1782.65 necessarily1782.89 need1783.45 HAZWOPER.1786.1 So,1786.26 I1786.26 just1786.34 wanted1786.49 to1786.82 make1786.89 sure,1787.05 because1787.69 it1787.86 was1788.02 referenced1788.17 a1788.58 couple1788.65 times1788.89 very1789.21 well1789.45 and1789.62 clearly,1789.69 by1790.26 the1790.41 way.1790.49 So1791.45 I1791.69 was1791.78 just1791.93 kind1792.1 of1792.34 like,1792.34 alright,1792.73 what's1792.97 going1792.97 on1793.29 here?1793.45 Alright,1794.58 that1794.73 makes1794.73 sense.1795.05 This1799.61 is1799.85 a1800.01 persnickety1800.17 thing,1800.81 so1801.05 this1801.21 is1801.45 just1801.53 for1801.85 your1802.01 consideration.1802.25 The1804.57 documents1805.05 that1805.53 were1805.69 submitted,1805.93 traditionally,1806.89 it's1808.25 called1808.57 an1808.81 emergency1808.97 action1809.53 plan,1809.93 and1811.1 you1811.49 submitted1812.93 it1813.34 as1813.41 a1813.89 contingency1815.97 plan,1816.62 which1816.93 is1817.26 fine,1818.45 however,1820.69 in1820.69 your1821.1 health1822.63 monitoring1822.95 and1824.95 health1825.19 surveillance1825.43 document,1826.15 you1827.19 reference1827.43 the1827.83 EAP,1828.15 which1828.71 doesn't1828.95 exist1829.27 technically,1829.67 at1830.47 least1830.63 in1830.95 the1831.11 documents1831.27 that1831.99 have1832.55 been1832.71 submitted1832.95 to1833.35 us.1833.51 So,1833.99 I1834.15 would1834.31 recommend1834.47 either1835.19 in1835.83 your1836.07 and1837.03 this1837.29 isn't1837.44 something1837.61 that1837.77 has1837.92 to1838.09 be1838.24 done1838.33 before1838.57 you1838.88 see1838.96 the1839.05 board1839.2 of1839.44 health,1839.53 just1840.57 for1840.81 your1840.96 own1841.13 internal1841.44 records.1842.4 Either1842.88 change1843.2 the1843.53 emergency1843.85 action1844.24 plan1844.48 to1844.72 the1844.81 contingency1844.96 plan1845.53 or1845.77 rename1846.01 the1846.4 contingency1846.57 plan1847.05 to1847.29 the1847.37 emergency1847.53 action1848.01 plan1848.24 because1848.64 I1848.88 could1848.96 see1849.13 OSHA1849.37 being1849.68 confused1849.92 by1850.33 that1850.48 if1850.72 they1850.88 were1851.05 ever1851.29 doing1851.53 an1853.18 audit.1853.34 1854.14 DAILEY1854.14 -1854.14 Thank1854.14 you1854.3 for1854.46 flagging1854.7 that.1855.02 We1855.18 recently1855.5 upgraded1856.06 from1856.54 an1856.7 EAP1856.94 to1857.26 a1857.42 contingency1857.58 plan1858.14 when1858.46 they1858.62 became1858.78 an1859.1 LQG,1859.26 and1860.14 so1860.38 that1860.62 must1860.86 also1861.1 be1861.42 a1861.58 relic.1861.66 So,1862.06 thank1862.22 you1862.38 for1862.54 catching1862.7 that,1862.94 and1863.1 we'll1863.26 certainly1863.42 update1863.74 that.1863.98 1864.94 PARSONS1864.94 -1864.94 No1865.34 problem.1865.66 I1868.54 always1868.7 have1869.03 at1869.18 least1869.27 one1869.51 question1869.66 on1870.14 the1870.3 chemical1870.46 hygiene1870.78 plan,1871.18 and1871.83 there1871.98 is1872.14 a1872.46 section1872.63 on1873.03 hydrofluoric1873.27 acid1873.98 use1874.87 and1875.18 safety1875.35 and1875.66 stuff1875.83 like1875.98 that.1876.14 Are1876.38 you1876.7 using1876.94 