Watertown Board of Health
Wednesday April 16, 2025
The order of items in transcripts appear in the chronological order in which they were taken up. Some Agenda items may have been skipped.
DOMINIC14.97 AMIRTHARAJ14.97 -14.97 BOARD14.97 OF14.97 HEALTH14.97 CHAIR14.97 -14.97 Good14.97 evening.15.21 It's16.26 7:1116.73 on17.61 4/16.17.86 This19.7 is19.93 the20.18 Board20.89 of21.14 Health21.38 monthly23.38 meeting.23.86 Please25.52 note25.76 we26.4 do26.48 not26.64 have26.88 a27.04 quorum27.28 but28.16 we28.4 will28.56 review29.36 the29.76 presentation29.92 today.31.2 Sorry.34.4 Hold34.8 on34.96 135.2 second.35.44 My35.84 agenda36.08 disappeared.37.04 There38.52 we38.76 go.39.43 So40.43 I40.67 call40.91 the41.31 meeting41.4 to41.63 order.41.8 At44.52 this44.67 time,44.91 we'll45.88 open46.67 the47.31 floor47.55 to48.03 public48.27 comment.48.67 Anything49.95 related50.43 to50.75 health50.91 matters.51.16
SHOW NON-ESSENTIAL DIALOGUE
65.64 AMIRTHARAJ65.64 -65.64 Okay.65.64 The67.35 next67.44 agenda67.83 point68.39 is69.35 approval69.92 of70.39 a70.47 permit70.63 for71.03 the71.11 application71.28 of71.75 Prime71.92 Medicine72.23 at72.56 50072.72 Arsenal73.28 Street.73.67 So75.35 we75.59 can75.75 hear76.08 the76.39 presentation76.8 from77.44 Prime77.59 Medicine77.99 and78.56 then78.72 we78.95 can79.03 put79.27 this79.52 to79.67 a79.83 vote79.99 at80.31 the80.39 next80.56 monthly81.03 meeting.81.44 Is83.01 someone83.17 from83.41 Prime83.97 Medicine84.29 available84.29 to84.77 speak?85.97
SHOW NON-ESSENTIAL DIALOGUE
EMILY91.97 DAILEY91.97 -91.97 PRIME91.97 MEDICINE91.97 -91.97 Excellent.91.97 Okay.92.61 I92.93 think93.01 that93.25 Bridge93.81 and94.13 I94.21 are94.37 gonna94.53 be94.85 sharing95.01 presenting96.05 today,96.44 but96.92 my97.25 name97.41 is97.56 Emily97.81 Daly.98.13 I98.77 am99 the99.48 EHS99.89 manager100.28 at100.77 Prime100.92 Medicine,101.17 and102.28 I'll102.53 sort102.69 of,102.92 I103.81 guess103.97 I'll104.13 hand104.2 it104.36 over104.53 to104.69 Bridge104.84 immediately105.08 because105.48 he's105.72 gonna105.89 work106.13 through106.36 the106.53 company106.69 overview107.08 for107.56 us.107.72
SHOW NON-ESSENTIAL DIALOGUE
126.02 BRIDGE126.02 HUNTER126.02 -126.02 PRIME126.02 MEDICINE126.02 -126.02 We126.02 can126.17 go126.25 on126.33 to126.49 the126.66 next126.73 slide.126.97 Yeah.127.61 So127.77 I127.94 just128.01 wanna128.09 give128.41 you128.57 a128.74 little129.22 overview.129.53 Well,130.66 first130.9 of131.06 all,131.13 I'm,131.29 Bridge131.61 Hunter.131.94 I'm132.18 a132.25 senior132.33 director132.74 of133.46 nonclinical133.61 development134.33 at134.81 Prime135.06 Medicine,135.38 and135.85 I'm136.09 the136.33 biosafety137.47 officer138.19 at138.67 500139.15 Arsenal139.79 Street.140.27 So142.19 a142.43 little142.51 bit142.67 about142.91 Prime143.23 Medicine.143.47 Prime144.99 was,145.47 really,148.19 founded148.43 in148.83 2019,149.07 came149.79 out149.95 of150.11 an150.35 academic150.51 publication151.99 published153.43 in153.75 Nature153.91 about154.31 a155.1 technology155.19 which155.75 we155.99 call156.15 prime156.39 editing.156.78 And,159.1 essentially,159.67 what160.31 it160.47 does160.63 is160.78 it's160.94 a162.22 technology162.39 that162.94 allows163.67 for164.06 very164.31 specific164.63 gene165.1 editing.165.43 And167.1 so167.34 our167.58 company167.82 is168.14 a168.3 publicly168.46 traded168.86 company169.58 with169.98 just169.98 over170.38 200170.78 people,171.34 currently.173.66 And173.9 we173.9 have,174.14 one176.22 new,176.3 actually,176.3 one177.34 new177.58 site177.82 at178.06 500178.22 Arsenal.178.62 We're178.94 actually179.18 moving179.5 just179.82 from180.06 across180.3 the180.62 street.180.78 But182.81 we182.97 also183.13 have183.38 one184.09 location184.34 in,184.81 Cambridge185.46 in185.94 Kendall186.25 Square186.57 at186.9 61st187.38 Street.187.62 Next188.97 slide,189.22 please.189.53
192.01 So192.01 what192.18 is193.29 Prime193.69 Medicine?193.69 So193.69 without193.85 going194.18 into194.42 the194.74 real195.22 nitty195.53 gritty195.94 details196.25 here196.66 about197.6 the197.76 molecular198.8 mechanism199.12 of199.6 this,199.76 essentially,200.16 what200.72 it200.88 is200.96 as201.2 I201.28 alluded201.52 to201.84 before202.08 is202.4 what203.04 it203.2 is,203.28 it's203.52 a203.6 technology203.76 that204.48 allows204.72 you205.2 to206.24 go206.32 in206.48 and206.88 edit209.42 or210.29 change210.46 a211.25 gene211.42 sequence.211.9 And212.46 so,212.69 as213.34 you213.5 may214.22 well214.46 know,214.69 there's215.01 a215.25 lot215.34 of216.14 genetic216.29 mutations216.78 out217.34 there217.5 that217.74 cause217.9 a219.66 variety219.81 of220.38 diseases,220.53 and221.19 there's221.35 thousands222.39 of222.87 rare223.43 genetic223.83 diseases224.31 out224.87 there,226.47 and227.03 this227.03 technology227.27 is228.07 designed228.39 to229.99 help230.15 with230.39 that.230.55 So230.79 what230.95 it231.11 does231.27 is,231.51 a231.83 patient231.91 may232.39 have232.55 a232.71 specific232.87 mutation233.35 that234.07 causes234.31 a234.63 specific234.97 disease.235.92 And236.88 what237.04 our237.28 technology237.53 does238.16 is238.41 it238.49 allows,238.64 we239.53 have239.76 a239.92 multi240.25 component,240.56 molecule241.92 that242.49 goes242.81 in,243.04 gets243.69 inside243.92 a244.32 cell,244.56 recognizes245.36 the246.08 mutation,246.25 and246.97 then247.13 swaps247.69 it248.08 out248.25 for248.49 a248.72 healthy250.1 gene250.82 sequence251.22 and251.62 end252.5 up252.66 being252.82 a252.98 healthy253.06 gene.253.46 And254.66 so,254.9 again,255.06 multi255.46 component257.86 product258.74 and258.74 process259.06 to259.78 this259.94 whole260.18 thing.260.34 But,260.58 again,260.74 at261.06 the261.14 end261.22 of261.46 the261.54 day,261.7 we're262.42 able262.66 to262.9 go262.98 in263.14 and263.38 treat265.56 rare266.29 genetic266.76 diseases267.25 and268.05 really268.29 cure268.61 them.268.93 And269.08 so269.32 once269.65 and269.96 done270.13 therapy270.37 with270.85 one271 treatment271.25 goes271.88 in272.05 and272.21 edits272.44 and272.76 does272.93 his273.17 thing273.32 and273.56 then274.21 moves274.37 on.274.69 And,274.85 you275.81 know,275.88 with276.13 all,276.76 hopefully,278.25 some278.57 good278.81 luck,278.97 we'll279.13 be279.61 able279.77 to,279.93 you280.09 know,280.25 treat280.49 lots280.73 of280.97 patients.281.13 Next283.29 slide,283.69 please.284.01
