BRAD15.13 PARSONS15.13 -15.13 BIOSAFETY15.13 COMMITTEE15.13 -15.13 CHAIR15.13 -15.13 Good15.13 evening,15.46 everyone.16.02 Maureen,17.45 we're17.54 gonna17.54 call17.77 the18.02 meeting19.61 to20.1 order20.26 at20.65 7:0220.89 on22.26 06/05/2025.22.89 Welcome25.67 everyone.26.07 Good26.47 evening26.63 to27.19 the27.43 June27.67 202528.39 version29.11 of29.51 the29.67 Watertown29.75 Biosafety30.23 Committee30.79 meeting.31.11 Thank31.35 you31.51 for31.67 being31.83 here.32.07 We32.31 appreciate32.47 your33.03 time.33.27 Maureen,41.19 for41.51 attendance41.51 everyone41.51 but41.51 Ralph41.75 is,42.07 I42.55 mean,42.7 everyone43.02 but43.34 Tim43.51 is43.83 present.44.07 44.87 MAUREEN44.87 FOLEY44.87 -44.87 CITY44.87 OF44.87 WATERTOWN44.87 -44.87 Okay.44.87 47.98 PARSONS47.98 -47.98 Alright.47.98 Number49.44 2,50 acceptance50.96 of51.52 minutes.51.76 Does54.16 anyone54.4 have54.72 any54.88 comments55.12 or55.84 questions56.72 or57.12 suggestions57.44 for57.92 edits58.16 for58.56 the,58.72 draft59.28 minutes59.52 as59.92 submitted60.08 by60.48 Maureen60.64 for61.2 the61.28 May61.52 861.8 meeting?62.08 Alright.67.47 Seeing67.86 none,68.19 we'll69.47 do69.47 a69.58 quick69.7 vote.70.03

70.27 All70.27 those70.34 in70.58 favor70.74 approving71.06 the71.47 minutes71.63 as71.94 submitted,72.1 please72.5 say72.83 aye72.98 or73.22 raise73.38 your73.63 hand.73.78

77.88 Maureen,77.88 everyone78.28 voted78.76 yes.79.16

82.44 And,82.44 again,82.6 thank83 you83.08 so83.32 much83.4 for83.56 all83.8 your83.96 hard84.12 work.84.36 We84.84 really85.16 appreciate85.48 it.85.96 88.52 PARSONS88.52 -88.52 Next88.52 on88.84 the88.92 agenda89.08 is89.48 public89.56 comment.90.06 So90.38 I'm90.77 pretty90.85 sure91.09 everyone91.25 here91.58 is91.81 representing92.13 a94.22 company,94.38 but94.77 just95.02 in95.17 case95.33 you're95.58 not,95.81 so96.13 this96.38 is96.61 the96.69 time96.85 when97.09 the97.33 public,97.66 if98.05 they98.22 have98.3 any98.45 comments98.69 or99.09 questions99.25 actually99.73 for100.05 the100.13 committee,100.3 now101.58 is101.81 your101.89 time.102.13 Members105.81 of106.29 the106.45 public106.53 do107.01 not107.17 have107.57 the107.81 right108.05 to108.21 ask108.45 questions108.69 to109.25 the109.73 companies110.37 that110.77 are110.93 presenting111.09 here.111.49 That113.17 role113.33 and113.57 responsibility113.81 is114.69 for114.85 the115.01 Watertown115.09 Biosafety115.57 Committee.116.13 So116.37 this116.61 is116.77 more116.85 for,117.17 do117.65 you117.81 have117.97 any118.13 questions118.29 or118.69 comments118.93 for119.61 the119.92 committee?120.64 So121.69 if122 you122.17 do,122.33 please122.64 raise122.97 your123.2 hand123.44 virtually.123.77 Seeing129.04 none,129.53 we130.08 will130.32 go130.56 straight131.04 into131.37 the131.69 meat131.84 of132.08 the132.25 agenda.132.32 Alright.134 So135.12 this135.36 is135.52 a135.68 new135.92 agenda.136.48 I137.12 don't137.2 think137.36 we've137.52 ever137.76 had137.92 an138.08 agenda138.24 just138.96 of139.2 registrations.139.44 So,140.56 we'll142.24 follow142.48 the142.96 order143.12 that's143.44 here.143.84 So144.88 first145.52 up145.92 is,146.4 RealNose,150.03 so150.26 I150.26 believe150.34 that's150.58 Doctor151.38 Mershin.152.5 152.5 ANDREAS152.5 MERSHIN152.5 -152.5 REALNOSE152.91 -152.91 Correct.152.91 Yes.152.91 Hi.153.31 I154.03 am154.19 the154.43 cofounder154.66 and155.15 chief155.38 science155.63 officer155.94 of156.34 RealNose,156.75 which156.99 is157.22 an157.38 MIT157.63 spin158.1 out.159.06 And159.47 we159.47 have159.94 created161.01 sensors161.41 similar162.61 to163.01 a163.25 dog's163.41 nose163.81 that164.29 can164.53 be164.69 trained164.85 on165.33 human165.57 urine165.89 samples166.45 and167.49 be167.81 taught168.13 to168.45 diagnose168.69 prostate169.17 cancer.169.57 And169.97 that170.13 is170.29 what170.45 we're170.61 doing170.77 in171.09 the171.25 Watertown171.89 lab,172.45 in173.82 a173.99 shared174.15 lab174.47 operated175.5 by175.82 Cambridge175.99 Science176.47 Laboratories.177.34 180.78 PARSONS180.78 -180.78 That180.78 sounds181.11 very181.43 interesting.181.82 Okay.182.63 So,185.03 Mia,186.31 I'm186.63 gonna186.79 kinda187.11 kick187.75 this187.99 to188.15 you188.23 a188.39 bit188.47 because188.79 I'm188.95 not189.11 sure189.27 what189.51 we're189.99 doing190.23 other190.63 than,190.87 so191.19 we191.75 have191.99 human192.15 samples,192.87 right?193.19 So193.19 I'm193.43 assuming193.67 we194.15 wanna194.31 discuss194.71 as195.11 a195.27 committee,195.35 does196.23 this196.47 require196.87 a197.35 permit197.51 or197.83 a198.07 registration?198.15 Am198.79 I199.03 going199.19 down199.43 the199.67 right199.75 path199.99 here?200.23 Okay.200.39 Alright.201.03 So,201.79 Doctor204.35 Mershin,204.91 are204.91 your205.23 samples205.56 screened206.03 for206.44 any206.67 type207.07 of207.39 pathogens207.56 or208.44 things209 of209.31 that209.47 nature?209.72 210.51 MERSHIN210.51 -210.51 They210.51 are210.75 screened210.91 for211.23 prostate211.47 cancer.211.95 The213.23 patients213.39 who213.95 donate214.28 these214.67 samples214.91 have215.56 undergone215.79 a216.28 biopsy,216.35 and217.37 the217.53 biopsies217.69 come218.17 out218.25 either218.49 positive218.97 with219.29 a219.53 Gleason219.61 score220.09 or220.41 negative.220.57 And221.21 that's221.61 the222.09 information222.33 that222.73 we222.89 have222.97 about223.21 this223.37 urine.223.53 It224.09 is224.25 frozen224.49 to225.05 minus225.21 20,225.53 and226.17 it's226.33 kept226.57 frozen226.81 until227.29 it228.09 is228.17 inserted228.49 into228.97 the229.13 machine229.29 in230.09 very230.41 small230.65 volumes,231.37 1.5231.85 ml.232.49 And233.13 then233.34 the233.5 machine233.66 does234.15 it234.47 smelling234.54 for234.94 a235.1 few235.19 minutes,235.91 and236.38 then236.63 that's237.43 it.237.66 243.5 MIA243.5 LIEBERMAN243.5 -243.5 BIOSAFETY243.99 COMMITTEE243.99 MEMBER243.99 -243.99 Yeah.243.99 So244.22 part244.38 of244.63 the244.71 questions,244.78 I245.03 think,245.26 that245.5 came245.66 up245.91 from246.54 the246.71 last246.87 meeting247.1 was,248.19 I248.99 guess,249.15 the249.39 volume,249.63 if250.19 it250.43 was,250.83 like,251.15 sort251.39 of251.55 safety251.71 precautions252.03 for252.51 handling,252.75 like,253.39 if253.71 it253.87 was253.95 more254.11 of254.27 a254.35 closed254.43 loop254.83 system.255.07 256.11 MERSHIN256.11 -256.11 Yeah.256.43 So256.83 there's256.99 no257.31 venting257.63 of258.35 any258.51 fumes259.23 anywhere.259.71 In260.57 fact,260.65 because260.81 we261.13 are261.29 dependent261.53 on261.94 the262.1 fumes,262.18 we262.41 make262.5 sure262.74 that262.89 nothing263.06 wafts263.38 away.263.77 So264.33 we264.5 don't264.65 get264.81 to264.97 smell265.06 it265.29 ourselves,265.45 and266.25 that's266.41 why266.65 everybody266.89 is268.01 okay268.18 with268.5 us268.65 sharing268.89 the269.45 space,270.01 you270.18 know?270.18 Like,272.18 no272.5 dogs272.74 or273.21 human273.69 nose274.01 is274.41 involved.274.41 There's274.81 nothing,275.06 you276.25 know,276.33 no276.41 nothing276.73 living.277.05 The278.81 urine279.05 is279.45 frozen279.61 and279.93 it280.09 is280.17 procured280.33 from280.81 my281.05 clinic281.13 in281.61 Ingham,281.77 which282.65 is282.81 fully283.05 certified283.45 to283.93 do284.01 all284.25 this284.33 work.284.49 They285.21 have285.61 a285.77 urology285.85 clinic.287.69 We289.27 used289.44 to289.6 be289.75 there,289.92 actually.290.07 We290.63 used290.88 to291.04 share291.19 their291.44 lab,291.6 but291.83 they292 have292.24 decided292.48 to292.8 no293.04 longer293.19 do293.44 anything294.15 on-site.294.48 They're294.96 outsourcing295.19 all295.75 that295.92 so296.15 we296.31 have296.48 to296.63 go296.71 as296.88 well.297.04 299.44 PARSONS299.44 -299.44 Okay.299.44 304.45 LIEBERMAN304.45 -304.45 And304.45 you304.77 guys304.93 do305.17 have,305.41 it305.73 looks305.89 like,306.05 an306.21 occupational306.45 health307.01 contract.307.41 I308.05 saw308.13 that308.37 was308.53 submitted.308.77 So309.33 this309.65 is309.81 a309.89 little310.05 bit310.21 of310.37 a310.45 hybrid310.61 area311.09 for311.73 the313.09 committee,313.57 because313.57 historically,314.61 like,315.25 sort315.49 of315.73 clinical315.89 patient316.37 samples316.85 had317.25 their319.2 own319.2 permit.319.2 319.2 MERSHIN319.2 -319.2 Yeah.319.2 These319.52 are320 considered320.25 lowest322.25 or323.2 lowest323.69 possible324.08 risk324.56 for325.2 anything325.37 that325.69 has325.85 to326.08 do326.17 with326.32 humans,326.49 because,328.64 you329.13 know,329.29 the329.52 exposure330.17 is330.64 minimal.330.88 All331.97 that332.13 is332.29 required332.37 of332.85 our333.01 workers333.17 is333.49 regular333.81 VL1335.01 wet335.49 lab335.73 PPE,336.45 which336.93 means337.17 gloves,337.65 masks,338.61 optional,339.01 goggles,339.01 optional,339.01 because341.17 we341.57 don't341.65 really341.89 have342.61 anything.342.85 And,343.65 there's344.32 no344.65 chemicals344.88 involved346.17 in346.49 this.346.65 There347.53 are347.69 some347.93 chemicals348.88 involved349.29 in349.69 the349.85 creation350 of350.4 these350.49 chips,350.73 but351.05 that351.21 all351.44 happens351.61 off-site352.09 in352.81 other353.05 places.353.21 And353.61 then353.69 the354.25 only354.4 thing354.65 we354.88 use355.05 in355.21 Watertown356 is356.73 the356.88 machines357.05 that357.53 are357.76 fully358 assembled.358.25 360.78 PARSONS360.78 -360.78 So360.78 when361.02 you361.18 receive361.34 the361.74 samples361.9 from362.22 Hingham,362.46 do364.14 you364.3 know364.38 if364.62 they're364.78 shipped364.94 as365.18 human366.14 specimens?366.54 368.06 MERSHIN368.06 -368.06 We368.06 bring368.3 them368.54 ourselves,368.7 and369.42 we369.74 will369.98 bring,370.14 we370.38 haven't370.46 brought370.7 anything370.94 yet371.18 because371.34 we371.58 haven't371.74 got371.98 this372.14 permission372.38 yet.372.7 So372.94 the373.26 lab373.42 373.82 PARSONS373.82 -373.82 Oh,373.82 right.373.9 374.46 MERSHIN374.46 -374.46 Yeah.374.46 We374.67 haven't374.82 brought374.91 anything374.99 yet.375.38 But375.55 the376.02 fact376.35 is376.5 in376.75 fact376.82 and377.06 to377.55 bring377.71 them377.94 tomorrow378.11 morning.378.35 So379.38 we379.63 have,379.79 literally,381.46 because381.79 we've382.02 been382.19 waiting382.35 a382.75 whole382.82 month383.71 to383.94 start.384.11 We384.35 hired384.58 the384.82 lab384.99 a385.23 month385.31 ago.385.46 We're385.87 a386.11 small386.19 start386.5 up386.67 with386.82 precede,387.06 so387.63 we387.79 don't387.94 have388.19 the389.4 luxury389.56 to389.96 be390.36 renting390.68 the391 space391.08 and391.32 not391.48 running391.88 it.392.04 So,392.2 tomorrow393.08 morning,393.48 the393.8 plan393.96 is394.12 that394.36 we394.6 go394.84 to395.08 Acme395.24 Ice,395.64 which396.04 will396.92 sell397.08 us397.32 the397.56 containers397.8 and398.28 the398.44 dry398.6 ice.398.84 And399.32 then399.48 we399.64 go399.88 to400.2 Hingham,400.44 which401.08 is401.28 about401.37 an401.52 hour401.6 and401.76 15,401.93 and402.4 then402.56 we402.81 bring402.96 it403.2 back403.28 and403.44 we403.69 show403.76 it,404 although404.56 there's404.88 about405.2 50405.37 of405.6 them.405.69 50405.93 urine406.25 samples,406.49 about406.81 20407.04 ml407.37 each.407.69 So408.25 they'll408.4 fit408.96 in409.37 a409.52 small409.76 sub411.84 bench412.16 up412.49 under412.64 the412.88 bench413.04 freezer,413.37 minus413.99 90414.31 freezer414.39 that414.79 is414.87 already415.03 in415.27 place.415.43 There415.67 is415.83 a415.99 second416.07 freezer416.39 that417.19 we417.43 will417.51 also417.67 use417.99 eventually418.23 when418.55 we418.79 have418.87 more419.03 samples.419.19 Currently,419.99 that's420.39 what421.11 we421.27 got.421.27 422.95 LIEBERMAN422.95 -422.95 Are423.43 there423.51 any423.67 sharps423.91 used424.31 on-site?424.63 425.67 MERSHIN425.67 -425.67 Any425.67 what?425.99 426.55 LIEBERMAN426.55 -426.55 Sharps.426.55 429.32 MERSHIN429.32 -429.32 Yes.429.32 We429.88 have430.2 needles430.85 that431.56 we431.96 use432.13 to432.37 pierce432.69 the433.32 rubber433.88 top434.2 containers435.96 so436.69 that436.85 the437.81 urine437.96 can438.29 be438.52 sniffed.438.76 Those440.37 are440.6 blunt442.04 needles.442.2 And442.2 we442.2 have442.37 sharp442.6 needles442.93 and444.42 also444.58 razor445.22 blades445.54 to445.86 open446.02 boxes446.26 and446.74 cut446.98 tape447.3 and447.54 things447.62 like447.86 that.448.02 And448.66 the448.82 sharp448.98 needles449.22 we449.54 have449.7 just449.86 because,450.1 I451.14 guess,451.22 we451.46 don't451.54 really451.78 need451.94 them.452.1 We452.98 could453.14 get453.3 rid453.46 of453.54 the453.62 sharp453.78 needles.453.94 We454.26 could455.3 be455.46 happy455.62 with455.94 just456.1 the456.34 blunt456.42 nose,456.74 but456.9 as457.32 a457.56 lab,457.65 you457.73 know,457.88 by458.37 default,458.6 I458.81 guess,459 we459.17 bought459.32 a459.49 bunch459.56 of459.81 sharp459.88 needles460.13 as460.44 well.460.6 Now461.81 that461.96 you462.04 say462.2 it,462.37 you're462.6 right.462.76 We462.93 don't463 need463.25 the463.32 sharp463.4 needles.463.64 That464.04 would464.29 reduce464.52 the464.93 risk.465 But,466.44 anyway466.76 yeah.467.32 The468.6 people468.85 around469.08 us,469.4 let469.64 me469.81 tell469.96 you,470.13 have470.2 a470.37 lot470.44 more470.6 stuff470.93 than471.17 we471.32 do.471.49 We471.56 are471.73 very471.81 sparse.472.13 It's472.69 just472.93 one473.22 bench473.46 and474.66 two475.06 machines,475.54 and475.54 the475.78 urine.475.94 That's476.26 it.476.42 477.46 LIEBERMAN477.46 -477.46 And477.46 the477.7 benches477.86 sit478.26 on478.58 the,478.82 I'm479.14 sorry.479.22 The479.54 machines479.62 sit479.86 on480.1 the480.18 bench480.34 top480.58 or480.74 in480.82 a481.06 biosafety481.14 cabinet?481.7 482.74 MERSHIN482.74 -482.74 No.482.74 They482.98 do483.14 not483.22 need483.38 a483.54 biosafety483.62 cabinet484.1 and484.5 they484.58 do484.74 not484.9 need485.06 a485.38 hood485.54 because485.86 there's486.18 nothing486.34 vented.486.66 There's488.83 very489.15 small489.39 flows,490.68 we're490.91 talking490.91 under491.24 a491.39 liter491.56 a491.88 minute,491.95 and492.68 sometimes493.07 it's493.47 under493.71 ml494.12 a494.44 minute.494.51 It's494.75 very494.91 small495.24 flows495.63 that495.88 we496.03 use.496.19 And496.44 then,496.68 whatever497.15 is497.56 exhausted497.71 just498.6 passes498.75 through499.15 a499.31 filter,499.47 which499.79 is,499.95 you500.27 know,500.35 done500.6 with501 anything501.15 out.501.56 So,502.1 what504.26 else504.5 to504.74 tell504.9 you504.98 about505.14 this?505.3 Yeah.505.62 The506.82 risks,506.98 I507.7 think,507.86 would508.1 be508.42 just,509.14 you509.46 know,509.62 anything509.78 that510.18 is510.58 a510.74 BL1511.14 has,511.46 you512.1 know,512.34 a513.38 level513.78 of514.1 risk514.18 that's514.42 higher515.61 than515.76 a515.92 kitchen,516.17 but516.4 not516.64 by516.8 much.517.05 And517.61 in517.85 fact,518.8 you518.88 know,518.88 the519.05 lack519.21 of519.45 heat519.61 sources519.76 and520.17 things520.33 like520.49 this,520.64 in520.8 some521.05 cases,521.21 can521.52 make521.76 it521.92 even522.09 less.522.4 So522.57 we522.88 don't523.05 have523.29 any523.37 harsh523.61 chemicals,523.92 and524.33 we524.49 don't524.57 plan524.73 to524.97 bring525.05 any,525.21 but525.45 we525.61 will525.76 be525.92 disinfecting526.4 everything527.05 with527.45 70%527.61 isopropanol.528.57