hydrofluoric1877.27 acid?1877.9 1878.96 DAILEY1878.96 -1878.96 Not1878.96 in1879.2 this1879.44 section1880.16 of1880.56 the1880.72 facility,1880.88 but1881.36 there1881.52 is1882.64 one1882.88 specific1882.88 fume1883.36 hood1883.6 for1883.84 some1884 particular1885.04 work1885.36 that1885.6 the1885.84 chemists1885.92 will1886.56 use,1886.8 not1887.36 hydrofluoric1887.6 acid1888.24 itself,1888.88 they1889.12 use1889.12 some1889.28 safer1889.6 alternatives,1890.16 but1891.04 they1891.2 are1891.36 still1891.6 fluorinating1891.92 agents,1895.12 so,1895.28 TBAF,1895.28 and1895.28 we1895.28 do1895.36 have1895.52 a1895.67 whole1895.84 HF,1896.15 safety,1897.76 program.1899.12 So1899.6 we1899.76 have1899.91 specific1900.23 HF1900.63 safety1901.04 training,1902.08 only1902.39 authorized1902.39 users1902.8 can1903.2 work1903.43 with1903.6 the1903.76 material.1903.84 We1904.23 have1904.39 calcium1904.63 gluconate1905.04 gel1905.6 on-site1905.84 and1906.32 spill1907.28 kits1907.52 and1907.84 first1908.44 aid1908.68 kits,1908.84 and1909.16 it's1909.4 very1910.04 consolidated1910.6 to1911.24 one1911.4 very1911.64 clearly1911.88 marked1912.2 view1912.52 pod.1912.68 1913.8 PARSONS1913.8 -1913.8 Alright.1922.12 So1922.36 that's1922.52 all1922.68 the1922.84 questions1922.92 I1923.32 had.1923.48 So,1928.58 Fatima,1929.45 you've1929.93 got1930.17 all1930.49 the1930.82 updates1932.17 that1932.58 we're1932.73 requesting?1932.97 1933.93 GUEVARA1933.93 -1933.93 Yes.1934.26 1936.74 PARSONS1936.74 -1936.74 So1936.74 we1936.98 should1937.22 get1937.38 those1937.54 as1937.78 soon1937.86 as1938.1 you1938.26 can,1938.34 because,1939.78 Maureen,1940.26 when1940.74 is1940.98 the1941.22 board1941.38 of1941.62 health1941.7 meeting?1941.94 1943.86 MAUREEN1943.86 FOLEY1943.86 -1943.86 CITY1945.62 OF1945.62 WATERTOWN1945.62 -1945.62 April1946.02 16th.1947.46 1947.46 PARSONS1947.46 -1947.46 Yes,1948.1 so1948.42 we1948.42 should1948.66 get1948.82 that1948.98 information1949.22 before1949.78 you1950.1 present1950.34 to1950.66 the1950.82 board1950.98 of1951.3 health.1951.46 1952.13 GUEVARA1952.13 -1952.13 Yes,1952.13 I1952.44 will1952.85 get1953.09 that1953.24 to1953.48 you1953.57 by1953.8 the1954.04 end1954.13 of1954.28 the1954.44 day1954.53 tomorrow.1954.77 Would1955.96 you1956.2 like1956.28 me1956.44 to1956.68 just1956.77 upload1956.92 it1957.24 onto1957.33 the1957.64 portal?1957.72 1958.77 PARSONS1958.77 -1958.77 Yes,1958.77 please.1959.01 Perfect.1963.33 So,1968.05 I'll1968.05 make1968.21 to1968.37 make1968.53 a1968.69 motion1968.77 that1969.17 the1969.57 Watertown1969.81 Biosafety1970.37 Committee1972.29 recommends1973.49 Prime1973.49 Medicine's1973.81 application1975.65 with1976.61 the1977.41 updates1978.13 and1978.45 clarifications1978.61 as1979.41 requested1979.65 to1981.17 the1981.41 Board1981.49 of1981.73 Health.1981.89 1984.3 LIEBERMAN1984.3 -1984.3 Second.1984.3 1987.51 PARSONS1987.51 -1987.51 Maureen,1987.9 why1988.22 don't1988.3 we1988.46 take1988.63 a1988.79 vote?1988.87 It's1989.11 been1989.35 a1989.51 while1989.59 since1989.74 we've1989.98 done1990.22 this.1990.3