287.05 So,287.05 currently,287.69 our289.21 technology289.37 is290.25 able290.49 to,290.81 you291.21 know,291.38 treat291.74 any292.1 gene292.5 that292.98 is293.21 in293.54 the293.69 body.295.54 But,295.78 however,296.01 there's,296.62 as296.98 I297.13 mentioned,297.3 it's297.69 a297.78 multi297.94 component298.25 molecule.299.94 And300.18 part300.18 of300.42 the300.57 challenges301.69 around302.34 this302.65 molecule303.31 and303.63 molecules304.27 similar304.75 to305.07 this305.15 is305.39 the306.19 delivery306.35 to306.83 specific306.99 tissues.307.47 And307.95 so308.11 currently,308.43 we308.91 are309.15 focused309.31 on,309.63 you310.91 know,311.07 while311.15 we311.39 can311.55 treat311.71 any312.03 mutation312.83 throughout313.31 the313.55 body,313.71 the314.43 delivery314.59 to315.07 all315.15 of315.31 those315.47 different315.71 locations316.03 can317.07 be317.24 challenging.317.56 So318.12 right318.36 now,318.51 we're318.75 focused,319.48 we319.71 have319.71 a319.8 specific319.96 component320.75 of321.4 our321.63 molecule321.96 that322.44 allows322.6 it322.92 to323.15 get323.24 into323.48 specific323.88 locations.324.27 So,324.75 into325.88 the326.12 liver,326.36 primarily.326.92 We328.27 also328.44 are328.83 treating329 blood329.31 diseases,329.48 and329.88 we're330.04 also330.19 focused330.51 on331.48 lung332.54 diseases333.1 as333.66 well.333.74 And333.98 so334.14 those334.3 are334.46 the334.62 three334.7 areas334.94 that335.26 we're335.42 currently335.66 focused336.22 on336.62 at337.66 the337.74 moment.337.82 Next338.86 slide,339.18 please.339.42 Okay,340.86 one341.1 more.341.1
341.9 Okay.341.9 So342.22 I342.38 think342.54 this342.78 is342.94 actually343.1 maybe343.42 a343.82 little343.98 bit344.22 older344.46 slide,345 and345.31 it345.48 was345.56 really345.79 geared346.19 towards,346.51 maybe347.48 not347.79 the348.12 work348.19 that's348.44 going348.68 on348.83 in349.07 Watertown,349.24 but349.71 what's349.95 also350.27 going350.6 on350.83 in351 Cambridge.351.15 So,352.19 essentially,352.35 what353.47 our354.04 company,354.6 or355 what355.24 we355.47 will355.63 be355.88 doing356.04 in356.27 Cambridge356.51 is357 really,357.24 aside358.83 from359.39 the359.71 chemical361.37 work361.93 that's362.17 going362.41 on,362.57 the362.89 chemistry363.05 work363.45 that's363.69 going363.85 on,364.09 we'll364.89 have365.29 a365.61 animal365.85 facility366.41 there,366.81 and369.05 working369.45 solely371.45 on371.85 mice372.73 and372.97 rats.373.21 And,373.61 basically,373.77 what374.17 we're374.33 doing374.49 is374.81 we're375.05 using375.21 those375.53 species376.45 to376.86 test378.29 out378.62 our378.86 molecules379.74 before380.29 we380.62 go380.77 into381.01 patients.381.25 And381.89 so382.06 we382.21 test382.38 out382.94 our385.01 technology385.42 on386.06 those386.21 to386.45 see,386.62 you386.85 know,387.01 whether387.18 it's387.5 safe387.65 and387.98 efficacious.388.62 And389.98 so390.06 from390.46 that390.78 too,391.02 so391.26 we're391.42 working391.66 on391.9 mice392.14 and392.62 rats.394.62 And395.98 we395.98 currently396.38 have396.94 a399.26 CRO400.22 that400.62 actually400.86 manages401.18 all401.66 of401.82 this,401.9 a402.06 company402.06 called402.38 Osgene,402.7 and403.34 they403.58 take403.74 care403.98 of404.22 all404.38 of404.54 the404.7 animal405.56 care406.21 in406.61 that.406.93 We407.25 have407.49 people407.96 that408.29 are408.44 working408.61 in408.93 there409 to409.32 support410.13 that,410.61 but411.49 they're411.65 also411.88 not412.44 only412.69 doing413.49 the413.73 husbandry413.88 or414.44 taking414.61 care414.85 of415 the415.09 animals,415.25 but415.56 also415.81 they're416.13 involved417.25 in417.73 the417.81 IACUC.418.52
418.85 And418.85 so419.09 if419.17 you419.25 don't419.4 know419.65 that,419.81 that's419.96 just420.13 really420.29 the420.52 oversight420.98 into421.22 the421.86 care422.18 and422.42 management422.98 of423.54 animals,425.14 so425.38 they'll425.38 be425.54 taking426.26 care426.58 of426.82 that.426.98 What428.26 it428.42 does428.58 say428.82 here,429.3 too,429.46 is429.46 there430.34 are,430.66 it431.62 says431.78 we're432.02 using432.18 standard432.5 mammalian432.82 cell433.38 culture.433.54 We're433.86 actually434.1 not434.5 really434.82 doing435.06 cell435.3 culture435.54 there.435.86 We436.1 do,436.26 you437.46 do437.62 some437.77 primary438.01 cell438.57 work,438.81 and439.13 so439.38 these439.62 are439.77 not,439.94 I443.62 think443.69 it443.86 says444.01 in444.25 there444.33 we're444.57 using,444.74 immortalized445.38 cell445.94 lines.446.1 We're446.33 actually446.5 not446.81 using446.98 that447.21 test447.38 for447.54 our447.77 Cambridge447.86 site,448.25 but448.42 what448.57 we448.74 do448.89 is449.06 we449.21 sometimes449.54 harvest449.94 tissues451.06 from451.54 either452.65 mites452.89 or452.97 rats453.21 into453.53 some453.93 primary454.17 culture454.65 there.454.97 What455.77 we456.01 also456.17 do456.49 is,457.05 we457.29 have457.45 a457.61 cell457.77 replacement458.01 therapy458.57 for459.05 patients,459.37 and459.77 so459.93 we460.09 are460.25 using460.41 human461.77 stem462.25 cells462.49 that463.45 we463.69 will463.85 go464.01 in464.17 and464.33 edit.464.49 And465.4 then465.88 we466.2 test466.44 out466.76 some467 of467.16 those467.25 in467.72 our468.2 animal469.49 models.469.81 So470.69 those470.93 are471.08 the471.16 two471.32 main471.49 areas471.81 that472.2 we're472.37 working473.08 in473.49 the475.32 animal475.49 facility475.96 there.476.44