535.52 SPEAKER1535.52 -535.52 Yeah.535.52 Any535.76 any536 questions?536.24 539.12 DEB539.12 MCEWAN539.12 -539.12 BIOSAFETY539.12 COMMITTEE539.12 MEMBER539.12 -539.12 No.539.12 And,539.84 I540.88 mean,541.04 I541.2 know541.28 we541.52 haven't541.6 really541.92 discussed542.16 it,542.48 but542.64 I542.8 don't542.88 see543.12 anything543.36 that543.68 would544 rise544.24 to544.56 needing544.72 a545.04 permit545.2 from545.68 this.545.92

549.57 SPEAKER1549.57 -549.57 Ralph,549.57 any,549.98 questions550.45 or550.86 comments551.1 or551.74 thoughts?551.98 552.7 RALPH552.7 MELE552.7 -552.7 BIOSAFETY552.7 COMMITTEE552.7 MEMBER552.7 -552.7 No552.7 questions.552.93 555.01 PARSONS555.01 -555.01 Okay.555.01 Yeah.560.49 I561.13 don't561.37 either,561.61 and562.01 I562.17 agree562.33 with562.57 Deb's562.89 statement.564.81 Mia,566.97 what567.13 are567.29 your567.45 thoughts?567.61 568.89 LIEBERMAN568.89 -568.89 I568.89 mean,568.97 I569.21 think569.29 given569.53 the569.77 sample570.01 population570.41 is571.05 a571.21 fairly571.69 low572.17 risk572.41 of572.65 infectious572.81 disease573.37 possibilities573.77 from574.49 urine,575.66 I575.82 don't575.99 think576.23 it's576.38 0,576.54 but576.87 I577.02 think577.11 it's577.26 pretty577.42 low.577.75 So578.79 I579.26 think579.35 given579.5 that579.75 there's579.9 an580.14 occupational580.23 health580.87 contract581.11 in581.5 place,581.66 that's581.9 really582.14 good.582.3 Is584.3 there584.47 a584.87 exposure586.23 control586.79 plan587.18 if587.5 somebody,587.66 for588.07 some588.47 reason,588.79 gets589.26 splashed589.5 in589.9 the590.07 eye590.14 with590.38 a590.54 urine590.63 sample?590.95 591.69 MERSHIN591.69 -591.69 Yes.591.69 We591.93 have592.09 these592.41 protocols592.65 in593.13 place.593.29 It's593.53 following593.85 standard594.17 procedures.594.65 We595.13 copy595.69 pasted596.01 what596.33 they596.57 had596.73 at596.89 the597.05 urology597.85 clinic,598.33 and598.65 we're598.73 following598.97 the599.29 same.599.45 600.01 LIEBERMAN600.01 -600.01 Okay.600.01 601.21 FOLEY601.21 -601.21 I601.21 have601.37 one601.61 question.601.85 You603.13 said603.37 you603.61 have603.77 50604.01 samples.604.49 How605.13 large608.13 is608.13 a608.13 ml608.13 each?608.13 609.34 MERSHIN611.01 -611.01 So,611.01 they611.18 vary611.18 a611.34 little611.5 bit611.65 because611.89 these612.13 are612.3 full612.54 urination613.18 events613.82 and614.06 it614.22 kinda614.38 depends614.7 on615.01 how615.34 much615.5 of615.74 it615.82 got615.98 into616.22 the616.46 sample616.62 cup,617.01 but617.18 they617.34 go617.5 between617.65 20618.06 and618.3 50.618.46 We620.81 can621.05 get,621.13 you621.53 know,621.61 we621.93 can622.09 get622.25 maybe,622.49 you623.29 know,623.53 between623.69 15624.09 and,624.65 I625.77 don't625.93 know,626.17 25626.57 or627.21 30627.37 experiments627.85 per629.21 sample629.37 per629.77 person.629.93 635.65 PARSONS635.65 -635.65 Okay.635.65 Well,635.98 this636.54 is636.7 fascinating636.93 stuff.637.5 Thank638.54 you638.77 very638.93 much639.17 for639.58 coming640.13 here640.38 this640.62 evening,640.86 answering641.82 our642.22 questions642.46 and642.77 explaining643.01 your644.7 processes.644.93 And646.05 yeah.646.77 So647.17 we're647.5 gonna647.74 stick648.05 with648.22 the648.38 registration.648.54 I'm651.76 sure652.08 you652.32 guys652.48 can't653.28 wait653.52 to653.68 get653.84 started654 tomorrow654.4 morning,655.92 so656.16 656.16 MERSHIN656.16 -656.16 Yes.656.16 Thank656.16 you.656.32 That's656.64 a656.88 relief656.96 because657.36 we657.68 were658.32 very,658.72 very,658.96 surprised659.36 that659.76 we659.92 couldn't660 start660.24 a660.48 month660.56 ago.660.8 But,661.12 anyway,661.36 we're661.76 here.662 663.04 PARSONS663.04 -663.04 Yeah.663.04 We663.28 appreciate663.45 your663.92 patience.664.16 This664.49 is,664.64 like665.61 Mia665.92 said,666.25 this666.49 is,667.76 like,668 right668.16 in668.4 that668.57 liminal669.04 zone669.52 of669.85 what670.64 we've671.13 done671.28 before671.52 and,671.92 you672.09 know672.25 so,672.4 anyway,672.57 thank672.96 you673.13 for673.28 your673.45 patience.673.61 We674 appreciate674.16 it.675.3 And676.34 best676.34 of676.58 luck676.74 with676.9 your677.14 research.677.3 678.02 MERSHIN678.02 -678.02 Thank678.02 you678.18 so678.34 very678.5 much.678.66

