Watertown Biosafety Committee
Thursday December 4, 2025
The order of items in transcripts is the chronological order in which they were taken up. Some Agenda items may have been skipped.
BRAD14.34 PARSONS14.34 -14.34 BIOSAFETY14.34 COMMITTEE14.34 CHAIR14.34 -14.34 The14.34 meeting14.5 to14.89 order.15.13 Thank16.41 you,16.73 Mia.16.98 Just20.26 for20.73 the20.98 record,21.14 all23.7 members24.02 are24.41 present.24.49 Alright.29.21 Next31.05 up,31.45 we31.77 have32.01 approval32.81 of33.29 draft33.53 minutes33.85 for34.97 November.36.01 The37.58 November37.73 meeting38.22 as38.45 submitted38.61 by38.93 Maureen,39.17 on40.85 Tuesday.41.49 I43.9 feel44.13 like44.3 we44.45 just44.61 met.44.85 Was45.25 it45.38 is45.57 it45.73 just45.89 me?46.05 Like,46.53 I47.57 felt48.05 like48.3 yesterday48.45 we48.93 had49.09 our49.34 November49.49 meeting.49.98 So,50.38 does51.83 anyone52.07 from52.39 the52.55 committee52.71 have53.03 any,53.27 questions53.91 comments54.55 or54.95 clarifications55.11 for55.99 the56.23 minutes56.63 as57.27 submitted?57.51 All60.15 right.60.23 I60.55 see60.79 none.61.11 I63.51 move63.67 that63.91 we64.15 approve64.31 the64.63 minutes,64.71 as65.75 submitted65.99 by66.47 Marie.66.71 Alright.70.56 Me71.52 raise71.67 your72 hand.72.08 Quick73.35 show73.67 of73.92 hands.74 I74.88 let75.03 the75.19 record75.28 show,75.59 all76.08 members76.23 voted76.64 yes.77.03 79.28 MIA79.28 LIEBERMAN79.28 -79.28 BIOSAFETY79.28 COMMITTEE79.28 MEMBER79.28 -79.28 Okay.79.28 79.93 PARSONS79.93 -79.93 Okay.79.93 Okay.80.49 The80.65 names80.81 look81.13 familiar,81.37 but81.85 nonetheless,82.09 I'm82.57 gonna82.65 do82.89 my83.05 normal83.21 spiel83.61 for84.09 public84.25 comments.84.65 At85.85 this86.17 is86.41 the86.49 time86.65 if86.97 anyone87.13 from87.45 the,87.69 public88.33 wishes88.73 to89.05 make89.21 any89.45 comments89.69 to90.09 the90.25 committee,90.41 or91.93 ask92.17 us92.41 any92.57 questions.92.81 Happy93.93 to94.25 hear94.41 them.94.57 But96.81 please97.38 be97.61 aware97.85 that98.17 all98.42 questions,98.81 to100.42 applicants,100.97 are102.42 reserved102.66 for103.06 the103.13 committee.103.3 So104.09 if104.33 you104.42 have104.58 any104.73 public105.77 comments106.09 or106.66 questions106.89 that107.22 you107.38 would107.53 like107.61 to107.85 ask107.94 us,108.09 please108.81 raise109.22 your109.45 hand109.53 and,110.49 identify111.37 yourself111.85 by112.33 full112.49 name112.73 and112.97 address.113.13 Okay.121.61 Seeing122.25 none.122.65 We123.13 will123.29 get,123.53 right124.81 to125.21 it.125.37 So128.54 permits128.94 to129.43 review.129.59 So129.99 new130.39 permits,130.87 Century131.82 Therapeutics132.22 for135.91 the136.31 biosafety137.5 committee138.31 that138.94 is139.1 BTP298.139.34 Thank143.29 you,143.53 Maureen,144.65 for144.97 including145.21 that145.61 in145.93 the146.09 email.146.25 Sorry.150.33 I'm150.65 just150.81 pulling151.05 up151.29 my,151.53 your155.5 application.155.81 156.94 LIEBERMAN156.94 -156.94 Logged156.94 in156.94 to156.94 open157.09 gov,157.41 and157.66 it157.81 just157.97 logged158.53 me158.85 off,159.01 but159.89 I'm160.13 back160.29 in.160.46 What163.17 number163.41 did163.66 you163.74 say163.89 it164.06 was?164.13 165.09 PARSONS165.09 -165.09 298.165.09 BTP-298.166.88 You168.88 know,169.04 ever169.12 since169.36 they169.52 did169.68 the,169.84 the170.72 authentication170.8 thing,171.52 my171.84 problem172 went172.32 away,172.56 and172.8 I've172.96 had173.2 no173.44 problem173.6 at174.08 all,174.24 getting175.68 into176 OpenGov.176.32 So177.2 alright.177.68 Sorry.178.08 So180.41 Centric.180.81 So181.37 if181.76 anyone182.09 has182.32 a182.49 presentation,182.65 