Watertown Biosafety Committee
Thursday February 6, 2025
The order of items in transcripts appear in the chronological order in which they were taken up. Some Agenda items may have been skipped.
BRAD14.97 PARSONS14.97 -14.97 BIOSAFETY14.97 COMMITTEE14.97 CHAIR14.97 -14.97 Welcome14.97 everyone15.38 to15.94 the16.1 February16.26 202517.03 edition18.89 of19.7 the19.93 Watertown20.1 Biosafety20.57 Committee21.21 meeting.21.45 Thank21.86 you22.02 very22.1 much22.34 for22.49 being22.65 here22.89 this23.05 evening.23.21 We23.54 appreciate23.77 your24.18 time.24.49 Before30.51 we30.83 approve31.07 the31.31 draft31.47 minutes,31.71 for32.03 the32.19 record,32.27 Maureen,32.67 everyone33.55 is33.95 present34.11 from35.15 the35.31 biosafety35.55 committee.36.11 Alright,40.54 that40.7 was40.7 1.5,41.9 now42.3 number42.3 two42.54 on43.5 the43.73 agenda,43.9 any45.41 comments45.9 from46.38 the46.54 committee46.77 about47.5 the47.98 draft48.62 minutes49.02 as49.5 submitted49.73 from51.34 Maureen?51.66 54.08 MIA54.08 LIEBERMAN54.08 -54.08 BIOSAFETY54.08 COMMITTEE54.08 MEMBER54.08 -54.08 I54.08 just54.24 realized54.48 I54.88 didn't55.04 actually55.36 see55.76 them.56 I58.72 just58.8 went59.04 on59.2 the59.28 website,59.36 and59.76 I59.84 didn't59.92 see60.24 them.60.32 67.86 MAUREEN67.86 FOLEY67.86 -67.86 CITY67.86 OF67.86 WATERTOWN67.86 -67.86 You're67.86 a68.1 little68.19 lower68.58 the69.7 way69.86 the70.19 software70.5 is70.98 set71.06 up?71.31 73.14 PARSONS73.14 -73.14 Yes,73.14 it's73.27 a73.27 little73.38 wonky.73.7 75.47 LIEBERMAN75.47 -75.47 It's75.47 where?75.7 77.22 FOLEY77.22 -77.22 It's77.22 like77.38 at77.63 the77.78 bottom82.01 of82.01 the82.01 website.82.17 84.25 LIEBERMAN84.25 -84.25 Okay,84.89 there85.13 they85.13 are,85.53 that's85.93 weird.85.93 Sorry87.05 about87.29 that.87.53 They89.21 keep89.37 changing89.69 where90.01 things90.25 go.90.73 94.88 PARSONS94.88 -94.88 Mia,94.88 would95.19 you95.36 like95.44 a95.67 moment95.84 to96.48 review96.8 that?97.19 97.92 LIEBERMAN97.92 -97.92 I97.92 just98.16 skimmed99.12 them,99.44 and99.67 I99.84 am99.92 good,102.08 they102.23 were102.23 concise.102.56 Thank104.08 you.104.31 105.59 FOLEY105.59 -105.59 So105.59 who105.92 wants106.16 to106.4 make106.48 a106.64 motion?106.8 108.62 PARSONS108.62 -108.62 I108.62 move108.78 that109.02 we109.18 accept109.34 the109.66 minutes109.74 as110.14 submitted110.38 by110.78 Maureen111.02 for111.42 the111.66 January111.98 2025112.82 meeting.113.66 115.9 LIEBERMAN115.9 -115.9 Second.115.9
SHOW NON-ESSENTIAL DIALOGUE
118.54 SPEAKER4118.54 -118.54 Roll118.54 call.118.86 122.81 Mia122.81 Lieberman.123.53 124.56 SPEAKER2124.56 -124.56 Yes.124.56 125.28 SPEAKER4125.28 -125.28 Brad125.28 Brad127.37 Parsons.127.92 Yes.129.53 Deb130.32 McEwen.130.65 131.53 SPEAKER2131.53 -131.53 Yes.131.53 132.81 SPEAKER4132.81 -132.81 Tim132.81 McGuire.133.04 133.93 SPEAKER3133.93 -133.93 Yes.133.93 135.2 SPEAKER4135.2 -135.2 Ralph135.2 136.08 SPEAKER5136.08 -136.08 Milly?136.08 Yes.136.64 143.04 SPEAKER1143.04 -143.04 Great.143.04 And143.36 143.6 PARSONS143.76 -143.76 As143.76 always,143.76 Martin,144.08 thank144.4 you144.56 very144.72 much144.96 for145.2 your145.36 hard145.52 work,145.92 we146.16 really146.16 appreciate146.4 it.146.72 Next149.74 up149.97 is150.29 public150.53 comment.150.94 Quick152.06 reminder,152.46 this152.85 is153.09 an153.18 opportunity153.34 for153.81 the153.97 public154.13 to154.53 make154.62 a154.94 comment155.01 to155.34 the155.42 biosafety155.57 committee,156.22 or157.25 we'd157.74 like157.97 to158.13 also158.29 entertain158.69 questions.159.09 But161.01 this162.13 for163.1 the163.26 members163.42 of163.82 the163.98 public,164.06 this164.62 is164.78 your164.94 opportunity165.18 to165.66 ask165.74 us165.98 questions.166.22 When166.7 the167.5 members168.46 of169.1 the169.58 companies170.38 that170.86 are171.02 here171.18 are171.5 represented,171.66 questions172.3 are172.78 reserved173.02 for173.5 the173.74 biosafety.173.9 So,175.81 actually,176.21 looking176.69 at176.93 everyone177.09 here,177.41 I177.65 believe177.81 there178.44 are178.76 no178.84 members179.09 from179.41 the179.65 public179.72 looking180.21 to180.44 make180.6 a180.76 comment180.93 or181.25 ask181.49 a181.65 question.181.81 Patrick,184.76 because185.16 I185.41 recognize185.56 your186.04 name186.28 as186.44 well,186.6 so186.93 I187.56 think187.72 we188.21 are188.37 good188.6 too.198.1 Alright.198.1 So198.58 first198.98 up,199.46 I203.93 was204.09 a204.25 little204.32 confused204.56 by204.88 adding205.13 like,205.6 this205.76 isn't206 an206.25 amendment,209.53 it209.53 is209.6 an209.84 amendment?210 211.28 MEGHAN211.28 REGO211.28 -211.28 ADDGENE211.76 INC211.76 -211.76 Yes,211.76 we211.93 added211.93 a212.41 very212.65 limited212.88 amount213.28 of213.53 retroviral213.69 work.214.32 So,214.56 previously,214.72 we215.28 just215.37 talked215.6 about215.84 our216.09 AV216.32 plasmids216.81 and217.44 lentivirus,217.6 and218.51 this218.59 would218.75 be218.83 the218.91 addition219.15 of219.31 retroviral.219.55 221.07 PARSONS221.07 -221.07 Gotcha.221.07 So222.11 my222.35 apologies,222.67 I223.07 got223.31 you223.55 confused223.79 with224.27 another224.91 company225.23 that225.63 applied225.95 for226.27 a226.43 permit226.59 for227.15 storage227.31 only,227.79 and229.55 there229.71 was229.87 in230.11 the230.27 minutes230.35 a230.75 lot230.91 about231.15 minus231.78 80232.09 storage232.42 and232.81 then233.06 this233.46 addition233.69 of234.25 a234.5 tissue235.62 culture235.94 room,236.25 and236.5 I236.74 was236.81 like,236.97 it's237.78 been238.01 that238.25 been238.42 that238.66 kind238.81 of239.06 month.239.14 Okay.239.46 So,239.94 Meghan,240.18 if241.06 you241.22 wouldn't241.38 mind,241.62 you242.25 know,242.42 just242.58 very242.9 brief,243.14 big244.41 picture,244.57 you245.85 know,246.09 why247.05 are247.29 you247.37 here247.53 for247.85 the248.01 amendment248.09 for248.81 Adgene?249.05 249.93 REGO249.93 -249.93 Sure.249.93 So,250.17 Addgene250.33 is250.73 a250.81 nonprofit250.97 biorepository.251.45 We252.57 were252.73 founded252.89 in253.29 2004,254.41 we254.57 mainly254.57 did254.89 plasmids255.13 for255.61 a255.85 very255.93 long256.09 time,256.66 our256.82 collection256.82 is257.14 about257.22 100,000257.78 now.258.19 In258.58 2016,258.75 we259.46 started259.63 making259.94 viral260.19 vectors,261.38 these261.63 were261.63 