477.24 And477.24 the478.84 molecule479.16 that479.56 we479.72 work479.88 with480.12 is,480.44 basically,481.88 it's482.2 a482.44 lipid482.68 nanoparticle.483.16 So484.52 it's484.68 just484.84 formed485.24 with485.64 a485.88 bunch485.96 of486.2 different486.36 lipids487.16 that487.56 encapsulate489 a489.96 RNA,490.76 and491.16 that's491.32 the491.56 technology491.72 that492.29 we492.44 have492.6 that492.93 does493 the493.32 editing.493.49 And495.16 we495.4 do495.56 have495.81 some496.93 work497.25 we're497.4 really497.64 not497.88 doing498.13 much,498.37 if498.85 at499 all,499.16 anymore499.32 around499.81 some500.2 replication500.52 and501.08 competent501.16 lentiviral501.64 and502.69 AV503.25 work503.72 that503.96 we504.13 will504.29 use.504.52 We504.85 don't505 generate505.71 any506.11 of506.35 those506.43 materials506.67 there507.23 in508.19 Watertown.508.43 Those509.07 are509.39 actually509.71 generated510.03 in510.43 Cambridge.510.99 And511.15 we511.15 actually511.39 just511.63 use511.95 those512.19 for512.43 administration513.23 into514.03 animals.514.51 So516.91 as517.15 I518.11 mentioned,518.19 we518.59 do518.83 all519.15 the519.39 murine520.12 work520.43 will520.75 occur521 at521.55 500521.88 Arsenal522.43 Street.522.83 It523.32 mentions523.48 here523.88 about524.12 nonhuman524.83 primate525.39 work.525.79 We525.95 actually526.12 do526.43 not526.6 do526.83 any527 of527.24 that528.67 at529.08 Prime529.32 Medicine529.55 internally,530.2 whether530.67 it's531 in531.15 Cambridge531.32 or531.79 Watertown.533.48 It's534.04 just535.16 mice535.8 and536.04 and536.28 rats.536.6 So538.2 I538.32 think538.44 that's538.84 it539.08 for539.32 this.539.56 I540.28 think540.44 yep.541.64 It's542.2 back542.52 onto542.76 you,543 Fatima.543.32
545.76 FATIMA545.76 GUEVARA545.76 -545.76 PRIME545.76 MEDICINE545.76 -545.76 Perfect.545.76 Thanks,546.33 Bridge.546.88 So547.68 I'll547.93 just548 walk548.33 through548.57 our549.21 BSL549.45 2550 procedures550.25 that551.61 we'll551.76 be551.93 using552.09 at552.4 the552.49 500552.64 Arsenal553.21 Way553.61 facility.554 So555.37 they're555.61 sort555.76 of556 standard.556.17 The557.37 expectation557.52 is558.17 that558.33 we'll558.49 have558.73 biohazard558.97 signs559.68 on,560.09 you560.33 know,560.72 doors560.88 and561.36 on561.6 instrumentation561.84 where562.56 biological562.88 materials563.52 are564.08 anticipated564.48 to565.04 be565.12 handled.565.36 Of566.88 course,567.04 folks567.68 will567.92 be568.08 wearing568.16 their568.48 PPE,568.64 so569.28 buttoned569.68 lab570.16 coats,570.32 safety570.72 glasses,571.04 and572 gloves572.24 when572.64 handling572.96 lab573.36 materials.573.68 That's574.32 Prime's574.64 policy575.12 throughout.575.6 Anytime577.5 that577.89 folks578.13 are578.46 potentially578.7 generating579.17 aerosols,579.74 so580.21 whether580.46 they're,580.77 you581.41 know,581.5 pipetting,581.82 or,582.38 I583.74 guess,583.89 centrifuging584.21 as584.77 well,585.01 we're585.25 considering585.89 aerosol586.38 containment.586.93 So587.5 for587.98 centrifuge588.29 tubes,588.77 we589.25 have589.33 the589.58 caps.590.05 And590.29 the590.29 expectation590.46 is591.01 that591.25 folks591.83 would592.15 use592.87 those593.19 lids593.43 when593.75 they're593.99 centrifuging594.15 and594.71 then594.95 wait595.19 10595.35 minutes595.59 to595.91 open596.07 up596.39 the596.47 lids596.63 or597.03 just597.27 open597.43 them597.67 inside597.91 of598.23 a598.31 BioCp598.47 cabinet599.03 so599.99 that600.15 we600.23 don't600.39 have600.63 those,600.79 you600.95 know,601.11 aerosols601.35 popping601.91 out602.23 at602.47 the602.63 user.602.79
604.6 When604.6 folks604.84 are605.08 generating605.32 their605.88 liquid606.2 waste,606.51 we607.15 have607.63 our608.12 0.2608.67 micron609.32 filters610.03 to610.75 protect610.91 the611.32 house611.48 vacuum611.79 line612.2 and612.91 then613.08 we613.39 have613.63 double614.43 aspiration615.24 flasks.615.79 So616.2 we616.36 have616.43 an616.6 overflow616.75 flask,617.32 and618.18 both618.42 flasks618.66 are619.14 prebleached619.3 with619.94 bleach621.06 to621.38 the621.54 10%621.7 by622.34 volume622.5 line,622.9 and623.86 that's624.02 changed624.34 out624.74 daily.624.98 At625.46 the625.62 end625.7 of625.86 the625.94 day,626.1 the626.42 last626.5 user626.82 dumps627.22 that627.46 waste627.62 on627.86 the628.02 sink628.1 and628.34 then628.5 we628.66 start628.82 fresh629.06 the629.38 next629.46 day.629.7 For631.39 disinfection633.13 of633.68 surfaces,633.85 folks634.8 work635.21 with635.45 either636 freshly636.49 mixed636.8 10%637.04 bleach637.52 or637.85 more638.09 likely638.25 shelf638.73 stable639.04 bleach.639.45 70%640.8 ethanol641.68 or642.49 isopropanol,642.64 and643.37 then643.52 surfaces643.85 are644.4 also644.64 being645.89 decontaminated646.21 with647.17 VertCon.647.49 I648.13 just648.29 chatted648.53 with648.85 the649.17 ACF649.57 manager650.13 last650.53 week650.85 and651.01 that651.17 is651.33 another651.73 disinfectant652.21 that652.85 we'll653.09 be653.33 using.653.49 And654.53 then654.69 personnel654.85 should655.25 be655.41 washing655.57 their655.89 hands656.05 after656.29 they656.53 handle656.77 lab657.09 material.657.57 And657.73 we657.73 do657.89 have658.05 a658.21 sink658.29 available658.61 in659.17 the659.33 ACF659.49 for660.05 that660.21 purpose.660.37 Yeah.662.24 Ready662.48 for662.79 the662.88 next663.03 slide.663.27
667.03 So667.03 we667.36 also667.51 have667.83 a668.32 relatively668.63 robust669.27 biosafety669.75 program670.39 in670.79 general670.95 at671.27 Prime671.43 Medicine.671.67 So672.15 bio672.63 work673.19 is673.43 new673.67 in674 Watertown674.32 at674.95 our675.03 Watertown675.27 location677.01 but677.17 this677.17 has677.41 been677.49 ongoing677.73 in678.05 Cambridge678.21 since678.77 2022.679.09 So680.77 we681.01 have681.25 a681.57 robust681.73 safety682.13 training682.45 program.682.77 New683.17 hires683.41 are683.81 given683.97 emergency684.77 procedure,685.33 HAZCOM,686.13 biosafety,687.09 and687.89 VBP688.13 training,689.2 within689.83 the690.15 first690.32 10690.55 days690.71 of690.96 hire,691.12 generally,691.51 actually,691.83 on692.15 their692.32 first692.48 day692.71 or693.03 their693.27 second693.43 day.693.75 And694.79 then694.96 we695.03 also695.2 give695.51 NHP695.83 training696.32 and696.96 