you're183.13 welcome183.37 to183.69 do183.76 it.183.93 I184.09 believe,184.25 Mia185.04 has185.37 made185.69 a186.17 couple186.25 of186.44 people,186.65 presenters,188.41 or,188.88 panelists.190.09 There190.88 we191.13 go.191.28 So193.33 Drake193.73 is194.29 sharing.194.61 So195.09 yeah.195.41 Why198.45 don't198.69 you198.77 show198.93 us199.09 what199.25 you199.41 got,199.49 and199.65 we'll199.89 see200.05 if200.21 we200.29 have200.45 any200.61 questions.200.77 201.73 DRAKE201.73 SMITH201.73 -201.73 CENTURY201.73 THERAPEAUTICS201.73 INC.201.73 -201.73 Alright.201.73 Thank203.65 you203.81 for203.97 taking204.13 thank204.53 you204.69 for204.93 allowing205.17 us205.49 the205.65 time205.73 to205.97 present206.13 this206.37 today.206.61 Again,207.14 please207.29 questions207.62 during208.18 or208.66 whenever208.97 is209.38 appropriate,209.78 I210.25 can210.34 handle.210.5 So211.78 I'm,212.01 my212.5 name212.57 is212.74 Drake212.9 Smith.213.22 I'm213.53 a213.69 principal213.86 scientist214.34 at214.9 Century215.06 Therapeutics,215.46 and216.01 I'll216.18 be216.34 running216.5 through216.74 a217.06 few217.14 slides217.29 here.217.62 We'll217.78 try218.09 to218.34 keep218.42 this,218.66 brief.219.06 So219.29 just219.46 ask219.78 if219.94 you'd220.09 like220.25 any220.42 more220.57 detail.220.81 So222.56 I'll222.72 go222.96 right223.36 into223.6 kind223.92 of,224 a224.48 big224.56 overview224.8 of225.2 Century's225.44 vision.225.76 Again,226.56 I'll226.72 keep226.88 this227.04 as227.36 brief227.52 as227.76 I227.84 can.228 In228.64 the228.88 current228.96 landscape,229.28 building230.48 a230.88 scalable,231.12 consistent,231.76 and232.24 broadly232.88 therapeutic,233.36 modality234.32 is234.88 difficult.235.12 And236.19 so236.35 part236.59 of236.75 how236.91 we're237.07 trying237.39 to237.72 address237.96 that,238.35 and239.07 one239.24 of239.39 the239.47 big239.56 limitations239.79 of240.28 other240.44 therapies240.75 is241.24 the241.47 kind241.88 of242.03 fragile242.19 source242.67 of243 primary243.16 cells243.56 that243.88 are244.03 out244.11 there.244.19 That's244.67 both244.91 autologous245.16 and245.72 donor245.88 derived.246.28 So247.07 in247.24 order247.31 to247.63 do247.72 that,247.88 we're248.11 trying248.35 to248.59 use,248.75 a250.21 foundry250.37 of250.85 induced251.01 pluripotent251.41 stem252.13 cells252.37 to252.85 supply253.57 cells253.97 for254.29 our254.45 therapeutic254.61 for255.33 our255.65 therapies.255.81 To258.05 date,258.21 many258.45 other258.69 people258.93 have259.17 tried259.41 this,259.65 but260.29 there's260.45 poor260.69 protection260.93 when261.49 you261.65 try261.81 to262.05 transplant262.21 these262.85 into263.09 patients,263.33 and264.62 the264.69 differentiation265.01 process265.81 in266.21 the266.38 lab266.54 is266.94 imprecise,267.42 and268.21 so268.38 we're268.54 putting268.86 effort269.1 into269.42 both269.65 of269.9 those,269.98 avenues270.62 as271.01 well.271.18 272.06 And272.06 so272.21 the272.38 solution272.62 we273.01 have273.18 here273.34 at273.5 the273.57 bottom273.65 really273.98 kind274.13 of274.3 has274.46 three274.78 focuses274.94 is,275.5 three275.98 focus.276.21 One277.02 is277.26 building277.5 a277.82 cell278.06 foundry,278.38 our278.86 actual279.1 process279.5 to280.06 differentiate280.54 these281.18 cells281.34 in281.66 the281.82 lab.281.9 The282.86 second283.02 is283.26 this283.5 immune283.82 cloaking284.3 engine,284.7 and285.1 this285.26 addresses285.5 the286.06 issue286.3 that286.62 sometimes286.94 comes287.34 when287.58 you287.74 try287.9 to288.06 transplant288.3 cells288.86 into289.26 patients.289.5 Specifically,290.81 I291.21 believe291.38 that291.62 