mainly261.78 AAV262.35 neuroscience262.9 focused263.63 tools263.94 and264.43 a264.58 little264.66 bit264.82 of264.99 lentiviral265.14 stuff,265.78 mostly266.02 things266.35 used266.66 for266.82 CRISPR266.99 screens,267.38 and267.78 that's267.94 about268.19 700268.43 at268.99 this269.14 point.269.31 Then270.02 in270.1 2022,270.26 we270.98 started271.14 making271.46 recombinant271.78 antibodies272.42 as272.9 well,273.3 and273.54 these273.54 get273.7 distributed273.94 around274.34 the274.58 world274.66 mainly274.98 for275.3 academic275.46 scientists.276.02 But277.7 this277.94 year,278.18 we278.42 would278.58 like278.82 to,279.06 you279.3 know,279.46 historically,279.78 we280.9 have281.06 been281.22 the281.46 distributor281.62 of282.26 other282.42 people's282.66 tools,283.99 this284.15 year,284.15 one284.55 of284.71 our284.87 focuses284.94 is285.43 gonna285.59 be285.82 to285.99 try286.06 to286.31 fill286.38 in286.63 the286.71 gaps286.87 and287.67 kind288.06 of288.46 meet288.46 scientists288.79 like289.35 some289.59 unmet289.82 need.290.15 So,290.63 if290.79 we290.87 can291.02 identify291.19 tools291.67 that291.99 are292.15 missing292.23 from292.55 our292.71 collection,292.94 we'd293.5 like293.75 to293.9 make294.06 them294.23 ourselves294.38 and295.11 make295.35 them295.5 available295.75 to296.15 scientists.296.31 We297.08 found297.4 some297.72 plasmid298.04 tools298.52 that298.84 are299.08 lacking299.24 in299.72 our299.88 retroviral300.04 collection,301.56 they're301.72 pretty301.72 simple.301.96 Scientists302.52 just303 want303.16 empty303.48 backbones303.8 that304.44 they304.6 can304.76 clone305 their305.56 gene305.72 of305.96 interest306.12 into.306.44 So,307.16 we307.32 just307.48 like307.72 to307.88 make308.04 a308.2 series308.28 of308.76 retroviral309.5 backbones310.22 based310.86 on311.01 MMLV,311.74 gamma312.62 retroviral,313.01 just313.57 the313.81 really313.9 basic314.06 stuff314.38 that314.62 academic314.86 scientists315.25 use.315.74 We316.54 would316.69 not316.86 be317.01 distributing317.25 the317.74 retroviruses,319.25 we319.42 just319.42 want319.66 to319.9 distribute319.9 the320.3 plasmids,320.46 but321.01 we321.18 don't321.34 want321.5 to321.81 distribute321.81 anything322.3 unless322.78 we323.1 know323.25 that323.42 it323.57 works.323.66 So324.48 the324.8 goal324.96 of325.2 these325.36 experiments325.68 would326.16 to326.4 be326.48 to327.04 just327.28 make327.44 them327.68 probably328 in328.32 6328.48 well328.8 dish,328.96 you329.28 know,329.36 less329.52 than329.76 5330 mil330.24 scale,330.48 make331.6 some332 retrovirus,332.24 put333.04 them333.28 onto333.36 HeLa333.76 cells,334.08 and334.32 make334.48 a334.64 stable334.72 cell335.12 line335.28 expressing335.6 a336 GFP336.16 so336.64 that336.96 we337.05 can337.21 show337.29 customers337.61 that338 the338.17 tools338.32 work338.73 before338.96 they339.29 kind339.61 of339.85 go339.85 and340 purchase340.09 them340.32 and340.49 then340.56 hopefully340.73 have341.13 protocols341.29 for341.76 them341.85 that342.09 they342.25 could342.32 follow342.56 if342.81 they342.96 did343.05 buy343.21 the343.44 tool.343.61 346.4 PARSONS346.4 -346.4 Okay,347.37 now347.69 I347.69 get347.85 it.348.81 Thank349.05 you349.37 very349.53 much.349.76 So352.09 I352.41 didn't352.49 have352.81 any352.97 questions353.13 other353.69 than353.93 explanation354.41 of354.81 the354.97 new355.13 work355.29 procedures,355.45 which355.93 you356.09 did,356.57 thank356.73 you.356.73 So,360.57 real361.77 simple362.09 question362.41 here,363.05 when363.37 you're363.61 doing363.85 your,364.17 like,364.49 basically364.99 proof365.38 of365.7 concept365.87 of366.19 what367.14 you367.46 just367.55 described,367.79 I368.26 assume368.43 you're368.82 then369.06 destroying,369.38 like,370.02 hey,370.99 it371.14 works.371.14 But372.5 that372.99 thing373.31 and374.11 you374.26 document374.43 that374.9 and375.06 you375.23 can375.38 demonstrate375.54 that.376.11 But376.67 is376.9 that377.14 also377.31 then377.63 stored377.94 on-site,378.26 or378.58 is378.75 that378.9 just379.06 sent379.38 out379.63 as,379.79 like,379.94 bio380.11 waste?380.35 381.28 REGO381.28 -381.28 No,381.36 we381.6 wouldn't381.6 need381.92 to382 keep382.08 it.382.32 So,382.48 we'd382.64 bleach382.88 the383.2 cells383.36 like383.68 we383.92 normally384.08 do384.4 for384.56 our384.8 lentiviral384.96 procedures.385.6 Everything386.4 too386.8 would386.96 be387.04 done387.2 in387.36 BSL2.387.84 So388.08 we388.24 pretty388.4 much388.56 just388.8 want389.04 the389.2 pictures389.36 and389.76 the389.92 procedures390.08 that390.64 we'll390.88 share390.96 with391.28 scientists.391.44 392.96 PARSONS392.96 -392.96 Okay,393.76 thank394 you.394 Any396.63 questions396.87 from397.19 the397.5 committee?397.67 No?403.43 Tim,404.23 you404.54 look404.7 very405.02 still,405.67 everyone's406.06 shaking406.06 their406.38 head406.54 but406.7 you.406.87 407.9 TIMOTHY407.9 MAGUIRE407.9 -407.9 BIOSAFETY407.9 COMMITTEE407.9 MEMBER407.9 -407.9 No,407.9 I'm407.9 good,408.23 thank408.46 you.408.46 I408.63 appreciate408.94 the409.82 additional410.38 clarification.410.87 415.08 PARSONS415.08 -415.08 Okay.415.08 Well,416.12 this418.44 doesn't418.68 need418.92 to419.04 go419.16 to419.32 the419.4 board419.56 of419.8 health419.88 for420.2 any420.52 type420.76 of422.12 approval423.56 or424.04 anything424.12 like424.52 that.424.68 So,427.5 Meghan,427.82 thank427.82 you427.9 very427.99 much428.14 for428.63 coming428.78 here,429.1 taking429.66 time429.99 out430.14 of430.38 your430.46 evening430.63 to431.26 explain431.5 to431.82 us431.99 what432.14 you're432.31 doing.432.46 We433.43 really433.58 appreciate433.82 it,434.22 and,434.38 best434.87 of435.1 luck435.19 with435.43 your435.9 work.436.14 436.78 REGO436.78 -436.78 Thanks436.78 a437.02 lot.437.1 Thanks437.35 for437.58 your437.75 time.437.9 443.72 PARSONS443.72 -443.72 Alrighty.443.72 So448.44 next448.84 up,449.16 we449.4 have449.64 digital450.2 biology,451.08 which451.64 for452.2 the452.44 biosafety453.8 committee454.44 is455 BTP21E.455.4 So467.77 I468.34 think,468.42 Emma,468.65 you468.98 said469.13 you're469.38 here469.86 from470.1 digital470.25 biology?471.3 472.84 EMMA472.84 WEST472.84 -472.84 DIGITAL472.84 BIOLOGY472.84 INC472.84 -472.84 Yes.472.84 472.92 PARSONS472.92 -472.92 Did472.92 I473 remember473.64 that473.8 correctly?473.96 Okay.474.28 So474.68 kind474.84 of475.16 