1991.18 SPEAKER101991.18 -1991.18 Exactly.1991.18

1993.98 Ralph1993.98 Bailey?1994.3

1995.42 SPEAKER91995.42 -1995.42 Yes.1995.42

1996.63 SPEAKER101996.63 -1996.63 Definitely.1996.63 He1997.19 wins.1997.75 Yes.1998.39 Brad2000.39 Parsons?2000.71

2002.07 SPEAKER12002.07 -2002.07 Yes.2002.07

2003.19 SPEAKER102003.19 -2003.19 Ralph2003.19 Neely?2003.67

2006.79 SPEAKER12006.79 -2006.79 We2006.79 got2006.95 his2007.11 vote.2007.35 Oh,2007.83

2009.26 SPEAKER102009.26 -2009.26 you2009.26 didn't2009.34 We2009.58 got2009.65

2009.86 SPEAKER12009.86 -2009.86 Tim2009.86 and,2010.06 Mia2010.46 left.2010.7 Yeah.2011.82 Yes.2012.22 For2012.46 Tim.2012.7 Yep.2013.1

2014.13 SPEAKER102014.13 -2014.13 Okay.2014.13 Tim2014.93 I2015.26 don't2015.49 see2015.74 you,2015.89 Chris.2016.13 Tim2016.7 and2018.46 Yep.2018.86 Mia.2019.17 Yes.2020.38

2022.85 SPEAKER12022.85 -2022.85 Great.2022.85

2023.09 PARSONS2023.09 -2023.09 Well,2023.09 thank2023.17 you2023.41 everyone2023.73 for2024.13 presenting,2024.37 from2025.09 Prime.2025.33 Best2025.65 of2025.89 luck2026.05 with2026.29 your2026.45 research,2029.97 and,2030.53 yes,2030.53 look2030.53 forward2030.77 to2031.09 success.2031.25 2032.69 DAILEY2032.69 -2032.69 Thank2032.69 you.2032.93

2033.25 SPEAKER12033.25 -2033.25 Oh,2033.25 and2033.33 you're2033.57 free2033.73 to2033.97 go.2034.13 We2036.37 don't2036.53 get2036.77 offended2036.92 when2037.4 when2037.72 people2038.13 present2038.53 and2038.92 then2039.09 leave.2039.88 We2040.85 get2041.01 that.2041.16 It's2041.48 totally2041.88 okay.2042.29 So,2043.64 thank2044.61 you2044.85 for2044.92 your2045.09 time,2045.24 and2045.64 take2046.05 care.2046.29

2047.16 SPEAKER32047.16 -2047.16 Thank2047.16 you.2047.48 Have2047.72 a2047.85 good2047.96 night,2048.2 you2048.36 all.2049.49

2049.49 SPEAKER12049.49 -2049.49 Bye.2049.49

2053.94 Okay.2053.94

2054.42 PARSONS2054.42 -2054.42 Up2054.42 next,2054.98 we2056.34 have2056.5 an2056.66 amendment2056.74 from2057.38 Dyno.2060.58 Let2060.74 me2060.74 pull2061.06 up2061.22 my2061.38 notes2061.62 real2062.02 quick.2062.34 So2063.06 the2064.71 adding2064.95 to2065.28 project2065.91 registration2066.32 2020-001,2069.03 cloning,2070.07 recombinant2070.07 adenos2070.64 associated2071.99 bioreactors2073.03 in2073.76 e2073.84 coli2073.99 and2074.32 then2074.55 manipulation2074.71 in2075.68 mammalian2075.91 cell2076.64 lines,2076.95 and2077.51 then2077.76 adding2077.99 human2078.65 serum2078.89 and2079.21 three2079.37 new2079.61 cell2079.85 lines2080.09 to2080.49 the2082.09 list.2082.41 Did2082.73 I2082.97 get2083.05 that2083.29 correct,2083.61 Luke?2084.17 2085.37 LUKE2085.37 AMIRAULT2085.37 -2085.37 DYNO2085.85 THERAPEUTICS2086.01 -2086.01 Yes,2086.01 you2086.01 did.2086.01 How's2086.33 it2086.65 going?2086.73 2087.69 PARSONS2087.69 -2087.69 I'm2087.69 well,2088.09 thank2088.25 you.2088.25

