Watertown Biosafety Committee
Thursday March 6, 2025
The order of items in transcripts appear in the chronological order in which they were taken up. Some Agenda items may have been skipped.
BRAD15.13 PARSONS15.13 -15.13 BIOSAFETY15.13 COMMITTEE15.13 CHAIR15.13 -15.13 Welcome.15.13 This16.18 intimate16.5 gathering16.98 this17.61 evening17.77 on18.34 Thursday,18.89 March19.86 6th.20.3 Maureen21.05 will21.38 call21.61 me21.86 to22.1 order22.34 at22.57 07:03.22.73 You25.01 already25.17 took25.49 attendance,26.21 so,26.45 yes,26.45 Deb27.25 is27.57 not27.65 present29.81 this29.89 evening,30.05 but30.85 we30.93 do31.09 have31.25 a31.41 forum.31.57 I35.65 got35.73 to36.05 do36.05 it,36.45 so,37.09 you37.09 know,37.25 so37.81 next38.37 up38.77 is38.93 approval39.88 of40.07 minutes.40.27 So,45.16 there45.31 is45.55 a45.88 comment45.95 from50.91 Mia51.23 about...51.71 52.11 MIA52.11 LIEBERMAN52.11 -52.11 BIOSAFETY52.11 COMMITTEE52.11 MEMBER52.11 -52.11 I52.11 just52.27 sent52.43 a52.67 minor52.84 correction.53.16 54.27 PARSONS54.27 -54.27 Yes,57.26 Maureen,57.26 did57.66 you57.82 get57.98 that58.14 email?58.3 60.3 MAUREEN60.3 FOLEY60.3 -60.3 CITY60.3 OF60.3 WATERTOWN60.3 -60.3 I60.3 don't60.54 have,61.1 my62.38 computer62.54 is63.02 not63.18 working.63.42 64.3 PARSONS64.3 -64.3 Okay.64.86 So,65.26 Mia66.86 sent67.26 you67.42 just67.82 a68.14 minor69.1 edit,69.42 06:4870.42 this71.14 evening,72.25 so,72.66 it72.66 went72.97 to73.3 you.73.53 So74.25 does76.09 anyone76.25 have76.66 any76.89 other,77.14 suggestions78.17 or78.73 edits78.89 for79.38 the79.53 minutes80.02 from80.42 February80.66 6th?84.23 Okay.84.23 So84.55 then84.63 I84.95 make85.11 a85.27 motion85.35 that85.75 we85.99 approve86.31 the86.63 minutes86.79 with87.19 the87.43 edit88.31 that88.95 Mia89.51 sent89.99 to90.23 Maureen90.47 as91.19 submitted.91.35 Do93.51 we93.67 have93.75 a93.91 second?93.99 95.27 RALPH95.27 MELE95.27 -95.27 BIOSAFETY95.27 COMMITTEE95.27 MEMBER95.27 -95.27 Second.95.27 96.75 PARSONS96.75 -96.75 I96.75 would96.92 just97.16 do97.23 a97.31 quick97.39 raise97.63 of97.88 hands.97.95 All98.59 those98.75 in98.99 favor?99.16 Alright.101.08 Maureen,101.23 all101.88 four102.03 members102.27 of102.52 the102.67 Watertown102.75 Bio103.23 Safety103.47 Committee103.8 voted105.39 yes.105.8 107.23 FOLEY107.23 -107.23 Okay.107.23 109.52 PARSONS109.52 -109.52 And109.52 thank109.68 you109.84 again110.24 for110.64 your110.8 great110.96 work.111.2 Okay.113.44 At113.68 this113.92 point,114 we're114.32 at114.48 public115.2 comment.115.76 This116.96 is117.2 the117.28 time117.44 when117.68 anyone117.92 from118.24 the118.4 public118.56 can118.96 make120.32 a120.56 comment120.64 to120.96 the121.12 committee121.2 or121.68 ask121.84 the122.08 committee122.24 any122.64 questions.122.88 As123.68 a123.84 friendly123.92 reminder,124.4 when125.47 it125.64 comes125.72 time126.19 for126.52 questions135.16 and135.56 answering135.79 with136.35 our136.68 Diagonal138.17 Therapeutics,138.73 those139.45 questions139.69 are140.17 reserved140.49 for140.97 the141.53 members141.77 of142.17 the142.33 committee.142.41 I'm144.73 pretty144.89 sure145.13 everyone145.45 here145.93 is146.25 not,146.41 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reason199.67 for199.91 the200.15 amendment200.23 is200.55 to200.79 include200.87 work201.43 involving201.91 third202.63 and202.87 fourth203.19 