specialized697.27 trainings,698 you699.2 know,699.27 as699.51 folks699.67 start700.08 their700.32 work700.48 with700.63 NHP700.88 or701.51 certain701.75 viral702.08 vectors,702.48 etcetera,703.03 etcetera.703.51 For704.73 our705.77 medical705.85 surveillance706.25 program,706.81 post707.37 exposure707.69 prophylaxis,708.09 vaccination709.05 clinics,709.61 we710.81 offer711.13 those711.45 through711.85 Mount712.17 Auburn712.33 Occupational713.21 Health.713.45 They're713.45 our713.69 occupational713.85 health714.41 partner.715.37 And715.53 we715.53 do715.77 offer716.25 vaccine716.81 clinics,717.37 seasonally718.39 for719.04 the719.12 flu719.27 and719.68 then719.84 hepatitis720.08 b,720.63 as721.51 needed.722.15 When722.32 we722.32 have,722.48 you722.72 know,722.8 folks723.04 asking723.6 for724.08 vaccines724.48 and724.96 titers,725.04 we725.44 organize725.6 clinics726 on-site.726.39 We727.2 have727.36 active727.51 safety727.84 committees728.15 in728.56 Watertown728.72 and729.2 Cambridge729.27 and729.84 have730.08 for730.32 the730.48 last730.63 couple730.8 years.731.2 And731.95 we732.27 have732.43 risk733.31 assessments733.63 done734.11 when734.35 folks734.51 are734.75 bringing734.91 new735.31 materials735.55 on-site736.03 or736.51 working736.75 with737.07 materials737.31 in737.79 a737.95 largely738.03 different738.43 way.738.75 Next739.63 slide,739.87 please.740.19
742.11 So742.11 the742.27 biological742.51 agents743.07 that'll743.39 be743.63 in743.79 use744.03 at744.43 the744.75 animal744.99 care745.39 facility745.63 and746.03 biospace746.19 at747.07 500747.15 Arsenal747.75 will748.46 be,748.7 like748.87 Bridge749.18 mentioned,749.5 potentially749.9 a750.38 little750.54 bit750.7 of750.87 use750.94 of751.35 lentiviral751.58 vectors752.23 and752.7 AAV.752.87 While754.23 these754.63 AAVs,755.18 you756.06 know,756.23 are757.42 not757.58 used757.75 with757.99 helper758.06 virus758.38 and758.7 could758.87 potentially759.11 be759.5 handled759.58 at759.99 biosafety760.06 level760.54 1,760.87 the761.45 whole761.61 ACF761.85 and762.57 biospace762.97 will763.53 be763.69 BSL763.93 2.764.33 So764.57 BSL764.81 2,765.37 facility,766.33 you767.13 know,767.29 safeguards767.53 and768.17 practices768.33 will768.89 be769.05 in769.13 place.769.29 And770.01 then770.25 I770.57 think770.65 Bridge770.89 also771.21 might771.53 have771.69 mentioned771.77 that772.81 we773.05 will773.29 be773.45 working,773.61 or774.17 the774.41 team774.57 will774.81 potentially774.97 be775.45 working775.61 with,775.93 human776.7 stem777.01 cells.777.25 So777.65 those,778.05 of778.29 course,778.38 are778.62 risk778.86 group779.01 2779.33 agents.779.5 So780.13 we'd780.29 handle780.45 those780.77 at780.93 biosafety781.1 level781.58 2.781.82 So782.05 all782.21 of782.29 our782.45 work782.62 is782.77 BSL782.93 2.783.41 Next784.29 slide,784.53 please.784.86 We787.58 use787.74 Triumvirate788.13 as789.98 our790.14 waste790.46 hauler790.86 and791.26 also791.42 as791.66 our791.82 spill792.06 response792.3 vendor.792.7 And793.66 in793.98 terms794.14 of795.5 boxing795.74 up796.22 solid797.1 biomedical797.5 waste,798.14 pathogenic798.78 waste,799.34 sharps799.66 waste,799.98 that's800.7 all801.02 shipped801.18 off-site801.42 by801.98 Triumvirate,802.22 and802.86 it's803.02 packaged803.26 by,803.74 inside804.86 the805.1 ACF,805.34 largely,805.89 Ausgene.806.38 And807.01 then807.17 in807.5 the807.65 biolab,807.89 adjacent809.25 to809.65 the809.82 ACF,809.98 that810.7 could810.86 be811.01 boxed811.17 up811.41 by811.65 Boston811.82 Lab812.13 Services,812.38 potentially813.01 Triumvirate,813.58 or814.22 Safety814.46 Partners814.77 staff.815.34 And816.05 then,816.29 you817.65 know,817.82 we817.9 send818.14 those818.22 off818.46 with818.7 our818.94 waste819.74 hauler.820.06 Next820.94 slide.821.26
823.9 In823.9 terms824.14 of824.38 the824.54 types824.62 of824.86 waste825.02 that825.26 we825.34 generate,825.5 so,825.82 of825.98 course,826.14 solid826.46 waste.826.78 At827.9 Prime,828.14 we828.54 consider828.62 pipette829.34 tips829.74 and830.06 serological830.3 and830.86 pasteur831.02 pipette831.42 sharps.831.9 So832.6 those832.84 go833.08 into833.48 floor834.6 unit834.84 sharps835.15 containers835.39 or836.12 small836.43 sharps836.75 containers.837.08 On837.8 the837.96 bench838.04 top,838.36 we838.6 also838.75 do839 allow839.32 for839.72 the840.51 biohazard840.75 bags,841.39 the841.8 little841.96 bags842.2 inside842.6 the842.92 BSCs843.15 when843.63 folks843.8 are844.04 working844.2 in844.43 BSCs,844.51 so845 for845.15 collecting845.32 things845.63 like845.96 pipette846.12 tips.846.43 And847.17 then847.33 for847.57 other847.65 non848.13 sharps848.37 waste,848.61 those848.93 all849.17 go849.33 into849.49 just849.81 the850.05 standard850.21 red850.61 bag850.85 waste851.09 biohazard851.41 bins.852.05 Next852.69 slide,852.93 please.853.25 For854.53 our854.69 liquid854.85 waste,855.17 like855.49 I855.65 mentioned855.81 before,856.13 we856.53 use856.77 10%857.57 bleach,858.29 max858.77 20%859.09 bleach,859.65 0.5860.83 sodium861.79 hypochlorite862.18 solution.862.83 For863.87 liquid864.42 waste864.83 disinfection,865.14 we866.26 allow866.42 that866.59 to866.83 sit866.9 for867.07 30867.23 minutes,867.47 and867.87 then868.11 they868.42 follow-up868.67 with869.07 sink869.23 disposal,869.55 pretty870.02 standard.870.35 And871.55 then871.71 pathological871.95 waste872.75 at873.07 Prime873.23 will873.55 be873.71 any873.87 sort874.18 of874.42 mirroring874.67 materials875.14 from876.12 the876.28 actual876.36 animals.876.84 And877.72 these877.96 materials878.28 are878.76 double878.92 bagged,879.24 put879.56 into879.72 dedicated880.12 freezer880.68 until881 pickup,881.32 and882.28 then882.44 they'll882.68 be882.92 transferred883.08 to883.56 a883.72 biohazard883.88 container884.44 labeled884.84 for886.92 incineration.887.08 And887.08 then887.08 TEI887.4 will887.8 also887.96 be888.2 taking888.36 that888.6 material888.76 off-site889.24 as889.56 well.889.8 Next890.41 slide,890.65 please.891.05