our291.77 application291.94 here292.33 is292.57 for292.74 using292.81 recombinant293.13 DNA,293.62 and294.1 that294.25 is294.41 necessary294.81 to295.38 have295.45 on-site295.69 to296.25 kind296.57 of296.74 address296.89 our297.29 immune297.45 cloaking.297.85 And299.13 the299.38 last299.53 point300.25 is300.5 the300.65 scalable300.81 platform.301.29 So302.25 this302.41 is302.57 the302.65 actual302.74 the303.06 platform303.13 so303.53 that303.69 we303.77 can303.94 make304.1 enough304.25 of304.5 these304.65 cells304.81 to305.13 treat305.29 more305.69 people.308.15 So308.55 in308.71 this308.87 next309.03 slide,309.19 I309.43 again,309.51 I've309.67 I've309.91 kinda309.99 pulled310.23 out310.47 these310.63 three310.79 specific311.03 points,311.43 the311.75 cloaking311.91 engine,312.23 where312.55 we312.71 need312.79 to312.95 use313.03 this313.27 recombinant313.43 DNA313.99 to314.31 actually314.47 mitigate314.95 this315.35 or315.51 mediate315.75 this.316.23 The316.95 universal317.11 targeting,317.67 we're318.07 trying318.23 to318.55 build318.63 this318.87 big319.03 foundation319.27 to319.75 create319.91 many320.37 therapies320.69 for321.16 many321.4 different321.72 diseases.322.04 And322.85 then323.08 the323.25 cell323.32 foundry,323.56 again,324.04 to324.28 be324.37 able324.52 to324.69 making324.76 large325.16 batches325.49 of325.88 these325.96 cells326.13 to326.44 treat326.69 many327.08 patients.327.32 329.64 I329.64 think329.81 something330.04 else330.28 here330.52 to330.69 really330.84 focus331 on331.25 is331.49 this331.56 off-the-shelf332.13 cell332.37 therapy332.6 so332.93 that333.08 this333.25 is333.49 not333.56 a333.72 one-to-one334.2 therapy.334.44 This334.84 is335 something335.16 that's335.49 purchased,335.9 you336.3 know,336.38 much336.78 like337.02 any337.26 drug337.5 you337.74 would337.9 get.338.06 So340.38 for340.62 our340.78 manufacturing341.98 infrastructure342.7 here,343.34 really,343.9 again,344.22 this344.46 is344.7 a344.86 reiteration345.18 of345.74 the345.82 earlier345.98 points.346.38 We're346.7 trying346.94 to347.18 do347.26 a347.42 scalable,347.58 reproducible348.3 process,348.94 with350.15 consistent350.38 quality.350.87 And351.19 then,351.43 again,351.59 I351.82 think351.9 specific352.23 to352.55 this352.71 panel352.87 is353.19 this353.35 precise353.99 genomic354.38 control.354.94 So356.15 take356.46 or356.79 take356.94 we're357.19 taking357.35 cells,357.59 engineering358.71 them359.26 into359.43 pluripotent359.82 stem360.94 cells,361.19 engineering362.26 them362.58 so362.9 that363.06 they363.22 will363.54 have364.34 their364.58 therapeutic364.82 effect365.38 and365.7 be365.94 safe366.1 in366.42 patients.366.58 And367.7 then367.78 we're368.02 trying368.18 to368.42 make368.74 the369.06 cells369.22 to369.54 actually369.7 treat370.26 the370.5 patients,370.66 in371.38 a371.54 range371.94 of372.18 diseases.372.26 For375.25 a375.56 brief375.88 facility376.2 overview,376.69 I'm377.64 presenting377.88 from378.29 Century.378.61 Century379.32 acquired380.37 Clayd380.76 Therapeutics381.08 in381.73 2024.381.96 Clayd383.32 was383.64 launched383.81 in,384.2 Alexandria384.85 Launch385.4 Labs385.73 in386.04 2020.386.2 We're387.11 currently387.35 at387.75 201387.99 Brookline388.63 Avenue,389.19 and389.91 then390.07 we're390.23 planning390.87 to391.19 move391.27 into391.51 the391.75 99391.99 Coolidge392.47 Avenue,392.95 in393.75 January,394.15 February.394.55 Access396.39 control396.71 is397.11 key397.27 card397.43 access397.67 for397.99 the398.15 building.398.31 Pretty398.63 standard,399.19 several399.83 other400.23 companies400.47 in400.87 the401.03 building401.19 as401.51 well.401.67 Slide403.1 