2088.41 How2088.41 are2088.57 you?2088.73 Good.2089.37 Feel2091.86 like2092.09 Dynos2092.26 here2092.66 a2092.89 lot.2092.97 I2093.22 love2093.3 that.2093.53

2095.86 SPEAKER72095.86 -2095.86 Definitely.2095.86

2096.26 SPEAKER12096.26 -2096.26 Community2096.26 engagement.2096.74 It's2097.3 wonderful.2097.61 2098.26 PARSONS2098.26 -2098.26 So2098.26 I2098.66 don't2098.74 you2099.22 know,2099.3 if2099.53 you2099.7 didn't2099.86 bring2100.09 a2100.34 deck,2100.41 that's2100.97 totally2101.3 cool.2101.61 2101.93 AMIRAULT2101.93 -2101.93 Yes,2101.93 I2103.05 did2103.14 not2103.3 bring2103.53 a2103.7 deck2103.86 this2104.01 time,2104.26 but2104.49 that2104.82 was2104.97 pretty2105.3 nice.2105.53 Maybe2105.78 next2106.09 time,2106.26 I'll2106.49 do2106.66 that.2106.82 2108.39 PARSONS2108.39 -2108.39 No,2108.71 you2108.95 don't2108.95 have2109.11 to.2109.19 2110.71 AMIRAULT2110.71 -2110.71 So,2111.51 yes,2111.83 we2113.19 did2113.27 our2113.51 renewal2113.67 back2114.23 in,2114.47 I2114.95 think,2115.11 December2115.99 or2116.31 January,2116.39 and,2116.95 I'm2117.99 just2118.15 adding,2118.39 like2118.87 you2119.11 said,2119.27 or2121.41 amending2121.57 one2122.68 of2122.81 our2122.93 project2123.09 registrations2123.41 and2124.05 adding2124.29 human2124.93 serum2125.24 and2125.81 three2126.05 cell2126.36 lines.2126.61 So2127.41 at2128.05 Dyno,2128.2 we2130.29 engineer2130.45 AAV2131.01 capsids,2131.41 design2133.88 and2134.2 manufacture2134.28 them2134.84 for2135.08 gene2135.96 delivery.2136.2 So,2136.68 this2139.08 time2139.24 around2139.4 for2140.12 the2140.28 human2140.44 serum,2140.68 we2141.32 had2142.44 to2142.6 run,2143 we2143.24 did,2143.32 like,2143.56 a2143.64 risk2143.8 assessment2144.04 with2145.82 myself2145.97 and2146.22 the2146.38 scientist,2146.61 I'm2146.93 the2147.1 EHS2147.34 manager,2148.7 so2148.86 we2148.86 did2149.02 that.2149.18 We2149.34 went2149.58 to2149.74 the2149.97 internal2150.38 IBC,2150.86 reviewed2153.49 the2153.82 risk2153.89 assessment,2154.14 you2155.82 know,2155.97 answered2156.14 any2156.45 questions2156.7 we2157.1 had,2157.26 and2157.9 then,2158.14 we2158.54 all2158.78 approved,2159.58 we2159.82 ended2160.06 up2160.38 adjusting2160.54 our2162.7 protocol2162.94 as2163.42 well2163.58 and2163.82 then2163.98 approved2164.14 that2164.46 and,2165.34 included2165.9 the2166.38 additional2166.94 cell2167.42 lines.2167.66 And,2168.94 yes,2169.74 submitted2170.06 them2170.46 on2171.66 Viewpoint,2171.82 and,2172.46 yes,2173.64 that's2173.89 why2174.2 I'm2174.53 here2174.61 tonight.2174.77 2176.68 PARSONS2176.68 -2176.68 Great.2176.68 Thank2177.16 you.2177.33 Any2180.68 questions2181.01 from2181.64 the2182.2 committee2182.36 for2182.85 Luke?2183.09 2184.68 LIEBERMAN2184.68 -2184.68 Yes,2184.68 I2185.01 actually2185.09 have2185.41 one.2185.97 So,2186.45 the2186.45 IBC2188.3 minutes2189.34 were2189.34 dated2189.82 from2190.54 November2194.06 16th,2195.34 so2195.5 was2195.5 there2195.66 a2195.9 follow-up2196.06 meeting2196.46 for2196.78 the2196.94 serum?2197.1 2199.5 AMIRAULT2199.5 -2199.5 So2199.5 