893.21 Alright.893.21 And893.53 I893.62 can893.7 do893.86 a894.01 little894.1 bit894.25 of894.41 a894.58 facility894.74 overview895.21 as895.62 well.895.86 So896.17 this896.33 is896.58 where896.74 500897.53 Arsenal898.1 is898.58 nestled.898.74 So899.29 you899.77 can899.86 see900.01 right900.33 above900.58 Arsenal900.89 Way,901.38 there's901.62 a902.01 pin902.37 for902.61 the902.69 New902.77 England902.85 Sports903.25 Network.903.49 That's903.89 the904.13 old904.29 facility904.53 and904.93 we905.01 just905.17 moved905.41 right905.65 across905.89 Arsenal906.21 Way906.53 to906.69 500906.85 Arsenal907.33 Street.907.73 Next908.85 slide,909.17 please.909.49 This911.57 is911.73 the911.89 facility912.13 layout.912.53 So912.85 the913.01 space913.17 that913.41 we're913.57 talking914.85 about915.09 today915.41 is915.9 in915.95 the915.99 middle916.23 of916.54 the916.63 screen916.71 so917.02 you917.11 can917.26 see917.35 where917.5 it917.59 says917.67 In-vivo918.23 and918.63 Animal919.26 Facility.919.99 And919.99 I920.14 know920.23 at920.38 the920.54 last920.71 meeting,920.95 Mia921.67 had921.99 mentioned922.23 that922.63 the922.95 top923.83 box924.07 saying924.38 in924.79 vivo924.95 was925.35 confusing.925.5 So925.99 just926.14 to926.38 be926.47 clear,926.63 the927.42 pink927.59 area927.83 is928.23 the928.61 animal928.77 care929.01 facility.929.17 That's929.65 the929.97 only930.13 area930.37 where930.69 animals931.09 will931.57 be931.73 housed.931.81 And932.45 then932.61 the932.77 In-vivo933.09 references933.81 the934.45 team934.61 name934.93 of935.17 the935.33 team935.41 that935.65 will935.81 be935.97 working936.05 in936.37 that936.45 other936.61 space,936.85 but937.17 that937.33 will937.49 be937.73 a937.81 more937.97 standard938.21 biology938.69 lab.939.97 There940.21 won't940.45 be940.61 live941.17 animals941.41 in941.89 that941.97 area.942.21 And942.88 then943.03 the943.2 rest943.27 of943.51 the943.6 facility943.83 is944.32 taken944.48 up944.79 with945.03 Prime945.36 office946.48 space946.79 and947.67 chem948.15 space.948.71 And948.88 then948.88 you949.03 can949.12 see949.27 the949.43 large949.51 biology949.83 lab950.48 to950.71 the950.79 right950.95 is951.27 completely951.83 out952.24 of952.39 commission952.55 right952.95 now.953.12 We953.27 have953.43 signage953.6 that954 it's954.15 not954.32 to954.48 be954.55 used954.81 for.955.05 So,955.93 yep,956.09 that956.33 that956.49 facility956.81 we957.29 don't957.37 need957.61 to957.69 worry957.77 about958.01 today.958.25 Next959.21 slide,959.45 please.959.85
960.97 And960.97 then961.13 this961.29 is961.53 the961.85 overall962.09 facility962.49 map963.05 with963.37 locations963.69 of964.17 things964.33 like964.49 fume964.73 hoods964.97 and965.21 biosafety965.37 cabinets965.93 as966.41 well966.57 as966.73 all966.89 of967.05 our967.13 safety967.29 equipment.967.61 So968.25 I968.47 think968.63 the968.79 slide968.87 after969.18 this969.5 is969.83 a969.99 zoomed970.14 in970.47 version970.63 of971.26 just971.67 the971.9 area971.99 that972.3 we're972.47 talking972.63 about.972.95 Yes.973.75 This974.07 is974.23 the974.38 slide.974.47 So974.79 you974.87 can974.95 see975.18 we975.26 have975.42 a975.67 few975.75 BSCs975.99 in976.63 the976.79 area.976.95 We977.35 have977.5 a977.59 couple977.67 fume977.99 hoods,978.23 and978.87 then979.02 we979.26 have979.42 a979.67 variety979.83 of980.23 safety980.38 equipment980.71 available.981.11 So981.67 safety981.99 showers,982.3 eye982.71 wash982.95 stations,983.18 first983.67 aid983.99 kits,984.67 spill984.99 kits,985.23 you985.79 know,985.95 all986.11 of986.27 the986.43 standard986.59 stuff.987.23 And987.31 then987.31 an987.47 AED987.71 is988.11 available988.27 on989.23 the989.31 other989.47 side989.71 of990.11 the990.27 In-vivo990.59 facility.991.39 And992.59 I992.75 think992.83 that993.07 that993.31 is993.55 all993.95 we994.19 have.994.43 So994.83 happy995.39 to995.71 take995.79 any996.03 questions,996.44 comments,996.92 concerns997.4 that997.88 you998.04 all998.2 have,998.44 and998.61 thank998.85 you999 all999.25 for999.49 giving999.8 us1000.13 the1000.28 time1000.44 to1000.61 present.1000.76
1004.13 AMIRTHARAJ1004.13 -1004.13 Well,1004.13 thank1004.44 you1004.61 for1004.76 the1004.85 presentation.1005 So1008.76 just1008.92 to1009.16 clarify,1009.32 so1009.8 the1010.52 animals1010.76 are1011.32 kind1012.42 of1012.66 treated1012.74 with1013.22 your,1015.7 like,1016.18 the1016.34 lipid1016.5 capsule,1017.06 and1017.62 you're1017.78 sacrificing1018.34 them1018.98 on-site1019.14 and1019.54 then1019.7 kind1019.94 of1020.18 checking1020.18 various1021.54 organs1021.78 to1022.26 confirm1022.42 if1023.22 there's1023.38 been1023.7 uptake?1024.1
1025.14 HUNTER1025.14 -1025.14 Yes.1025.14 Exactly.1025.62 And1027.64 some1027.8 of1027.96 that1028.2 work1028.53 will1028.85 be1029.01 done,1029.24 you1029.72 know,1029.88 on-site1030.2 in1030.68 Watertown,1030.85 and1031.57 sometimes1031.8 the1032.37 samples1033.24 will1033.64 be1033.8 shipped1033.96 to1034.29 our1036.2 facility1036.44 in1037.09 Cambridge,1037.57 and1038.05 we'll1038.2 use1038.37 a1038.53 courier1038.61 for1039.09 that,1039.24 obviously.1039.48
1040.71 AMIRTHARAJ1040.71 -1040.71 Okay.1040.71 And1041.51 just1041.75 a1041.99 like,1042.23 an1042.39 acronym1042.55 question.1042.95 What1043.75 is1043.99 a1044.15 CRO?1044.39
1045.83 HUNTER1045.83 -1045.83 Contract1045.83 research1046.39 organization.1046.87 So1047.51 it's1047.67 just1047.83 a1048.07 a1048.79 third1048.87 party1049.19 vendor1049.51 that1049.83 does1049.99 work1050.39 for1050.71 us.1050.87
1051.75 AMIRTHARAJ1051.75 -1051.75 Got1051.75 it.1051.99 And1052.91 then,1053.08 yeah,1053.47 I1053.71 don't1053.88 work1055.08 in1055.23 that1055.39 field.1055.47 So1055.79 yeah.1055.95 Alright.1056.03
1057.23 HUNTER1057.23 -1057.23 Yep.1057.23 Sorry1057.55 about1057.79 that.1058.03