generation203.59 multivirus?204.31 205.35 AISHWARYA205.35 VISHWANATHAN205.35 -205.35 DIAGONAL205.35 THEREPEUTICS205.35 -205.35 Yes.205.35 206.39 PARSONS206.39 -206.39 Okay.206.39 So207.35 the208.59 floor208.75 is209 yours209.24 if209.47 you209.63 want209.79 to210.03 give210.03 a210.35 brief210.51 presentation211 or211.79 overview212.51 of213 your214.03 new214.35 work.214.59 If216.28 you216.44 have216.51 it,216.75 the217.63 deck217.88 that218.12 was218.35 shared218.51 with218.75 us,219 fine,219.72 you219.88 can219.88 do220.19 it.220.28 But220.44 if220.68 you220.75 don't,220.91 people221.24 aren't221.47 actually221.79 required,222.12 especially222.44 for222.83 an223 amendment,223.16 to224.24 make224.4 a224.64 presentation224.8 with225.28 the225.44 deck,225.76 it's226 completely226 up226.56 to226.64 you.227.36 227.36 VISHWANATHAN227.36 -227.36 No,227.6 I227.84 think227.92 I228.16 should228.32 because228.64 I229.84 think230 it'll230.24 be230.48 much230.64 easier231.36 and231.84 quicker231.92 to232.4 bring232.64 why233.84 we234.08 are234.32 doing234.64 the234.88 amendment.235.04
SHOW NON-ESSENTIAL DIALOGUE
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is276.15 to276.39 make276.95 an277.12 amendment277.35 to278.07 include278.39 the278.88 use279.6 of279.83 lentiviral280 vectors280.63 in281.19 our281.35 experiments281.6 just282.24 starting282.56 this282.88 year.283.12 We284.52 know284.68 that284.92 depending285.16 on285.48 the285.64 agents285.8 that286.2 we286.36 would286.6 be286.76 using286.92 in287.16 our287.32 experiments,287.56 they288.04 are288.28 categorized288.52 into289.08 different289.4 groups,289.88 and291.08 this291.4 is291.8 associated292.28 with293.48 the293.72 factor293.88 that294.44 the295 agent295.24 that295.8 we'll296.04 be296.28 using296.44 is297.54 not297.62 associated298.1 or298.74 associated298.98 with299.69 the300.18 disease300.34 in301.38 immunocompetent301.69 adult302.65 humans.303.06 Most303.46 of303.78 what303.94 we304.1 use304.25 just,304.57 is305.86 restricted306.18 to306.65 risk306.9 group307.13 1307.3 and307.54 risk307.78 group307.94 2308.18 agents,308.65 we308.81 don't308.81 do309.06 anything309.13 with309.62 risk309.86 group310.1 3310.42 or310.57 4.310.81 313.05 Also313.05 depending313.45 on313.93 the314.97 agents315.13 that315.45 we315.69 handle315.85 as316.33 well316.57 as316.73 the316.89 other317.05 reagents,317.29 we318.09 have318.41 several318.81 levels319.21 of319.53 biosafety319.69 contaminants,322.33 and322.57 this322.57 is322.81 a322.89 combination323.05 of323.61 engineering323.77 controls,324.25 the324.81 PPEs,324.97 and325.85 hard326.41 work326.57 practices327.06 for327.38 handling327.62 these328.01 biological328.18 materials.328.89 Most330.65 of330.89 the331.06 work331.13 that331.45 we331.62 do331.77 is332.18 confined332.57 to333.06 biosafety333.21 1333.77 and334.18 biosafety334.41 2334.89 levels,335.13 and335.85 our336.5 lab336.74 is337.06 a337.62 certified337.85 biosafety338.41 level338.89 2.339.38 As341.16 I341.4 said,341.48 there341.8 is342.04 group342.2 and342.6 the342.84 biosafety342.92 level343.48 both343.8 are344.04 1344.2 and344.44 2344.52 for344.84 all345.08 the345.24 reagents345.4 that345.8 we346.04 use.346.12 This347.16 is347.4 a347.64 schematic347.8 of348.52 the348.84 Diagonal349 Therapeutics349.48 office350.12 in350.6 the350.76 200350.92 Arsenal351.32 Yards351.8 