there2199.82 was,2199.98 like,2200.22 a2200.46 asynchronous2201.02 review.2201.9 So2202.94 we2203.26 sent2203.95 out2204.28 the2205.95 risk2206.2 assessment2206.43 to2206.91 everyone2207.07 for2207.47 review,2207.64 and,2208.59 any2209.88 questions2210.2 were2210.59 directed2210.91 via,2212.51 it2212.68 wasn't2212.76 an2213.16 in2213.39 person2213.55 meeting,2213.95 but2214.28 it2214.43 was,2214.51 like,2214.68 over2215.24 email,2216.43 and2216.59 then,2216.59 answered2217.8 that2218.2 way,2218.43 basically.2218.59 2219.89 LIEBERMAN2219.89 -2219.89 Is2219.89 there,2220.13 like,2220.21 a2220.53 summary2224.21 or2224.53 documentation2224.77 of2225.73 that2225.89 risk2227.41 assessment2227.65 or2228.13 discussion2228.29 so2228.93 that2230.45 as2231.25 the2231.49 biosafety2231.65 committee,2232.29 have,2232.77 I2234.85 don't2235.01 want2235.09 to2235.33 say,2235.33 like,2235.41 proof2235.57 because2235.89 I'm2236.2 sure2236.29 it2236.61 happened,2236.77 but,2237.24 like,2237.49 you2237.97 guys2238.2 are2238.36 covered2238.53 that2238.77 there2238.93 was2239.09 documentation2239.24 that2239.89 the2240.13 IBC2240.68 reviewed2242.2 it2242.61 even2242.77 if2243.01 it2243.16 was2243.24 sort2243.49 of2243.72 over2243.97 email,2244.29 which,2244.68 I2245.33 mean,2245.49 I2245.64 think2245.72 is2245.97 acceptable2246.13 as2246.53 long2246.61 as2246.85 people2246.93 have2247.16 time2247.41 to2247.57 weigh2247.64 in.2247.89 2249.44 AMIRAULT2249.44 -2249.44 Yes,2249.44 I2249.56 mean,2249.68 I2250 can,2250.08 send,2250.8 like,2251.52 a2251.76 summary2252.16 overview2252.48 of2252.88 that.2252.96 I2253.12 can2253.28 also2253.36 send2253.68 a2254 risk2254.16 assessment2254.4 if2254.88 that's2255.04 helpful.2255.2 But,2257.52 yes,2257.92 I2258.04 didn't2258.16 have2258.4 any,2258.64 like,2258.8 meeting2259.04 minutes2259.36 to2259.76 attach,2259.92 but,2260.32 yes,2260.8 I2261.04 can2261.12 attach2261.86 additional2262.59 documentation2263.07 with2264.82 the2264.99 members2265.07 that2265.63 reviewed.2267.07 2267.07 LIEBERMAN2267.07 -2267.07 And2267.07 the2267.3 serum2267.55 is2267.86 being2268.03 sourced2268.26 from2268.66 where?2269.78 If2270.34 you2270.51 could2270.66 just2270.91 remind2271.3 us.2271.78 2272.91 AMIRAULT2272.91 -2272.91 It's2272.91 called2273.07 Innovative2273.47 Research.2274.34 2277.39 LIEBERMAN2277.39 -2277.39 So2277.39 it's2277.79 said2277.95 they're2278.27 screening,2278.51 or2279.79 what's2279.87 their2280.19 progress2280.51 for?2280.99 2281.95 AMIRAULT2281.95 -2281.95 Yes,2282.19 we2282.35 have2282.35 a2282.51 certificate2282.59 of2283.07 analysis2283.23 from2283.71 them.2283.95 So2286.43 the2286.67 screen2286.75 to2286.99 be2287.07 noninfectious.2287.23 So2289.63 they're2289.79 going2291.15 to2291.39 be2291.39 in,2291.55 I2292.27 think,2292.57 52293.2 milliliter2293.45 bottles,2294.64 and2295.05 then2295.2 aliquoted2296.64 out2297.28 into,2297.45 I2299.05 think2299.13 it2299.28 was,2299.45 like,2299.61 5002299.77 microliters.2300.24 It's2301.28 a2301.45 pretty2301.61 small2301.77 scale2302.09 in2302.8 the2302.97 