like475.16 what475.32 Meghan475.48 just475.72 did,475.88 you476.12 know,476.2 just476.44 high476.68 level478.44 why479.8 you're480.12 here480.2 and,480.68 what481.64 you481.88 do.481.96 483.32 WEST483.32 -483.32 Absolutely.483.32 So,484.2 first484.6 of484.84 all,484.92 thank485 you485.16 all485.32 for485.4 your485.56 time,485.88 really486.12 appreciate486.12 it,486.36 and486.52 thanks486.76 for487.08 having487.56 us.487.96 So,488.56 yes,488.73 we're488.96 fundamentally,489.93 a490.4 spatial490.49 measurement490.81 company.491.13 So491.44 we491.61 developed491.76 a492 new492.17 technology492.32 for492.81 DNA493.44 photolithography,493.85 which494.64 allows494.88 us495.13 to495.29 print495.44 DNA495.69 barcodes496.08 using496.56 light496.96 onto497.61 transcriptomes498.08 and498.81 fixed498.88 tissues.499.21 In499.85 this500 way,500.17 we500.32 can500.49 unify500.64 imaging501.05 and501.37 sequencing501.52 data,501.93 which502.17 are502.32 two502.49 of502.64 the502.73 most502.81 powerful503.09 measurement503.41 platforms503.89 in504.37 biology.504.69 So505.73 much505.89 of506.13 our506.21 work506.37 in506.61 the506.77 last506.93 few507.17 years507.41 has507.73 been507.89 focused508.05 on508.37 that.508.53 We're508.77 proud509.01 residents509.33 of509.73 313509.89 Pleasant510.45 Street510.77 in511.09 Watertown511.25 in512.37 a512.45 BSL2513.09 lab,513.33 so513.89 no514.13 major514.37 updates514.61 on514.93 our515.09 end,515.25 but515.41 we515.57 have515.73 started516 emphasizing516.4 more517.37 functional517.61 work.518 So518.25 we518.4 have518.49 started518.64 working519.04 more519.37 with519.76 cell519.92 culture520.16 and521.04 human521.37 cell521.68 lines.521.92 522.16 Everything522.16 is522.57 really522.64 BSL1523.28 that523.45 we're523.61 sourcing523.85 from524.33 cell524.8 culture,525.13 but525.85 we're525.92 also526.08 doing526.33 some526.49 lentiviral526.64 transduction527.37 work528 to528.88 express529.04 really529.52 antibodies529.84 from530.48 the530.8 surface530.88 of531.2 mammalian531.44 cells531.92 and532.48 co532.64 culture532.8 them533.12 with533.28 t533.44 cells.533.6 So534 the535.04 big535.2 shift535.44 for535.68 us535.84 is536 just536.24 more536.4 of536.56 an536.64 emphasis536.72 on537.12 that537.28 work.537.44 So537.68 we537.76 had537.92 some538.08 modifications538.32 that539.68 were539.84 approved540 by540.32 our540.48 IBC540.64 meeting541.04 back541.36 in541.6 May541.84 for542.41 the542.57 addition542.74 of543.21 CRISPR543.53 toolkit544.1 into544.98 our545.21 repertoire.545.45 We're546.57 really546.82 using547.05 RNPs547.53 for548.89 CRISPR549.13 knockouts549.53 in549.93 mammalian550.01 cell550.57 lines,550.74 and551.38 the551.62 loss551.7 of551.93 function552.1 is552.41 expected552.57 to552.98 be553.05 non-toxic,553.21 non553.77 oncogenic.554.01 We555.53 are555.86 also556.89 sourcing558.49 more558.89 primary559.21 materials,560.09 like560.97 human561.13 cell561.53 lines,561.77 that562.25 previously562.49 we562.89 hadn't562.97 been563.21 working563.29 with.563.53 We563.61 were563.77 working563.85 really564.17 with564.33 just564.49 fixed564.73 tissues565.05 and565.45 fresh565.61 frozen565.77 tissues566.09 that566.41 were566.57 immediately566.73 fixed567.21 in567.53 our567.61 facilities.567.77 So,569.21 yes,569.37 that's569.61 the569.85 majority570.01 of570.41 what570.49 we570.65 do570.81 are571.05 the571.61 combination571.77 of572.33 tissue572.74 measurements573.06 and573.38 sequencing.573.7 That574.25 was574.42 all,574.58 like,574.89 very575.13 well575.38 covered575.62 over576.01 our576.25 previous576.34 few578.25 years578.5 working578.89 with579.22 you579.38 guys,579.94 but580.1 now580.1 a580.25 lot580.34 more580.5 work580.65 on580.89 the580.98 mammalian581.13 cell581.62 culture581.86 front582.1 and582.42 the582.65 coculture582.82 of583.3 tumor583.38 cells583.7 and583.94 t584.1 cells584.25 and584.82 the585.06 intersection585.22 with585.7 biologics.585.94 590.54 PARSONS590.54 -590.54 Great.590.54 Thank590.86 you591.1 very591.26 much.591.5 So594.3 I594.54 don't594.7 have594.86 any595.02 questions.595.26 Does596.78 anyone597.02 from597.5 the597.66 committee597.82 have598.38 any598.7 questions598.94 for599.42 Emma?599.58 600.7 LIEBERMAN600.7 -600.7 Yes,600.7 I600.93 just601.01 wanted601.25 to601.58 follow-up601.65 on602.05 the602.21 types602.38 of602.7 human603.58 and603.89 NHP604.13 tissues.604.62 Are605.1 you605.25 getting605.41 any605.65 nervous605.98 system606.38 materials,607.25 or607.82 what608.13 organ609.58 lines609.98 or610.21 tissue610.38 lines610.7 are610.93 you611.1 actually611.25 getting?611.58 612.7 WEST612.7 -612.7 So612.7 for613.33 the613.65 fixed613.98 tissues614.29 that614.62 we're614.77 getting?614.93 615.71 LIEBERMAN615.71 -615.71 For615.71 the615.79 fresh.616.03 616.91 WEST616.91 -616.91 The616.91 fresh617.15 tissues.617.39 We617.79 actually618.03 are618.43 not618.59 currently618.83 working619.31 with619.63 fresh619.87 human620.67 and620.99 NHP621.23 tissues,621.55 although621.79 that622.03 is622.19 in622.35 the622.43 permit622.59 so622.91 that623.07 we623.63 might623.79 anticipate623.95 working624.43 with624.67 partners624.83 who625.23 have625.39 those625.55 tissues.625.79 We626.67 haven't626.83 done627.15 it627.31 yet,627.55 we627.71 have627.71 worked627.87 with628.11 fresh628.35 frozen628.75 pig629.23 tissues,629.99 which630.23 was630.54 in630.71 our630.87 previous633.18 permit,634.3 and634.46 for634.46 that,634.63 that635.59 was635.83 not636.07 central636.3 nervous636.63 system636.95 tissues.637.26 We637.83 have637.99 worked638.14 with638.3 fixed638.46 central638.78 nervous639.11 system639.35 tissues,639.66 but639.9 only640.14 from640.38 the640.54 mouse.640.71 But641.9 all642.07 of642.14 our642.3 fresh642.95 frozen643.18 tissues643.66 are644.07 treated644.61 as644.93 BSL2.645.49 We645.81 have645.89 a646.05 dedicated646.21 cryostat646.61 for647.25 all647.41 of647.65 the647.89 sectioning,648.05 and648.61 all648.69 of648.85 the648.93 prefixation649.09 work649.73 is649.97 in650.05 a650.21 very650.29 dedicated650.53 area650.93 of651.25 the651.33 lab,651.49 with652.85 dedicated653.57 machinery654.21 and,654.85 very656.13 tight656.45 BSL2657.09 control.657.25 658.54 LIEBERMAN658.54 -658.54 Are658.54 you658.71 anticipating658.87 getting659.66 any659.99 nervous660.38 system660.78 tissue661.11 from661.83 humans662.07 or662.38 NHPs662.54 