Boulevard,352.44 so352.69 220.352.93 Everything353.64 that353.96 we354.13 see354.37 in354.52 the354.69 pink354.76 is355.17 the355.49 office355.64 area,356.05 and356.69 the357.08 ones357.25 that357.49 are357.88 shaded358.93 in359.25 blue359.49 is359.88 our360.05 lab360.29 space.360.61 So,363.17 before364.05 coming364.37 to364.69 the364.76 amendment,364.85 I366.29 just366.44 want366.69 to367 give367 a367.25 brief367.32 understanding370.58 of371.14 what371.22 Diagonal371.38 does.371.86 So372.18 Diagonal373.06 Therapeutics,373.54 as373.54 you373.7 all373.78 know,374.02 is374.26 a374.42 biotech374.5 company,374.82 and375.3 we375.46 are375.54 trying375.7 to376.5 pioneer376.66 an377.14 approach377.3 to377.78 discover377.94 and378.34 develop378.58 agonist379.62 antibodies.380.1 380.82 So,380.82 the381.06 company's381.14 platform381.7 basically382.42 combines384.24 the384.56 computational384.88 as385.44 well385.68 as385.84 experimental386.07 techniques386.63 to387.12 overcome387.36 some387.68 challenges388 that388.56 are388.96 already389.44 associated389.84 with390.96 agonist391.19 antibody391.68 drug392.56 discovery.392.88 Our394 pipeline394.15 essentially394.71 uses395.28 a395.68 platform395.92 which396.56 has396.8 the397.04 potential397.19 to397.84 deliver398.59 some398.91 life399.15 changing399.39 therapies,400.35 and400.59 our400.59 main400.83 focus401.39 as402.43 of402.59 now402.83 is403.23 therapies404.59 for405.07 vascular405.23 malformations.405.71 The406.99 goal407.15 of407.47 this407.63 particular407.87 project408.59 is409.07 to409.23 generate409.39 a409.87 stable410.03 cell410.43 line410.75 that'll411.42 express411.9 a412.46 specific412.62 receptor413.33 on413.98 the414.13 cell414.38 surface414.77 using415.98 a416.38 commercially416.69 available417.57 vector,418.13 which418.62 is418.86 either419.01 the419.25 third419.42 or419.65 fourth419.81 gen420.06 venti420.38 vector420.62 so421.42 our421.57 cells421.74 can422.13 express423.1 the423.5 desired423.65 gene.424.06 Having424.93 this425.33 stored425.65 in425.89 vitro426.21 enables426.77 us427.25 to427.49 mimic427.73 the428.13 patient428.37 populations428.85 who429.57 have429.81 these430.13 vascular430.45 malformation431.01 so432.05 we432.29 can432.37 test432.69 our433.01 drug433.25 and433.73 also434.21 choose434.61 the434.93 most435.09 effective435.41 dose435.97 of436.29 the436.45 antibody.436.61 The439.77 reason440.01 why440.42 we440.57 need440.89 to441.06 generate441.21 this441.62 table442.18 cell442.5 line442.65 is442.89 that443.13 the444.18 drug444.42 that444.81 we444.98 are445.13 trying445.29 to445.69 build,445.77 only447.21 works447.62 on448.1 the448.33 patient448.5 population.448.89 449.45 So449.45 we449.69 do449.85 not450.01 currently450.25 have450.81 any451.21 existing451.62 model452.01 that's452.41 available,452.74 commercially454.31 to455.11 test455.27 it.455.59 So,456.63 the456.87 third457.11 and457.35 fourth457.59 gen457.75 lenti457.99 vectors458.39 are458.79 devoid459.03 of459.35 any459.59 virulence459.91 factor,460.79 they461.03 are461.03 very,461.19 very461.51 commonly461.75 used462.31 in462.71 research463.03 to463.43 generate463.59 stable463.99 cell464.39 lines464.63 in464.95 order465.11 to465.35 express465.51 the465.91 protein.466.07 After467.39 the467.71 transgene467.95 is468.59 integrated,468.83 the469.31 lentiviral469.47 backbone470.12 