my403.66 windows404.38 here.404.78 406.06 Those406.06 lab406.38 design,406.63 has407.19 a407.5 main407.75 labs407.99 and408.31 also408.46 specific408.78 to409.26 your409.43 culture409.5 rooms,409.9 which410.22 are410.46 designated410.63 as411.1 a411.43 BSL411.58 2412.06 biosafety412.38 level413.5 2,413.82 and414.31 there's414.46 a414.7 dedicated414.87 waste415.26 room415.5 for415.82 the415.9 storage416.06 of416.38 biological416.54 waste.417.1 The418.14 building418.3 is418.7 managed418.94 by419.26 Alexandria419.66 Real420.22 Estate420.46 Equities,420.78 ARE.421.34 The422.46 office422.7 and423.18 laboratory423.42 spaces423.98 are424.46 located424.7 on425.02 the425.18 2nd425.26 Floor.425.58 The426.46 total426.7 square427.02 footage427.26 will427.58 be427.74 16,734428.94 with429.7 about429.87 10,000430.1 as430.66 this430.9 lab430.99 space431.22 and431.54 about431.7 7,000431.94 as432.66 office432.82 space.433.14 The436.26 next436.5 one.436.75 And437.7 for437.94 our438.34 actual438.5 biosafety438.9 program439.46 at440.1 Century,440.26 so441.06 safety441.31 training441.63 is441.87 conducted442.02 for442.43 all442.58 new442.82 hires442.99 and443.31 then443.46 annually443.63 thereafter.444.1 Emergency445.24 preparedness,445.8 chemical446.36 safety,446.76 biosafety,447.24 bloodborne448.52 pathogens,448.84 because449.24 we449.48 do449.56 work449.72 with449.88 human450.04 material,450.36 is450.92 given451.16 to451.4 all451.56 lab451.72 staff.452.04 Century453.08 Therapeutics453.4 is453.96 contracted454.12 with454.6 Mount454.76 Auburn455 Occupational455.48 Health456.04 for456.36 surveillance456.6 post457.16 exposure457.48 response,457.96 anything458.57 to458.9 do458.98 with459.13 that.459.38 And,460.01 again,460.18 because460.5 we460.74 do460.81 work460.98 with461.13 human461.3 material,461.62 a461.94 hue462.1 hepatitis462.42 B462.81 vaccination463.06 is463.54 offered463.77 to464.01 all464.18 lab464.5 staff464.81 free465.13 of465.3 charge.465.46 I468.18 wanted468.42 to468.74 keep469.06 it469.13 keep469.3 it469.46 tight.469.62 I469.86 know469.94 we've470.1 got,470.25 other470.65 people470.81 on471.13 the471.21 agenda.471.38 So471.77 that's472.01 the472.34 end472.5 of472.65 the472.74 slides472.81 I473.21 have473.3 there,473.54 but474.09 I'm474.17 happy474.25 to474.57 take474.65 any474.89 and475.13 all475.21 questions.475.45 479.69 PARSONS479.69 -479.69 Great.479.69 Thank480.01 you,480.25 Drake.480.49 So483.13 it's483.29 quite483.53 a484.09 change484.25 from484.65 Brookline485.61 Ave486.09 to,486.41 CoolJav.487.57 If,488.54 so490.13 are490.69 you490.77 affiliated492.13 with492.62 the492.77 Visa492.94 now493.33 or493.57 just,493.81 happen494.94 to495.25 be495.33 next495.5 door495.74 kinda496.06 thing,496.38 at497.5 in497.89 Boston?498.13 500.16 SMITH500.16 -500.16 In500.16 collaboration500.4 with,500.8 the501.28 Wiese,501.44 like,501.76 the501.84 Wiese502 Institute?502.32 503.28 PARSONS503.28 -503.28 Yeah.503.28 503.92 SMITH503.92 -503.92 Yeah.503.92 They're504.24 in504.4 the504.56 same504.72 building.504.96 In505.36 the,505.52 the505.92 building506 we506.32 work506.48 in506.72 has506.96 a507.2 is507.52 like507.68 a507.84 I508.16 call508.24 it508.4 an508.56 incubator508.72 space509.2 that509.36 has509.6 several509.76 other510 companies510.24 in510.64 there.510.72 So511.04 this511.28 is511.52 part511.76 of512 that,512.16 but512.32 we're,512.56 I'm513.52 not513.76 aware514 of514.25 any514.32 direct514.57 correlation514.8 there,515.2 but515.37 I'm515.52 sure515.61 there's515.85 a516 lot516.08 of,516.25 talks516.64 that516.88 occur517.13 between.517.37 518.64 PARSONS518.64 -518.64 Gotcha.518.64 Because519.2 so519.68 I520.25 work520.57 