679.62 SPEAKER1679.62 -679.62 And679.62 you're679.78 free680.02 to680.18 go,680.34 by680.5 the680.66 way.680.74 Everyone681.06 once681.54 you're681.86 done,682.02 everyone682.26 can683.22 take683.38 it.683.46

683.7 SPEAKER2683.7 -683.7 Very683.7 good.683.78 Thank684.02 you684.18 very684.34 much.684.5 Bye.684.9

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little779.3 thumbnail779.54 sketch780.02 of780.42 what780.59 we're780.75 doing.781.07 We782.59 have782.75 two782.9 different,783.14 projects,784.31 but784.71 our784.95 lead785.19 candidate785.43 project785.91 is786.63 we787.59 use789.99 nanoparticle,791.43 we791.43 created791.59 a791.99 nanoparticle792.15 delivery792.79 system.793.35 And794.71 I795.19 had795.35 founded795.51 another795.99 company796.39 that797.03 went798.05 public798.38 and798.77 still799.1 is799.33 public,799.57 about801.1 eight801.41 years801.57 ago,801.74 nine802.05 years802.29 ago.802.53 And802.93 we're803.57 using803.82 a804.45 very804.62 similar804.93 nanoparticle805.41 structure806.21 that806.7 they806.93 used807.17 but808.05 they808.21 were808.38 pursuing808.53 an809.01 RNA,809.33 avenue,810.45 so810.93 targeting811.81 different812.21 RNA812.77 structures813.25 and813.65 cancer813.97 cells.814.29 And815.01 we're815.25 targeting,815.65 we're816.13 actually816.37 going816.69 to817.01 marry817.65 chemotherapy819.01 agents819.89 to820.37 our820.61 nanoparticle820.77 delivery821.49 system821.89 to822.53 target822.77 chemotherapy823.57 delivery824.45 directly825.17 to825.89 tumors825.97 and827 avoid827.24 normal828.43 tissue.828.84 So829.96 in830.27 this830.51 way,830.67 we831 think831.15 that831.48 we831.63 can831.79 lower832.04 and833 almost833.15 completely833.79 reduce834.43 the834.91 toxicity835.08 effects835.79 of836.2 chemotherapy836.36 yet837.39 gain837.72 the838.04 same838.2 efficacy.838.6 840.6 You840.6 know,840.68 I840.84 think841 a841.16 lot841.24 of841.4 people,841.56 whether841.96 they've842.2 had842.52 cancer842.68 or843 not,843.16 you843.4 know,843.48 they843.64 probably844.52 know845 someone845.32 that's845.8 had846.12 cancer846.36 and846.76 has846.92 been847.16 treated847.32 with847.64 chemotherapy.847.88 And849.4 a849.64 lot849.72 of849.88 people849.96 know850.28 that,850.52 you850.68 know,850.76 there's850.92 a851.24 lot851.32 of851.48 toxic851.56 side851.96 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one920.61 of920.76 the920.85 reasons921 why921.25 I921.37 love921.49 being921.64 on921.88 this921.96 committee.922.21 Hearing924.68 cutting926.76 edge,927.16 experiments928.18 like928.74 this929.14 is929.3 very929.3 exciting.929.54 Thank930.02 you.930.26 931.54 DUDLEY931.54 -931.54 Sure.931.54 Yeah.932.42 The932.58 other932.74 thing932.82 that's933.14 that's933.38 interesting933.86 about934.5 this934.74 is934.9 because935.14 chemotherapy935.46 is936.18 very936.42 well936.74 understood.937.14 Most937.94 chemotherapy938.26 agents938.9 are939.38 already939.54 off939.86 patent940.28 and941.16 so941.33 their941.64 generic941.88 drugs942.45 are942.85 very943.09 inexpensive,944.28 they're944.52 very944.52 easy944.76 to945 manufacture.945.33 So946.52 there's946.68 a946.85 lot946.92 of947.09 benefits947.25 of947.8 kind949.16 of949.4 transitioning949.64 from950.45 the950.68 systemic950.92 use951.57 of951.88 this952.04 agent952.37 and952.85 then953 make953.25 it953.49 targeted953.64 because955.29 then955.53 we955.69 can955.77 develop956.01 additional,956.41 you956.73 know,956.89 new957.13 intellectual957.45 property.958.01 It959.61 can959.69 become,959.93 we961.13 can961.29 actually961.45 use962.33 a962.65 different962.73 pathway,963.13 regulatory963.85 pathway964.41 to964.89 get964.97 to965.21 the965.29 FDA.965.45 And966.25 so966.41 we966.57 can966.73 actually966.89 go967.21 to967.37 market967.53 a968.01 lot968.17 faster.968.41 We969.48 can969.55 shave970.2 about970.43 50%970.75 of971.32 the971.55 time971.63 off971.96 of972.12 the972.36 development972.6 path973.15 and973.72 about973.96 50%974.2 of974.84 the974.92 cost975.08 also.975.48 So977.24 it's977.79 really978.04 beneficial.978.36 And979.32 we're979.55 kinda979.72 surprised980.04 that980.36 nobody's980.43 ever980.92 done981.08 this,981.32 but,981.63 you983.23 know,983.39 we983.47 think983.55 it's983.79 a984.03 pretty984.11 novel984.43 way984.83 of,985.31 you985.95 know,986.11 delivering986.35 chemotherapy.986.83 988.27 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treated1045.1 with1045.42 doxorubicin1045.58 right1046.54 now.1046.7 So1047.02 they're1047.18 good1047.5 representative1047.74 cell1049.66 lines1049.9 to1050.3 test1050.7 our1051.02 therapy1051.26 against.1051.74 1053.08 PARSONS1053.08 -1053.08 Okay.1053.08 And1055.63 I1055.88 assume1056.03 ATCC1057.63 has,1059.95 like,1060.19 a1060.36 certificate1061.08 of1061.47 analysis1061.63 of1062.36 that1062.6 same1062.84 nature?1062.99 1063.47 DUDLEY1063.47 -1063.47 Yeah.1063.47 Absolutely.1063.88 Yeah.1064.36 Yeah.1064.67 1065.08 PARSONS1065.08 -1065.08 Yeah.1065.08 I1065.79 am1066.03 kind1066.27 of1066.43 asking1067.89 questions1068.21 I1068.53 know1068.69 the1068.85 answers1069.01 to.1069.25 I1069.57 just1069.73 wanna1069.97 make1070.29 sure.1071.01 1071.17 DUDLEY1071.17 -1071.17 Yeah.1071.17 That's1071.17 fine.1071.49 1073.41 PARSONS1073.41 -1073.41 I1073.41 realized1073.65 after1073.89 I1074.13 asked1074.21 that,1074.37 I'm1074.53 like,1074.69 wow.1074.85 He1075.17 probably1075.33 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it1148.13 maybe1148.68 less1149.33 representative1149.81 of1150.68 the1150.77 initial1150.92 cell1151.4 line.1151.64 So1152.29 that's1152.45 they1152.77 also1152.92 give1153.24 you1153.48 a1153.64 certificate1153.73 that's,1154.54 you1154.74 know,1154.94 indicating1155.5 that1156.06 the1156.54 cell1156.62 line1156.86 that1157.02 you're1157.18 purchasing1157.34 actually1157.98 meets1158.3 that1158.62 requirement.1158.86