elements470.59 are471.07 all471.24 either471.39 degraded471.71 or472.35 they472.51 do472.68 not472.83 remain473.07 functional473.63 in474.27 vitro.474.51 The475.63 specific475.88 experiment476.59 that477.07 we477.39 would477.71 aim477.95 to478.12 do478.27 will478.59 involve478.91 transducing479.47 this480.44 commercially480.75 bought481.63 third482.57 gen482.73 lentiviral483.13 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have553.05 minimal553.38 to553.86 no554.01 risk554.33 of554.81 producing554.98 any555.62 replication556.01 competent556.65 viruses.557.13 This559.62 table560.25 just560.65 shows560.89 the562.7 proprietary562.86 versions563.5 of563.98 the564.78 lentiviruses564.94 that566.06 they566.22 have566.46 off566.7 the566.94 shelf,567.5 we567.66 would567.66 be567.82 purchasing567.98 it568.62 from568.78 them.568.94 These570.06 are570.22 third570.46 gen,570.62 as570.94 I571.1 said,571.18 BSL2,571.98 level573.34 friendly,574.38 and574.94 they575.26 fall575.58 under575.82 the576.14 risk576.22 group576.54 too.576.78 I577.48 also577.63 added577.88 a578.08 couple578.27 of578.6 cell578.75 lines579.08 because579.39 as580.43 we580.6 are580.75 working580.92 with581.24 a581.39 new581.48 disease581.72 platform,582.12 we582.68 might582.84 require584.75 the585.24 use585.39 of585.63 it585.8 in585.96 the586.12 near586.27 future.586.6 The588.2 list588.43 of588.75 cell589 lines589.32 that589.8 we589.96 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own733.54 set733.77 of733.93 disposal.734.17 Solids734.98 are735.38 collected,736.2 packaged737.64 by738.52 Viola.738.52 Sharps,738.52 on738.84 the739 other739.16 hand,739.32 have739.96 go740.04 into740.28 a740.52 puncture740.6 resistant741 container742.12 and742.76 also,743.08 shipped744.12 via744.52 the744.76 licensed745 waste745.56 hauler745.88 Viola.746.2 That's748.12 that's748.51 all749 I749.15 have749.24 to749.48 say.749.55 Open750.6 to751.07 any751.39 questions751.71 that,752.36 we753.48 all753.55 have,753.79 and754.6 I754.91 can755.07 stop755.48 sharing.755.88 759.39 PARSONS759.39 -759.39 Great.759.39 Thank759.79 you760.03 very760.19 much.760.43 Mia,762.58 do762.82 you762.9 have763.02 any763.14 questions?763.38 765.14 LIEBERMAN765.14 -765.14 Yes.765.14 Is765.46 there765.62 going765.78 to765.94 be765.94 any766.18 additional766.42 PPE766.9 worn767.38 for767.7 those767.86 working768.1 with?768.42 770.26 VISHWANATHAN770.26 -770.26 So770.26 we770.5 currently770.66 have771.62 the774.42 coats,774.66 we774.66 have774.66 glasses,774.82 gloves,776.18 everything777.71 in778.26 place,778.42 and778.75 we778.99 function779.14 as779.54 BSL779.71 2780.18 even780.59 with780.83 all781.3 of781.46 the781.63 other781.71 experiments.782.02 So,783.71 the784.26 lentiviral784.42 being,785.46 again,785.95 risk786.35 group786.59 two,788.42 BSL2,789.33 we'll789.33 have789.57 all789.69 of789.81 the790.05 PPEs790.29 in790.85 place791.01 while791.25 working791.49 with791.73 lentivirus791.89 too.792.53 797.17 ADELAINE797.17 -797.17 DIAGONAL797.17 THERAPEUTICS797.17 -797.17 Just797.17 to797.49 add797.73 to797.97 that,798.37 hi,798.61 I'm798.61 Adeline,798.85 the799.49 safety799.73 consultant800.13 for801.01 Diagonal.801.25 Just801.81 to801.97 add802.13 to802.29 that,802.37 we802.69 do802.85 have803.09 optional803.41 tie804.05 back804.21 sleeve804.53 covers804.85 and805.63 tie805.78 back806.26 lab806.42 