at520.8 Harvard.520.88 So521.2 in521.44 my521.52 mind,521.76 when521.92 I522.08 hear522.25 201522.49 Brookline,523.04 like,523.92 a524.4 little524.49 arrogantly525.52 Harvard526.08 centric,526.49 I'm526.88 like,527.04 oh,527.28 the527.37 Wyss527.52 Institute.527.76 There528.69 could528.93 be529.17 nothing529.41 else.529.73 530.77 SMITH530.77 -530.77 They're530.77 on,531.09 I531.33 think531.41 they're531.65 on531.73 the531.81 Top531.97 Floor.532.21 533.17 PARSONS533.17 -533.17 Okay.533.17 Alright.533.73 Alright.534.93 Cool.535.25 Alright.535.65 So,536.05 thank536.53 you536.69 very536.85 much.537.09 Yeah.538.93 I539.09 just539.25 have539.49 a539.73 couple539.97 of540.37 questions540.45 for541.25 you.541.49 So544 I544.15 see544.32 that544.39 you544.63 have544.71 a544.88 very544.96 small545.12 quantity545.36 generator545.91 for546.39 hazardous546.63 waste.547.03 What548.63 kind548.88 of549.2 hazardous549.27 waste549.75 are550.08 you550.24 generating?550.39 552.15 SMITH552.15 -552.15 So552.15 for552.39 I552.71 think552.79 this552.96 is553.12 probably553.2 specific553.51 to553.91 chemical554 waste.554.32 Our554.55 previous554.71 chemical555.03 waste555.36 is555.6 there's555.67 there's555.91 something556.24 to556.55 do556.71 with,556.88 and557.6 please,558.16 if558.88 David559.36 or559.68 Billy559.84 want560.32 to,560.48 also561.2 members561.52 from561.84 my562 company562.08 wanna562.4 wanna562.72 jump562.96 in563.28 here,563.36 they're563.52 welcome563.76 too.564.08 I565.12 think565.2 part565.44 of565.6 that565.68 chemical565.92 waste566.24 is,566.72 dyes568.16 used568.56 to568.88 stain569.12 cells569.44 when569.84 you're570 counting570.24 them.570.64 So571.33 they're571.4 specific,571.49 like,572.13 nucleic572.29 acid572.85 dyes.573.09 And574.21 that's574.61 why574.76 it's574.92 such575.09 a575.25 small575.33 batch575.57 because575.8 it's576.04 very,576.21 very576.45 small576.61 quantities.576.92 That's577.8 the578.13 that's578.37 the578.61 chemical578.76 waste579.09 I'm579.4 most,579.73 like,580.21 aware580.45 of.580.68 583.48 PARSONS583.48 -583.48 Okay.583.48 And583.96 you584.2 actually584.28 kinda,584.6 that585.72 segues585.96 into586.36 my586.68 next586.76 question,587 based588.12 off588.36 of,588.6 one589.08 of589.32 the589.4 things589.48 that589.72 you589.88 said,590.04 during590.84 your591.16 presentation,591.32 with592.76 the593 with593.16 the593.4 goal593.48 of593.8 creating593.88 large594.36 bat594.76 large595.16 batches595.56 of596.04 cells.596.2 But,596.76 like,596.92 what597.16 does597.32 that597.48 mean,597.64 like,597.96 in599.49 terms599.64 of599.96 actual600.21 volume?600.76 Like,601.25 the601.33 like,602.13 I603 know603.16 1000000603.28 cells603.8 can604.21 fit604.45 in604.76 a604.92 very605.08 small605.4 space,605.64 but,605.96 like,606.21 when606.52 you606.76 say,607 like,607.4 in607.64 your607.8 mind,608.13 in608.45 your608.61 company's608.76 mind,609.25 what609.73 does609.88 a610.04 large610.21 batch610.54 of610.86 sales611.02 mean611.34 in611.66 terms611.82 of612.06 volume?612.14 SMITH613.26 -613.26 Certainly.613.26 That's613.82 a614.06 great614.22 question,614.38 and614.7 it's614.94 a615.26 probably615.42 a615.74 clarification615.9 I616.46 need616.54 to616.7 give.616.78 So617.02 the617.18 location617.26 we'll617.74 be617.9 at618.06 at618.22 9618.38 Century618.78 has,619.34 labs620.22 in620.54 Philadelphia620.78 as621.42 well621.58 as621.74 New621.9 Jersey.622.14 So623.34 the623.5 lab623.82 we624.06 have624.22 is624.38 research624.54 scale.624.94 So625.46 the625.54 scale625.77 we625.93 work626.1 at626.34 is626.65 usually,626.89 like,627.13 under627.54 10627.93 liters.628.17 But629.62 