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all,1483.43 titration1484.08 of1484.72 drugs,1484.96 say,1485.43 using1485.91 doxorubicin1486.32 or1487.36 our1487.6 nanodrug,1487.84 various1488.8 different1489.28 concentration.1489.67 We1490.56 cultured1490.8 the1491.28 cell1491.43 and1492.36 then1492.6 count1492.92 the1493.24 cells,1493.48 collect1494.12 the1494.52 cells,1494.68 and1495.48 then1495.72 that1496.6 will1496.84 be1497 in1497.16 the1497.32 flask,1497.48 the1498.52 stock1498.68 culture,1499 where1500.36 it1501.24 will1501.4 be,1501.64 you1501.96 know,1502.12 inside1502.92 the1503.48 incubator.1503.64 As1504.28 you1504.44 know,1504.6 they1504.84 are1505 5%1505.76 carbon1506.09 dioxide1506.57 as1507.2 well1507.37 as1507.61 the,1507.76 humidity.1508.57 And1509.52 then1509.68 cell,1510.09 we'll1510.4 have1510.72 to1510.96 count.1511.13 Then1512.57 we1512.8 decide,1513.04 okay,1513.92 we1514.09 have1514.09 961514.4 well1515.04 plate.1515.28 It's1516.72 21517.13 to1517.37 51517.52 thousand1518.33 cells1518.33 per1518.8 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know,1558.52 and1558.76 then1559 little1559.24 more1559.56 higher,1559.88 721560.36 hours.1560.92 And1561.72 then1561.88 once1562.99 it1563.32 exposed1564.43 the1564.84 drug,1565.08 then1566.03 there1566.36 is1566.52 this1566.76 chemical,1566.99 like1568.28 MTT.1568.67 If1570.03 you1570.19 add1570.43 that,1570.76 101571.23 microliter1571.47 and1572.36 then1572.52 eventually1572.76 and1574.36 wrap1574.6 it1574.99 for,1575.32 like,1575.63 three1576.12 to1576.36 four1576.52 hours,1576.76 Then1577.8 if1578.04 dead1578.76 cell,1579.08 there1580.52 will1580.76 be1580.92 certain1581.16 no1581.88 binding,1582.04 but1582.6 live1582.92 cell,1583.16 it1583.56 go1583.64 inside1583.88 and1584.36 then1584.52 develop1584.76 blue1585.64 color.1586.04 And1586.6 then1586.76 you1587 measure,1587.16 I1587.8 think,1587.96 4501588.2 something1589.64 absorbance,1590.68 color1591.4 reading,1591.72 and1592.12 then1592.28 you1592.44 can1592.6 see1592.84 how1593.41 many1593.58 dead1594.78 cells1595.1 and1595.49 live1595.82 cell1596.21 there.1596.45 So1596.78 if1596.93 you1597.17 there1597.34 is1597.49 a1597.65 cell1597.82 death1598.13 you1598.38 measure,1598.54 you1599.17 can1599.34 call1599.58 it1599.73 proliferation1599.97 or1600.86 cell1601.97 viability.1602.21 That1603.58 is1603.82 one1604.21 thing.1604.45 1604.86 Doctor1605.17 Rubinstein1605.49 generally1605.97 does1606.38 sometimes1606.78 cell1607.26 proliferation1607.49 block1608.13 so1608.68 tumor1609.64 don't1609.88 grow1610.12 much.1610.52 That1611.24 doesn't1611.4 mean1611.8 that1612.04 cell1612.92 death.1613.4 So1614.28 we'll1614.6 measure1614.76 cell1616.12 death,1616.44 which1617.08 is,1617.32 by1618.84 different1619.24 kind1619.64 of1619.88 enzyme.1620.04 Like,1620.52 one1620.68 of1620.92 them1621 is1621.24 caspase1621.48 31622.04 assay,1622.36 where1623.3 we1623.62 can1623.86 find1624.1 how1625.38 many1625.62 cell1625.86 there,1626.17 cell1626.65 date,1626.89 how1627.3 much1627.45 caspase1628.02 enzyme1628.58 activated1629.06 by1630.02 some1630.26 fluorescence1630.49 assay1631.13 or1631.7 some1632.34 color1632.58 assays.1633.21 We'll1633.93 find1634.17 that1635.06 this1635.93 is1636.17 happening.1636.34 Good1637.69 thing1637.85 is1638.09 we'll1638.49 compare1638.89 them1639.45 with1640.17 doxorubicin1640.49 mediated.1641.37 Say1641.85 doxorubicin1642.17 work1643.77 in1644.01 a1644.17 full1644.33 fledged1644.57 when1645.13 you1645.37 have1645.53 a1645.65 101645.77 micromolar,1646.01 but1646.97 our1647.21 drug1647.53 may1647.85 works1648.09 one1649.45 micromolar.1649.69 We'll1650.92 have1651.16 series1651.48 of1651.72 things.1651.88 We'll1652.13 see1652.37 the1652.61 same1652.85 peak.1653.09 One1653.88 has,1654.2 like,1654.53 in1654.85 101654.92 micromolar,1655.24 then1655.88 you1656.05 get1656.29 similar1656.77 result1657.24 using1657.81 the1658.13 other1658.29 one.1658.53 Okay.1658.92 That's1659.24 the1659.48 preliminary1659.64 of1660.77 the1660.92 test.1661.09 1661.81 And1661.81 then1662.05 we'll1662.86 compare1663.26 all1663.98 of1664.22 those1664.38 experiments1664.7 in1665.26 sensitive1665.5 cell1666.06 line1666.38 as1666.7 well1666.86 as1667.5 doxorubicin1667.66 resistant1668.62 cell1669.26 line,1669.5 where,1670.54 generally,1671.1 doxorubicin1671.66 get1672.46 resistant1672.7 for1673.34 a1673.5 patient.1673.66 We'll1674.7 have1675.02 the1675.18 cells1675.34 called1675.66 triple1675.98 negative1676.3 breast1676.78 cancer.1677.02 Triple1677.84 negative1678.08 means1678.63 ERPR1679.52 estrogen1680.08 progesterone1680.72 receptor1681.6 and1682.24 heart1682.56 21682.88 receptor1683.04 is1683.67 negative.1683.99 There1684.88 is1685.12 no1685.28 treatment1685.43 for1685.99 that.1686.15 So1687.36 one1687.6 of1687.84 the1687.91 cell1688.08 line1688.32 is1688.56 heart1688.8 21689.04 or1689.43 all,1689.76 triple1690.48 negative.1690.8 And1692.36 doxorubicin1692.44 is1693.16 the1693.32 only1693.4 treatment1693.64 chemotherapy.1694.04 And1695 then1695.16 after1695.32 one1695.72 or1695.88 two1696.52 years,1696.76 they1696.76 get1696.76 resistant.1697.08 Person,1697.72 can1699.32 die1699.56 after1699.88 some1700.28 time1700.52 is1700.76 the1700.92 problem.1701.16 So1701.96 why1702.68 it1702.92 happened?1703.08 Doxorubicin1703.99 get1704.63 lost1704.88 in1705.19 the1705.36 plasma.1705.52 Our1706.08 drug1706.39 will1706.95 circulate1707.27 in1707.76 the1707.91 plasma.1708.08 Plasma1708.88 protein1709.36 can1709.76 recognize.1709.99 We'll1710.47 do1710.71 testing.1710.88 And1711.6 then1711.76 also,1711.99 Doxorubicin1712.39 won't1713.12 get1713.27 to1713.43 the1713.6 cancer1713.76 cell.1714.08 Cancer1714.88 cell1715.36 membrane1715.67 has,1716.15 a,1717.12 b,1717.27 c1717.52 cassette1717.76 kind1718.15 of1718.39 enzyme.1718.88 They1719.79 will1720.03 it1720.43 plaques.1720.59 1721.39 So1721.39 once1722.51 it1722.83 get1722.99 in,1723.15 they1723.47 throw1723.71 them1723.95 out.1724.11 But1724.99 our1725.63 drug,1725.95 nanoparticle1726.35 bound,1727.07 doxorubicin1729.15 won't1729.63 be1729.87 recognized1730.11 by1730.83 those1730.99 enzyme.1731.31 So1731.95 they1732.19 go1732.35 clearly1732.99 inside.1733.55 And1734.11 then,1734.27 here,1735.33 the1735.48 thing1735.72 is,1735.96 the1736.85 cellular1737.16 anything1737.72 happened1738.13 by1738.44 doxorubicin1738.68 is1739.81 they1740.13 must1740.37 get1740.68 into1740.85 the1741.16 nucleus1741.4 of1741.96 the1742.13 cell1742.2 where1743.16 it1743.72 binds1744.05 to1744.44 DNA1744.68 and1745.64 block1745.88 certain1746.29 enzyme.1746.85 That's1747.81 the1748.05 way.1748.45 And1748.85 not1749.17 cytosolic1749.41 matter1750.13 or1750.41 some1750.69 of1750.93 them1751.01 is1751.41 mitochondrial1751.81 stuff1752.85 also.1753.17 They1753.49 can,1753.73 we1754.45 can1754.61 take1754.85 the1755.81 mitochondria.1756.13 Also,1757.33 there1757.65 is1757.81 a1757.97 DNA.1758.13 It's1758.61 called1758.77 mitochondrial1759.01 DNA1759.73 circle,1760.13 a1760.37 different1760.61 kind,1761.01 and1761.49 they1761.65 just1764.3 get,1764.62 damage1764.62 the1764.62 mitochondria.1764.78 Then1765.34 ATP1765.65 generation,1766.06 everything1767.02 will1767.41 be1767.58 gone.1768.38 So1768.7 there1768.93 is1769.1 two1769.58 ways1769.82 to1769.82 see.1769.98 So1770.78 this1771.26 is1771.41 very1771.65 unique.1771.98 And1772.38 then1772.62 another1772.93 thing1773.26 we'll1773.49 do,1773.73 localization1774.86 of1776.22 our1776.62 drug,1776.93 doxorubicin.1777.58 So1778.69 when1778.93 you1779.09 have1779.25 pre1779.49 doxorubicin,1779.81 we1781.41 can1781.57 measure1781.81 inside1782.45 in1783.17 resistant1783.49 cell,1784.05 you1784.37 will1784.53 see1784.77 doxorubicin1785.65 how1787.17 much1787.41 is1787.81 in1788.29 the1788.53 by1789.41 confocal1789.73 microscopy.1790.53 1791.66 We1791.66 will1791.9 take1792.07 the1792.38 cells1792.63 and1793.11 will1793.27 stain1793.59 with1793.9 nuclei.1794.14 It's1795.59 called1796.87 DAPI,1797.18 and1797.9 then1798.07 it1798.38 will1798.46 stain1798.7 the1799.02 nuclei.1799.18 And1799.83 the1800.07 good1800.46 thing1800.63 about1800.87 doxorubicin,1801.42 this1802.54 has1802.78 fluorescence,1803.02 about1805.43 4801805.91 to1806.23 5901806.79 nanometer.1807.19 So1808.31 if1809.67 we1809.91 see1810.15 that1810.31 nucleus,1811.19 and1812.39 doxorubicn,1813.03 they1814.07 are1814.31 in1814.63 the1814.87 same1814.95 location,1815.27 which1815.75 means1816.07 they1816.47 are1816.63 in1816.79 nuclear.1816.95 But1818.06 if1818.3 it1818.38 is,1818.62 so1820.06 we1820.78 are1821.02 expecting1821.17 pre1821.97 doxorubicin1822.62 in1822.62 this1823.82 stem1823.89 cell,1823.89 they1823.89 may1823.89 not1824.06 be1824.3 there,1824.46 very1825.26 little,1825.49 and1826.46 then1826.7 our1827.02 drug1827.17 will1827.49 be1827.65 there.1827.89 Then1828.3 we1828.54 improve1828.7 the1829.02 localization1829.17 of1829.97 drug1830.54 is1830.86 happening1831.1 inside.1831.65 And1832.46 that1832.7 kind1832.93 of1833.17 thing,1833.34 no1834.21 need.1834.37 241834.69 hours.1835.17 Couple1835.57 of1835.81 hours.1835.97 Three,1836.77 four1837.01 hours1837.01 will1837.25 do,1837.57 and1837.97 then1838.13 fix1838.29 the1838.61 cell1838.85 and1839.73 then1839.89 transfer1840.21 those1840.69 things1841.01 into1841.25 the1841.57 slide,1842.53 and1843.25 then1843.41 fix1843.73 it,1843.97 and1844.21 then,1844.37 bring1845.09 it1845.33 to1845.49 the1845.65 confocal1846.05 microscope.1846.53 So1847.93 that1848.1 will1848.73 clear1849.7 away1850.26 everything.1850.65 1851.54 And1851.54 really1851.78 sophisticated1852.17 systematic1853.06 experiment1853.7 really1854.26 is1854.82 not,1855.38 it1855.86 will1856.02 prove1856.26 that1857.13 eventually1858.02 those1858.58 triple1858.82 negative1859.13 breast1859.54 cancer1859.78 patient1860.26 can1860.95 have1861.27 this1861.35 treatment.1863.11 And1863.35 also1863.35 we'll1864.95 do1865.19 in1865.91 vivo1866.15 assay1866.95 using1867.35 mouse.1869.51 So1870.23 in1870.71 that1870.87 case,1871.11 it's1871.67 easy1871.91 to1872.31 prove.1872.47 Doxorubicin1873.35 major1873.51 problem1873.83 is1874.23 cardiotoxicity.1874.9 People1876.35 get1876.74 heart1877.14 problems,1877.38 and1878.35 then1878.51 we'll1878.74 compare1878.98 with1879.46 our1879.7 drug1879.94 and1880.51 doxorobicin.1880.98 So1881.55 in1881.87 animal1882.03 model,1882.51 like1883.55 in1883.7 mouse,1883.94 serum1885.38 will1885.79 collect,1886.03 and1886.74 that1886.98 serum1887.7 will1888.18 do1889.2 laser1889.84 based1890.72 testing.1891.12 So1893.12 troponin1894.32 is1895.04 called1895.2 the1895.52 protein,1895.92 and1896.88 it1897.28 will1897.52 be1897.68 in1897.92 the1898.08 mouse1898.48 serum.1898.8 So1899.36 troponin1899.68 detection1900.24 will1901.7 indicate1901.93 that1902.65 too1902.98 much1903.06 troponin1903.46 in1904.02 doxorubicin1904.89 treated1906.1 mouse1906.89 and1907.3 less1907.93 troponin1908.41 in1910.17 nanoparticle1911.46 attach,1911.46 you1912.26 know,1912.41 doxorubicin.1913.86 That1914.98 include1914.98 less1914.98 cardiotoxicity.1914.98 1914.98 MCEWAN1914.98 -1914.98 That's1914.98 just1915.22 mouse1915.7 tissue,1916.82 right?1917.94 1917.94 GHOSH1917.94 -1917.94 Sorry?1917.94 1918.74 MCEWAN1918.74 -1918.74 That1918.74 mouse1919.54 tissue?1919.86 1921.46 GHOSH1921.46 -1921.46 No.1921.46 That1921.78 is1922.02 purely1922.34 these1922.82 things.1923.06 And,1923.54 of1923.86 course,1924.1 we'll1924.34 collect1924.58 all1924.98 the1925.14 tissue.1925.3 First1925.94 of1926.18 all,1926.34 we1926.58 will1926.66 see1926.9 lot1927.62 of1927.86 things1927.93 we1928.26 can1928.41 learn.1928.73 One1929.69 is,1930.17 we'll1930.17 collect1930.49 all1930.89 the1932.02 tumors1932.1 from1933.69 cell1934.02 control.1934.58 1935.13 MCEWAN1935.13 -1935.13 So,1935.38 just1935.62 for1935.86 11936.17 sec.1936.41 So1936.73 mouse1937.86 work,1938.17 is1938.49 that1938.65 happening1938.82 at1939.29 this1939.38 location?1939.62 1940.65 DUDLEY1940.65 -1940.65 No.1940.65 We1942.85 have1943.01 a1943.17 separate1943.25 vivarium1943.57 that1944.13 we1944.29 do1944.53 all1944.69 the1944.85 animals1945.01 testing.1945.49 1946.29 MCEWAN1946.29 -1946.29 Right.1946.29 Yeah.1947.49 Like.1947.81 1948.77 GHOSH1948.77 -1948.77 And1948.77 then1949.01 tissue,1949.25 the1949.65 person1949.81 will1950.21 collect1950.37 tissue1950.77 for1951.17 us,1952.85 also.1953.17 Those1953.17 tissue1953.17 will1953.65 put1953.89 in1954.13 OCT1954.69 freezing1955.41 to1956.39 make1956.55 slides1957.6 section1958.23 and1958.95 then1959.12 put1959.36 in1959.51 the1959.67 slide.1959.84 And1960.55 those1960.79 things1961.03 will1961.36 do1961.67 staining1961.99 like,1962.47 HNA1964.79 staining,1965.36 which1965.91 will1966.15 indicate1966.39 erosion1967.43 or1968.15 tissue1968.63 damage,1969.12 which1970.24 you1970.4 will1970.56 have1970.64 to1970.88 prove.1971.12 Yeah.1971.6 Because1971.84 the1972.4 nanodrug1972.64 will1973.28 go1973.44 to1973.68 the1973.84 liver1974.08 and1974.48 any1975.04 other1975.28 body1975.6 parts1975.92 also,1976.16 but1976.56 it1976.88 won't1977.04 damage1977.68 anything.1978.16 So1978.56 that1979.04 we1979.36 will1979.52 do1979.76 only.1979.84 So,1980.32 basically,1980.56 in1981.2 mouse1982.8 experiment,1983.12 we'll1983.68 be1983.92 collecting1984.08 only1984.48 the1985.49 tumor.1985.73 Size1986.38 of1986.7 the1986.86 tumor1986.93 will1987.34 reduce,1987.58 number1988.54 1.1988.93 Then1989.82 we'll1990.3 check1990.54 the1990.78 weight1990.93 of1991.26 the1991.41 mouse1992.22 or1992.86 size1993.26 of1993.49 the1993.65 tumor1993.82 we'll1994.22 measure,1994.46 and1995.17 then1995.41 all1995.73 the1995.89 serum1997.99 stuff1998.39 we'll1998.63 collect.1998.87 1999.99 MCEWAN1999.99 -1999.99 Thank1999.99 you.2000.23 That2000.95 was2001.11 really2001.35 helpful2001.67 to2002.07 understand2002.23 what's2003.35 happening2003.51 in2004.15 the2004.31 lab.2004.47 So,2005.51 in2005.67 the2005.83 confocal2005.99 microscopy2007.19 and2007.59 all2007.75 of2007.91 that2008.07 is2008.23 gonna2008.39 be2008.71 at2008.79 this2008.95 location,2009.11 or2009.75 that's2009.91 somewhere2010.15 else?2010.47 2011.28 GHOSH2011.28 -2011.28 No.2011.28 We'll2011.52 go2011.99 to2012.15 some2012.47 facility2012.88 somewhere,2013.67 pay2014.47 money,2014.63 and2015.28 then2015.52 they2015.84 will2015.91 help2016.15 us.2016.39 2018.47 MCEWAN2018.47 -2018.47 So2018.47 and2018.72 these2019.6 assays,2019.91 they2020.32 are2020.56 all,2020.8 like,2021.2 962021.43 well2021.99 plates?2022.23 Just2023.36 to2023.52 get2023.6 an2023.68 idea2023.84 of2024.02 volume.2024.2 2024.56 GHOSH2024.56 -2024.56 962024.56 well2025.44 and2025.92 242027.44 well.2028.08 When2028.64 I2028.96 do2030.88 one2031.36 focal2031.6 microscopy,2032.08 then2033.28 we'll2033.6 do2033.84 in2034.08 242034.4 well2034.96 plate.2035.52 And2036.8 the2036.8 circular2036.88 slide2039.34 will2039.82 put2040.13 into2040.38 the2040.77 well2040.93 so2041.26 that2041.41 cell2041.73 will2042.13 grow2042.38 over2043.41 the2043.82 circle2043.97 and2045.02 then2045.26 take2045.49 it2045.73 out2045.89 and2046.38 put2046.62 upside2046.93 down2047.34 on2047.97 the2048.21 slide.2048.45 2052.02 MCEWAN2052.02 -2052.02 Yeah.2052.02 I2052.02 mean,2052.1 in2052.5 terms2052.82 of2053.22 safety,2053.38 right,2053.86 there2054.18 is2054.34 going2055.38 to2055.7 be2055.78 quite2055.94 a2056.18 bit2056.26 of2056.5 sort2056.66 of2056.82 handling2056.98 of2058.18 the2059.22 drug2060.26 conjugate,2062.9 right?2063.38 2063.38 GHOSH2063.38 -2063.38 All2063.38 will2063.54 be2063.7 2064.1 MCEWAN2064.1 -2064.1 But2064.1 they're2064.1 in2064.1 small2064.26 volumes.2064.58 2066.09 GHOSH2066.09 -2066.09 All2066.09 will2066.34 be2066.5 under2067.86 a2068.11 safety2068.11 cabinet.2068.11 2068.11 DUDLEY2068.11 -2068.11 Yeah.2068.11