biosafety2303.05 cabinet.2303.61 2305.64 LIEBERMAN2305.64 -2305.64 Okay,2305.88 thank2306.12 you2306.12 for2306.28 clarifying2306.44 that.2306.92 2308.28 AMIRAULT2308.28 -2308.28 I'm2308.68 just2308.84 going2309.16 to2309.56 clarify;2309.56 22309.56 milliliter2309.8 stocks2310.44 and2311.24 552311.4 microliters,2311.88 samples.2313 2314.04 PARSONS2316.44 -2316.44 So2316.44 quite2316.68 small?2317 2324.8 AMIRAULT2325.05 -2325.2 Yes.2325.2 2325.2 LIEBERMAN2325.2 -2325.2 I2326.57 guess2326.64 going2326.8 back2327.05 to2327.2 what2327.36 you2327.53 had2327.61 submitted2327.76 for2328.16 reason2328.32 for2328.57 amendment,2328.72 it2329.13 said2329.2 work2329.44 with2329.61 human2329.76 serum2330.09 is2330.32 undergone2330.48 on2330.8 biological2330.89 risk2331.44 assessment2331.61 with2332.01 and2332.32 reviewed2333.05 by2333.53 the2333.68 IBC.2336.11 So,2336.43 however2336.43 that2338.59 review2338.99 happened,2339.47 we2339.87 should2340.11 definitely2340.27 have2340.59 some2340.83 kind2340.99 of2341.07 document2341.79 with2342.83 a2343.07 more2343.23 current2343.47 date2343.79 submitted.2345.07 2346.76 AMIRAULT2346.76 -2346.76 Okay.2346.76 So,2346.92 I2346.92 was2347.01 also2347.24 wondering,2347.48 if2349.09 I2349.24 should2349.48 have2349.8 sent2350.05 out2350.28 for,2350.61 like,2350.84 a2351.09 signature2351.24 review2352.13 with2352.61 the2352.76 risk2352.92 assessment.2353.24 Would2355.96 that2356.13 also2356.53 be2356.92 helpful2357.09 for2357.57 future?2357.8 Because2359.09 I2359.31 know2359.39 for,2359.63 like,2359.67 our2359.71 IBC2360.03 minutes,2360.43 we2360.75 could,2360.91 like,2361.15 have2361.39 signatures2361.63 on2362.19 that,2362.35 but2363.07 I2363.55 didn't2364.03 have2364.27 signatures2365.15 on2365.63 this2365.71 review.2365.95 So,2366.43 I2366.91 wasn't2367.07 sure2367.23 if,2367.47 like,2367.63 that2367.87 would2368.03 be2368.19 also2368.43 helpful2368.67 in2369.39 the2369.55 future.2369.63 2371.91 PARSONS2371.91 -2371.91 So,2371.91 actually,2372.15 Luke,2372.63 I'm2372.8 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project2408.46 itself,2409.03 that's2410.22 been2410.94 approved.2411.34 I2413.2 think2413.28 for2413.6 for2413.84 our2414.24 own2414.4 peace2414.88 of2415.2 mind,2415.36 and2415.92 that2416.08 sounds2416.32 heavy,2416.64 and2417.12 it2417.36 is,2418 so2418.24 I2418.24 guess,2418.4 like,2418.8 just2419.12 for2419.36 checking2419.52 off2419.92 to2420.4 be2420.72 extra2421.04 sure.2421.36 To2422.48 Mia's2422.88 point,2423.04 it's2423.36 just2423.52 more2423.68 of,2426.16 the2426.47 committee2426.64 just2427.03 wants2427.19 to2427.43 make2427.51 sure2427.67 that2428.07 that2428.39 risk2428.64 assessment2428.95 took2430.07 place2430.32 and2430.8 that2430.95 you2431.28 are2431.76 able2431.91 to2432.16 document2432.39 in2432.8 case2432.88 you2433.19 get2433.43 called2433.59 out2433.84 on2433.99 it2434.16 kind2434.32 of2434.55 thing.2434.55 2436.39 AMIRAULT2436.39 -2436.39 Gotcha.2436.39 Happy2441.99 to,2442.31 you2445.83 know,2445.91 going2446.15 forward,2446.39 provide2448.87 