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1084.55 HUNTER1084.55 -1084.55 Yeah.1084.55 And1084.79 so1085.03 we1085.27 do.1085.43 We1085.67 have,1085.84 it's1087.91 basically1088.15 a1088.71 GalNAc,1089.03 if1089.99 you're1090.15 familiar1090.32 with1090.63 that1090.88 protein1092.88 that's1093.19 incorporated1093.75 in1094.47 that.1094.55 And1094.79 there1095.29 are1095.61 receptors1096.33 in1099.37 the1099.53 liver1099.69 and1100.01 hepatocytes1100.25 that1101.29 help1102.01 with1102.25 the1102.41 uptake.1102.57 There's1102.97 also1103.69 uptake1104.09 that's1104.49 just1104.65 more1105.53 by1105.85 engulfing1107.94 it,1108.35 but1108.51 there's1108.66 also,1108.9 you1109.22 know,1109.3 kind1109.54 of1109.79 site1110.27 directed1110.74 uptake,1111.94 and1112.42 that's1112.59 where1112.74 we1112.98 use1113.07 this1113.3 this1113.54 GalNAc1113.7 molecule1114.35 to1114.98 enhance1115.46 that.1115.94 So1116.18 we1116.42 have1116.51 a1116.66 little1116.74 more,1117.22 and1117.38 so1117.38 we1117.54 can1117.63 target1117.79 the1118.11 liver1118.27 specifically1118.66 and1119.54 less1119.7 to1120.03 other1120.11 areas1120.42 where1120.74 we1120.9 don't1121.07 want1121.3 it1121.46 to1121.63 go.1121.7
1123.3 AMIRTHARAJ1123.3 -1123.3 Oh,1123.3 it's1123.54 really1123.62 interesting.1123.94 Good1124.34 luck1124.5 with1124.66 the1124.82 research.1124.98
1125.54 HUNTER1125.54 -1125.54 Oh,1125.54 thank1125.78 you.1126.02
1128.66 AMIRTHARAJ1128.66 -1128.66 Yeah.1128.66 So1128.98 I1129.22 think,1129.3 you1129.86 know,1130.02 we're1130.1 gonna1130.26 unfortunately,1130.5 we're1130.74 gonna1130.9 have1131.06 to1131.22 table1131.3 this1131.54 until1131.7 the1131.94 next1132.1 meeting,1132.34 but1133.38 I1133.78 don't1133.86 see1134.34 any1134.58 issues,1134.82 you1135.46 know,1135.54 when1135.78 I1136.02 review1136.18 it1136.5 with1136.66 the1136.9 rest1136.98 of1137.22 the1137.38 board.1137.46
1138.63 ABBEY1138.63 MYERS1138.63 -1138.63 CITY1138.63 OF1138.63 WATERTOWN1138.63 -1138.63 Yes.1138.63 Sorry.1139.12 Oh,1140.47 sorry.1140.72 I1142.47 can1142.8 administratively1143.43 approve,1144.56 this,1145.91 and1146.23 the1146.56 board1146.72 can1147.6 reaffirm1149.12 it1149.76 at1149.99 our1150.15 May1151.2 meeting1151.52 just1152.94 so1153.18 we1153.42 don't1153.58 delay1153.98 Prime1155.18 Medicine1156.06 if1156.06 that1156.38 is1156.62 amenable1157.1 to1157.5 you.1157.66
1159.1 AMIRTHARAJ1159.1 -1159.1 Yeah.1159.1 I1159.42 have1159.58 no1159.82 objection1159.98 to1160.38 that.1160.46
1161.26 MYERS1161.26 -1161.26 I1161.26 believe1161.42 there1161.74 was1161.98 no,1162.54 Maureen,1163.02 were1163.02 there1163.26 any1163.5 conditions1163.82 set1164.38 by1164.78 the1165.18 biosafety1166.62 committee?1167.26
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1765.38 AMIRTHARAJA1765.38 -1765.38 From1765.38 the1766.58 site1766.66 licensure,1767.06 I1768.02 think,1768.1 number1768.58 13,1768.82 the,1769.78 like,1771.45 presenting1771.69 their1772.26 application1773.05 to1773.62 the1773.78 board.1773.93 Like,1774.26 was1774.41 that1774.58 for1776.17 new1777.13 permits?1777.45
1779.38 MYERS1779.38 -1779.38 Yes.1779.38 So1782.34 we1782.34 were1782.58 discussing1782.97 to1783.62 ensure,1783.86 because1785.21 this1786.27 has1786.59 been1786.83 widely1787.07 unregulated1787.55 before,1788.35 but1789.39 we1789.55 already1789.71 have1789.95 preexisting1790.43 establishments.1791.07 We1791.87 were1792.03 trying1792.35 to1792.59 figure1792.75 out1793.07 if1793.31 they1793.55 would1793.71 need1793.95 to1794.11 come1794.27 before1796.27 the1796.59 board.1796.83 Our1797.79 attorney's1798.03 office1798.59 stated1799.42 that1799.74 it1799.98 is1800.14 in1800.31 their1800.46 opinion1800.63 that1800.95 they1801.18 do1801.35 need1801.59 to1801.74 come1801.83 forth1802.22 to1803.03 the1803.18 board1803.35 and1803.9 present.1806.87 And1808.46 a1808.87 couple1809.03 other1809.42 minor1809.83 comments1811.27 were1811.66 about1811.9 retention1812.22 rates.1812.79 There1814.48 was1814.72 a1816.48 notation1816.72 about1817.36 seeing1817.84 if1818.16 we1818.24 could1818.48 take1818.72 out1821.76 having1821.76 some1822.48 the1823.04 application1823.36 notarized1823.92 just1825.04 because1825.28 that1825.52 gets1825.68 a1825.92 little1826 bit1826.24 tricky1826.4 when1826.8 we're1827.04 doing1827.89 applications1828.21 online.1828.93 And1831.49 then1831.65 some1832.21 about1832.54 assigned1832.93 passport1833.41 photo.1833.89 I1834.54 think1834.62 my1834.93 lingering1835.26 questions1837.02 that1837.89 I1838.62 want1838.93 to1839.34 bring1839.58 to1840.21 the1840.69 board1840.93 are,1846.32 there1847.44 was1847.84 questions,1853.76 so,1855.44 sorry,1855.44 I1855.44 have1855.52 a1855.68 grayed1855.76 out1856 version.1856.24
1858.78 Yes.1858.78 So1860.54 in1860.87 a1861.35 section1861.35 of1863.66 under1863.98 personnel,1864.3 our1866.78 attorney's1867.11 office1867.66 put1867.98 no1868.38 person1868.54 in1868.87 an1870.16 establishment1870.16 shall1870.16 be1870.48 unclothed1870.72 including1871.36 patrons.1872.08 So1873.68 there1873.92 was1874.72 some1874.88 discussion,1875.12 internally1876.4 to1877.12 talk1877.28 about1877.44 if1878.8 they1880.56 are1880.8 doing1881.12 certain1882 body1882.32 works1882.64 things.1882.96 Does1884.9 it1885.07 need1888.02 to1888.18 be1888.35 someone1888.66 need1888.98 to1889.14 be1889.3 disrobed?1889.46 So1890.98 that1891.14 was1891.3 kind1891.46 of1891.63 a1891.78 question1891.87 we1892.42 were1892.59 going1892.83 back1893.07 and1893.3 forth1893.46 with1893.78 and1894.66 we1894.98 wanted1895.22 to1895.54 present1895.7 it1896.11 to1896.26 the1896.35 board.1896.51 We1896.98 are1897.14 going1897.3 to1897.54 do1897.7 a1897.94 little1898.02 bit1898.26 more1898.42 research.1898.74 Generally,1900.05 the1900.77 other1901.01 model1901.65 regulations1902.05 in1902.69 other1902.85 towns1903.17 state1904.21 no1904.53 one1904.93 shall1905.49 be1905.73 unclothed,1905.97 but1907.17 it1907.33 was1907.41 just1907.57 something1907.81 that1908.13 we1908.45 brought1908.69 up1908.93 when1909.09 we1909.33 did1909.49 a1909.65 reading1909.73 of1910.05 it1910.21 after1910.45 the1911.89 edits.1912.21 Additionally,1914.02 there1914.58 was1914.89 a1916.49 notation1916.82 of,1917.7 exposes1920.26 parts1922.26 of1922.82 the1923.46 body.1923.7 So1925.3 we1925.54 were1925.7 potentially1927.35 just1927.99 trying1928.31 to1928.71 bring1928.87 it1929.11 so1929.35 it1929.67 is1929.83 inclusive1929.99 of1930.63 everyone,1930.87 but1931.51 we1931.75 wanted1931.99 to1932.39 ensure1932.55 that1933.03 the1934.39 board1934.71 was1935.03 okay1935.19 with1935.51 that.1935.67