2078.22 SPEAKER62078.22 -2078.22 I2078.22 don't2080.06 know.2080.22 I'm2080.38 thinking.2080.54 He2081.42 wants2081.66 to.2082.06 2083.82 PARSONS2083.82 -2083.82 Ralph,2083.82 do2084.22 you2084.54 have2084.7 any2084.86 questions,2085.1 for2086.14 Michael2086.62 or2087.02 Subrata?2087.18 2088.22 MELE2088.22 -2088.22 I2088.22 think2088.38 for2088.62 this2088.94 stuff,2089.18 I'm2089.34 staying2089.5 in2089.74 my2089.9 wheelhouse.2090.06 Sounds2090.63 like2090.86 the2091.03 light2091.11 chemistry2091.26 portion2091.82 of2092.14 it2092.39 is2092.55 the2092.78 mixing2093.51 of2093.82 the2093.99 drug2094.14 or2094.47 making2094.63 the2094.86 drug.2095.11 And2095.59 then,2095.82 am2096.7 I2096.86 right?2096.95 That's2097.18 the2097.43 light2097.51 chemistry2097.74 portion2098.14 of2098.39 it?2098.55 2099.43 PARSONS2099.43 -2099.43 Yeah.2099.43 2100.22 MELE2100.22 -2100.22 Okay.2100.22 So,2100.78 yeah,2101.11 other2101.34 than2101.59 that,2101.74 I'm2101.83 like2102.07 I2102.22 said,2102.3 I'm2102.55 staying2102.63 in2102.95 my2103.03 lane2103.51 here.2103.82 2104.7 PARSONS2104.7 -2104.7 Okay.2104.7 So2107.59 that's2107.83 actually2108.07 kind2108.39 of2108.63 the2108.71 theme2108.87 that2109.35 I2109.91 wanna2110.07 stick2110.71 with,2111.03 is2111.35 staying2111.59 in2111.83 Lane.2112.07 So,2120.21 looking2120.21 at2120.45 the2120.61 way2120.78 our2121.01 regulations2121.18 are2121.73 written,2121.89 looking2122.45 at2122.78 the2122.93 way2123.09 our2123.49 FAQs2123.97 are2124.86 written,2125.01 and,2127.18 yes,2127.49 I2128.21 love2129.73 to2129.97 live2130.14 in2130.38 the2130.45 gray,2130.61 and2131.18 I2131.57 love2131.73 to2131.97 find2132.05 ways2132.3 around2132.61 regulations.2132.93 That's2133.66 kind2134.23 of2134.35 what2134.47 I2134.71 do.2134.87 So2136.71 that2136.87 being2137.19 full2137.43 disclosure,2137.75 from2140.71 face2141.11 value2141.35 what2143.59 this2143.83 committee2143.99 can2144.47 do2144.63 and2144.79 cannot2144.95 do2145.27 and2145.43 what2145.59 the2145.83 Board2145.91 of2146.15 Health2146.31 can2146.47 do2146.71 and2146.87 cannot2147.03 do,2147.35 this2148.07 to2148.68 me2148.84 feels2149.16 like2149.32 a2149.64 permit,2149.72 I2150.68 mean,2150.84 a2151.39 registration.2151.55 Safety2155.55 concerns2156.04 aside,2156.59 I2159.24 don't2159.39 know2159.64 how2159.95 we2160.36 would2160.59 call2161.22 this2161.46 a2161.62 permit2162.1 based2162.82 off2163.06 of2163.3 the2163.46 Watertown2163.62 regulations.2164.26 And,2166.42 personally,2166.58 I'm2167.46 comfortable2167.7 with2168.34 the2168.5 registration2168.66 because,2169.46 1,2170.66 the2170.98 chemistry2171.14 is2171.62 light2171.86 and2172.18 done2172.42 in2172.82 a2172.9 fume2173.06 hood,2173.3 not2174.5 on2174.66 the2174.82 benchtop,2174.98 etcetera2177.21 etcetera.2177.78 And2178.89 then2179.14 the2179.7 manipulation2179.93 of2180.57 the2180.73 cells,2180.89 same2181.45 thing.2181.78 It2182.26 seems2182.57 to2182.89 be2182.97 very2183.78 small2184.01 volume2184.34 and2184.82 quite2186.01 controlled.2186.41 And2187.53 3,2187.86 nano2188.49 pot,2188.89 working2189.93 with2190.26 nanomaterials,2190.49 still2192.24 is2192.64 a2193.68 great2193.84 unknown2194.24 to2194.8 some2195.04 degree.2195.2 But2196.96 the2197.28 fact2197.36 that2197.6 we're2197.76 talking2198.24 about2198.64 iron2199.04 compounds2199.44 here2199.92 and2200.16 not2200.32 silver2200.8 or2201.44 something2202.88 like2203.36 that2203.6 makes2204.08 me2204.4 feel2204.72 even2206.43 more2206.66 comfortable2207.07 about2207.79 if2208.18 something2208.43 were2208.82 to2208.99 go2209.07 wrong,2209.22 i.e.2209.79 an2210.03 exposure2210.18 to2210.91 an2211.79 iron2212.11 oxide,2212.34 nanoparticle.2214.18 I'm2215.63 a2215.86 lot2216.03 less2216.34 concerned2216.59 than2217.07 if2217.22 it2217.39 was2217.47 silver2217.7 based2218.11 or2218.43 something2218.59 like2218.91 that.2219.14 So2219.79 that2219.95 is2220.18 my2220.34 opinion.2220.59 2227.63 LIEBERMAN2227.63 -2227.63 I2227.63 mean,2227.79 if2228.03 there2228.19 is2228.43 an2228.59 exposure,2228.83 it's2229.39 still2229.55 a2229.87 nanoparticle2229.95 conjugated2230.59 to2231.15 a2231.23 chemotherapeutic2231.39 agent,2232.27 though.2232.67 2233.63 PARSONS2233.63 -2233.63 Right.2233.63 2234.64 LIEBERMAN2234.64 -2234.64 So,2234.64 I2234.8 mean,2234.89 it's2235.05 not,2235.68 you2236.72 know,2236.89 some2237.05 nanoparticles2237.28 are2237.93 I2238.8 guess2238.96 that's2239.2 sort2239.68 of2239.93 the2240.09 part2241.68 I'm2242.01 struggling2242.24 with2242.64 just2242.89 because,2244.16 like,2244.32 I2244.32 understand2244.57 the2245.05 goal,2245.2 and,2245.36 like,2245.61 I2245.76 think2245.84 it's2246.09 a2246.24 great2246.32 idea.2246.57 And,2246.96 yeah,2247.2 we2247.44 obviously2247.61 wanna,2248.94 doxorubicin2249.26 has2249.26 terrible2249.5 side2249.82 effects,2249.98 and2250.22 anything2250.38 we2250.62 can2250.78 do2250.86 to2251.1 sort2251.18 of2251.34 lower2251.42 that2251.66 exposure2251.82 for2252.22 cancer2252.38 patients2252.7 would2253.02 be2253.18 phenomenal.2253.42 It's2254.54 just2254.7 more,2254.94 you2255.74 know,2255.82 what2255.98 are2256.22 the2257.1 committee's2257.34 obligations2257.82 sort2258.46 of2258.7 the2258.78 safety2258.94 of2259.34 the2259.42 people2259.58 working2259.82 in2260.14 the2260.22 lab2260.3 and2260.54 how2260.94 we2261.1 handle2261.18 these2261.58 types2261.74 of2262.06 applications.2263.22 2264.82 PARSONS2264.82 -2264.82 Right.2264.82 So2265.3 I2265.46 think,2265.55 I2266.43 was2266.66 just2266.74 saying,2266.91 I2267.07 think2267.22 our2267.39 obligation2267.63 is2268.43 based2268.59 off2268.98 of2269.14 what2269.3 we2270.66 can2270.82 and2271.14 cannot2271.22 enforce.2271.78 Well,2273.22 we2273.46 can't2273.55 enforce2273.78 anything,2274.11 but2274.51 we2276.9 can2277.06 recommend2277.22 to2278.1 the2278.26 Board2278.34 of2278.46 Health2278.58 yes2278.9 or2279.06 no.2279.22 You2279.34 know,2279.46 stuff2279.7 like2279.94 that.2280.02 So2280.26 sorry.2280.58 I2280.9 used2280.98 the2281.22 wrong2281.3 word.2281.54 So2283.78 we're2283.86 abundantly2284.1 clear2284.74 that2285.14 this2285.3 committee2285.46 does2285.94 not2286.18 enforce2286.42 anything.2286.98 Ralph2287.54 has2287.86 enforcement2288.02 powers2288.74 through2289.49 the2289.73 Watertown2289.97 Fire2290.53 Department,2290.93 and2291.89 his2293.01 part2293.26 is2293.49 separate2293.65 from2294.05 this2294.21 committee,2294.38 or2296.3 that2296.53 power2297.26 is2297.65 separate2297.82 from2298.21 this2298.38 committee.2298.53 So,2300.38 yeah,2304.4 I2304.88 guess2305.04 because2307.28 it's2307.52 also2307.68 important2308 setting2309.2 precedents2309.52 and,2310 like,2310.24 you2310.56 know,2310.88 moving2312.72 forward2313.04 if2313.6 a2314.24 similar2314.4 situation2314.8 comes2315.44 up.2315.68 2318.96 It's2319.28 the2319.28 same2319.45 argument2319.68 if2320.16 a2320.72 chemistry2320.89 lab2321.45 opens2321.84 up2322.09 right2322.41 now2322.57 in2323.68 Watertown,2323.93 the2325.61 only2325.76 regulatory2326.24 obligations2327.36 that2328.16 they'd2328.41 have2328.57 to2328.72 fulfill2328.89 in2330.09 Watertown2330.24 are2331.45 fire2332.3 department,2332.54 flammability,2333.82 you2333.9 know,2333.98 all2335.06 that2336.14 important2336.54 stuff,2337.02 building2337.98 code,2338.38 all2339.18 that2339.34 other2339.58 stuff.2340.54 But2340.78 there's2340.78 no2341.02 one2341.18 in2341.34 Watertown2341.82 to2342.3 enforce2342.54 OSHA2342.94 hygiene,2343.74 chemical2344.3 hygiene2344.62 plan2345.02 stuff2345.9 for2346.3 a2346.46 chemistry2346.62 lab2347.26 in2348.18 Watertown.2348.51 I'm2349.94 seeing2350.18 this2350.51 as2350.66 kinda2350.82 the2351.14 same2351.22 way,2351.63 as2351.78 like,2351.78 yes,2352.03 lab2354.42 laboratory2355.14 personnel2355.78 safety2356.26 is2356.66 paramount,2356.82 and2357.3 it's2357.46 extremely2357.78 important.2358.26 And2358.66 we're2358.74 here2358.98 for2359.14 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reagent2427.47 cell2427.71 is2427.71 already2427.95 dead.2428.43 Nothing2428.99 is2429.39 there2429.55 for2430.09 that2430.26 spreading2431.05 certain2431.53 things.2431.86 And2432.49 then2432.65 according2432.89 to2433.38 ATCC,2433.69 this2435.78 both2436.57 cell2436.82 are2437.3 designated2437.3 as,2437.93 like,2438.09 BSL2438.57 1,2439.21 not2439.69 22440.01 even.2440.17 So2441.45 that's2442.01 a2442.41 great2442.82 thing,2443.05 sir.2443.38 2444.14 PARSONS2444.14 -2444.14 Yeah.2444.14 So2444.38 to2444.78 be2444.94 clear,2445.1 we're2445.34 not2445.58 questioning2445.9 your2446.7 ability2448.06 to2448.54 do2448.7 safe2448.94 science2449.26 at2449.82 all.2449.98 So2450.3 I2450.46 hope2450.62 you2450.78 didn't,2450.94 I2451.42 hope2451.5 we're2451.74 not2451.82 coming2452.06 across2452.38 that2452.7 way.2452.94 It's2453.58 more2453.9 of2454.3 the2454.7 two2455.42 parts2455.66 of2455.9 accidents2456.22 happen,2457.74 right?2457.98 We've2457.98 all2458.22 been2458.46 in2458.7 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versus4058.81 registration.4059.21 4066.34 WALKER4066.34 -4066.34 Okay.4066.34 So4066.66 it4066.91 sounds4067.07 like4067.39 the4067.63 next4068.11 step4068.66 is4069.22 for4069.7 us4070.03 to4070.34 submit4070.66 a4071.07 IBC4071.78 application.4073.14 4075.32 LIEBERMAN4075.32 -4075.32 Your4075.32 safety4075.8 consultant4076.2 can4076.68 help4077.4 you4077.96 form4078.28 and4078.76 organize4079 an4079.4 IBC4079.64 minute4080.04 meeting,4080.6 where4081.8 you4082.04 would4082.12 sort4082.36 of4082.52 basically,4082.92 you4083.64 would4083.8 present4084.04 sort4084.6 of4084.84 what4085.24 you4085.48 do4085.64 and4086.2 the4086.52 safety4086.68 precautions4087.08 used4087.72 for4088.04 handling4088.28 the4089.55 bloods,4089.7 and4089.95 that's4090.11 what4090.27 you're4090.43 using4090.66 in4090.99 this4091.07 case.4091.22 And4091.7 then4091.86 it's4092.03 the4092.27 community's4092.43 job4092.91 to4093.22 review4094.11 sort4094.59 of4094.83 the4094.91 safety4095.07 handling,4095.39 disinfection4095.86 practices,4096.59 and4096.98 sort4097.23 of4098.43 vote4098.66 to4099.23 approve4099.47 your4100.82 protocol4101.47 for4102.1 how4102.66 you're4102.91 handling4103.15 blood4106 or4106.24 any4106.4 infectious4106.64 material,4107.12 Or4107.6 what's4108.4 the4108.72 term4108.88 potentially4109.28 infectious4109.92 agent?4111.6 4111.76 PARSONS4111.76 -4111.76 PIA,4112.4 yeah.4113.04 4113.04 LIEBERMAN4113.04 -4113.04 I4113.04 know4113.2 there's,4113.68 like,4113.92 some4114.08 acronym4114.24 for4114.64 it.4114.8 And4115.04 then4115.2 you'll4115.36 need4115.52 to4115.68 submit4115.76 a4116.08 floor4116.16 plan,4116.4 a4116.72 plot4116.8 plan,4117.12 your4118.24 safety4118.4 manuals.4118.8 You4119.2 already4119.36 have4119.6 your,4119.76 I4120.65 guess,4120.8 your4120.89 contract4120.97 if4121.76 it's4121.93 not4122.09 already4122.16 on4122.4 there.4122.48 I4122.65 saw4122.73 you4122.89 have4122.97 your4123.13 pest4123.28 control4123.44 contract4123.76 already4124.16 there.4124.4 You4124.8 already4124.97 have4125.2 your4125.36 workers'4125.52 comp4126.01 and4126.4 your4126.56 COL.4128.24 So4128.8 most4129.05 of4129.28 the4129.36 other4129.52 documentation4129.76 should4130.48 probably4130.73 be4131.13 pretty4131.28 straightforward.4131.52 So4133.52 probably4133.86 just4134.18 organizing4134.42 the4134.9 IBC4135.06 meeting4135.46 and4135.7 then4136.18 submitting4136.34 those4136.74 minutes4136.9 would4137.7 be4137.94 sort4138.18 of4138.42 the4138.5 main4138.66 thing4138.9 that's4139.06 missing.4139.38 4141.54 WALKER4141.54 -4141.54 Yeah.4141.54 Okay.4141.94 4144.9 LIEBERMAN4144.9 -4144.9 And4144.9 if4145.06 you4145.22 have4145.38 any4145.54 questions,4145.7 feel4146.82 free4147.06 to4147.3 email4147.38 me.4147.62 That4147.86 being4148.02 said,4148.26 I4148.5 will4148.58 be4148.74 on4149.38 vacation4149.72 for4150.03 the4150.11 second4150.28 half4150.52 of4150.76 this4150.84 month,4150.99 so,4151.31 it4152.03 may4152.2 get4152.35 turfed4152.6 to4152.91 Brad.4153.07 But4155.4 safety4155.95 consultants4156.35 are4156.84 usually4156.99 pretty4157.31 good4157.56 at4157.8 getting4159.16 everything4159.4 straightened4159.88 out4160.2 for4160.35 you.4160.52 4161.56 FOLEY4161.56 -4161.56 And,4161.56 also,4161.88 I4162.75 will4162.99 refund4163.71 you4164.19 your4164.43 $1004164.99 and4166.59 then4166.75 you4167.15 will4167.39 pay4167.63 5004168.91 for4170.03 the4170.27 permit.4170.43 4172.83 WALKER4172.83 -4172.83 Mhmm.4172.83 Okay.4175.15 4175.47 FOLEY4175.47 -4175.47 So4175.47 I'll4175.71 refund4175.95 it4176.27 tomorrow4176.51 morning.4176.83 4178.76 WALKER4178.76 -4178.76 Okay.4178.76 Thanks.4179.16 4183.72 PARSONS4183.72 -4183.72 Yeah.4183.72 And4183.89 please4184.05 don't4184.28 hesitate4184.44 to4185.01 reach4185.16 out4185.4 with4185.72 any4186.2 questions4186.44 along,4186.84 you4187.32 know,4187.4 as4188.05 you4188.2 guys4188.36 move4188.6 along4188.76 the4189.09 way.4189.24 4190.88 ZAGHLUL4190.88 -4190.88 Thank4190.88 you4191.12 very4191.2 much.4191.52 Should4191.68 be4191.92 pretty4192.24 straightforward4192.48 to4193.04 get4193.2 the4193.84 IBC4194.32 rolling4194.32 and4194.64 get4194.8 you4195.12 the4195.36 minutes.4195.52 4196.24 PARSONS4196.24 -4196.24 Yeah.4196.24 Excellent.4196.8 4198.32 WALKER4198.32 -4198.32 Okay.4198.32 Anything4198.96 else?4199.28 4199.6 PARSONS4199.6 -4199.6 Thank4199.6 you4199.84 very4200 much.4200.32 No.4200.8 That4201.12 should4201.28 do4201.52 it.4201.6 Though,4201.92 so,4202.32 next4203.84 month4204.08 we're4206.26 scheduled4206.43 to4206.82 meet4206.9 on4207.06 July4207.22 3,4207.64 but4208.18 we're4208.43 most4208.59 likely4208.74 won't.4209.14 So4209.94 just4210.18 keep4210.34 an4210.59 eye4210.74 out4210.9 on4211.39 the,4211.63 on4212.66 our4212.82 website4212.98 when4213.47 our4213.63 next4213.78 meeting4214.02 is4214.34 or4214.59 just4215.06 email4215.47 us4215.78 or4216.02 something4216.1 like4216.43 that.4216.66 4218.74 WALKER4218.74 -4218.74 Good.4218.74 Okay.4219.14 Will4220.63 do.4220.95 Thank4221.75 you4222.07 all4222.23 very4222.47 much.4222.63