any2449.19 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have2473.47 done2473.55 that2473.71 at2474.43 all,2475.95 no,2476.51 that2476.51 was2476.67 the2476.91 process2476.99 you2477.39 chose,2477.55 and2477.79 it2477.95 doesn't2478.03 seem2478.27 like2478.59 a2478.75 bad2478.83 process2479.07 to2479.71 me2479.87 at2480.11 all.2480.27 It's2480.75 just2480.91 more2481.15 of2481.39 a,2481.55 okay,2482.03 it's2482.19 a2482.19 little2482.35 different,2483.11 which2483.74 is2483.91 still2484.78 okay,2485.11 but2486.14 just2486.63 make2486.78 sure2486.94 that2487.18 there2487.59 is2489.11 just2489.18 proof2489.51 that2490.39 that2490.7 risk2490.86 assessment2491.18 took2491.59 place.2491.82 That's2492.07 all.2492.3 2495.31 LIEBERMAN2495.31 -2495.31 So,2495.31 why2495.47 don't2495.55 you2495.79 just2495.95 reupload2496.43 a2496.91 copy2497.07 of2497.31 that2497.39 first2497.55 page2497.79 of2497.95 the2498.11 signatures2498.27 on2498.67 it,2498.75 and2498.91 I2499.07 think2499.15 then2499.31 that's2499.47 all2499.71 probably2499.87 we2500.19 need.2500.35 2501.23 AMIRAULT2505.23 -2505.23 I2505.23 can2505.39 do2505.47 that.2505.63 2507.15 PARSONS2507.15 -2507.15 Thank2507.71 you.2508.03 Tim,2508.91 any2509.31 questions2509.47 for2509.87 Luke?2510.11 2511.68 MAGUIRE2511.68 -2511.68 No,2511.68 I'm2511.99 good.2512.16 Thank2512.32 you2512.72 for2512.8 updating2513.04 us2513.43 again,2513.91 and,2514.16 we2514.16 really2514.32 appreciate2514.56 you2514.95 following2515.04 the2515.36 process.2515.43 2516.64 PARSONS2516.64 -2516.64 Deb,2518.72 any2518.95 questions?2519.2 2523.61 MCEWAN2523.61 -2523.61 A2523.61 question2523.77 just2524.33 a2524.65 comment2524.81 that2525.13 with2525.29 the2525.61 IBC2525.77 minutes2526.33 being2526.89 older,2528.49 right?2528.73 Like,2528.73 there2528.81 are2529.05 some2529.37 paragraphs2529.69 in2530.25 there2530.41 talking2530.73 about2531.05 new2531.53 cell2531.85 lines2532.17 and2533.21 making2533.45 the2533.69 Lenti2533.93 in2534.33 house,2534.49 and2534.97 so2535.13 that2535.37 was2535.53 a2536.8 little2536.95 confusing2537.28 about2537.99 if2538.39 that2538.64 was2539.43 the2539.59 new2539.76 edition2539.99 or2541.28 it2541.51 was2541.68 just2541.76 the2541.99 serum2542.24 edition.2542.64 2545.99 AMIRAULT2545.99 -2545.99 That2545.99 was2546.24 from2546.39 the2546.72 last2546.8 renewal.2547.11 So2547.99 this2548.24 was2548.39 kind2548.64 of2548.8 another2549.68 confusing2551.46 thing2551.86 for2552.1 me2552.26 because2552.34 I'm2552.5 trying2552.66 to2552.98 update2553.3 you2553.7 all2553.86 of2554.02 the2555.22 new2555.38 work2555.62 with2556.02 the2556.34 serum2556.58 and2556.98 new2557.14 cell2557.3 lines,2557.54 but2557.78 I2560.18 didn't2560.26 go2560.58 back2560.74 and,2560.9 like,2561.14 update2561.38 that2562.34 part2562.66 of2562.82 it2562.98 from2563.06 the2563.22 last2563.38 renewal.2563.54 I2563.94 just2564.02 added2564.26 on2564.5 the2564.66 organisms2564.82 list,2565.46 and2566.11 the2566.34 description2566.43 of2566.91 that.2567.07 Sorry2568.18 for2568.51 the2568.66 