1936.87 AMIRTHARAJ1936.87 -1936.87 Yep.1936.87 Oh,1938.39 just1938.55 there1938.79 was,1938.87 on1939.59 that1939.83 personnel1939.99 part,1940.55 there1940.79 was1941.43 just1941.47 a1941.5 typo1941.75 there1942.15 for1942.63 patron,1942.79 just1943.74 FYI.1944.14
1945.35 MYERS1945.35 -1945.35 Oh,1945.35 that1945.98 would1946.38 be1946.63 great.1946.95
1949.35 AMIRTHARAJ1949.35 -1949.35 And1949.35 then,1949.59 I1951.11 know1951.27 when1951.42 we1951.59 do1951.74 physical1951.98 exam,1952.47 we1953.27 try1953.9 to1954.23 only1954.38 expose1954.87 the1955.9 part1956.07 that1956.55 we're1957.11 examining.1957.42
1958.92 MYERS1958.92 -1958.92 Yes.1958.92
1959.24 AMIRTHARAJ1959.24 -1959.24 Maybe1959.24 there1959.48 could1959.72 be1959.88 some1960.04 kind1960.2 of1960.44 wording1960.68 to1961.24 that1961.32 effect.1961.64 Like,1961.96 we1962.28 will1962.84 only1963.08 expose1963.32 the1963.88 part,1964.04 like,1965 for1965.24 a1965.4 needle1965.56 or1965.88 a1966.2 stone,1966.44 or1966.84 a1968.28 massage1968.84 or1968.84 whatever.1969 Like1969.4 yeah.1969.64
1970.6 MYERS1970.6 -1970.6 Expose1970.6 what1971.16 is1971.4 necessary1972.42 for1973.14 the1973.38 treatment.1973.54
1974.26 AMIRTHARAJ1974.26 -1974.26 Yeah.1974.26
1982.42 MYERS1982.42 -1982.42 That1986.65 is1986.81 a1987.13 really1987.37 good1987.61 point,1987.85 and1988.17 I1988.73 definitely1988.97 did1989.37 not1989.53 think1989.69 of1989.85 that.1990.01 So1990.25 thank1990.57 you.1990.73
1991.53 AMIRTHARAJ1991.53 -1991.53 Sure.1991.53 And1992.33 then,1992.49 for1993.13 that1993.37 section1993.61 91994.01 advertising,1994.41 I1998.84 get1999.15 it,1999.39 but2000.76 I2000.99 guess2001.15 my2001.63 question2001.71 would2002.03 be,2002.27 is2002.51 that,2002.67 like,2002.84 a2003.08 free2003.23 speech2003.47 thing2003.71 that2004.03 we2004.27 would2004.36 be2004.51 kind2004.76 of2006.51 infringing2006.76 on,2007.95 or?2008.27
2008.27 MYERS2008.27 -2008.27 I2008.27 can2008.27 bring2008.84 that2009.15 question2009.32 to2009.63 our2009.79 attorneys2010.03 because2010.51 they2010.91 wrote2011.71 that2012.03 section2012.36 entirely2013.32 or2014.73 they2014.97 added2015.13 that2015.45 entirely.2015.69 I2016.17 don't2016.25 think2016.49 it2016.65 was2016.81 in2017.13 my2017.69 draft2017.93 of2019.45 it,2020.01 so2020.25 I2020.25 will2020.41 ask.2020.65
2021.77 AMIRTHARAJ2021.77 -2021.77 I2021.89 mean,2022.01 I2022.97 understand2023.13 what,2023.93 I2024.17 mean,2024.33 they2024.65 would2024.81 know2025.05 that.2025.21 I'm2025.45 assuming2025.61 what2025.93 they2026.09 would2026.25
2026.49 MYERS2026.49 -2026.49 I2026.49 wouldn't,2027.05 but2027.05 it's,2027.37 I2027.59 rather2027.65 answer2027.72 any2027.78 questions2027.84 that2027.9 you2027.97 may2028.03 have2031.67 than2033.84 just2033.84 leave2033.99 it2034.08 up2034.23 to2034.47 them.2034.56 So2034.8 it2035.04 certainly,2035.28 I2035.91 can2036.08 follow2036.32 back2036.63 up2036.8 with2037.04 them2037.19 and2037.99 just2038.23 see2038.47 the2038.56 rationale2038.8 behind2039.43 it.2039.84
2041.19 AMIRTHARAJ2041.19 -2041.19 And2041.19 the2041.36 last2041.52 thing2041.76 I2042.08 had2042.39 was,2042.71 under2046.18 hearings,2046.58 section2047.7 4.2048.18 I2050.34 think2050.42 it2050.54 said2050.66 any2050.9 person2051.22 can,2051.94 like,2052.18 file2053.14 a2053.46 complaint2053.62 or2054.18 petition2054.74 the2055.14 court.2055.3 Does2056.02 that2056.18 include2056.42 clients2056.82 or2057.54 only2058.02 the2058.42 personnel,2059.45 the2059.82 facility?2060.18
2061.3 MYERS2061.3 -2061.3 I2061.3 would2061.45 say2061.78 any2063.14 applicant,2063.86 but2064.58 I2064.97 will2065.22 speak2065.7 to2066.02 them2066.09 to2066.49 see2066.66 if2066.89 we2067.06 can2067.22 change2067.45 it2067.7 to2068.41 applicant2068.82 or2069.61 personnel2071.06 versus2071.7 the2072.49 client2072.66 and2073.06 see2073.38 their2073.61 interpretation2074.26 of2074.82 it.2074.98
2075.78 AMIRTHARAJ2075.78 -2075.78 Yeah.2075.78
SHOW NON-ESSENTIAL DIALOGUE
MYERS2086.1 -2086.1 Perfect.2086.1 Yeah.2087.47 I2087.72 can2088.04 certainly2092.6 ask2092.6 our2092.91 attorney2093.24 that2093.72 is2094.04 working2094.28 on2094.6 this,2094.68 and2094.91 then2095.08 I2095.32 can2095.47 bring2095.72 you2096.43 the2096.6 answers2096.76 at2097.08 the2097.24 next2097.39 board2097.64 meeting.2097.88
2098.6 AMIRTHARAJ2098.6 -2098.6 Sure.2098.6 But2098.99 yeah.2099.16 I2099.28 mean,2099.39 it2099.64 looks2099.72 really2100.28 good2100.52 to2100.76 me.2100.91 I2101.72 mean,2101.8 I2102.04 don't2102.43 really2102.6 in2104.81 terms2104.97 of,2105.29 like,2105.45 fines2105.77 and2106.01 that2106.17 sort2106.33 of2106.49 stuff,2106.65 I2106.89 don't2107.05 really2107.21 know2107.37 what2107.69 the2107.93 standard2109.53 is2110.01 for2110.41 that.2110.57 So2111.05 I'm2111.29 deferring2111.45 to2111.85 you2111.93 guys2112.09 on2113.93
2113.93 MYERS2113.93 -2113.93 Yes.2113.93 I2114.41 believe2114.65 they2115.82 use2116.3 what2116.62 was2116.93 in2117.26 the2117.58 model2117.82 state2118.3 regulations2118.62 for2120.78 it2121.02 all.2121.18 I2121.41 think,2121.49 at2121.82 the2121.97 end2122.06 of2122.3 the2122.38 day,2122.93 and2123.58 what2123.58 I2124.86 like2125.02 to2125.41 tell2126.7 everyone2128.37 that2128.77 I'm2128.93 working2129.09 with2129.49 is2129.89 that,2130.29 I'm2130.61 not2130.93 here2131.49 to2131.73 fine2131.89 people2132.13 I'm2132.37 here2132.53 to2132.69 educate2132.85 people.2133.33 And2134.13 at2134.29 the2134.45 end2134.53 of2134.69 the2134.85 day,2134.93 I2135.25 just2135.49 want2135.89 a2136.37 safe2136.69 sanitary2137.49 establishment2138.29 that2139.57 is2139.73 following2140.3 the2141.18 directions.2141.43 So2142.07 if2142.7 any2143.03 Body2143.51 Works2143.82 establishments2145.82 ends2146.7 up2146.86 watching2147.11 this,2147.43 it's2147.82 that2148.46 we2148.78 just2148.94 want2149.26 to2149.43 ensure2149.66 that2150.22 you2151.59 are2152.07 being2152.39 saved2152.63 and2153.11 your2153.43 safety2155.55 is2156.03 a2156.19 priority2156.35 to2156.83 us2156.99 as2157.23 well2157.39 as2157.55 your2157.71 clients.2157.95 And2158.59 fines2160.51 aren't2161.07 meant2161.47 to2162.19 threaten2163.23 or2163.63 intimidate,2163.87 that2165.79 we2166.51 only2166.75 fine2167.07 when2167.31 we2167.55 really2169.07 need2169.47 to2172.24 enforce2172.89 something.2172.89 Education2172.89 is2172.89 always2173.13 my2174.16 kind2174.64 of2174.89 first2174.97 go2175.2 to.2175.37