in662.95 the663.02 future?663.11 665.18 WEST665.18 -665.18 We665.18 are,665.42 which665.66 is665.9 why666.07 it666.23 is666.38 in666.71 the666.87 permit.667.02 We667.42 don't667.5 have667.75 anything667.83 lined668.23 up668.46 specifically668.63 for669.11 that,669.26 but669.42 it669.59 is669.66 an669.83 area669.9 of670.14 interest670.3 for670.54 a670.71 number670.78 of671.02 our671.18 business671.26 development671.59 conversations.672.07 673.56 LIEBERMAN673.56 -673.56 Okay.673.56 Because,673.8 are675 there675.16 plans675.4 for675.96 consideration676.36 of677.24 Prion677.64 Biosafety?678.44 Because679.72 that679.96 was680.12 not680.28 explicitly681 discussed681.72 in682.2 the682.36 IBC682.52 minutes683 that683.32 I683.48 saw,683.56 so683.8 I683.96 don't684.12 know.685 685 WEST685 -685 I685.72 think685.8 we686.04 had687.98 spoken688.21 about688.46 this688.7 last688.93 year,689.1 I689.25 believe,689.41 actually689.65 at689.98 this690.13 meeting690.38 with690.7 you,692.13 and692.62 for692.62 that,692.86 we693.17 treat693.89 all694.13 of694.29 these694.38 tissues694.62 as694.93 if695.01 they're695.17 infectious.695.34 So,696.29 all696.62 of696.77 the696.86 safe697.01 precautions697.25 that697.74 we're697.89 using698.05 for698.29 any698.46 of698.7 our698.77 fresh699.1 frozen699.41 tissues699.74 are700.13 applied700.29 in701.5 the701.74 context701.82 of702.29 the703.65 fresh703.89 frozen704.13 human704.45 tissues704.77 as705.17 well.705.33 SHOW NON-ESSENTIAL DIALOGUE
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online1924.94 identity.1925.35 I1925.74 don't1925.83 know1926.07 who1926.14 they1926.3 are1926.94 and1926.94 that's1927.18 when1927.35 I1927.59 had1927.66 to1927.83 kind1927.98 of1928.22 go1928.22 chase1928.38 them1928.63 down.1928.79 1931.03 MELE1931.03 -1931.03 That's1931.03 something1931.35 that1931.59 can1931.67 be1931.91 added1931.99 to1932.31 the1932.39 form1932.55 if1932.79 you'd1932.95 like1933.59 as1933.99 well.1934.15 1934.95 LIEBERMAN1934.95 -1934.95 Yes.1934.95 So1935.19 I1935.35 think1935.43 we'll1935.67 add1935.91 that1935.99 next1936.23 year.1936.39 But,1936.63 otherwise,1937.03 I1937.51 think,1937.67 overall,1938.23 once1938.63 I1938.87 received1938.95 the1939.35 renewal,1939.51 it1940.31 was1940.47 a1940.63 pretty1940.71 smooth1940.95 process.1941.27 1942.71 PARSONS1942.71 -1942.71 Okay.1942.71 Alright.1943.67 So1943.84 then1943.99 instead1944.63 of1944.95 waiting1945.12 until,1945.52 like,1945.91 September,1946.32 then1947.03 maybe1950.55 we1950.55 should1950.79 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ease2166.4 that2166.89 side2167.13 of2167.36 it,2167.44 it2167.68 definitely2167.84 felt2168.32 like2168.48 it2168.64 was2168.72 an2168.89 improvement.2169.13 2172.4 LIEBERMAN2172.4 -2172.4 Yes.2172.4 Certainly2172.4 over2172.8 the2173.05 old2173.13 version2173.36 on2173.68 Teams2173.92 with2174.64 8002175.2 pages2175.68 of2176.09 renewal2176.64 paperwork.2177.44 2178.57 FOLEY2178.57 -2178.57 Exactly.2181.48 2185.32 PARSONS2185.32 -2185.32 Okay.2185.32 Well,2185.8 I'll2186.04 consider2186.2 that2186.6 a2187.08 success2187.24 story2187.64 then.2187.96 But2189.56 like2189.96 anything2190.12 else2190.52 for2190.76 improvement,2191.64 so2191.8 we'll2191.8 do2191.96 that2192.12 with2192.28 the2192.44 community2192.6 member2193.08 then.2193.48 So2196.09 items2196.96 that2197.28 were2197.44 not2197.61 anticipated2197.92 before2198.64 the2198.96 publication2199.13 of2200.16 the2200.48 agenda,2201.44 so2201.68 we2201.68 do2201.92 have2202.16 that.2202.48 A2204.32 flurry2204.57 of2205.05 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companies.2351.09 If2351.33 a2351.49 company2351.57 is2351.89 just2352.05 receiving,2352.36 we'll2353.57 say,2353.81 regulated2354.13 materials,2355.59 but2356.55 is2356.79 just2357.03 storing2357.27 them2357.59 in2357.83 a2357.91 freezer2358.07 and2358.47 not2358.63 doing2358.79 anything2359.03 with2359.43 them,2359.59 do2360.15 they2360.31 need2360.47 a2360.63 permit?2360.79 That's2364.47 part2364.63 two.2365.19 2365.75 PARSONS2365.75 -2365.75 I2366.15 think2366.31 part2366.87 two2367.43 is2367.67 a2367.75 little2367.91 straightforward2371.32 in2371.32 the2371.47 sense2371.64 of,2372.76 for2373.39 the2373.64 lack2373.72 of2374.04 a2374.2 better2374.28 word,2374.52 manipulation.2374.84 So,2375.71 having2381.95 a2382.28 registration,2382.43 in2384.77 my2384.93 opinion,2385.09 is2385.49 sufficient2385.73 provided2386.53 that2387.57 it's2387.73 kind2387.97 of2388.21 like2388.29 a2388.45 registration2388.69 slash2389.49 enhancement2389.89 where,2391.09 you2391.81 know,2391.97 I2393.01 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that2426.14 wants2426.38 to2426.53 do2426.78 this,2426.93 and2427.26 we2427.49 gave2427.57 them2427.82 that2427.89 info,2428.38 and2428.45 I2428.45 have2428.61 not2428.78 yet2429.01 seen2429.34 their2430.14 registration2434.86 application2434.86 yet.2435.41 I'm2437.09 trying2437.26 to2437.49 find2437.66 the2437.89 email.2438.05 2443.97 PARSONS2443.97 -2443.97 So,2443.97 Deb,2444.29 I2444.53 can2444.61 tell2444.77 you2445.01 are2445.17 ready.2445.97 2445.97 MCEWAN2445.97 -2445.97 I2445.97 agree2446.85 that2447.25 it2447.89 seems2448.77 unnecessary2449.81 that2450.45 they2450.53 would2450.61 need2450.85 a2451.01 permit2451.17 because2451.65 if2454.28 they're2454.52 getting2454.68 material,2454.99 immediately2455.64 storing2456.28 it,2456.68 taking2457.32 it2457.47 out,2457.72 there's2459.24 no2459.64 risk2459.95 to2460.28 the2460.43 community,2461.16 there's2461.39 no2461.39 risk2461.56 to2461.88 the2462.04 user2462.2 for2463.16 a2463.39 typical2463.47 scenario.2463.95 So2464.52 as2464.76 long2464.91 as2465.24 the,2465.56 like,2465.88 extreme2466.74 circumstances2467.3 that2468.1 Brad2468.34 mentioned2468.66 have2469.86 been2470.02 thought2470.42 through,2470.74 then2471.78 that2471.94 should2472.18 cover2472.5 any2472.98 safety2473.22 concerns.2473.62 2478.34 LIEBERMAN2478.34 -2478.34 Okay.2478.34 This,2478.82 came2479.46 from2479.7 actually2479.94 Avanta.2480.34 So2481.09 they2481.26 are2481.41 leasing2481.65 space,2482.21 and2483.82 they're2483.97 going2484.21 to2484.45 have2484.45 commercial,2486.14 sera,2486.78 animal,2487.17 humans,2487.57 kits,2488.05 regions,2488.3 media,2488.69 human2489.01 and2489.34 animal2489.49 cell2489.89 lines,2490.05 proteins,2490.38 