coats806.66 that808.02 scientists808.26 can808.75 put808.99 on809.38 top809.54 of809.87 their810.11 lab810.35 coats810.5 and810.83 to811.07 cover811.23 the811.54 space811.63 between812.02 gloves812.35 and,812.75 the813.3 lab813.46 coat813.71 as813.87 well.814.02 815.71 PARSONS815.71 -815.71 Okay.815.71 So816.02 kind816.18 of816.5 like816.5 BSL816.75 2817.3 plus?817.54 819.21 ADELAINE819.21 -819.21 We819.21 are819.45 keeping819.69 it820.09 optional820.33 as822.09 needed.822.33 822.97 LIEBERMAN822.97 -822.97 And822.97 are823.21 you823.45 standardly823.77 double824.25 gloving824.49 or824.97 single825.21 gloving?825.53 827.13 ADELAINE827.13 -827.13 We827.13 are827.61 single828.33 gloving828.73 for829.13 now,829.37 but831.29 with831.53 the831.77 option831.93 of832.25 double832.41 gloving.832.65 838.76 PARSONS838.76 -838.76 Okay.838.76 Tim,839.49 any839.8 questions839.96 for840.37 diagonal?840.61 841.49 TIMOTHY841.49 MAGUIRE841.49 -841.49 BIOSAFETY841.49 COMMITTEE841.49 MEMBER841.49 -841.49 Sure.841.49 In842.13 the842.28 list842.52 of842.76 organisms,843 I843.8 see843.96 the844.13 three844.28 that844.52 you'd844.68 mentioned844.92 in845.25 the845.33 slide845.4 deck.845.64 Also,845.88 thank846.13 you846.28 for846.37 the846.52 slides,846.68 I846.92 really847 appreciate847.25 that.847.64 Were848.22 the848.38 rest848.46 already848.86 in849.58 use850.78 with851.02 Diagonal?855.18 The855.9 rest856.14 of856.38 the856.46 various,856.62 human857.34 primary857.74 cells858.3 and858.7 cell859.02 lines?859.26 860.35 VISHWANATHAN860.35 -860.35 Yes.860.35 Those860.5 were860.9 already861.07 approved.862.5 So,863.07 the863.31 ones863.55 that863.79 I864.02 mentioned,864.11 even865.14 in865.47 there,865.55 there865.87 was866.02 a866.26 there866.5 was866.83 a866.99 term867.07 HMEK,867.31 which867.79 is868.02 already868.26 in868.59 use868.75 and868.99 approved.869.23 The869.63 other869.87 two870.11 is870.35 something870.43 that870.83 we871.79 don't871.95 have872.18 it872.35 yet,872.5 but872.75 we872.9 might873.14 need873.55 it873.79 if874.11 the875.1 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preference901.15 would901.72 be901.96 to902.12 try902.27 it902.51 in902.68 the903.32 cell903.48 line903.72 that's903.88 already904.2 approved904.68 and905.08 we905.32 have905.48 been905.63 using.905.88 The906.86 other907.02 is907.26 just907.5 a907.74 backup907.9 in908.7 case,908.94 you909.26 know,909.34 hail909.66 Mary909.9 doesn't910.14 work,911.66 we911.9 have911.98 a912.14 fallback912.3 option,912.7 and912.94 we913.1 don't913.26 have913.5 to913.66 reconvene914.3 again914.78 just915.18 for915.42 a915.58 cell915.66 line.915.98 SHOW NON-ESSENTIAL DIALOGUE
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in1150.57 the1150.72 Greater1150.88 Boston1151.29 area.1151.61 I1153.44 do1153.53 like1153.85 the1154.01 diameter1154.24 thing1155.05 because1155.44 then1155.68 you1155.85 just1156.01 put1156.57 it1156.72 on1156.88 a1156.96 map,1157.13 pick1157.53 a1157.68 compass1157.85 if1158.24 people,1158.48 well,1158.81 hopefully,1159.61 everyone1159.93 here1160.09 knows1160.49 what1160.73 a1160.81 compass1160.97 is.1161.29 Not1161.69 navigation1162.57 compass,1163.21 but1163.53 drafting1164.25 compass.1164.81 Run1166.97 your1167.13 circle,1167.37 and1167.85 then,1168.01 yes,1168.17 that1168.41 actually1168.65 makes1168.97 it1169.21 quite1169.29 