2178.41 AMIRTHARAJ2178.41 -2178.41 Great.2178.41 And2179.37 then,2179.61 Maureen,2180.57 I2181.05 may2181.13 have2181.29 missed2181.53 it,2181.68 but2181.85 did2182.09 we2182.24 have2182.49 the2183.9 minutes2184.06 from2184.3 the2184.7 last2184.78 meeting2185.1 in2185.42 the2185.58 email?2185.74
2190.14 FOLEY2190.14 -2190.14 I2190.14 thought2191.34 I2191.58 did.2191.74 Didn't2192.78 I2193.02 usually2193.18 attach2193.58 everything?2194.14
2195.26 AMIRTHARAJ2195.26 -2195.26 Yeah.2195.26 I2195.9 see2196.06 the2196.3 Q12196.86 report,2197.1 the2200.3 Body2200.47 Works2200.78 regulation,2201.18 and2202.39 the2202.55 agenda.2202.78
2204.39 FOLEY2204.39 -2204.39 I2204.86 didn't2205.11 send2205.11 the2205.11 minutes?2205.11 They're2207.34 attached2207.66 to2208.14 the,2208.3
2209.74 AMIRTHARAJ2209.74 -2209.74 Unless2209.74 they're2210.14 attached2210.3 to2210.63 something2210.7 else.2211.03
2211.83 FOLEY2211.83 -2211.83 No.2211.83 They're2212.27 attached2212.71 to2213.83 the,2214.15 then2215.03 that2215.51 was2215.67 my2215.91 fault2216.07 for2216.39 not2216.55 sending2216.87 it2217.11 via2217.35 email,2217.67 but2218.55 it2218.95 is2219.11 on2219.51 this2220.07 agenda.2220.31
2222.55 MYERS2222.55 -2222.55 I2222.55 am2222.79 sending2223.03 them2223.43 over2223.75 right2224.31 now2224.55 just2224.95 because2225.11 I2225.43 had2225.75 it2225.99 up2226.23 anyways.2226.98 Not2230.66 that2230.91 we2231.14 can2231.3 vote2231.46 on2231.7 it2231.86 but2231.95 it2232.18 is2232.43 nice2232.74 to2233.14 read2233.39 them.2233.63
2235.55 FOLEY2235.55 -2235.55 I2235.55 can2235.7 send2235.95 them2236.18 tomorrow.2236.34
2237.22 AMIRTHARAJ2237.22 -2237.22 Okay.2237.22 Yeah.2237.55 I2237.7 think2237.78 it's2238.03 just2238.18 me2238.51 showing2239.35 my2240.31 advancing2240.63 age.2241.11 I'm2241.67 not2241.83 being2242.31 technologically2242.63 savvy.2243.35
SHOW NON-ESSENTIAL DIALOGUE
2266.4 FOLEY2266.4 -2266.4 Just2266.4 so2266.89 you2267.13 know,2267.2 the2267.7 next2267.94 meeting2268.58 would2268.9 be2269.14 May2269.46 21.2270.03 That's2270.98 the2271.22 third2271.38 Wednesday.2271.7
2272.58 AMIRTHARAJ2272.58 -2272.58 Alright.2272.58 Let2272.9 me2273.06 just2273.22 check2273.46 my2273.7 work2273.94 schedule.2274.26
2275.7 MYERS2275.7 -2275.7 And,2275.7 Maureen,2275.94 I2276.42 just2276.5 sent2276.74 them2276.98 on2277.3 over.2277.54 I2277.86 had2278.02 the2278.66 agenda2278.82 up2279.3 on2279.78 my2279.94 computer2280.1 anyways.2280.58
SHOW NON-ESSENTIAL DIALOGUE
2287.64 AMIRTHARAJ2287.64 -2287.64 Yep.2287.64 I2287.88 can2288.19 make2288.43 that.2288.68 No2288.91 problem.2289.16 Okay.2290.11
SHOW NON-ESSENTIAL DIALOGUE
2292.36 FOLEY2292.36 -2292.36 Oh,2292.36 I2293.32 think2293.47 I'm2293.71 gonna2293.88 be2294.19 out2294.36 of2294.51 town.2294.59
2295.73 AMIRTHARAJ2295.73 -2295.73 Oh,2295.73 okay.2295.89
2296.29 FOLEY2296.29 -2296.29 That's2296.29 alright.2296.53
2296.93 MYERS2296.93 -2296.93 I2296.93 will2297.09 be2297.33 here.2297.49 We'll2300.29 have2300.53 Lauren2300.77 take2301.09 the2301.33 minutes.2301.49
2302.29 FOLEY2302.29 -2302.29 Alright.2302.29 Oh,2303.25 yeah.2303.49 I'll2303.81 be2304.05 out2304.21 of2304.29 town.2304.37 Alright.2305.65
2306.29 MYERS2306.29 -2306.29 Perfect.2306.29
2307.17 AMIRTHARAJ2307.17 -2307.17 Alright.2307.17 So2307.73 I2307.89 guess2308.05 we'll2308.29 see2309.17 you2309.33 at2309.33 the2309.33 next2309.33 board2309.33 of2309.57 health2309.65 meeting.2309.97
2311.01 MYERS2311.01 -2311.01 Yes.2311.01 I2311.24 don't2311.4 think2312.53 we2312.84 need2313.01
2313.32 FOLEY2313.32 -2313.32 Ask2313.32 my2313.32 question.2313.4 So2317.89 what2318.2 Prime2318.76 is2319.24 doing,2319.4 they're2321.57 inserting2322.44 in2324.68 the2324.92 gene,2326.94 they're2327.34 inserting2327.34 a2328.38 good2328.62 gene,2332.46 but2333.18 do2333.18 you2333.34 just2333.5 take2333.82 one2334.06 cell?2334.46 Like,2335.1 say,2335.34 you2335.66 had2335.9 cystic2336.22 fibrosis2336.62 and2337.42 it's2337.66 in2337.82 the2337.98 lungs,2339.11 would2339.42 they2339.42 take2339.66 a2339.98 whole2340.07 bunch2340.3 of2340.63 cells,2340.86 or2341.82 would2341.98 they2342.14 take2342.39 just2342.7 one2343.18 cell2343.51 and2344.14 treat2345.34 that2345.82 one2346.14 cell2346.39 and2346.94 well2347.66 or2347.98 that2347.98 one2348.3 chromosome2350.22 and2351.11 or?2354.11
2354.19 AMIRTHARAJ2354.19 -2354.19 I2354.91 mean,2355.07 I2355.07 think2355.23 how2355.55 it2355.71 would2355.87 work2356.11 is,2356.35 like,2356.67 basically,2356.91 they2358.03 have2358.19 that2358.51 little2358.75 protein2359.23 proprietary2360.75 protein2361.47 thing2361.87 that2362.03 can2362.19 edit2362.35 the2362.67 gene.2363.71 And2363.87 then2363.87 they2365.06 would2365.41 inject,2365.78 like,2366.41 you2366.89 know,2367.06 millions2367.3 of2367.7 copies2367.93 of2368.34 that.2368.41 And2369.14 then2369.38 they2369.86 would2370.02 go2370.26 to2370.41 all2370.58 the2370.74 cells2370.89 in2371.22 the2371.38 lung2371.54 and2372.02 then2372.18 fix2372.49 that2372.74 one2373.06 specific2373.3 error2373.86 and2374.82 then2374.89 and2375.14 as2375.38 much2375.54 tissue2375.7 as2376.1 they2376.26 could.2376.41 And2377.14 then2377.3 that2377.61 would2377.86 be2378.02 the2378.26 goal.2378.34 Yeah.2378.74
2379.61 FOLEY2379.61 -2379.61 Okay.2379.61 I2380.71 was2380.87 just2381.11 curious2381.27 how2383.75 that2383.91 would2384.15 work.2384.39 Wow.2385.83
2386.39 MYERS2386.39 -2386.39 Perfect.2386.39
2387.35 FOLEY2387.35 -2387.35 Alright.2387.35 Thanks.2387.83