4223.43 SPEAKER14223.43 -4223.43 Alright.4223.43 Thank4223.75 you.4223.91 You.4224.23 And4225.11 you're4225.35 free4225.51 to4225.75 go4225.83 if4226.07 you4226.23 wish4226.31 because4226.63 that4226.95 is4227.19 pretty4227.43 much4227.59 the4228.47 end4228.71 of4228.95 the,4229.83 meet4230.39 of4230.63 the4230.71 agenda.4231.03 Okay.4232.87

4233.27 SPEAKER104233.27 -4233.27 Thanks.4233.27

4233.75 SPEAKER114233.75 -4233.75 Thank4233.75 you4233.91 all.4234.07 Have4234.23 a4234.47 good4234.55 night.4234.71

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because4267.16 Nexus4268.52 hasn't4271.89 renewed.4272.28 The4274.07 last4274.31 company4275.67 didn't4276.39 renew,4276.71 so4277.19 I4277.43 thought,4277.67 well,4277.99 maybe4278.23 they4278.63 morphed4279.11 themselves4279.43 into4280.07 this4280.39 company.4280.79 4281.59 LIEBERMAN4281.59 -4281.59 Well,4281.59 weren't4281.99 they4282.31 with,4282.47 Nexus4282.79 was4283.19 with4283.43 somebody4283.51 else,4284.39 right?4286.51 4286.51 FOLEY4286.51 -4286.51 I4286.51 don't4286.66 know.4286.74 4287.55 LIEBERMAN4287.55 -4287.55 I4287.55 thought4287.7 Nexus4287.95 was4288.43 partnered4288.59 with4288.91 another4289.15 company4289.86 because4290.1 right4290.1 now,4290.27 is4291.55 there4291.78 and4292.19 Digital4292.43 4293.63 FOLEY4293.63 -4293.63 I4293.63 reached4293.63 out4293.63 to4293.63 them4293.78 a4294.1 million4294.19 times,4294.59 and4294.91 I4294.99 got4295.15 nowhere,4295.39 so4295.86 I'm4296.27 done.4296.43 4298.8 LIEBERMAN4298.8 -4298.8 Did4298.8 they4298.88 renew4299.12 their4299.44 flammable4299.6 permit,4300.16 Ralph?4300.56 4301.36 MELE4301.36 -4301.36 Yeah.4301.36 They're4301.84 covered4302.24 for4302.24 the4302.4 year.4302.56 4303.68 LIEBERMAN4303.68 -4303.68 Oh,4303.68 okay.4304.4 Well,4304.8 maybe4308.56 Ralph4310.78 can4311.02 help4311.1 investigate4311.59 if4312.94 he4313.19 has4313.27 a4313.51 contact.4313.66 4314.55 PARSONS4314.55 -4314.55 Didn't4314.78 we4314.94 ever4315.27 get4315.35 an4315.51 inspector4315.98 for4316.63 the4316.78 Board4316.94 of4317.19 Health,4317.27 like,4317.82 for4318.23 lab4318.47 stuff?4318.78 4319.43 LIEBERMAN4319.43 -4319.43 I4319.43 don't4319.43 know.4319.43 That's4319.43 an4319.66 Abby4319.82 question.4320.15 4321.27 PARSONS4321.27 -4321.27 Yeah.4321.27 This4325.33 is4325.57 frustrating.4325.81 Did4331.65 I4331.97 come4332.05 across4332.29 too4332.85 much4333.01 of4333.25 as4333.57 of,4333.89 oh,4333.97 we're4334.13 being4334.37 recorded,4334.61 as4335.17 a4335.41 not4335.57 nice4335.81 person?4336.05 4337.94 FOLEY4337.94 -4337.94 No.4337.94 4338.9 LIEBERMAN4338.9 -4338.9 I4338.9 mean,4338.98 they4339.14 need4339.38 to4339.53 follow4339.7 the4340.02 rules4340.1 and4340.34 we4340.49 need4340.66 to4340.74 be4340.81 internally4341.06 consistent4341.53 with4342.02 how4342.18 we4342.34 handle4342.41 applications,4343.85 so.4344.02 4344.02 PARSONS4344.02 -4344.02 Not4344.34 even4344.49 that.4345.06 That4345.38 notwithstanding,4345.7 like,4346.49 just4346.9 like,4347.22 really?4350.99 Like,4351.39 nothing?4351.79 Not4352.35 even4352.59 a4352.75 registration4352.91 until4353.55 six4353.87 months4354.11 later?4354.35 Well,4355.71 five4356.03 if4356.59 we're4356.75 gonna4356.91 be4357.15 a4357.23 little4357.31 generous4357.55 with4357.95 the4358.11 time.4358.27 Jesus.4360.11 Yeah.4361.15 Okay.4362.99 Alright.4364.57 So4366.49 additional4366.9 business4367.38 also.4367.85 So4368.1 Abby4368.34 and4368.57 I4368.73 have4368.9 started4369.06 the4369.53 email4369.85 back4370.41 and4370.57 forth4370.73 about4371.14 Vivarium.4371.69 4373.61 FOLEY4373.61 -4373.61 Oh,4373.61 you4373.77 have?4373.94 She4374.26 didn't4374.41 tell4374.66 me4374.9 that.4375.06 4375.94 PARSONS4375.94 -4375.94 Well,4375.94 she4377.61 said4377.77 she4377.94 wants4378.1 to,4378.57 I4380.09 didn't4380.25 press4380.81 her4380.81 on4380.81 it.4380.81 4380.81 FOLEY4384.01 -4384.01 I4384.01 have4384.17 to4384.33 sit4384.41 down4384.65 with4384.89 her,4385.13 and4385.45 I4385.85 do4386.01 it4386.25 with4386.41 her.4386.65 And4386.97 I4387.29 have4387.69 all4388.25 of4388.49 Mia's4388.65 requirements.4389.45 4391.13 PARSONS4391.13 -4391.13 And4391.13 Oh,4391.45 no.4391.53 No.4391.69 This4391.85 is4392.01 a4392.17 different4392.25 thing,4392.49 Maureen.4392.73 This4393.13 just4393.44 the4393.6 what4394.01 is4394.16 the4394.32 biosafety4394.56 committee?4395.36 Deb's4396.09 holistic4397.36 big4398.01 picture4398.4 question4398.89 of4399.44 what,4400.48 like,4400.97 what4401.52 is4401.77 the4401.93 bio,4402.09 especially4402.56 when4402.97 it's4403.2 not4403.36 part4403.6 of4403.77 a4403.93 permit4404.01 initial4405.91 application,4406.47 what4407.11 is4407.35 the4407.51 biosafety4407.67 committee's4408.23 authority,4410.39 rules,4411.03 and4411.27 responsibilities4411.59 about4412.47 a4412.79 vivarium4412.87 if4413.99 the4414.23 research4414.31 is4414.71 not4414.87 and,4415.11 like,4415.35 in4415.59 fact,4415.75 the4415.99 in4416.23 the4416.31 regulations,4416.47 it4416.95 says4417.19 if4417.83 it's4418.71 exempt4418.87 for,4420.02 like,4420.43 breeding4420.59 rats4421.06 that4421.47 aren't4421.7 infected.4423.15 Like4423.63 so,4423.94 you4424.34 know,4424.51 it's4424.74 just4425.22 more4425.47 along4425.7 that4425.94 lines4426.02 of,4426.43 like,4426.66 okay.4426.9 Yeah.4427.94 Like,4428.26 we're4428.66 here4428.9 to4429.15 help.4429.3 Happy4429.55 to4429.78 do4429.94 it.4430.1 But4430.34 if4430.66 someone4430.82 really4431.22 wanted4431.47 to4431.7 push4431.86 back,4432.1 like,4432.72 someone4433.04 being4433.44 an4433.68 applicant4433.76 or4434.32 a4434.48 company,4435.44 you4435.6 know,4435.6 we'll4435.76 kind4436 of4436.16 be4436.32 standing4436.48 there4436.8 like,4436.96 well,4437.92 it's4438.08 the4438.24 right4438.4 thing4438.56 to4438.72 do,4438.88 and,4439.12 yes,4439.36 it4439.6 is.4439.76 But4441.04 lawyers4441.28 don't4441.68 care4441.92 about4442.08 that.4442.32 So4444.16 the4445.81 rules4446.14 are4446.45 the4446.53 rules4446.69 kinda4447.09 thing.4447.26 So4447.49 we4447.9 just4448.14 started4448.3 that,4448.53 like.4452.05 It's4452.3 been4452.3 four4452.45 years,4452.69 so4452.93 I4453.18 think4453.26 maybe,4453.49 you4453.9 know,4454.05 we've4454.22 learned4454.45 a4454.69 lot4454.77 in4454.93 four4455.18 years4455.34 since4455.65 we've4455.9 updated4456.14 the4456.45 regs.4456.69 So,4457.01 perchance,4457.97 that's4459.41 gonna4459.65 be4459.97 our4460.05 cycle.4460.22 Every4460.69 four4461.18 years4461.71 we4461.71 meet4462.11 with4462.27 the4462.35 lawyers4462.51 and4462.91 and4463.15 do4463.31 some4463.47 updates.4463.71 4465.55 LIEBERMAN4465.55 -4465.55 That4465.55 would4465.79 be4465.95 great4466.11 because,4466.59 yeah,4466.91 there's4467.15 definitely4467.31 things4467.71 that4467.95 I4468.11 think4468.19 could4468.35 be4468.59 clarified.4469.15 4470.35 PARSONS4470.35 -4470.35 Yeah.4470.35 I4472.43 mean,4472.51 every4472.75 year4472.99 is4473.15 excessive4473.39 and4473.87 not4474.11 healthy,4474.35 but4475.6 four4475.84 years4476.07 seems4476.32 reasonable.4476.64 4478.4 FOLEY4478.4 -4478.4 And4478.4 I4478.64 remember4478.8 Deb4479.36 in4479.84 the4479.99 early4480.16 days4480.48 said4481.84 she4483.76 said,4483.99 I'm4484.64 always4484.95 afraid4485.36 of4486.07 the4486.64 new4486.8 technology4487.11 coming4487.76 down4488.07 the4488.4 road.4488.56 4491.32 MCEWAN4491.32 -4491.32 Yeah.4491.32 We4491.56 haven't4491.72 encountered4492.04 much4492.6 new4493.08 technology4493.32 in4493.88 these4494.04 four4494.28 years.4494.52 Like,4495.24 nothing4495.48 4497.16 FOLEY4497.16 -4497.16 No.4497.16 But4497.48 you4497.64 were4497.72 definitely4501.72 aware4501.72 of4502.04 it.4502.2 4503.39 MCEWAN4503.39 -4503.39 At4503.39 some4503.78 point4504.66 they'll4504.9 turn4505.3 into4505.55 companies.4505.78 4507.06 PARSONS4507.06 -4507.06 Right.4507.06 Exactly.4507.39 Yeah.4507.94 4508.26 MCEWAN4508.26 -4508.26 But,4508.26 yeah,4508.43 there4508.51 was4508.66 a4508.82 lot4508.9 more,4509.06 there's4509.23 been4509.47 a4509.55 lot4509.63 more4509.86 lengthy4510.02 than4510.34 I4510.59 expected.4510.9 4512.66 PARSONS4512.66 -4512.66 Yeah.4512.66 A4513.86 lot.4514.02 And4516.26 resistance4516.66 of4517.23 gen4517.47 4,4517.78 oddly.4519.13 Well,4520.97 no.4521.29 Not4521.53 oddly.4521.69 Actually,4522.01 a4522.33 biosafety4522.41 officer4522.97 explained4523.29 