clear,1171.21 I1171.61 like1171.77 that.1172.01 1172.81 FOLEY1172.81 -1172.81 Does1172.81 Google1173.13 do1173.53 that?1173.77 1175.04 LIEBERMAN1175.04 -1175.04 I'm1175.04 sure1175.12 Google1175.52 could1175.84 do1175.91 it.1176.08 1176.56 MELE1176.56 -1176.56 Google1176.56 can1176.95 do1177.2 it.1177.28 And1177.43 if1177.6 they1177.76 can't1177.91 do1178.08 it,1178.23 I1178.32 can1178.39 do1178.56 it1178.71 in1178.8 another1178.88 mapping1179.2 thing1179.76 that1179.99 we1180.32 have1180.47 available.1180.71 1181.12 LIEBERMAN1181.12 -1181.12 The1181.43 fire1181.52 department1181.76 can1182.32 do1182.56 anything,1182.71 anytime,1183.91 anywhere.1184.88 1186.32 MELE1186.32 -1186.32 Not1186.32 quite,1186.56 but1186.88 we1187.04 can1187.12 figure1187.36 it1187.6 out.1187.67 1188.43 PARSONS1188.43 -1188.43 So,1188.99 it's1189.15 an1189.55 actual1189.71 circle.1190.03 Like,1190.35 you1190.59 would1190.99 be1191.15 able1191.23 to...1191.55 1191.63 MELE1191.63 -1191.63 I1191.63 can1191.63 draw1191.79 a1192.03 radius1192.19 with1192.59 it.1192.75 1193.39 PARSONS1193.39 -1193.39 Alright,1195.95 Ralph,1196.59 you1196.75 and1196.75 I1196.91 then1197.15 will1197.31 connect.1197.55 1200.61 LIEBERMAN1200.61 -1200.61 But1200.61 does1200.77 that1201.01 require,1201.33 I1202.05 guess1202.21 it's1202.45 not1202.68 really1202.92 defined1203.16 in1203.57 the1203.64 ordinance1203.81 what1204.37 the1204.53 community1204.68 member1205.16 is,1205.48 I1205.88 think1205.97 it's1206.21 more1206.29 of1206.45 a1206.61 guideline1206.68 that1207.16 the1207.33 biosafety1208.45 committee1209.16 came1209.57 up1209.72 with.1209.88 I1214.05 think1214.13 at1214.29 this1214.45 point,1214.61 we1214.77 had1214.92 grandfather.1215.16 Is1216.11 that1216.27 a1216.51 politically1216.59 correct1217.23 term1217.63 to1217.87 use1218.03 anymore?1218.19 I1218.59 don't1218.67 know1218.83 what1218.99 the1219.15 term1219.23 is.1219.47 Anybody1220.11 who's1220.43 currently1220.67 in1220.99 a1221.07 community1221.15 member1222.03 can1222.91 remain1223.07 a1223.39 community1223.47 member,1223.87 and1224.11 then1224.35 going1224.59 forward,1224.83 any1225.23 new1225.47 community1225.63 members1226.03 would1226.35 have1226.51 to1226.67 be1226.75 subject1226.83 to1227.23 the1227.39 radius.1227.47 1228.51 PARSONS1228.51 -1228.51 Exactly,1229.31 and1229.55 whether1230.65 the1231.06 company's1231.21 been1231.62 here1231.86 for1232.02 a1232.13 day1232.26 or1233.45 five1233.93 years,1234.34 if1234.65 that1234.82 community1235.06 member1235.62 changes,1235.93 then1236.49 the1237.06 new1237.13 rules1237.38 would1237.7 apply1237.93 to1238.26 that1238.41 community1238.82 member,1239.21 not1239.62 the1239.86 company1240.97 in1241.38 terms1241.62 of1241.86 grandfathering,1242.02 you1242.65 mean?1242.82 1243.38 LIEBERMAN1243.38 -1243.38 Yes.1243.38 1244.15 PARSONS1244.15 -1244.15 Right.1244.15 So1244.39 current1244.55 members1245.03 are1245.51 state.1246.71 1247.91 LIEBERMAN1247.91 -1247.91 Right.1247.91 Because1248.15 if1248.39 somebody1248.55 is,1249.11 like,1249.43 an1249.75 East1250.07 Waltham1250.31 or1251.27 a1252.23 company1252.39 in1252.87 East1254.63 Watertown1255.03 and1255.83 is1256.07 over1256.31 whatever1256.63 the1256.95 radius1257.11 is,1257.51 like,1257.75 I1257.83 don't1257.91 want1258.15 to1258.39 kick1258.39 for1258.92 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