antibodies,2490.93 enzymes,2491.57 DNA,2492.05 RNA,2492.45 viral,2492.86 and2493.17 bacterial2493.26 samples.2493.89 They2494.3 say2494.45 no2494.69 GMP,2494.93 select2495.41 agents,2495.73 BLC32496.53 plus2497.01 radioactive2497.33 or2497.89 clinical2498.13 samples2498.45 will2498.85 be2499.01 stored.2499.17 They're2499.73 not2499.97 going2500.13 to2500.37 freeze2500.37 our2500.69 aliquot,2502.61 they2502.77 just2502.77 return2503.01 them2503.33 to2503.49 the2503.65 client2503.73 for2504.05 disposal.2504.21 So,2504.93 at2505.09 that2505.25 point,2505.41 we2505.65 said2505.81 you2506.05 can2506.21 do2506.29 a2506.45 registration2506.61 that2507.17 we'd2507.33 like2507.49 to2507.65 see2507.73 a2507.89 written2507.97 statement2508.29 regarding2508.69 the2509.01 emergency2509.09 response2509.57 in2509.97 the2510.13 event2510.69 of2510.93 a2511.09 fridge2511.17 or2511.41 freezer2511.57 malfunction.2511.89 What2512.68 is2512.84 the2513.01 response2513.09 plan2513.48 for2513.72 defrosted2513.97 BL22514.76 material2514.93 if2515.32 it2515.48 were2515.57 to2515.8 spill?2515.97 But2516.45 I2516.61 have2516.76 not2516.84 yet2517.09 seen2517.32 their2517.64 application.2517.89 Okay,2520.13 sounds2520.36 good.2520.36 2521.01 PARSONS2521.01 -2521.01 Because2521.01 that2521.32 company2521.48 began2521.8 with2522.05 an2522.2 A,2522.36 and2522.53 we2522.68 had2522.84 two2526.27 A's2526.67 tonight,2526.67 the2526.67 Addgene2526.91 one2528.03 started2528.19 hard2528.91 and2529.15 fast2529.31 with2529.71 storage,2529.95 and2530.51 then2530.67 it2530.91 was2531.07 all2531.23 about2532.03 working2532.27 with2532.59 viral2532.83 vectors2534.43 in2534.99 a2535.23 tissue2535.47 culture2535.79 room,2536.11 and2536.35 I2536.51 got2536.67 a2537.23 little2537.39 angry.2538.03 2538.91 LIEBERMAN2538.91 -2538.91 Not2539.71 them,2540.75 different2541.41 one.2541.41 2541.41 PARSONS2541.41 -2541.41 Because2541.41 that2541.65 is2541.65 not2541.89 what2542.21 I2542.38 agreed2542.53 to.2544.3 But2544.78 then2544.93 I2545.17 was2545.26 like,2545.34 well,2545.49 wait2545.57 a2545.73 minute,2545.89 why2546.05 are2546.05 they2546.13 here2546.3 if2546.38 we2546.49 but,2546.86 anyway2547.01 okay.2547.49 So2548.3 cool.2549.41 Part2549.89 two,2551.97 that2552.53 seems2552.69 like2552.93 a2553.09 reasonable2553.26 thing,2553.97 right?2555.2 Back2555.2 to2555.44 why2556 Corey's2556.32 here2556.8 and2557.28 specifically,2557.76 Jeevan.2561.76 2563.28 LIEBERMAN2565.36 -2565.36 I2565.36 think2565.44 it's2565.68 pronounced2565.76 Jeevan.2566.24 Corey,2566.64 did2566.96 I2567.12 butcher2567.2 that?2567.52 2570.97 COREY2570.97 MARTINS2570.97 -2570.97 SPOTLIGHT2570.97 SAFETY2570.97 INC2570.97 -2570.97 They2570.97 call2571.14 it2571.3 Jeevan.2571.54 2572.41 LIEBERMAN2572.41 -2572.41 Jovan.2572.41 Sorry,2574.34 that's2574.57 why2574.57 I2574.74 asked.2574.89 2575.3 PARSONS2575.3 -2575.3 The2576.26 TX2576.49 is2577.61 separate2577.7 for2578.18 therapeutics.2578.49 Alright,2579.3 Jovan,2580.57 got2580.82 it.2580.82 2583.88 LIEBERMAN2585.48 -2585.48 I'm2585.48 going2585.64 to2585.88 screw2585.88 this2586.12 up2586.28 multiple2586.44 times,2586.84 so2587.08 I'm2587.24 going2587.4 to2587.64 apologize2587.64 in2588.12 advance2588.28 for2588.6 that.2588.76 Okay.2591.88 So,2592.2 yes,2592.36 hack2592.68 2932593.08 cells.2593.64 2598.51 MARTIN2598.51 -2598.51 Do2598.51 you2598.74 want2598.82 me2598.99 to2599.22 explain2599.47 kind2599.95 of2600.11 where2600.74 we2601.63 see2602.11 this2602.43 line2602.74 falling?2603.3 2604.82 PARSONS2604.82 -2604.82 It's2604.82 important2605.14 to2605.55 see2605.7 both2606.03 sides2606.26 here2607.39 to2608.43 understand2608.74 where2609.47 the2609.7 disconnect2609.86 might2610.99 be.2611.22 2611.97 MARTIN2611.97 -2611.97 Yes.2611.97 So2612.29 the2612.61 way2612.77 that2613.17 we2613.33 view2613.57 this2613.81 line2614.05 is2614.61 it's2616.53 a2616.77 permanent2616.93 line,2617.57 it's2617.73 a2618.05 little2618.13 bit2618.37 of2618.53 a2618.69 misnomer2618.85 to2619.33 call2619.41 it2619.57 a2619.73 stable2619.89 line2620.29 because2620.53 it's2620.85 not2621.01 intentionally2621.49 transduced2623.57 to2624.21 the2624.29 way2624.45 that2624.69 most2624.93 stable2625.86 lines2626.09 in2626.66 the2626.89 labs2627.05 are2627.45 created.2627.78 This2628.34 was2628.49 just2628.74 a2628.97 shared2629.14 adenovirus2630.09 creation2630.82 that2631.61 created2631.86 HEC2632.26 lines,2632.57 and2633.53 this2633.78 is2634.01 one2634.26 iteration2634.57 of2635.38 kind2635.7 of2635.86 the2635.93 HEC2636.09 lineage.2636.34 But2637.45 it's2637.93 not2638.18 hosting2639.6 the2640.24 entire2640.8 adenovirus2641.6 genome2643.2 at2644.48 once.2644.64 So,2645.84 it's2646.56 a2646.8 very2646.88 popular2647.2 line2647.76 to2648.24 package2649.12 in.2649.76 So,2650.48 like,2650.72 when2650.96 they're2651.12 creating2651.36 viral2651.84 vectors2652.24 in2652.8 the2653.03 labs,2653.19 they2653.59 package2653.84 in2654.23 these2654.39 cells2654.64 because2654.95 they2655.28 grow2655.43 quickly2655.76 and2656.32 they2656.88 create2657.11 really2657.36 nice2657.67 titers.2657.99 But2658.88 the2659.11 line2659.28 itself2659.59 doesn't2660.23 contain2661.11 the2661.59 entire2661.84 genome2662.32 in2662.8 a2662.95 way2663.03 that2663.19 will2663.36 just2663.59 randomly2664.32 shed2664.88 or2665.11 produce2665.28 adenovirus.2666.23 It's2667.33 the2667.49 introduction2667.73 of2668.37 the2668.53 plasmids2668.77 that2669.41 are2670.05 typically2670.21 used2670.61 in2670.93 viral2671.17 vector2671.49 construction2671.89 that2672.69 would2672.93 then2673.81 lead2674.21 to2674.37 the2674.61 replication2675.01 competency2675.65 reversion2676.37 concerns2677.01 that2677.73 are2678.05 highlighted2678.61 in2679.09 a2679.17 lot2679.25 of2679.41 those2679.49 papers.2679.65 The2680.53 thing2681.43 I2681.59 want2681.76 to2681.84 highlight2681.84 here2682.23 is2682.55 they're2682.72 not2682.95 doing2683.11 any2683.51 introduction2683.91 of2684.72 any2684.95 plasmids2685.36 with2685.91 these2686.16 cells,2686.8 they're2687.03 just2687.03 using2687.36 the2687.76 qualities2687.91 that2688.64 are2688.95 here2689.99 from2690.39 a2690.72 platform2690.8 standpoint2691.36 with2691.99 them2692.23 growing2692.47 quickly2692.8 and2693.11 being2693.36 a2693.51 good2693.59 recipient2693.84 for2694.32 some2694.47 of2694.64 their2694.72 screening2694.95 lines.2695.36 