it4523.61 to4523.69 me,4523.85 and4524.17 now4524.33 I4524.49 get4524.65 it.4524.81 And4524.97 I4525.13 was4525.21 like,4525.45 alright.4525.61 Well,4526.01 we'll4526.25 just4526.49 deal4526.81 with4527.05 that4527.13 as4527.37 it4527.53 comes4527.69 along.4527.85 Okay.4531.95 So4532.27 more4533.47 to4533.7 come4533.86 on4534.27 the4534.43 vivarium4534.59 and4535.23 what4535.31 the4535.47 Watertown4535.63 Biosafety4536.19 Committee's4536.74 role4537.23 is4537.63 and4537.95 is4538.35 not.4538.66 4540.82 MCEWAN4540.82 -4540.82 My4540.82 question4541.39 about4541.78 the4542.03 vivarium4542.19 is4542.82 that4542.99 if4543.23 it4543.47 does4543.7 become4544.1 part4544.59 of4545.12 this4545.36 committee's4545.6 responsibility,4546.24 we4549.6 have4549.84 one4550.08 member4550.32 who4550.8 knows4550.96 vivariums4551.28 well.4551.92 I4552.16 feel4552.24 like4552.48 we4552.56 need4552.72 to4552.96 get4553.04 a4553.36 backup4553.6 person4554.08 to4554.64 consult4554.88 if4555.68 that4555.84 one4556.16 member4556.4 is4556.8 not4557.04 available.4557.2 4558.31 PARSONS4558.31 -4558.31 Well,4558.31 this4558.55 meeting4558.7 is4559.02 being4559.27 recorded4559.9 4560.23 MCEWAN4560.23 -4560.23 I4560.23 don't4560.31 know4560.47 vivariums.4560.63 4562.63 PARSONS4562.63 -4562.63 So4562.63 exactly.4563.02 So4563.59 this4563.98 meeting4563.98 is4563.98 being4563.98 recorded.4563.98 4563.98 LIEBERMAN4563.98 -4563.98 But4563.98 you4564.47 know4564.63 what?4564.78 It's4564.94 not,4566.63 yeah.4566.63 But4566.63 let4566.78 me4566.86 say4567.02 something.4567.27 It's4567.59 not4567.82 our4568.78 job4568.94 to4569.1 regulate4569.27 vivariums.4569.74 It's4570.23 the4570.39 job4570.55 of4570.7 the4570.86 IACUC4571.31 to4571.63 regulate4571.79 the4572.19 vivarium.4572.27 So4572.91 if4573.07 we4573.15 just4573.39 say,4573.55 you4574.27 need4574.43 an4574.67 IACUC4574.83 to4575.31 sign4575.39 off4575.63 on4575.87 your4575.95 vivarium4576.19 in4576.67 your4576.75 protocol,4576.91 that's,4577.47 like,4577.63 where4577.87 it4578.03 ends4578.11 as4578.35 far4578.51 as4578.67 I'm4578.75 concerned.4578.91 It's4579.23 not4579.39 our4579.71 job4579.95 to4580.27 come4580.35 in4580.51 and4580.83 say,4581.07 you4581.87 know,4582.03 that's4582.59 why4582.75 when4582.91 people4583.07 show4583.31 me,4583.47 oh,4583.71 it's4583.79 a4583.87 BL-2,4584.19 and4584.35 it's4584.51 positive4584.67 pressure.4585.15 I'm4585.47 like,4585.63 you4585.87 should,4586.03 like,4586.68 that's4586.84 your4587.07 IBC,4587.4 and4587.95 you4588.76 and4588.99 IACUC4588.99 need4588.99 to4589.24 talk4589.32 about4589.56 how4589.8 you4590.03 wanna4590.11 do4590.28 biocontainment.4590.52 Like,4591.48 we4591.64 can4591.8 make4592.03 suggestions,4593.16 but,4593.88 ultimately,4594.11 like,4594.68 it's4594.91 not4595.07 this4595.4 committee's4595.56 job4596.03 to4596.28 say,4596.44 you4596.68 know,4596.84 you4596.91 really4597.07 shouldn't4597.4 have4597.64 a4597.8 BL-24598.28 at4598.44 positive4598.6 pressure.4599.07 You4599.64 know,4599.8 that's4600.03 their4600.28 decision.4600.52 But4603.47 no,4603.95 that's4604.43 the4604.43 role4604.59 of4604.91 the4604.99 IACUC.4605.07 And4605.39 so4605.47 the4605.95 way4606.43 I4606.67 see4606.83 it,4607.07 the4607.79 only4607.95 role4608.27 for4608.43 the4608.59 regulation4608.75 would4609.39 be4609.55 requiring4610.43 an4610.91 IACUC,4611.23 which,4611.63 like4611.87 I4612.03 said,4612.11 since4612.43 everybody4612.67 so4614.66 far4614.82 has4615.07 one.4615.39 And4616.74 then4616.91 I4617.07 guess4617.15 the4617.39 question4617.47 is4617.78 do4618.82 we4618.99 extend4619.31 the4621.15 purview4621.39 outside4622.27 companies4622.74 not4623.23 doing4623.86 regulated4624.19 work?4624.74 So,4624.99 like,4625.15 if4625.31 they're4625.39 just4625.63 breeding4625.95 animals4626.27 for4626.66 PK4626.82 studies4627.23 and4627.55 there's4627.7 no4628.03 you4629.46 know,4629.62 does4629.78 that4629.94 fall4630.1 under4630.34 us?4630.5 Does4630.74 that4630.9 fall4630.98 under4631.22 something4631.38 else?4631.7 I4631.94 don't4632.02 know.4632.26 4633.22 PARSONS4633.22 -4633.22 The4633.86 regs4634.34 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don't4657.07 even4657.7 bother4658.03 showing4658.35 up4658.66 kind4658.91 of4659.15 thing.4659.23 Even4660.17 though4660.25 you4660.49 did4660.81 give4661.05 an4661.61 example4661.85 where4662.25 there4662.81 could4662.97 be4663.13 a4664.09 case4664.17 where4665.05 you4665.21 could4665.37 have4665.53 a4665.77 vivarium,4665.85 right,4666.41 without4666.57 IACUC,4667.37 or4667.93 was4668.09 it4668.33 something4668.49 else?4668.81 4669.53 LIEBERMAN4669.53 -4669.53 Well,4669.53 if4670.33 you4670.41 are4670.57 a4670.73 private4670.81 company4671.13 not4671.61 receiving4671.77 4672.41 PARSONS4672.41 -4672.41 Private.4672.41 That's4672.41 what4672.65 it4672.81 was.4672.97 4673.37 LIEBERMAN4673.37 -4673.37 And4673.37 working4673.53 with4673.93 mus4674.7 of4675.02 the4675.1 genus4675.27 mus4675.66 and4675.91 rats4676.15 of4676.39 the4676.63 genus4676.7 rattus,4677.1 you4677.59 are4677.74 not4677.91 required4678.15 to4678.47 have4678.55 an4678.7 IACUC.4678.86 You4679.19 are4679.43 only4679.51 required4679.74 if4680.23 you4680.39 are4680.63 fall4680.86 under4681.19 the4681.43 Animal4682.39 Welfare4682.63 Act,4682.63 which4682.63 is4682.95 regulated4683.91 species,4684.39 which4684.86 mus4686.23 and4686.47 rattus4686.63 are4687.02 excluded,4687.19 or4687.91 if4688.23 you4688.47 are4689.35 receiving4689.59 NIH4690.92 funds4691.16 and4691.4 subject4691.56 or,4691.96 you4692.12 know,4692.2 one4692.36 of4692.52 the4692.6 other4692.76 government4693.08 sups4693.96 and4694.28 subject4694.52 to4694.92 4695.64 PARSONS4695.64 -4695.64 But4695.64 no4695.8 one4696.04 is4696.2 anymore.4696.44 4697.56 LIEBERMAN4697.56 -4697.56 I4697.56 know,4697.88 right?4697.88 Like,4697.88 we4699.32 will4699.8 not4700.04 expand4700.36 on4701 that4701.08 right4702.76 now.4703 Okay.4707.59 So,4708.15 I4708.27 mean,4708.39 that's4708.55 sort4709.27 of4709.43 what4709.59 Cambridge4709.82 I4710.31 mean,4710.39 obviously,4710.63 Cambridge4711.02 has4711.43 a4711.59 very4711.74 strict4711.98 regulation4712.31 with4712.86 the,4713.02 you4714.06 know,4714.23 a4715.02 full4715.19 time4715.43 person4715.59 who4715.9 is4716.15 responsible4717.27 for4717.9 visiting4718.63 all4719.1 of4719.35 the4719.43 labs.4719.51 We're4721.17 obviously4721.25 not,4722.21 going4722.93 down4723.25 that4723.41 route4723.65 most4723.97 likely.4727.01 But4727.33 I4727.33 think4727.49 requiring4727.81 IACUCs4731.01 is4731.49 a4731.65 pretty4731.81 reasonable4732.13 and4732.69 low4732.93 low4733.7 bar4734.02 that4734.49 I4734.81 think4734.98 the4735.78 community4735.78 of4736.18 Watertown4736.34 would4736.9 appreciate4737.14 having4737.7 that4738.1 safeguard4739.7 in4740.26 place.4740.41 4741.53 PARSONS4741.53 -4741.53 I4741.53 agree.4741.7 Alright.4742.18 So,4742.49 yeah,4742.81 we've4743.85 started4744.18 it.4744.57 And4746.72 I4747.36 guess4747.68 knowing4748 the4748.24 way4748.32 things4748.56 work,4748.8 by4749.12 December4749.28 of4749.68 this4749.76 year,4749.92 hopefully,4750.16 we'll4750.48 have4750.72 some4750.88 draft,4751.04 well,4751.6 no.4751.84 Like,4752.08 some4752.24 actual4752.48 draft4752.8 regulation4755.2 that4756.72 can4758.16 be4758.32 reviewed4758.48 and4758.96 stuff4759.12 like4759.36 that.4759.52 And4759.92 whatever4760.85 the4761.05 magical4761.26 process4761.9 is4762.22 at4762.69 city4763.81 hall,4764.05 get4765.57 that4765.81 in4765.98 effect4766.22 for4766.53 2026.4766.69 That4767.98 is4768.14 always4768.3 very4768.77 aggressive,4769.02 but4769.57 we'll4769.81 see.4770.05 I4770.94 don't4771.02 think4771.18 we4771.41 need4771.57 huge4772.05 changes4772.38 but4772.94 some4773.18 tweaks4773.34 here4773.65 and4773.73 there4773.9 certainly4774.14 wouldn't4774.45 hurt.4774.77 Alright.4778.86 Actually,4781.9 I4782.14 just4782.22 had4782.38 a4782.54 thought.4782.7 This4783.18 might4783.42 be4783.58 a4783.74 bad4783.82 thought,4784.14 but4784.54 it's4784.78 still4784.94 a4785.18 thought.4785.34 It4787.74 would4787.82 be4787.98 nice4788.14 to4788.38 invite4788.54 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Maureen,4819.65 for4821.16 one4821.97 of4822.13 our4822.28 upcoming4822.52 agendas.4826.93 4826.93 That4827.24 was4827.4 something4827.65 else.4827.97