for630.01 century,630.42 like,630.98 GMP631.38 manufacturing,631.86 it'll632.42 be632.74 dozens633.38 of633.77 liters,633.93 but634.25 that634.42 will634.58 not634.74 be634.89 done634.98 at635.13 this635.22 point.635.54 635.54 PARSONS635.54 -635.54 Okay.636.5 Alright.637.13 So637.38 that637.54 explains637.77 why638.1 on638.34 some638.58 of638.74 the638.82 documentation,638.98 there's639.62 a639.86 Philadelphia639.93 address,640.74 for641.91 ensure642.23 okay.642.55 643.43 SMITH643.43 -643.43 Exactly.643.43 643.91 PARSONS643.91 -643.91 Okay.643.91 Those644.31 are644.47 all644.63 my644.79 questions.645.03 Thank645.35 you.645.59 I'm646.47 just646.71 gonna646.87 go647.19 clockwise647.91 for648.71 how649.19 I649.51 see649.59 things649.83 for650.31 the650.47 committee.650.55 So,651.03 Mia,651.59 do651.83 you651.99 have652.07 any652.23 questions652.39 for652.79 Drake?653.03 654.02 LIEBERMAN654.02 -654.02 Yeah.654.02 I654.18 think654.26 this654.58 is654.9 a655.07 minor655.14 point655.46 that655.71 I'd655.78 put655.95 in656.18 the656.26 message.656.35 I656.58 think656.66 we're656.83 just656.99 waiting657.14 for657.38 the657.54 updated657.78 plan658.18 to,658.58 for660.02 the660.18 emergency660.35 representatives.660.9 I661.46 sent661.54 some661.71 language,661.95 I662.26 think,662.35 by662.5 email.662.75 So665.23 if665.38 we665.54 could665.71 get665.95 that666.02 uploaded,666.18 that666.58 would666.75 be666.9 appreciated.667.07 I667.92 don't668 think668.24 I668.32 had668.68 other669.04 quest669.52 oh,669.92 there670.16 was670.32 a670.48 question670.64 about,671.2 I674.08 think674.24 one674.48 of674.72 the674.96 documents676.48 didn't677.44 have677.84 the678.32 Watertown678.72 the679.36 workman's679.52 comp.680.08 Maureen,680.64 their681.21 workman's681.52 comp681.85 needs682.09 to682.17 have682.25 the682.4 Watertown682.57 address682.97 on683.28 it.683.52 Right?683.61 Okay.684.64 So684.88 we685.13 need685.28 an685.45 updated685.61 workman's686 comp686.4 with686.64 the686.8 Watertown686.97 address687.45 as687.76 well.687.92 688.73 PARSONS688.73 -688.73 Okay.688.73 I'm689.13 working689.37 on689.68 those689.85 changes690.09 now.690.49 So691.21 we691.61 should691.76 we692 should692.09 have692.33 those692.49 soon.693.21 694.24 LIEBERMAN694.24 -694.24 Okay.694.24 Great.694.56 Thank694.72 you694.96 for695.12 confirming.695.28 That695.76 was695.84 all696 for696.16 me.696.32 697.92 PARSONS697.92 -697.92 Ralph,697.92 any698.24 questions698.48 for698.88 Drake699.12 or699.44 Billy699.6 or699.92 Dave?700.08 RALPH700.88 MELE700.88 -700.88 BIOSAFETY700.88 COMMITTEE700.88 MEMBER700.88 -700.88 No700.88 questions.701.12 702.72 PARSONS702.72 -702.72 K.702.72 Coming703.04 back.703.36 Tim,704.08 you're704.48 up.704.8 Any705.12 questions?705.36 706.41 TIMOTHY706.41 MAGUIRE706.41 -706.41 BIOSAFETY706.41 COMMITTEE706.41 MEMBER706.41 -706.41 No.706.41 And706.74 I,707.05 know707.77 Greg708.1 resided708.33 for708.74 a708.81 long708.89 time,709.13 so709.29 I709.45 told709.53 him,709.77 welcome710.1 to710.33 the710.57 neighborhood.710.65 So711.21 it's711.45 great711.62 to711.86 have711.93 you712.17 guys712.25 here.712.41 713.38 SMITH713.38 -713.38 Awesome.713.38 Great.713.77 I'll713.93 tell714.1 him714.25 to714.33 say714.41 hi.714.57 717.62 PARSONS717.62 -717.62 There's717.62 no718.01 conflict718.17 of718.57 interest718.74 for719.13 the,719.29 record.720.01 Deb,722.72 any723.2 questions,723.76 for724.72 Century?724.96 725.36 DEBORAH725.36 MCEWAN725.36 -725.36 BIOSAFETY725.36 COMMITTEE725.36 MEMBER725.36 -725.36 Thank725.36 you.725.76 Okay.726.8 Great.727.28 728.72 PARSONS728.72 -728.72 Alright.728.72 Then,729.12 so730.08 for730.8 Century731.12 