They're2696.16 not2696.39 introducing2697.3 anything2698.18 into2698.82 the2699.06 cells2699.3 that2699.7 would2699.86 then2700.18 allow2700.5 the2701.46 adeno2701.78 to2702.9 package2703.14 in2704.34 any2704.66 meaningful2706.02 sense.2706.58 So2708.42 that's2708.58 why2708.82 we're2708.98 kind2709.22 of2709.38 putting2709.46 it2709.7 in2709.86 the2710.02 BSL2,2715.11 it's2716.07 hard2716.32 to2716.47 say2716.55 it's2716.8 not2716.95 a2717.11 transgenic2717.28 material2718.07 because2718.71 it2719.11 does2719.28 have2719.51 viral2720.16 components2720.55 in2721.03 it,2721.28 that's2721.99 how2721.99 it2722.23 was2722.32 originally2722.47 made.2722.95 But2723.28 it's2723.43 not2723.67 producing2725.76 the2726.32 same2726.56 kind2726.96 of2727.12 particles2727.36 that2727.84 you2728 would2728.24 if2728.48 you2728.64 were2728.88 intentionally2729.84 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in2803.68 all2804.47 of2804.64 these2804.8 packaging2805.11 risks2805.52 and2806 things2806.48 associated2807.04 with2807.52 the2807.68 viral2807.76 vector2808.08 component2808.4 that2808.72 I2808.88 just2809.04 wanted2809.2 to2809.44 make2809.52 sure2809.68 we2810 had2810.64 out2810.96 there.2811.12 2814.32 LIEBERMAN2814.32 -2814.32 I2814.32 think2814.4 part2814.72 of2814.96 the2815.2 challenge2815.36 for2815.76 us2816 as2816.16 committee2817.36 or2817.76 at2817.92 least2818 me2818.24 reviewing2818.48 the2819.04 work.2819.2 I2819.52 mean,2819.6 obviously,2819.84 yes,2820.56 if2820.79 they're2820.79 trying2821.03 to2821.11 do2821.18 plasma2821.66 work,2821.99 that2822.22 definitely2822.55 should2823.03 fall2823.18 under2823.34 a2823.51 permit.2823.66 But2825.34 as2825.59 sort2825.66 of2825.83 for,2827.27 I2827.66 guess,2827.83 a2827.99 company2828.14 that's2828.55 not2828.79 working2829.11 with2829.59 you2829.66 and2830.55 might2830.79 be2831.03 doing2831.27 some2831.51 of2831.74 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really2907.86 useful2908.18 for2908.58 other2909.32 screening2909.4 purposes2909.48 and2910.84 not2911.09 necessarily2911.32 the2911.72 recombinant2912.13 work2913.32 that2913.64 it's2914.13 kind2914.84 of2915.16 favored2915.24 for.2915.64 2921.64 PARSONS2921.64 -2921.64 So,2928.36 Mia,2929.68 is2929.72 there2929.72 a2930.68 reasonable2930.76 way2931.32 in2931.96 a2932.12 review2932.28 process,2932.76 because2939.16 this2939.48 checkbox2941.24 thing2941.72 seems2943.16 to2943.48 be2943.57 working2943.72 well2945.16 for2945.57 the2945.72 amendment2947.09 slash2947.64 renewal.2948.05 2950.05 FOLEY2950.05 -2950.05 But2950.05 that's2950.28 only2950.53 for2952.11 permits,2953.71 not2954.19 registrations.2954.43 The2958.03 other2958.19 thing2958.19 is,2959.55 I2959.87 was2960.03 just2960.19 thinking2960.43 about2960.83 this.2961.07 Can2961.87 we2962.75 do2962.99 a2963.47 registration2963.71 with2964.51 restrictions?2964.83 Put2969.2 it2969.44 on2969.61 the2969.84 permit?2970.09 2970.48 LIEBERMAN2970.48 -2970.48 No,2971.68 because2972.01 that2972.01 defeats2972.4 the2972.89 whole2973.05 point2973.2 of,2973.44 like,2973.61 the2973.84 registration.2974.01 Maybe2975.2 like2975.76 another2975.92 stupid2976.32 question,2976.64 Corey.2977.05 Is2977.76 this2977.92 planning2978.16 to2978.48 convert2978.72 to2979.05 a2979.2 full2979.28 permit?2979.53 2980.4 MARTIN2980.4 -2980.4 No,2982.1 they2982.46 will2982.62 never2982.86 have2983.26 the2983.5 RDNA2983.66 portion2985.02 as2985.58 far2985.9 as2986.14 I'm2986.22 aware.2986.38 At2986.94 least2987.1 for2987.42 the2987.74 near2987.98 future2988.38 that2988.7 we2988.86 have2989.02 discussed2989.26 for2990.22 their2990.38 work,2990.62 there's2991.1 no2991.58 potential2992.06 to2992.7 revert.2992.94 Like,2993.53 sometimes2994.73 we2995.05 do2995.21 that,2995.53 right?2995.78 We'll2995.78 do2996.01 the2996.17 initial2996.41 registration2996.82 and2997.3 then2997.45 immediately2997.61 convert2998.09 it2998.41 in,2999.05 this2999.3 is2999.3 not2999.53 one2999.69 of2999.93 those3000.01 cases3000.26 where3000.66 they're3000.89 planning3001.05 to3001.53 then3001.86 take3002.09 the3002.34 next3002.41 step3002.73 immediately3003.21 into3003.69 the3004.01 RDNA3004.26 sphere.3004.89 3005.78 LIEBERMAN3005.78 -3005.78 Okay.3005.78 I3006.17 asked3006.34 because3006.57 then3007.14 a3007.38 month3007.45 from3007.69 now,3007.86 this3008.09 would've3008.89 been...3008.89 3008.89 MARTIN3008.89 -3008.89 Correct.3010.73 3014.49 LIEBERMAN3014.49 -3014.49 Okay.3014.49 I3014.49 mean,3014.65 is3014.89 this3015.05 the3015.29 kind3015.37 of3015.61 situation3015.85 where3016.25 if3016.49 a3016.57 company3016.65 is3017.05 going3017.21 to3017.45 have3017.45 a3017.61 registration3017.77 that3018.57 they3020.93 need3021.16 to3021.81 present3022.13 here3022.77 to3024.29 get3024.53 that3024.61 approved.3024.84 I3025.32 mean,3025.41 that3025.57 could3025.72 be3025.81 another3025.97 interim,3027.32 I3027.49 don't3027.57 know3027.81 what3027.89 makes3028.05 any3028.29 sense.3028.45 3029.49 PARSONS3029.49 -3029.49 That's3029.49 what3029.72 I3029.89 was3029.97 kind3033.53 of3033.85 going3033.85 with,3033.85 Mia3033.85 with3033.85 the3033.85 checkbox3033.93 thing3034.33 as3034.57 well,3034.73 and3034.89 if3035.05 that's3035.21 not3035.37 possible,3035.61 and3036.57 what3036.73 I3036.97 meant3037.05 by3037.29 too3037.53 granular,3037.77 I3038.25 was3038.33 going3038.49 to3038.73 say,3038.73 like,3038.89 check3040.17 off3040.41 a3040.65 box3040.73 that3041.05 says,3041.29 are3041.53 you3041.69 going3041.85 to3042.17 be3042.17 working3042.25 with3044.41 heck3044.97 2933044.97 cells3044.97 of3045.69 any3045.85 sort?3046.17 And3047.42 then3047.59 what3048.14 are3048.3 you3048.39 going3048.46 to3048.78 do3048.78 with3048.86 it,3050.7 if3051.18 yes.3051.51 But3054.14 I3054.3 like3054.46 your3055.59 suggestion3055.9 better3056.55 because3058.78 for3059.26 the3059.42 groups3060.57 that3060.81 aren't3061.05 using3061.37 a3062.09 consultant3062.25 that3062.81 can3062.97 come3063.13 here3063.37 and3063.61 explain3063.93 their3065.05 clients'3065.29 work3065.77 well,3066.01 they3067.29 should3067.53 be3067.77 able3067.93 to3068.17 come3068.33 here3068.57 and3068.89 answer3069.93 these3070.25 questions,3070.81 right?3070.97 They're3070.97 the3071.13 ones3071.29 doing3071.53 the3071.77 research,3072.25 and3072.33 I3072.33 think3072.41 these3072.65 are3072.81 legitimate3073.05 