confusion2568.91 there,2572.03 I2572.27 can2572.34 update2572.51 2572.99 MCEWAN2572.99 -2572.99 You2573.95 know,2574.18 everything2574.34 is2574.74 clear2574.99 now.2575.31 2576.11 PARSONS2580.05 -2580.05 Ralph,2580.05 any2580.45 questions2580.61 for2580.93 Luke?2581.17 2582.05 MELE2582.05 -2582.05 No2582.05 questions.2582.29 2584.21 PARSONS2584.85 -2584.85 Alright.2584.85 So,2585.25 yes,2585.49 this2585.97 does2586.21 not2586.37 need2586.53 to2586.77 go2586.85 to2586.93 the2587.09 board2591.96 of2592.13 health.2592.36 But,2593.72 yes,2593.96 Luke,2594.2 as2595.09 soon2595.24 as2595.41 you2595.57 can,2595.64 if2595.96 you2596.13 could2596.2 resubmit2597.8 so2601.01 we're2601.09 totally2601.24 clear,2601.57 it's2604.7 titled2605.02 Dyno2605.66 Therapeutics,2606.62 RDNA2607.5 project2607.98 2020-0012609.66 March2609.98 202610.3 252610.62 update2611.26 with2612.78 signatures2613.1 on2613.58 page2613.74 one,2615.74 and2616.14 that2616.14 would2616.3 be2616.46 cool.2616.62 2617.82 AMIRAULT2617.82 -2617.82 Okay.2617.82 If2618.63 we2618.79 have2618.95 time2619.18 really2619.82 quick,2620.07 I2620.22 just2620.3 have2620.55 a2620.7 quick2620.79 question2621.03 for2621.82 future2622.07 amendments.2622.55 I2625.18 think2625.34 Mia2625.59 had2625.91 mentioned2626.07 over2626.47 email,2626.79 and2627.11 there2627.27 was2627.34 some2627.51 back2627.66 and2627.82 forth2627.99 of,2628.3 like,2628.47 you2628.95 know,2629.11 for2629.18 cell2629.51 lines,2630.07 a2630.14 lot2630.14 of2630.3 that2630.47 can2630.63 be2630.79 done2630.95 administratively,2631.52 like2632.8 reviewed.2633.28 I'm2634.4 just2634.64 wondering2634.8 if2635.2 every2635.44 time2635.68 I2636.24 have2636.48 to2636.64 go2636.72 through2636.88 this2637.2 process2637.44 and2638.16 pay2638.64 the2638.88 $5002639.04 amendment2640.4 or2641.04 I2641.76 paid2642 a2642.16 $5002642.24 fee2643.04 for2643.7 uploading2644.66 this2645.05 amendment.2645.22 So,2645.53 I'm2645.7 just2645.86 wondering,2646.01 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another2671.34 human2671.51 cell2671.82 line2672.07 that2672.22 has2672.39 the2672.55 same2672.63 risk2673.42 factors2673.66 and2674.14 handling,2674.39 you2674.86 know,2674.94 we2675.11 can2675.26 handle2675.42 that2675.74 administratively2676.3 to2677.18 my2677.34 knowledge2677.51 without2677.98 you2678.3 having2678.46 to2678.7 pay2678.86 a2679.03 fee.2679.18 So,2679.51 this2679.66 one2679.82 was2680.07 just2680.22 because2680.39 you2680.63 haven't2680.78 had2681.03 human2681.26 serum2681.59 on2681.91 there2682.07 before,2683.91 and2683.99 so2683.99 that2684.15 represented2685.51 the2687.03 expansion2687.35 of2687.83 work2688.07 clause2689.19 in2690.47 our2690.63 process.2693.03 But2693.59 I'll2693.75 let2693.91 Brad2694.15 on2694.39 add2694.63 on2694.79 if2694.95 he2695.11 has2695.19 a2696.15 different2696.23 opinion.2696.55 2697.67 PARSONS2697.67 -2697.67 No,2697.67 I2697.83 totally2697.99 agree.2698.31 2700.66 AMIRAULT2700.66 -2700.66 Okay,2701.3 thank2701.47 you,2701.47 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