representatives,731.6 in732.72 case732.88 you're733.12 not733.28 aware,733.44 this733.92 is734.08 when734.16 the734.4 sad734.48 trombone734.72 kicks735.61 in.735.93 We736.64 don't736.88 give737.29 permits.737.85 The739.93 board740.09 of740.33 health740.4 gives740.64 permits.740.97 So741.45 the742.33 board742.49 of742.61 health,742.73 will743.68 move744 on744.4 our744.73 recommendations.745.05 So745.85 you746 do746.25 need746.49 to746.64 go748.14 to748.38 the748.46 board748.62 of748.86 health,748.94 to750.06 get750.62 your750.78 actual750.94 permit.751.42 So753.1 I753.34 make753.42 a753.66 motion753.74 that754.38 the754.7 Watertown754.86 Biosafety755.34 Committee,756.22 recommends758.46 the758.94 century759.18 application,759.74 as761.79 submitted762.02 with762.43 the762.83 addition762.9 of,763.55 with764.43 the764.67 clarification764.83 of765.55 the765.63 plan765.87 to766.11 orient766.35 Watertown768.11 representatives768.67 and769.55 clarification770.02 on770.9 the,771.38 workman's773.14 comp773.87 affidavit774.26 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SHOW NON-ESSENTIAL DIALOGUE
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therapies.1007.82 We're1009 a1009.15 partnership1009.32 model,1009.71 so1009.96 we1010.2 kind1010.36 of1010.51 partner1010.67 with1011 larger1013.08 pharmaceutical1013.63 companies,1014.6 and1014.91 they1015.08 kind1015.39 of1015.55 validate1015.63 and1016.03 test1016.12 their1016.36 capsids,1016.51 to1017.55 eventually1017.79 help1018.27 patients.1018.51 So1020.03 I'm1020.2 the1020.36 EHS1020.51 manager1020.91 there.1021.24 And,1022.54 historically,1022.86 we've1024.54 had1024.86 one1026.46 large1027.02 project1027.5 registration,1027.82 for1029.58 Dyno1029.9 Therapeutics1030.7 that1030.7 kind1030.94 of1031.1 included1031.18 all1031.5 of1031.66 our1031.82 work.1031.9 And,1033.42 I1033.9 think1033.98 I've1034.22 been1034.38 here1034.54 many1034.7 times1034.94 for1035.26 different1035.66 amendments1036.14 and1036.99 adjustments1037.15 as1037.63 well.1037.71 1038.6 So,1038.6 what1038.91 I1039.08 wanted1039.23 to1039.47 do,1039.56 a1039.88 goal1039.95 of1040.19 mine,1040.36 was1040.67 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work1164.57 with,1164.72 common1165.2 human1165.85 cell1166.16 lines,1166.4 such1168.24 as1168.48 2931169.61 T,1169.85 VPC1169.85 2,1170.4 and1171.04 HUH71172.32 cells.1172.72 So1173.6 these1173.76 are1174 already1174.16 cell1174.48 lines1174.56 that1174.8 we're1174.96 you1175.44 know,1175.6 we've1175.76 been1175.92 working1176 with.1176.24 They've1176.4 already1176.64 been1176.96 approved.1177.12 But,1178.88 basically,1179.04 we're1179.36 using1179.68 this1179.92 CRISPR1180.16 method,1180.56 with1181.92 the1182.24 protein1182.56 and1182.96 guide1183.04 RNAs1183.28 and1184.48 complex1185.04 them,1185.52 using,1186.32 we1187.41 talked1187.7 about1187.94 nuclear1188.11 affection1188.59 or1189.31 lipofection.1189.55 I1190.18 think1190.27 we're1190.35 leaning1190.59 towards1190.83 doing1191.07 lipofection1191.46 to1192.51 do1192.59 this.1192.66 Basically,1193.94 target1194.42 specific1194.74 genes1195.14 for1195.55 knockout.1195.79 This1197.79 will1197.94 kind1198.11 of1200.9 take1201.22 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like4774.43 that.4774.59 So,4776.51 yeah,4776.75 don't4777.23 don't4778.35 wait4779.07 three4781.05 days4781.36 before4781.76 well,4782.89 we're4783.2 gonna4783.44 decide4783.69 when4784.09 our4784.24 next4784.32 meeting4784.56 is,4784.89 that's4785.36 our4785.6 next4785.76 agenda4786.09 item.4786.56 You4787.6 know,4787.69 you4787.76 don't4787.93 have4788.09 to4788.24 do4788.32 that.4788.48 Just4788.8 