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4830.06 SPEAKER14830.06 -4830.06 closest4830.06 we4830.54 ever4830.62 got4830.86 to4831.1 pitchforks4831.26 over4832.14 something4832.46 that4832.78 wasn't4833.18 even4833.58 gonna4833.82 be4834.14 discussed.4834.3 Alright.4836.06 Where's4836.22 my4836.54 alright.4837.02 Back4837.42 alright.4837.74 4838.22 PARSONS4838.22 -4838.22 So4838.22 any4838.7 items4838.94 that4839.34 were4840.94 not4841.1 anticipated4841.26 before4841.82 this4842.14 meeting.4842.38 Okay.4848.11 So4848.44 future4848.76 meetings.4849.16 4854.52 FOLEY4854.52 -4854.52 7/10.4854.52 4854.52 PARSONS4854.52 -4854.52 Makes4854.52 the4854.84 most4854.91 amount4855.16 of4855.48 sense?4855.64 4857.24 LIEBERMAN4857.24 -4857.24 That4857.24 would4857.4 be4857.56 helpful.4857.64 4858.87 PARSONS4858.87 -4858.87 Deb,4858.87 are4859.11 you4859.19 available4859.35 on4860.07 July4860.79 10?4861.28 Ralph,4864.55 are4864.87 you4865.03 available4865.19 on4865.59 July4865.75 10?4866.16 4866.71 MELE4866.71 -4866.71 I4866.71 am4866.87 not.4867.03 4867.99 PARSONS4867.99 -4867.99 You4867.99 are4868.31 not.4868.47 Okay.4868.87 And,4871.11 Mia,4871.43 you4871.75 said4871.83 you4872.07 are?4872.23 4872.71 LIEBERMAN4872.71 -4872.71 Yep.4872.71 4873.51 PARSONS4873.51 -4873.51 Okay.4873.51 So4873.66 that's4873.82 three,4874.39 so4874.55 that's4874.55 a4874.7 quorum.4874.86 And4875.26 if4875.43 Tim4875.66 can4875.98 make4876.06 it,4876.3 we'll4876.63 have4876.86 four.4877.18 Because4879.02 I4879.34 cannot4880.15 make4880.47 the4880.7 third.4880.86 It4881.59 just4881.66 doesn't4881.82 make4882.15 sense4882.3 to4882.63 have4882.7 a4882.86 meeting4883.02 before4883.34 the4883.74 fourth4883.9 anyway.4884.15 It's4884.7 a4885.51 meanie4886.06 head4886.3 thing4886.55 to4886.78 do.4886.86 4887.02 FOLEY4887.02 -4887.02 That4887.02 would4887.18 be4887.43 mean.4887.66

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