questions3073.69 with3074.41 really3074.72 good3074.8 answers3075.2 so3075.68 far.3075.84 But,3077.61 yes,3077.93 for3078.16 company3078.8 Z3079.53 that3079.93 we3080.09 haven't3080.24 seen3080.57 yet,3080.8 if3084.96 they3085.05 qualify3085.28 for3086.41 a3086.64 registration,3086.8 they're3087.68 already3087.84 getting3088.24 a3088.41 break3089.53 financially3090.86 and3091.66 oversight3093.34 wise.3093.9 I3095.18 don't3095.26 think3095.42 it's3095.66 an3095.82 unreasonable3095.98 ask3096.78 for3097.18 someone3097.42 to3097.74 come3097.9 and3098.14 spend3098.38 153098.78 to3099.18 203099.34 minutes3099.66 defending3102.62 in3103.34 a3103.5 way.3103.58 It3104.38 doesn't3104.45 have3104.61 to3104.78 be3105.01 a3105.17 negative3105.34 statement,3105.97 but3106.45 at3106.93 least3107.09 presenting3107.49 to3109.17 answer3109.41 questions3109.73 that3110.3 justify3110.61 a3113.89 registration3114.05 versus3114.78 a3115.09 permit.3115.26 Because3115.49 we've3115.73 had3115.97 these3116.14 questions3116.3 before,3116.78 not3118.67 specific3118.87 to3119.19 the3119.35 cell3119.51 line3119.75 in3119.91 this3120.07 situation,3120.31 but3120.95 with3121.19 the3121.35 going3121.51 back3121.83 and3122.23 forth3122.31 with3124.07 the3124.31 emails.3124.47 But,3124.87 you3125.19 know,3125.35 in3125.51 the3125.67 spirit3125.83 of3126.15 having3126.23 the3126.55 committee3126.71 involved3127.11 and3127.43 stuff3127.59 like3127.75 that,3127.91 yes,3128.23 get3128.47 them3128.63 over3128.87 here,3130.15 come3130.31 and3130.47 talk3130.71 to3130.87 us,3131.03 and3131.27 we'll3131.51 talk3131.75 it3131.91 through3132.07 like3132.31 this.3135.89 I3136.05 think3136.13 that3136.68 sounds3136.93 reasonable3137.16 to3137.72 me.3137.97 SHOW NON-ESSENTIAL DIALOGUE
3144.36 SPEAKER33144.36 -3144.36 Deb?3144.36 3145.09 MCEWAN3145.09 -3145.09 So3145.09 how3145.97 do3146.29 we3146.45 get,3146.68 like,3148 a3148.12 comprehensive3148.24 list3149.68 of3150.4 the3150.8 cell3151.04 lines3151.36 that3151.68 would3151.84 trigger3152.08 this3152.48 special3152.72 behavior?3153.12 Like,3154.16 is3154.32 it3154.56 just3155.12 the3155.76 heck3156 one?3157.12 3159.04 PARSONS3159.04 -3159.04 That's3159.04 why3159.28 I3159.52 was3159.6 like,3159.76 that's3160 probably3160.24 too3160.64 prescriptive3160.8 if3161.44 it's,3161.6 like,3161.84 my3162.53 initial3162.68 suggestion3163.64 or3164.13 question3164.28 of,3164.68 like,3164.92 having3165.09 the3165.41 checkbox3165.48 for3165.96 that,3166.36 because3166.61 there's3166.61 going3166.76 to3167.01 be3167.01 something3167.16 else3167.41 in3167.64 three3168.36 months,3169.41 right?3169.41 3169.41 MCEWAN3169.41 -3169.41 Right.3169.41 Like,3169.72 I3169.96 think3170.13 not3171.72 opposed3172.05 to3173.72 having3173.89 that3174.2 be3174.53 something3174.76 that3175.09 comes3175.24 to3175.48 the3175.57 committee,3175.72 but3176.05 could3176.28 still3176.44 be3176.68 a3176.92 registration,3177.01 but3177.66 I3177.74 think3177.9 it3178.06 needs3178.3 to3179.5 be3179.66 thought3179.9 out3180.22 of3181.02 what3181.26 the3181.66 parameter3181.9 would3182.46 be,3182.7 like,3183.5 how3183.66 to3183.9 define3184.14 that3184.46 scenario3184.7 more3185.58 than3185.82 just3186.06 this3186.3 one3186.54 cell3186.78 line.3187.02 3188.22 PARSONS3188.22 -3188.22 Right.3188.22 Well,3192.63 Mia,3192.86 I3193.03 think3193.18 it3193.34 would3193.51 take3193.74 pressure3194.07 off3194.46 of3194.63 you3194.78 if3196.07 you3196.39 have3196.94 the3197.74 option3201.03 or3201.66 the3202.07 ability3202.3 to3203.31 say3203.63 to3204.27 the3204.51 chair3204.67 or3205.07 ask3205.31 the3205.55 chair,3205.71 hey,3207.15 do3207.31 you3207.31 think3207.47 this3208.19 group3208.83 should3209.15 come3209.39 and3209.87 justify3210.75 an3211.47 amendment3211.63 versus3212.03 a3212.35 registration3212.43 versus3213.39 the3213.87 onus3214.03 being3214.43 on3214.67 you3214.83 saying,3215.15 yes,3217.61 okay,3217.93 and3217.93 with,3217.93 like,3218.17 possibly3218.57 some3219.05 reluctance,3219.3 right,3220.09 which3220.26 you3220.49 don't3220.65 ever3220.97 want3221.13 to3222.01 do3222.01 in3222.17 your3222.34 role.3222.57 Sure,3224.73 this3224.97 time,3224.97 it'll3225.38 fly,3225.86 kind3227.13 of3227.45 thing.3227.45 3228.35 LIEBERMAN3228.35 -3228.35 Well,3228.35 that's3228.51 why3228.75 I3228.99 just3229.15 said3229.39 this3229.71 will3229.95 have3230.11 to3230.27 be3230.35 discussed3230.51 by3230.83 the3230.99 committee,3231.07 and3231.39 I'm3231.55 not3231.71 going3231.87 to3232.11 unilaterally3232.11 approve3232.83 this.3233.15 I3233.39 mean,3233.47 that's3233.63 what3233.79 I3234.03 basically3234.35 said3234.83 in3234.99 my3235.15 email.3235.31 3236.51 PARSONS3236.51 -3236.51 No.3236.51 But,3236.67 I3236.75 mean,3236.83 like,3237.07 you3237.87 know,3238.03 moving3238.27 forward3238.67 for3240.35 the3240.51 company3240.67 that3241.15 we3241.39 don't3241.55 have3241.87 an3242.11 a3242.43 good3242.59 interaction3242.83 with,3243.39 just3244.66 for3245.14 any3245.45 registration,3245.78 actually,3246.34 that3246.66 you3246.82 might3247.05 say,3247.38 hey,3248.82 this3249.14 is3249.38 squarely3249.61 in3250.09 the3250.18 gray,3250.34 and3251.22 you3253.38 need3253.61 to3253.78 come3253.86 to3254.01 the3254.49 committee.3254.66 3258.83 MCEWAN3258.83 -3258.83 I3258.83 mean,3258.99 an3259.31 advantage3259.47 of3259.87 coming3259.95 to3260.27 the3260.43 committee3260.51 is3260.99 that3261.15 if3261.31 they3261.47 weren't3261.71 aware3261.95 their3262.43 work3262.83 was3263.07 in3263.31 the3263.47 gray,3263.55 it3264.11 will3264.27 at3264.51 least3264.67 make3265.23 it3265.39 clear3265.55 to3265.87 them3266.03 of3267.31 what3267.39 concerns3267.71 there3268.19 might3268.43 be.3268.59 3270.17 PARSONS3270.17 -3270.17 And3270.17 hypothetically3270.73 delay3271.69 their3271.93 work3272.09 by3272.34 four3272.49 weeks,3272.73 like,3273.14 maximum,3273.45 almost,3274.01 like,3274.41 depending3274.73 on3275.05 when3275.3 they've3275.45 reached3275.78 out3275.93 and3276.17 stuff3276.41 like3276.65 that,3276.73 or3276.97 it3277.14 could3277.21 only3277.38 be3277.61 a3277.78 week.3277.93 So3280.09 we're3280.89 not3281.05 here3281.21 to3281.45 slow3281.53 things3281.69 down,3281.93 but3282.17 we're3282.34 here3282.41 to3282.65 do3282.73 things3282.89 well,3283.44 sometimes3283.68 we3283.92 are,3284.24 if3285.2 