please4789.13 some4790.09 peep4790.24 I4790.56 sometimes4791.13 I4791.52 get4791.6 the4791.76 sense4791.93 they4792.24 think4792.4 some4793.05 of4793.13 these4793.28 companies4793.52 in4794.83 Watertown4794.99 think4795.47 this4795.71 is4795.87 a4795.95 once-a-month4796.43 relationship,4796.83 or4798.51 worse,4799.31 once4799.79 a4800.11 year4800.19 in4800.75 from4801.63 November4801.87 to4802.35 December4802.51 when4802.99 we're4803.23 riding4803.79 them4804.11 to4804.51 get4804.67 their4804.91 up,4807.34 renewals4808.3 in.4808.85 It's4809.41 anytime.4810.14 Just4810.78 shoot4811.1 an4811.34 email4811.49 if4811.82 you4811.9 have4812.06 a4812.14 question,4812.22 please.4812.7 4813.1 BAXLEY4813.1 -4813.1 That's4813.34 good.4813.57 That's4813.74 one4814.06 of4814.06 the4814.14 things4814.3 I've4814.53 appreciated,4814.7 about4815.49 the4815.74 folks4816.06 at4816.38 Newton4816.53 is,4816.94 we4817.82 talk4818.06 a4818.22 lot4818.3 more4818.53 than4818.7 once4818.85 a4819.1 year.4819.26 4820.16 PARSONS4822.16 -4822.16 Yeah.4822.16 And4822.48 that's4822.72 a4822.88 good4822.96 thing.4823.12 4823.84 BAXLEY4823.84 -4823.84 Oh,4823.84 yes.4824.08 It4824.48 is.4824.56 Yeah.4824.88 We4825.28 agree.4825.52 4828.08 BORDEN4829.44 -4829.44 Thank4829.44 you4829.68 all.4829.92 Thank4831.52 you.4831.76 Well,4833.18 we're4834.45 very4834.7 much4834.85 looking4835.1 forward4835.34 to4835.57 being4835.66 in4835.81 Watertown.4835.9 This4836.38 is4836.53 an4836.7 extremely4836.94 exciting4837.49 expansion4838.61 of4839.1 our4839.57 business.4839.74 And,4840.45 you4840.85 know,4841.02 one4841.26 of4841.49 the4841.57 reasons4841.66 we4842.06 expanded4843.18 into4843.74 Watertown4843.98 was4844.53 with4844.77 some4844.94 of4845.1 the,4845.26 you4846 know,4846.24 the4847.04 amount4847.44 of4847.84 biz4848 of4848.4 life4848.48 science4848.72 business4849.04 that's4849.28 already4849.52 here.4850.16 With4850.96 support4851.36 from4851.36 you4851.6 folks4851.76 and4852.08 others,4852.48 the4852.88 institutions4853.52 that4854 have4854.16 been4854.24 built4854.4 have4854.8 created4855.04 a4855.36 great4855.52 cluster4855.76 that4856.24 we4856.72 wanna4856.88 be4857.2 a4857.36 part4857.44 of.4857.68 So,4858.02 you4858.26 know,4858.43 you4858.55 4858.9 PARSONS4858.9 -4858.9 Right.4858.9 And4859.06 while4859.22 you4859.39 that's4859.63 a4859.86 gorgeous4860.02 building4860.51 too.4860.9 4862.02 BORDEN4862.02 -4862.02 It4862.02 is.4862.1 It4862.59 is.4862.74 We're4862.9 excited4863.15 about4863.63 that.4863.78 So4864.34 4864.74 PARSONS4864.74 -4864.74 Yeah.4864.74 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I4899.96 just4900.12 had4900.36 this4900.52 I4901.88 can't4902.12 imagine4902.36 how4903.88 much4904.12 money4904.36 they're4904.6 spending4904.92 to4906.44 do4906.6 that4906.84 for4907.16 the4907.32 1st4907.48 Floor.4907.88 I4908.6 mean,4908.84 that4910.13 whole4910.2 space4910.52 was4910.85 built4911.01 with4911.24 the4911.41 dream4912.52 of4913.56 having4913.73 one4914.05 tenant.4914.28 Right?4914.6 I4914.85 mean,4914.93 that's4915.09 what4915.32 these4915.89 developers4916.13 do.4916.77 It's4917.32 cheaper4917.56 that4918.05 way,4918.2 and4918.85 it's4919.01 easier4919.24 for4920.45 building4920.77 management4921.09 to4921.89 have4922.05 a4922.45 tenant4922.6 versus4923.09 124923.56 per4924.54 floor.4924.86 And4925.74 so4926.06 that4926.22 to4926.54 put4926.7 all4926.94 those4927.02 walls4927.26 up,4927.5 my4927.66 god,4927.9 and4928.14 they4928.3 got4928.38 to4928.62 balance4928.78 the4929.26 air?4929.42 I4929.74 mean,4929.9 that's4930.14 these4932.54 clients4933.02 pay4933.9 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