it3285.44 makes3285.6 it3285.76 more3285.92 safe,3286.56 right?3286.8 Because3286.8 that's3287.04 why3287.6 we're3287.76 here.3288 Tim3289.84 or3290.08 Ralph,3290.24 any3290.56 thoughts?3291.12 3292.08 LIEBERMAN3292.08 -3292.08 I3292.08 guess3292.24 my3292.4 only3292.64 thought3292.8 is,3293.04 like,3293.2 are3293.44 there3293.6 occupational3293.76 health3294.56 reasons3295.97 why3296.53 we3296.77 would3296.93 want3297.16 anybody3297.97 working3298.45 with3298.85 these3299.16 lines3299.57 to3300.2 have3302.53 occupational3302.77 health3303.41 coverage3303.57 given3306.53 that3306.85 it3306.93 is3307.09 technically3307.24 a3307.72 BSL23308.29 line.3308.53 But,3309.36 I3309.48 mean,3309.6 then3309.76 then3309.92 obviously3310.32 extends3310.88 to3311.2 other3311.36 registrations3311.6 that3312.24 are3312.8 using3313.2 BSL23314 cell3314.16 lines.3314.48 I3316.48 mean,3316.56 if3316.72 somebody3316.88 stabbed3317.36 themselves3317.6 with3318 a3318.16 needle3318.24 with3318.64 a3318.88 cancer3319.84 cell3320.32 line,3320.56 you3322.06 know,3322.22 does3322.45 that3322.78 merit3322.93 having3323.89 occupational3324.14 health3324.78 coverage?3325.02 3328.06 MCEWAN3328.06 -3328.06 That's3328.06 a3328.3 slippery3328.45 slope.3329.02 3330.14 LIEBERMAN3330.14 -3330.14 Well,3330.7 I3330.93 know,3331.41 which3331.54 is3331.54 why3331.66 I3331.89 hate3331.97 to3332.14 bring3332.3 this3332.45 up.3332.7 But,3332.93 I3333.1 mean,3333.26 like,3333.58 the3333.97 job3334.14 of3334.38 the3334.45 committee3334.61 is3335.18 to3335.41 protect3336.3 the3337.58 health3337.74 of3338.14 people3339.5 working3339.82 at3340.14 the3340.22 companies3340.38 and3340.86 people3341.26 in3342.38 the3342.54 community.3342.62 3348.62 PARSONS3350.22 -3350.22 As3350.22 best3350.38 we3350.62 can.3350.78 3353.03 MARTIN3357.59 -3357.59 Deb,3357.59 to3357.91 your3358.07 point3358.32 about3358.55 the3358.8 other3358.95 cell3359.28 lines3359.51 that3359.84 would3360.07 potentially3360.39 apply,3360.88 it's3362.07 not3362.32 a3362.64 small3363.76 number3364.32 of3364.8 potential3365.11 cell3365.59 lines3365.91 that3366.24 were3366.47 originally3366.72 created3367.43 with,3367.99 or3369.15 immortalized3369.23 with3370.11 some3370.51 sort3370.75 of3370.91 viral3371.87 integration.3372.27 Sometimes3373.15 that3373.55 happens3373.71 naturally,3374.59 sometimes3374.91 that's3374.91 intentional,3376.19 but3376.83 the3376.83 vast3377.47 majority3377.79 of3378.27 these3378.43 cell3378.67 lines3378.83 were3379.23 immortalized3379.47 in3380.75 some3380.99 way3381.23 that,3381.79 you3382.41 know,3382.57 obviously,3382.81 causes3383.37 them3383.68 to3383.93 continue3384.01 to3384.41 replicate.3384.57 But,3385.29 you3385.45 know,3385.61 the3386.49 difference3386.81 with3387.2 the3387.37 heck3388.16 2933388.57 is3388.57 that3388.81 that's3389.68 the3390.09 most3390.33 common3390.64 one3391.05 to3391.37 package3391.53 in3391.93 for3392.33 our3392.97 DNA3393.13 purposes.3393.85 So,3394.57 the3395.45 other3395.68 ones3395.85 are3396.24 typically3396.49 only3397.13 going3397.37 to3397.68 come3397.68 up3397.85 because3398.13 they're3399.01 used3399.25 to3399.65 profile3400.45 a3401.01 specific3401.17 type3401.65 of3401.81 cell3401.97 or3402.29 a3402.53 particular3402.61 lineage.3403.17 So,3404.05 those3404.29 are3404.45 usually3405.17 screened3405.65 in3406.05 a3406.21 very3406.29 specific3406.61 way3407.01 based3407.33 on3407.57 their3407.73 tissue3407.97 type3408.29 or3408.53 their3408.69 kind3409.25 of3409.49 differentiation.3409.73 The3410.69 heck3410.85 2933411.41 is3411.57 just3411.73 used3411.97 in3412.21 a3412.37 much3412.45 broader3412.77 set3413.99 of3414.23 experiments,3414.47 both3415.2 as3415.51 a3415.59 packaging3415.76 agent3416.16 and3416.47 as3416.71 a3416.95 screening3417.2 tool.3417.59 So3420.95 this3421.28 really3421.43 is3421.76 the3421.91 one3422.07 that's3422.32 going3422.47 to3422.8 come3422.8 up3423.03 the3423.28 most3423.43 in3423.99 this3424.16 kind3424.47 of3424.64 gray3424.8 area3425.11 situation.3427.99 3433.64 MCEWAN3433.64 -3433.64 But3433.64 if3433.88 it's3433.96 not3434.6 being3436.28 used3436.6 for3437.56 packaging,3437.8 right,3438.28 like,3438.52 there's3438.68 no3439 inherent3439.4 risk3440.12 for3440.6 this3440.76 one3441.08 beyond3441.4 any3442.04 other3442.28 line.3442.6 3443.51 MARTIN3443.51 -3443.51 When3443.51 we3443.76 do3443.84 the3444.23 risk3444.47 assessment3444.88 for3445.68 the3446.07 situation3447.59 where3447.99 you're3448.23 not3448.39 packaging3448.64 in3449.11 it,3449.28 to3449.91 us,3450.16 it3450.47 is3450.55 equivalent3450.8 to3451.68 any3451.99 other3452.32 human3452.72 BSL23454.23 commercially3454.55 available3455.11 certificate3456.23 of3456.88 analysis3457.03 cell3463.11 line.3463.19 It's3463.35 even3464.23 under,3464.55 like,3464.95 HeLa3465.19 cells,3465.51 which3465.83 would3465.99 have3466.23 HPV3468.95 considerations3469.27 or3470.95 some3471.11 of3471.26 the3471.3 other3471.34 ones3471.59 that3471.82 have3472.55 inherent3472.95 CMV.3473.51 So,3474.63 from3474.95 our3475.18 perspective,3475.43 there3475.99 are3476.14 actually3476.3 ones3476.63 that3477.03 are3478.22 more3478.47 of3478.7 the3478.86 wild3479.11 type3479.43 persuasion3479.66 that3480.3 are3480.47 actually3480.63 a3481.11 little3481.26 bit3481.51 higher3481.91 risk3482.22 based3482.78 on3483.11 what3483.34 caused3483.66 them3484.07 to3484.3 immortalize3484.47 instead.3487.62 So,3488.02 it's3488.5 kind3488.66 of3488.82 a3488.98 spectrum,3489.14 but3489.62 when3490.34 we3490.5 look3490.66 at3490.82 heck3490.9 2933491.46 that3491.78 are3491.94 outside3492.1 of3492.42 the3492.58 rDNA3492.74 viral3493.7 vector3494.02 component,3494.42 it's3494.82 kind3495.06 of3495.22 mid3495.38 level3495.54 BSL2.3496.34 There3496.98 are3497.46 certainly3497.54 ones3497.94 that3498.18 we3498.66 would3498.82 say3499.06 qualify3499.3 for3499.94 the3500.74 commercially3500.89 available3501.22 screen3501.7 cell3502.09 line3502.34 that3502.57 would3502.74 actually3502.89 be3503.14 a3503.3 little3503.45 bit3503.61 higher3503.86 risk3504.34 level3504.57 than3505.22 these3505.93 cells,3506.26 if3507.14 that3507.38 helps3507.53 put3507.86 it3507.93 into3508.09 perspective.3508.34 3510.49 MCEWAN3510.49 -3510.49 Yes,3510.82 that's3511.22 very3511.22 helpful.3511.61 I'm3517.16 pretty3517.4 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